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Q96P65 (QRFPR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyroglutamylated RFamide peptide receptor
Alternative name(s):
AQ27
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP receptor
SP9155
Gene names
Name:QRFPR
Synonyms:GPR103
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid. Ref.1 Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAL26488.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Pyroglutamylated RFamide peptide receptor
PRO_0000070097

Regions

Topological domain1 – 4646Extracellular Potential
Transmembrane47 – 6721Helical; Name=1; Potential
Topological domain68 – 8114Cytoplasmic Potential
Transmembrane82 – 10221Helical; Name=2; Potential
Topological domain103 – 12018Extracellular Potential
Transmembrane121 – 14121Helical; Name=3; Potential
Topological domain142 – 16221Cytoplasmic Potential
Transmembrane163 – 18321Helical; Name=4; Potential
Topological domain184 – 21229Extracellular Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 27138Cytoplasmic Potential
Transmembrane272 – 29221Helical; Name=6; Potential
Topological domain293 – 31119Extracellular Potential
Transmembrane312 – 33221Helical; Name=7; Potential
Topological domain333 – 43199Cytoplasmic Potential

Amino acid modifications

Glycosylation191N-linked (GlcNAc...) Potential

Natural variations

Natural variant611F → V.
Corresponds to variant rs17438900 [ dbSNP | Ensembl ].
VAR_049437
Natural variant1491H → Q.
Corresponds to variant rs11947418 [ dbSNP | Ensembl ].
VAR_049438
Natural variant3441L → S.
Corresponds to variant rs2302310 [ dbSNP | Ensembl ].
VAR_049439

Experimental info

Sequence conflict28 – 292LY → VH in BAC98938. Ref.3
Sequence conflict220 – 26647VILFL…SKIAR → SSSSSCLLW in AAL26488. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96P65 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 778D9AE70528024D

FASTA43149,488
        10         20         30         40         50         60 
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL 

        70         80         90        100        110        120 
FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM 

       130        140        150        160        170        180 
VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM 

       190        200        210        220        230        240 
WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE 

       250        260        270        280        290        300 
LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN 

       310        320        330        340        350        360 
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ 

       370        380        390        400        410        420 
RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE 

       430 
LAENSPLDSG H 

« Hide

References

[1]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"A new peptidic ligand and its receptor regulating adrenal function in rats."
Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411117 mRNA. Translation: AAL26488.1. Different initiation.
AB109629 mRNA. Translation: BAC98938.1.
RefSeqNP_937822.2. NM_198179.2.
UniGeneHs.368977.

3D structure databases

ProteinModelPortalQ96P65.
SMRQ96P65. Positions 46-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123897. 1 interaction.
STRING9606.ENSP00000335610.

Chemistry

BindingDBQ96P65.
ChEMBLCHEMBL5852.
GuidetoPHARMACOLOGY333.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96P65.

Polymorphism databases

DMDM47117904.

Proteomic databases

PaxDbQ96P65.
PeptideAtlasQ96P65.
PRIDEQ96P65.

Protocols and materials databases

DNASU84109.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394427; ENSP00000377948; ENSG00000186867.
GeneID84109.
KEGGhsa:84109.
UCSCuc010inj.1. human.

Organism-specific databases

CTD84109.
GeneCardsGC04M122249.
H-InvDBHIX0031352.
HGNCHGNC:15565. QRFPR.
HPAHPA014300.
MIM606925. gene.
neXtProtNX_Q96P65.
PharmGKBPA164725243.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149782.
HOGENOMHOG000136537.
HOVERGENHBG067831.
InParanoidQ96P65.
KOK08378.
OMAGNALVFY.
PhylomeDBQ96P65.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ96P65.
BgeeQ96P65.
CleanExHS_QRFPR.
GenevestigatorQ96P65.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPyroglutamylated_RFamide_peptide_receptor.
GenomeRNAi84109.
NextBio73381.
PROQ96P65.
SOURCESearch...

Entry information

Entry nameQRFPR_HUMAN
AccessionPrimary (citable) accession number: Q96P65
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries