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Protein

Pyroglutamylated RFamide peptide receptor

Gene

QRFPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamylated RFamide peptide receptor
Alternative name(s):
AQ27
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP receptor
SP9155
Gene namesi
Name:QRFPR
Synonyms:GPR103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15565. QRFPR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini68 – 8114CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 12018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 21229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 27138CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini293 – 31119ExtracellularSequence AnalysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini333 – 43199CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725243.

Polymorphism and mutation databases

BioMutaiQRFPR.
DMDMi47117904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Pyroglutamylated RFamide peptide receptorPRO_0000070097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96P65.
PaxDbiQ96P65.
PeptideAtlasiQ96P65.
PRIDEiQ96P65.

PTM databases

PhosphoSiteiQ96P65.

Expressioni

Tissue specificityi

Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.2 Publications

Gene expression databases

BgeeiQ96P65.
CleanExiHS_QRFPR.
ExpressionAtlasiQ96P65. baseline and differential.
GenevisibleiQ96P65. HS.

Organism-specific databases

HPAiHPA014300.

Interactioni

Protein-protein interaction databases

BioGridi123897. 1 interaction.
STRINGi9606.ENSP00000377948.

Structurei

3D structure databases

ProteinModelPortaliQ96P65.
SMRiQ96P65. Positions 41-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149782.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000136537.
HOVERGENiHBG067831.
InParanoidiQ96P65.
KOiK08378.
OMAiHPLKMKW.
PhylomeDBiQ96P65.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL
60 70 80 90 100
TGVLIFALAL FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP
110 120 130 140 150
VTMLQNISDN WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP
160 170 180 190 200
FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM WHVQQLEIKY DFLYEKEHIC
210 220 230 240 250
CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE LWIKKRVGDG
260 270 280 290 300
SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
310 320 330 340 350
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC
360 370 380 390 400
IVNKTFSPAQ RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL
410 420 430
CEQTEEKKKL KRHLALFRSE LAENSPLDSG H
Length:431
Mass (Da):49,488
Last modified:May 10, 2004 - v2
Checksum:i778D9AE70528024D
GO

Sequence cautioni

The sequence AAL26488.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292LY → VH in BAC98938 (PubMed:12960173).Curated
Sequence conflicti220 – 26647VILFL…SKIAR → SSSSSCLLW in AAL26488 (PubMed:11574155).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611F → V.
Corresponds to variant rs17438900 [ dbSNP | Ensembl ].
VAR_049437
Natural varianti149 – 1491H → Q.
Corresponds to variant rs11947418 [ dbSNP | Ensembl ].
VAR_049438
Natural varianti344 – 3441L → S.
Corresponds to variant rs2302310 [ dbSNP | Ensembl ].
VAR_049439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411117 mRNA. Translation: AAL26488.1. Different initiation.
AB109629 mRNA. Translation: BAC98938.1.
CCDSiCCDS3719.1.
RefSeqiNP_937822.2. NM_198179.2.
UniGeneiHs.368977.

Genome annotation databases

EnsembliENST00000394427; ENSP00000377948; ENSG00000186867.
GeneIDi84109.
KEGGihsa:84109.
UCSCiuc010inj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411117 mRNA. Translation: AAL26488.1. Different initiation.
AB109629 mRNA. Translation: BAC98938.1.
CCDSiCCDS3719.1.
RefSeqiNP_937822.2. NM_198179.2.
UniGeneiHs.368977.

3D structure databases

ProteinModelPortaliQ96P65.
SMRiQ96P65. Positions 41-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123897. 1 interaction.
STRINGi9606.ENSP00000377948.

Chemistry

BindingDBiQ96P65.
ChEMBLiCHEMBL5852.
GuidetoPHARMACOLOGYi333.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96P65.

Polymorphism and mutation databases

BioMutaiQRFPR.
DMDMi47117904.

Proteomic databases

MaxQBiQ96P65.
PaxDbiQ96P65.
PeptideAtlasiQ96P65.
PRIDEiQ96P65.

Protocols and materials databases

DNASUi84109.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394427; ENSP00000377948; ENSG00000186867.
GeneIDi84109.
KEGGihsa:84109.
UCSCiuc010inj.1. human.

Organism-specific databases

CTDi84109.
GeneCardsiGC04M122249.
H-InvDBHIX0031352.
HGNCiHGNC:15565. QRFPR.
HPAiHPA014300.
MIMi606925. gene.
neXtProtiNX_Q96P65.
PharmGKBiPA164725243.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149782.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000136537.
HOVERGENiHBG067831.
InParanoidiQ96P65.
KOiK08378.
OMAiHPLKMKW.
PhylomeDBiQ96P65.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiPyroglutamylated_RFamide_peptide_receptor.
GenomeRNAii84109.
NextBioi73381.
PROiQ96P65.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P65.
CleanExiHS_QRFPR.
ExpressionAtlasiQ96P65. baseline and differential.
GenevisibleiQ96P65. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
    Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
    J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "A new peptidic ligand and its receptor regulating adrenal function in rats."
    Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
    J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Fetal brain.

Entry informationi

Entry nameiQRFPR_HUMAN
AccessioniPrimary (citable) accession number: Q96P65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.