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Q96P65

- QRFPR_HUMAN

UniProt

Q96P65 - QRFPR_HUMAN

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Protein

Pyroglutamylated RFamide peptide receptor

Gene
QRFPR, GPR103
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamylated RFamide peptide receptor
Alternative name(s):
AQ27
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP receptor
SP9155
Gene namesi
Name:QRFPR
Synonyms:GPR103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:15565. QRFPR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Extracellular Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 8114Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini103 – 12018Extracellular Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini142 – 16221Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini184 – 21229Extracellular Reviewed predictionAdd
BLAST
Transmembranei213 – 23321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini234 – 27138Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini293 – 31119Extracellular Reviewed predictionAdd
BLAST
Transmembranei312 – 33221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini333 – 43199Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Pyroglutamylated RFamide peptide receptorPRO_0000070097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96P65.
PaxDbiQ96P65.
PeptideAtlasiQ96P65.
PRIDEiQ96P65.

PTM databases

PhosphoSiteiQ96P65.

Expressioni

Tissue specificityi

Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.2 Publications

Gene expression databases

ArrayExpressiQ96P65.
BgeeiQ96P65.
CleanExiHS_QRFPR.
GenevestigatoriQ96P65.

Organism-specific databases

HPAiHPA014300.

Interactioni

Protein-protein interaction databases

BioGridi123897. 1 interaction.
STRINGi9606.ENSP00000335610.

Structurei

3D structure databases

ProteinModelPortaliQ96P65.
SMRiQ96P65. Positions 46-340.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149782.
HOGENOMiHOG000136537.
HOVERGENiHBG067831.
InParanoidiQ96P65.
KOiK08378.
OMAiHPLKMKW.
PhylomeDBiQ96P65.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P65-1 [UniParc]FASTAAdd to Basket

« Hide

MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL    50
TGVLIFALAL FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP 100
VTMLQNISDN WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP 150
FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM WHVQQLEIKY DFLYEKEHIC 200
CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE LWIKKRVGDG 250
SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN 300
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC 350
IVNKTFSPAQ RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL 400
CEQTEEKKKL KRHLALFRSE LAENSPLDSG H 431
Length:431
Mass (Da):49,488
Last modified:May 10, 2004 - v2
Checksum:i778D9AE70528024D
GO

Sequence cautioni

The sequence AAL26488.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611F → V.
Corresponds to variant rs17438900 [ dbSNP | Ensembl ].
VAR_049437
Natural varianti149 – 1491H → Q.
Corresponds to variant rs11947418 [ dbSNP | Ensembl ].
VAR_049438
Natural varianti344 – 3441L → S.
Corresponds to variant rs2302310 [ dbSNP | Ensembl ].
VAR_049439

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292LY → VH in BAC98938. 1 Publication
Sequence conflicti220 – 26647VILFL…SKIAR → SSSSSCLLW in AAL26488. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411117 mRNA. Translation: AAL26488.1. Different initiation.
AB109629 mRNA. Translation: BAC98938.1.
CCDSiCCDS3719.1.
RefSeqiNP_937822.2. NM_198179.2.
UniGeneiHs.368977.

Genome annotation databases

EnsembliENST00000394427; ENSP00000377948; ENSG00000186867.
GeneIDi84109.
KEGGihsa:84109.
UCSCiuc010inj.1. human.

Polymorphism databases

DMDMi47117904.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411117 mRNA. Translation: AAL26488.1 . Different initiation.
AB109629 mRNA. Translation: BAC98938.1 .
CCDSi CCDS3719.1.
RefSeqi NP_937822.2. NM_198179.2.
UniGenei Hs.368977.

3D structure databases

ProteinModelPortali Q96P65.
SMRi Q96P65. Positions 46-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123897. 1 interaction.
STRINGi 9606.ENSP00000335610.

Chemistry

BindingDBi Q96P65.
ChEMBLi CHEMBL5852.
GuidetoPHARMACOLOGYi 333.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96P65.

Polymorphism databases

DMDMi 47117904.

Proteomic databases

MaxQBi Q96P65.
PaxDbi Q96P65.
PeptideAtlasi Q96P65.
PRIDEi Q96P65.

Protocols and materials databases

DNASUi 84109.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394427 ; ENSP00000377948 ; ENSG00000186867 .
GeneIDi 84109.
KEGGi hsa:84109.
UCSCi uc010inj.1. human.

Organism-specific databases

CTDi 84109.
GeneCardsi GC04M122249.
H-InvDB HIX0031352.
HGNCi HGNC:15565. QRFPR.
HPAi HPA014300.
MIMi 606925. gene.
neXtProti NX_Q96P65.
PharmGKBi PA164725243.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149782.
HOGENOMi HOG000136537.
HOVERGENi HBG067831.
InParanoidi Q96P65.
KOi K08378.
OMAi HPLKMKW.
PhylomeDBi Q96P65.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Pyroglutamylated_RFamide_peptide_receptor.
GenomeRNAii 84109.
NextBioi 73381.
PROi Q96P65.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96P65.
Bgeei Q96P65.
CleanExi HS_QRFPR.
Genevestigatori Q96P65.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
    Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
    J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "A new peptidic ligand and its receptor regulating adrenal function in rats."
    Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
    J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Fetal brain.

Entry informationi

Entry nameiQRFPR_HUMAN
AccessioniPrimary (citable) accession number: Q96P65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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