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Q96P65

- QRFPR_HUMAN

UniProt

Q96P65 - QRFPR_HUMAN

Protein

Pyroglutamylated RFamide peptide receptor

Gene

QRFPR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB
    2. neuropeptide Y receptor activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyroglutamylated RFamide peptide receptor
    Alternative name(s):
    AQ27
    G-protein coupled receptor 103
    Orexigenic neuropeptide QRFP receptor
    SP9155
    Gene namesi
    Name:QRFPR
    Synonyms:GPR103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:15565. QRFPR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725243.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Pyroglutamylated RFamide peptide receptorPRO_0000070097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96P65.
    PaxDbiQ96P65.
    PeptideAtlasiQ96P65.
    PRIDEiQ96P65.

    PTM databases

    PhosphoSiteiQ96P65.

    Expressioni

    Tissue specificityi

    Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.2 Publications

    Gene expression databases

    ArrayExpressiQ96P65.
    BgeeiQ96P65.
    CleanExiHS_QRFPR.
    GenevestigatoriQ96P65.

    Organism-specific databases

    HPAiHPA014300.

    Interactioni

    Protein-protein interaction databases

    BioGridi123897. 1 interaction.
    STRINGi9606.ENSP00000335610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P65.
    SMRiQ96P65. Positions 46-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini184 – 21229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 27138CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 43199CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149782.
    HOGENOMiHOG000136537.
    HOVERGENiHBG067831.
    InParanoidiQ96P65.
    KOiK08378.
    OMAiHPLKMKW.
    PhylomeDBiQ96P65.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96P65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL    50
    TGVLIFALAL FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP 100
    VTMLQNISDN WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP 150
    FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM WHVQQLEIKY DFLYEKEHIC 200
    CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE LWIKKRVGDG 250
    SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN 300
    FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC 350
    IVNKTFSPAQ RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL 400
    CEQTEEKKKL KRHLALFRSE LAENSPLDSG H 431
    Length:431
    Mass (Da):49,488
    Last modified:May 10, 2004 - v2
    Checksum:i778D9AE70528024D
    GO

    Sequence cautioni

    The sequence AAL26488.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 292LY → VH in BAC98938. (PubMed:12960173)Curated
    Sequence conflicti220 – 26647VILFL…SKIAR → SSSSSCLLW in AAL26488. (PubMed:11574155)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611F → V.
    Corresponds to variant rs17438900 [ dbSNP | Ensembl ].
    VAR_049437
    Natural varianti149 – 1491H → Q.
    Corresponds to variant rs11947418 [ dbSNP | Ensembl ].
    VAR_049438
    Natural varianti344 – 3441L → S.
    Corresponds to variant rs2302310 [ dbSNP | Ensembl ].
    VAR_049439

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411117 mRNA. Translation: AAL26488.1. Different initiation.
    AB109629 mRNA. Translation: BAC98938.1.
    CCDSiCCDS3719.1.
    RefSeqiNP_937822.2. NM_198179.2.
    UniGeneiHs.368977.

    Genome annotation databases

    EnsembliENST00000394427; ENSP00000377948; ENSG00000186867.
    GeneIDi84109.
    KEGGihsa:84109.
    UCSCiuc010inj.1. human.

    Polymorphism databases

    DMDMi47117904.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411117 mRNA. Translation: AAL26488.1 . Different initiation.
    AB109629 mRNA. Translation: BAC98938.1 .
    CCDSi CCDS3719.1.
    RefSeqi NP_937822.2. NM_198179.2.
    UniGenei Hs.368977.

    3D structure databases

    ProteinModelPortali Q96P65.
    SMRi Q96P65. Positions 46-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123897. 1 interaction.
    STRINGi 9606.ENSP00000335610.

    Chemistry

    BindingDBi Q96P65.
    ChEMBLi CHEMBL5852.
    GuidetoPHARMACOLOGYi 333.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96P65.

    Polymorphism databases

    DMDMi 47117904.

    Proteomic databases

    MaxQBi Q96P65.
    PaxDbi Q96P65.
    PeptideAtlasi Q96P65.
    PRIDEi Q96P65.

    Protocols and materials databases

    DNASUi 84109.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394427 ; ENSP00000377948 ; ENSG00000186867 .
    GeneIDi 84109.
    KEGGi hsa:84109.
    UCSCi uc010inj.1. human.

    Organism-specific databases

    CTDi 84109.
    GeneCardsi GC04M122249.
    H-InvDB HIX0031352.
    HGNCi HGNC:15565. QRFPR.
    HPAi HPA014300.
    MIMi 606925. gene.
    neXtProti NX_Q96P65.
    PharmGKBi PA164725243.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149782.
    HOGENOMi HOG000136537.
    HOVERGENi HBG067831.
    InParanoidi Q96P65.
    KOi K08378.
    OMAi HPLKMKW.
    PhylomeDBi Q96P65.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Pyroglutamylated_RFamide_peptide_receptor.
    GenomeRNAii 84109.
    NextBioi 73381.
    PROi Q96P65.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96P65.
    Bgeei Q96P65.
    CleanExi HS_QRFPR.
    Genevestigatori Q96P65.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155."
      Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.
      J. Biol. Chem. 278:27652-27657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "A new peptidic ligand and its receptor regulating adrenal function in rats."
      Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., Shintani Y., Hinuma S., Fujino M.
      J. Biol. Chem. 278:46387-46395(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiQRFPR_HUMAN
    AccessioniPrimary (citable) accession number: Q96P65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3