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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Gene

AGAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174194-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Imported
Short name:
AGAP-4
Alternative name(s):
Centaurin-gamma-like family member 1Imported
Centaurin-gamma-like family member 5Imported
Gene namesi
Name:AGAP4Imported
Synonyms:AGAP8Imported, CTGLF1Imported, CTGLF5Imported, MRIP2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23459. AGAP4.

Pathology & Biotechi

Organism-specific databases

DisGeNETi119016.
OpenTargetsiENSG00000188234.
PharmGKBiPA164715122.

Polymorphism and mutation databases

BioMutaiAGAP4.
DMDMi296434392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846731 – 663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Add BLAST663

Proteomic databases

PaxDbiQ96P64.
PeptideAtlasiQ96P64.
PRIDEiQ96P64.

PTM databases

iPTMnetiQ96P64.
PhosphoSitePlusiQ96P64.

Expressioni

Gene expression databases

BgeeiENSG00000188234.
ExpressionAtlasiQ96P64. baseline and differential.
GenevisibleiQ96P64. HS.

Organism-specific databases

HPAiHPA042490.

Interactioni

Protein-protein interaction databases

BioGridi125632. 2 interactors.
IntActiQ96P64. 1 interactor.
STRINGi9606.ENSP00000392513.

Structurei

3D structure databases

ProteinModelPortaliQ96P64.
SMRiQ96P64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 420PHPROSITE-ProRule annotationAdd BLAST162
Domaini441 – 561Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati600 – 629ANK 1Add BLAST30
Repeati633 – 662ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ96P64.
PhylomeDBiQ96P64.
TreeFamiTF317762.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV STVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRS LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
310 320 330 340 350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSK AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD KCV
Length:663
Mass (Da):73,070
Last modified:May 18, 2010 - v2
Checksum:i49F11692C58577E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334T → S in AAL10290 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031804661K → E.1 PublicationCorresponds to variant rs15718dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411132 mRNA. Translation: AAL10290.1.
AC012044 Genomic DNA. No translation available.
CCDSiCCDS7215.1.
RefSeqiNP_001263272.2. NM_001276343.2.
NP_597703.2. NM_133446.3.
UniGeneiHs.314437.
Hs.536192.
Hs.656384.

Genome annotation databases

EnsembliENST00000448048; ENSP00000392513; ENSG00000188234.
GeneIDi119016.
KEGGihsa:119016.
UCSCiuc057szm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411132 mRNA. Translation: AAL10290.1.
AC012044 Genomic DNA. No translation available.
CCDSiCCDS7215.1.
RefSeqiNP_001263272.2. NM_001276343.2.
NP_597703.2. NM_133446.3.
UniGeneiHs.314437.
Hs.536192.
Hs.656384.

3D structure databases

ProteinModelPortaliQ96P64.
SMRiQ96P64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125632. 2 interactors.
IntActiQ96P64. 1 interactor.
STRINGi9606.ENSP00000392513.

PTM databases

iPTMnetiQ96P64.
PhosphoSitePlusiQ96P64.

Polymorphism and mutation databases

BioMutaiAGAP4.
DMDMi296434392.

Proteomic databases

PaxDbiQ96P64.
PeptideAtlasiQ96P64.
PRIDEiQ96P64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448048; ENSP00000392513; ENSG00000188234.
GeneIDi119016.
KEGGihsa:119016.
UCSCiuc057szm.1. human.

Organism-specific databases

CTDi119016.
DisGeNETi119016.
GeneCardsiAGAP4.
HGNCiHGNC:23459. AGAP4.
HPAiHPA042490.
neXtProtiNX_Q96P64.
OpenTargetsiENSG00000188234.
PharmGKBiPA164715122.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ96P64.
PhylomeDBiQ96P64.
TreeFamiTF317762.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174194-MONOMER.

Miscellaneous databases

GenomeRNAii119016.
PROiQ96P64.

Gene expression databases

BgeeiENSG00000188234.
ExpressionAtlasiQ96P64. baseline and differential.
GenevisibleiQ96P64. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGAP4_HUMAN
AccessioniPrimary (citable) accession number: Q96P64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.