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Q96P63

- SPB12_HUMAN

UniProt

Q96P63 - SPB12_HUMAN

Protein

Serpin B12

Gene

SERPINB12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei370 – 3712Reactive bondBy similarity

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. negative regulation of protein catabolic process Source: UniProtKB
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B12
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:14220. SERPINB12.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: InterPro
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37859.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Serpin B12PRO_0000094119Add
    BLAST

    Proteomic databases

    MaxQBiQ96P63.
    PaxDbiQ96P63.
    PRIDEiQ96P63.

    PTM databases

    PhosphoSiteiQ96P63.

    Expressioni

    Tissue specificityi

    Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.

    Gene expression databases

    ArrayExpressiQ96P63.
    BgeeiQ96P63.
    CleanExiHS_SERPINB12.
    GenevestigatoriQ96P63.

    Organism-specific databases

    HPAiCAB032802.

    Interactioni

    Protein-protein interaction databases

    BioGridi124597. 12 interactions.
    IntActiQ96P63. 3 interactions.
    STRINGi9606.ENSP00000269491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P63.
    SMRiQ96P63. Positions 2-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    KOiK13966.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ96P63.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96P63-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS    50
    AHQIDEVLHF NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL 100
    SKLDRIKTDY TLSIANRLYG EQEFPICQEY LDGVIQFYHT TIESVDFQKN 150
    PEKSRQEINF WVECQSQGKI KELFSKDAIN AETVLVLVNA VYFKAKWETY 200
    FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA QILEMRYTKG 250
    KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP 300
    RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV 350
    EVDENGTQAA AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG 400
    RVCSP 405
    Length:405
    Mass (Da):46,276
    Last modified:December 1, 2001 - v1
    Checksum:iFFE12D4C9B7F3DFA
    GO
    Isoform 2 (identifier: Q96P63-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-81: K → KVLADSSLEGQKKTTEPLDQQ

    Note: No experimental confirmation available.

    Show »
    Length:425
    Mass (Da):48,446
    Checksum:i8D1E8023568E35B9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271K → E.
    Corresponds to variant rs35582068 [ dbSNP | Ensembl ].
    VAR_034513
    Natural varianti289 – 2891N → T.
    Corresponds to variant rs35352345 [ dbSNP | Ensembl ].
    VAR_034514
    Natural varianti338 – 3381N → S.
    Corresponds to variant rs11664907 [ dbSNP | Ensembl ].
    VAR_051952

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 811K → KVLADSSLEGQKKTTEPLDQ Q in isoform 2. 1 PublicationVSP_056279

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411191 mRNA. Translation: AAL05571.1.
    AC090307 Genomic DNA. No translation available.
    BC103885 mRNA. Translation: AAI03886.1.
    CCDSiCCDS11984.1.
    RefSeqiNP_536722.1. NM_080474.1.
    XP_005266835.1. XM_005266778.1.
    UniGeneiHs.348541.

    Genome annotation databases

    EnsembliENST00000269491; ENSP00000269491; ENSG00000166634.
    ENST00000382768; ENSP00000372218; ENSG00000166634.
    GeneIDi89777.
    KEGGihsa:89777.
    UCSCiuc010xen.2. human.

    Polymorphism databases

    DMDMi20140145.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411191 mRNA. Translation: AAL05571.1 .
    AC090307 Genomic DNA. No translation available.
    BC103885 mRNA. Translation: AAI03886.1 .
    CCDSi CCDS11984.1.
    RefSeqi NP_536722.1. NM_080474.1.
    XP_005266835.1. XM_005266778.1.
    UniGenei Hs.348541.

    3D structure databases

    ProteinModelPortali Q96P63.
    SMRi Q96P63. Positions 2-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124597. 12 interactions.
    IntActi Q96P63. 3 interactions.
    STRINGi 9606.ENSP00000269491.

    Protein family/group databases

    MEROPSi I04.016.

    PTM databases

    PhosphoSitei Q96P63.

    Polymorphism databases

    DMDMi 20140145.

    Proteomic databases

    MaxQBi Q96P63.
    PaxDbi Q96P63.
    PRIDEi Q96P63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269491 ; ENSP00000269491 ; ENSG00000166634 .
    ENST00000382768 ; ENSP00000372218 ; ENSG00000166634 .
    GeneIDi 89777.
    KEGGi hsa:89777.
    UCSCi uc010xen.2. human.

    Organism-specific databases

    CTDi 89777.
    GeneCardsi GC18P061196.
    HGNCi HGNC:14220. SERPINB12.
    HPAi CAB032802.
    MIMi 615662. gene.
    neXtProti NX_Q96P63.
    PharmGKBi PA37859.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    KOi K13966.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q96P63.
    TreeFami TF352619.

    Miscellaneous databases

    GenomeRNAii 89777.
    NextBioi 76255.
    PROi Q96P63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96P63.
    Bgeei Q96P63.
    CleanExi HS_SERPINB12.
    Genevestigatori Q96P63.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases."
      Askew Y.S., Pak S.C., Luke C.J., Askew D.J., Cataltepe S., Mills D.R., Kato H., Lehoczky J., Dewar K., Birren B., Silverman G.A.
      J. Biol. Chem. 276:49320-49330(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiSPB12_HUMAN
    AccessioniPrimary (citable) accession number: Q96P63
    Secondary accession number(s): Q3SYB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3