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Q96P63

- SPB12_HUMAN

UniProt

Q96P63 - SPB12_HUMAN

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Protein
Serpin B12
Gene
SERPINB12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3712Reactive bond By similarity

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. negative regulation of protein catabolic process Source: UniProtKB
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:14220. SERPINB12.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: InterPro
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Serpin B12
PRO_0000094119Add
BLAST

Proteomic databases

MaxQBiQ96P63.
PaxDbiQ96P63.
PRIDEiQ96P63.

PTM databases

PhosphoSiteiQ96P63.

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.

Gene expression databases

ArrayExpressiQ96P63.
BgeeiQ96P63.
CleanExiHS_SERPINB12.
GenevestigatoriQ96P63.

Organism-specific databases

HPAiCAB032802.

Interactioni

Protein-protein interaction databases

BioGridi124597. 12 interactions.
IntActiQ96P63. 3 interactions.
STRINGi9606.ENSP00000269491.

Structurei

3D structure databases

ProteinModelPortaliQ96P63.
SMRiQ96P63. Positions 2-405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
KOiK13966.
OrthoDBiEOG7327PB.
PhylomeDBiQ96P63.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P63-1 [UniParc]FASTAAdd to Basket

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MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS    50
AHQIDEVLHF NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL 100
SKLDRIKTDY TLSIANRLYG EQEFPICQEY LDGVIQFYHT TIESVDFQKN 150
PEKSRQEINF WVECQSQGKI KELFSKDAIN AETVLVLVNA VYFKAKWETY 200
FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA QILEMRYTKG 250
KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP 300
RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV 350
EVDENGTQAA AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG 400
RVCSP 405
Length:405
Mass (Da):46,276
Last modified:December 1, 2001 - v1
Checksum:iFFE12D4C9B7F3DFA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271K → E.
Corresponds to variant rs35582068 [ dbSNP | Ensembl ].
VAR_034513
Natural varianti289 – 2891N → T.
Corresponds to variant rs35352345 [ dbSNP | Ensembl ].
VAR_034514
Natural varianti338 – 3381N → S.
Corresponds to variant rs11664907 [ dbSNP | Ensembl ].
VAR_051952

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411191 mRNA. Translation: AAL05571.1.
CCDSiCCDS11984.1.
RefSeqiNP_536722.1. NM_080474.1.
UniGeneiHs.348541.

Genome annotation databases

EnsembliENST00000269491; ENSP00000269491; ENSG00000166634.
GeneIDi89777.
KEGGihsa:89777.
UCSCiuc010xen.2. human.

Polymorphism databases

DMDMi20140145.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411191 mRNA. Translation: AAL05571.1 .
CCDSi CCDS11984.1.
RefSeqi NP_536722.1. NM_080474.1.
UniGenei Hs.348541.

3D structure databases

ProteinModelPortali Q96P63.
SMRi Q96P63. Positions 2-405.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124597. 12 interactions.
IntActi Q96P63. 3 interactions.
STRINGi 9606.ENSP00000269491.

Protein family/group databases

MEROPSi I04.016.

PTM databases

PhosphoSitei Q96P63.

Polymorphism databases

DMDMi 20140145.

Proteomic databases

MaxQBi Q96P63.
PaxDbi Q96P63.
PRIDEi Q96P63.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269491 ; ENSP00000269491 ; ENSG00000166634 .
GeneIDi 89777.
KEGGi hsa:89777.
UCSCi uc010xen.2. human.

Organism-specific databases

CTDi 89777.
GeneCardsi GC18P061196.
HGNCi HGNC:14220. SERPINB12.
HPAi CAB032802.
MIMi 615662. gene.
neXtProti NX_Q96P63.
PharmGKBi PA37859.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
KOi K13966.
OrthoDBi EOG7327PB.
PhylomeDBi Q96P63.
TreeFami TF352619.

Miscellaneous databases

GenomeRNAii 89777.
NextBioi 76255.
PROi Q96P63.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96P63.
Bgeei Q96P63.
CleanExi HS_SERPINB12.
Genevestigatori Q96P63.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases."
    Askew Y.S., Pak S.C., Luke C.J., Askew D.J., Cataltepe S., Mills D.R., Kato H., Lehoczky J., Dewar K., Birren B., Silverman G.A.
    J. Biol. Chem. 276:49320-49330(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Entry informationi

Entry nameiSPB12_HUMAN
AccessioniPrimary (citable) accession number: Q96P63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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