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Protein

Serpin B12

Gene

SERPINB12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3712Reactive bondBy similarity

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: Ensembl
  2. negative regulation of endopeptidase activity Source: GO_Central
  3. negative regulation of protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:14220. SERPINB12.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: GO_Central
  3. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Serpin B12PRO_0000094119Add
BLAST

Proteomic databases

MaxQBiQ96P63.
PaxDbiQ96P63.
PRIDEiQ96P63.

PTM databases

PhosphoSiteiQ96P63.

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.

Gene expression databases

BgeeiQ96P63.
CleanExiHS_SERPINB12.
ExpressionAtlasiQ96P63. baseline and differential.
GenevestigatoriQ96P63.

Organism-specific databases

HPAiCAB032802.

Interactioni

Protein-protein interaction databases

BioGridi124597. 13 interactions.
IntActiQ96P63. 3 interactions.
STRINGi9606.ENSP00000269491.

Structurei

3D structure databases

ProteinModelPortaliQ96P63.
SMRiQ96P63. Positions 2-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ96P63.
KOiK13966.
OMAiQEFPICQ.
OrthoDBiEOG7327PB.
PhylomeDBiQ96P63.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS
60 70 80 90 100
AHQIDEVLHF NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL
110 120 130 140 150
SKLDRIKTDY TLSIANRLYG EQEFPICQEY LDGVIQFYHT TIESVDFQKN
160 170 180 190 200
PEKSRQEINF WVECQSQGKI KELFSKDAIN AETVLVLVNA VYFKAKWETY
210 220 230 240 250
FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA QILEMRYTKG
260 270 280 290 300
KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP
310 320 330 340 350
RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV
360 370 380 390 400
EVDENGTQAA AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG

RVCSP
Length:405
Mass (Da):46,276
Last modified:December 1, 2001 - v1
Checksum:iFFE12D4C9B7F3DFA
GO
Isoform 2 (identifier: Q96P63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: K → KVLADSSLEGQKKTTEPLDQQ

Note: No experimental confirmation available.

Show »
Length:425
Mass (Da):48,446
Checksum:i8D1E8023568E35B9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271K → E.
Corresponds to variant rs35582068 [ dbSNP | Ensembl ].
VAR_034513
Natural varianti289 – 2891N → T.
Corresponds to variant rs35352345 [ dbSNP | Ensembl ].
VAR_034514
Natural varianti338 – 3381N → S.
Corresponds to variant rs11664907 [ dbSNP | Ensembl ].
VAR_051952

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 811K → KVLADSSLEGQKKTTEPLDQ Q in isoform 2. 1 PublicationVSP_056279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411191 mRNA. Translation: AAL05571.1.
AC090307 Genomic DNA. No translation available.
BC103885 mRNA. Translation: AAI03886.1.
CCDSiCCDS11984.1. [Q96P63-1]
RefSeqiNP_536722.1. NM_080474.1. [Q96P63-1]
XP_005266835.1. XM_005266778.1. [Q96P63-2]
UniGeneiHs.348541.

Genome annotation databases

EnsembliENST00000269491; ENSP00000269491; ENSG00000166634. [Q96P63-1]
ENST00000382768; ENSP00000372218; ENSG00000166634. [Q96P63-2]
GeneIDi89777.
KEGGihsa:89777.
UCSCiuc010xen.2. human. [Q96P63-1]
uc010xeo.2. human.

Polymorphism databases

DMDMi20140145.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411191 mRNA. Translation: AAL05571.1.
AC090307 Genomic DNA. No translation available.
BC103885 mRNA. Translation: AAI03886.1.
CCDSiCCDS11984.1. [Q96P63-1]
RefSeqiNP_536722.1. NM_080474.1. [Q96P63-1]
XP_005266835.1. XM_005266778.1. [Q96P63-2]
UniGeneiHs.348541.

3D structure databases

ProteinModelPortaliQ96P63.
SMRiQ96P63. Positions 2-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124597. 13 interactions.
IntActiQ96P63. 3 interactions.
STRINGi9606.ENSP00000269491.

Protein family/group databases

MEROPSiI04.016.

PTM databases

PhosphoSiteiQ96P63.

Polymorphism databases

DMDMi20140145.

Proteomic databases

MaxQBiQ96P63.
PaxDbiQ96P63.
PRIDEiQ96P63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269491; ENSP00000269491; ENSG00000166634. [Q96P63-1]
ENST00000382768; ENSP00000372218; ENSG00000166634. [Q96P63-2]
GeneIDi89777.
KEGGihsa:89777.
UCSCiuc010xen.2. human. [Q96P63-1]
uc010xeo.2. human.

Organism-specific databases

CTDi89777.
GeneCardsiGC18P061196.
HGNCiHGNC:14220. SERPINB12.
HPAiCAB032802.
MIMi615662. gene.
neXtProtiNX_Q96P63.
PharmGKBiPA37859.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ96P63.
KOiK13966.
OMAiQEFPICQ.
OrthoDBiEOG7327PB.
PhylomeDBiQ96P63.
TreeFamiTF352619.

Miscellaneous databases

GenomeRNAii89777.
NextBioi76255.
PROiQ96P63.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P63.
CleanExiHS_SERPINB12.
ExpressionAtlasiQ96P63. baseline and differential.
GenevestigatoriQ96P63.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases."
    Askew Y.S., Pak S.C., Luke C.J., Askew D.J., Cataltepe S., Mills D.R., Kato H., Lehoczky J., Dewar K., Birren B., Silverman G.A.
    J. Biol. Chem. 276:49320-49330(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSPB12_HUMAN
AccessioniPrimary (citable) accession number: Q96P63
Secondary accession number(s): Q3SYB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.