Q96P63 (SPB12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin B12

Gene names

Name:

SERPINB12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Protease inhibitor Serine protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of protein catabolic process Non-traceable author statement Ref.1. Source: UniProtKB regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	enzyme binding Non-traceable author statement Ref.1. Source: UniProtKB serine-type endopeptidase inhibitor activity Inferred from mutant phenotype Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Serpin B12		PRO_0000094119
Sites
	Site	370 – 371	2	Reactive bond By similarity
Natural variations
	Natural variant	227	1	K → E. Corresponds to variant rs35582068 [ dbSNP | Ensembl ].		VAR_034513
	Natural variant	289	1	N → T. Corresponds to variant rs35352345 [ dbSNP | Ensembl ].		VAR_034514
	Natural variant	338	1	N → S. Corresponds to variant rs11664907 [ dbSNP | Ensembl ].		VAR_051952

Sequences

	Sequence		Length	Mass (Da)
	Q96P63 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: FFE12D4C9B7F3DFA	FASTA	405	46,276
	10 20 30 40 50 60 MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS AHQIDEVLHF 70 80 90 100 110 120 NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL SKLDRIKTDY TLSIANRLYG 130 140 150 160 170 180 EQEFPICQEY LDGVIQFYHT TIESVDFQKN PEKSRQEINF WVECQSQGKI KELFSKDAIN 190 200 210 220 230 240 AETVLVLVNA VYFKAKWETY FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA 250 260 270 280 290 300 QILEMRYTKG KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP 310 320 330 340 350 360 RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV EVDENGTQAA 370 380 390 400 AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG RVCSP

References

[1]

"SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases." Askew Y.S., Pak S.C., Luke C.J., Askew D.J., Cataltepe S., Mills D.R., Kato H., Lehoczky J., Dewar K., Birren B., Silverman G.A. J. Biol. Chem. 276:49320-49330(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF411191 mRNA. Translation: AAL05571.1.
IPI	IPI00033583.
RefSeq	NP_536722.1. NM_080474.1.
UniGene	Hs.348541.
3D structure databases
ProteinModelPortal	Q96P63.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96P63. 3 interactions.
STRING	9606.ENSP00000269491.
Protein family/group databases
MEROPS	I04.016.
PTM databases
PhosphoSite	Q96P63.
Polymorphism databases
DMDM	20140145.
Proteomic databases
PaxDb	Q96P63.
PRIDE	Q96P63.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269491; ENSP00000269491; ENSG00000166634.
GeneID	89777.
KEGG	hsa:89777.
UCSC	uc010xen.2. human.
Organism-specific databases
CTD	89777.
GeneCards	GC18P061196.
HGNC	HGNC:14220. SERPINB12.
HPA	CAB032802.
neXtProt	NX_Q96P63.
PharmGKB	PA37859.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOGENOM	HOG000238519.
HOVERGEN	HBG005957.
KO	K13966.
OrthoDB	EOG4HT8SC.
PhylomeDB	Q96P63.
Gene expression databases
ArrayExpress	Q96P63.
Bgee	Q96P63.
CleanEx	HS_SERPINB12.
Genevestigator	Q96P63.
GermOnline	ENSG00000166634. Homo sapiens.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	89777.
NextBio	76255.

Entry information

Entry name

SPB12_HUMAN

Accession

Primary (citable) accession number: Q96P63

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.