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Q96P63 (SPB12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B12
Gene names
Name:SERPINB12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Serpin B12
PRO_0000094119

Sites

Site370 – 3712Reactive bond By similarity

Natural variations

Natural variant2271K → E.
Corresponds to variant rs35582068 [ dbSNP | Ensembl ].
VAR_034513
Natural variant2891N → T.
Corresponds to variant rs35352345 [ dbSNP | Ensembl ].
VAR_034514
Natural variant3381N → S.
Corresponds to variant rs11664907 [ dbSNP | Ensembl ].
VAR_051952

Sequences

Sequence LengthMass (Da)Tools
Q96P63 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FFE12D4C9B7F3DFA

FASTA40546,276
        10         20         30         40         50         60 
MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS AHQIDEVLHF 

        70         80         90        100        110        120 
NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL SKLDRIKTDY TLSIANRLYG 

       130        140        150        160        170        180 
EQEFPICQEY LDGVIQFYHT TIESVDFQKN PEKSRQEINF WVECQSQGKI KELFSKDAIN 

       190        200        210        220        230        240 
AETVLVLVNA VYFKAKWETY FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA 

       250        260        270        280        290        300 
QILEMRYTKG KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP 

       310        320        330        340        350        360 
RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV EVDENGTQAA 

       370        380        390        400 
AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG RVCSP 

« Hide

References

[1]"SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases."
Askew Y.S., Pak S.C., Luke C.J., Askew D.J., Cataltepe S., Mills D.R., Kato H., Lehoczky J., Dewar K., Birren B., Silverman G.A.
J. Biol. Chem. 276:49320-49330(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411191 mRNA. Translation: AAL05571.1.
CCDSCCDS11984.1.
RefSeqNP_536722.1. NM_080474.1.
UniGeneHs.348541.

3D structure databases

ProteinModelPortalQ96P63.
SMRQ96P63. Positions 2-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124597. 12 interactions.
IntActQ96P63. 3 interactions.
STRING9606.ENSP00000269491.

Protein family/group databases

MEROPSI04.016.

PTM databases

PhosphoSiteQ96P63.

Polymorphism databases

DMDM20140145.

Proteomic databases

MaxQBQ96P63.
PaxDbQ96P63.
PRIDEQ96P63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269491; ENSP00000269491; ENSG00000166634.
GeneID89777.
KEGGhsa:89777.
UCSCuc010xen.2. human.

Organism-specific databases

CTD89777.
GeneCardsGC18P061196.
HGNCHGNC:14220. SERPINB12.
HPACAB032802.
MIM615662. gene.
neXtProtNX_Q96P63.
PharmGKBPA37859.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG005957.
KOK13966.
OrthoDBEOG7327PB.
PhylomeDBQ96P63.
TreeFamTF352619.

Gene expression databases

ArrayExpressQ96P63.
BgeeQ96P63.
CleanExHS_SERPINB12.
GenevestigatorQ96P63.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi89777.
NextBio76255.
PROQ96P63.
SOURCESearch...

Entry information

Entry nameSPB12_HUMAN
AccessionPrimary (citable) accession number: Q96P63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM