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Protein

WD repeat and FYVE domain-containing protein 2

Gene

WDFY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

GO - Biological processi

  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96P53.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 2
Alternative name(s):
Propeller-FYVE protein1 Publication
Short name:
Prof
WD40- and FYVE domain-containing protein 2
Zinc finger FYVE domain-containing protein 22
Gene namesi
Name:WDFY2
Synonyms:WDF2, ZFYVE22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20482. WDFY2.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi115825.
OpenTargetsiENSG00000139668.
PharmGKBiPA134870231.

Polymorphism and mutation databases

BioMutaiWDFY2.
DMDMi51316902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513361 – 400WD repeat and FYVE domain-containing protein 2Add BLAST400

Proteomic databases

EPDiQ96P53.
MaxQBiQ96P53.
PaxDbiQ96P53.
PeptideAtlasiQ96P53.
PRIDEiQ96P53.

PTM databases

iPTMnetiQ96P53.
PhosphoSitePlusiQ96P53.

Expressioni

Gene expression databases

BgeeiENSG00000139668.
CleanExiHS_WDFY2.
ExpressionAtlasiQ96P53. baseline and differential.
GenevisibleiQ96P53. HS.

Organism-specific databases

HPAiHPA066926.

Interactioni

Subunit structurei

Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi125458. 25 interactors.
IntActiQ96P53. 1 interactor.
STRINGi9606.ENSP00000298125.

Structurei

3D structure databases

ProteinModelPortaliQ96P53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati66 – 105WD 2Add BLAST40
Repeati112 – 150WD 3Add BLAST39
Repeati153 – 192WD 4Add BLAST40
Repeati197 – 236WD 5Add BLAST40
Repeati240 – 279WD 6Add BLAST40
Repeati364 – 399WD 7Add BLAST36

Domaini

The FYVE-type zinc finger is essential for its vesicular localization.1 Publication

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1409. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00670000098022.
HOGENOMiHOG000007835.
HOVERGENiHBG054128.
InParanoidiQ96P53.
OMAiFVLEMEW.
OrthoDBiEOG091G0ANN.
PhylomeDBiQ96P53.
TreeFamiTF314470.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV
60 70 80 90 100
WLKRDSGQYW PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED
110 120 130 140 150
YNKMTPVKNY QAHQSRVTMI LFVLELEWVL STGQDKQFAW HCSESGQRLG
160 170 180 190 200
GYRTSAVASG LQFDVETRHV FIGDHSGQVT ILKLEQENCT LVTTFRGHTG
210 220 230 240 250
GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG HNDRVQALSY
260 270 280 290 300
AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ
310 320 330 340 350
MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA
360 370 380 390 400
ITDEERAPTA TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS
Length:400
Mass (Da):45,154
Last modified:August 16, 2004 - v2
Checksum:i57868799A6C3C7C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110Y → C in AAL04162 (Ref. 1) Curated1
Sequence conflicti197G → E in AAL04162 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411978 mRNA. Translation: AAL04162.1.
AL136525, AL139183 Genomic DNA. Translation: CAH70585.1.
AL139183, AL136525 Genomic DNA. Translation: CAH73431.1.
CH471075 Genomic DNA. Translation: EAX08883.1.
BC014004 mRNA. Translation: AAH14004.1.
CCDSiCCDS9429.1.
RefSeqiNP_443182.1. NM_052950.3.
UniGeneiHs.208550.
Hs.46506.

Genome annotation databases

EnsembliENST00000298125; ENSP00000298125; ENSG00000139668.
GeneIDi115825.
KEGGihsa:115825.
UCSCiuc001vfp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411978 mRNA. Translation: AAL04162.1.
AL136525, AL139183 Genomic DNA. Translation: CAH70585.1.
AL139183, AL136525 Genomic DNA. Translation: CAH73431.1.
CH471075 Genomic DNA. Translation: EAX08883.1.
BC014004 mRNA. Translation: AAH14004.1.
CCDSiCCDS9429.1.
RefSeqiNP_443182.1. NM_052950.3.
UniGeneiHs.208550.
Hs.46506.

3D structure databases

ProteinModelPortaliQ96P53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125458. 25 interactors.
IntActiQ96P53. 1 interactor.
STRINGi9606.ENSP00000298125.

PTM databases

iPTMnetiQ96P53.
PhosphoSitePlusiQ96P53.

Polymorphism and mutation databases

BioMutaiWDFY2.
DMDMi51316902.

Proteomic databases

EPDiQ96P53.
MaxQBiQ96P53.
PaxDbiQ96P53.
PeptideAtlasiQ96P53.
PRIDEiQ96P53.

Protocols and materials databases

DNASUi115825.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298125; ENSP00000298125; ENSG00000139668.
GeneIDi115825.
KEGGihsa:115825.
UCSCiuc001vfp.4. human.

Organism-specific databases

CTDi115825.
DisGeNETi115825.
GeneCardsiWDFY2.
HGNCiHGNC:20482. WDFY2.
HPAiHPA066926.
MIMi610418. gene.
neXtProtiNX_Q96P53.
OpenTargetsiENSG00000139668.
PharmGKBiPA134870231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1409. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00670000098022.
HOGENOMiHOG000007835.
HOVERGENiHBG054128.
InParanoidiQ96P53.
OMAiFVLEMEW.
OrthoDBiEOG091G0ANN.
PhylomeDBiQ96P53.
TreeFamiTF314470.

Enzyme and pathway databases

SignaLinkiQ96P53.

Miscellaneous databases

GenomeRNAii115825.
PROiQ96P53.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139668.
CleanExiHS_WDFY2.
ExpressionAtlasiQ96P53. baseline and differential.
GenevisibleiQ96P53. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDFY2_HUMAN
AccessioniPrimary (citable) accession number: Q96P53
Secondary accession number(s): B1AL86, Q96CS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.