UniProtKB - Q96P53 (WDFY2_HUMAN)
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Protein
WD repeat and FYVE domain-containing protein 2
Gene
WDFY2
Organism
Homo sapiens (Human)
Status
Functioni
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).By similarity3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 281 – 352 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 72 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SignaLinki | Q96P53. |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat and FYVE domain-containing protein 2Alternative name(s): Propeller-FYVE protein1 Publication Short name: Prof WD40- and FYVE domain-containing protein 2 Zinc finger FYVE domain-containing protein 22 |
Gene namesi | Name:WDFY2 Synonyms:WDF2, ZFYVE22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139668.8. |
HGNCi | HGNC:20482. WDFY2. |
MIMi | 610418. gene. |
neXtProti | NX_Q96P53. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 115825. |
OpenTargetsi | ENSG00000139668. |
PharmGKBi | PA134870231. |
Polymorphism and mutation databases
BioMutai | WDFY2. |
DMDMi | 51316902. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051336 | 1 – 400 | WD repeat and FYVE domain-containing protein 2Add BLAST | 400 |
Proteomic databases
EPDi | Q96P53. |
MaxQBi | Q96P53. |
PaxDbi | Q96P53. |
PeptideAtlasi | Q96P53. |
PRIDEi | Q96P53. |
PTM databases
iPTMneti | Q96P53. |
PhosphoSitePlusi | Q96P53. |
Expressioni
Gene expression databases
Bgeei | ENSG00000139668. |
CleanExi | HS_WDFY2. |
ExpressionAtlasi | Q96P53. baseline and differential. |
Genevisiblei | Q96P53. HS. |
Interactioni
Subunit structurei
Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).By similarity2 Publications
Protein-protein interaction databases
BioGridi | 125458. 27 interactors. |
IntActi | Q96P53. 4 interactors. |
STRINGi | 9606.ENSP00000298125. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 61 | WD 1Add BLAST | 40 | |
Repeati | 66 – 105 | WD 2Add BLAST | 40 | |
Repeati | 112 – 150 | WD 3Add BLAST | 39 | |
Repeati | 153 – 192 | WD 4Add BLAST | 40 | |
Repeati | 197 – 236 | WD 5Add BLAST | 40 | |
Repeati | 240 – 279 | WD 6Add BLAST | 40 | |
Repeati | 364 – 399 | WD 7Add BLAST | 36 |
Domaini
The FYVE-type zinc finger is essential for its vesicular localization.1 Publication
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 281 – 352 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 72 |
Keywords - Domaini
Repeat, WD repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1409. Eukaryota. COG2319. LUCA. |
GeneTreei | ENSGT00670000098022. |
HOGENOMi | HOG000007835. |
HOVERGENi | HBG054128. |
InParanoidi | Q96P53. |
OMAi | TWHCSES. |
OrthoDBi | EOG091G0ANN. |
PhylomeDBi | Q96P53. |
TreeFami | TF314470. |
Family and domain databases
Gene3Di | 2.130.10.10. 1 hit. 3.30.40.10. 1 hit. |
InterProi | View protein in InterPro IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. |
Pfami | View protein in Pfam PF01363. FYVE. 1 hit. PF00400. WD40. 3 hits. |
PRINTSi | PR00320. GPROTEINBRPT. |
SMARTi | View protein in SMART SM00064. FYVE. 1 hit. SM00320. WD40. 5 hits. |
SUPFAMi | SSF50978. SSF50978. 1 hit. SSF57903. SSF57903. 1 hit. |
PROSITEi | View protein in PROSITE PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 2 hits. PS50178. ZF_FYVE. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q96P53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV
60 70 80 90 100
WLKRDSGQYW PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED
110 120 130 140 150
YNKMTPVKNY QAHQSRVTMI LFVLELEWVL STGQDKQFAW HCSESGQRLG
160 170 180 190 200
GYRTSAVASG LQFDVETRHV FIGDHSGQVT ILKLEQENCT LVTTFRGHTG
210 220 230 240 250
GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG HNDRVQALSY
260 270 280 290 300
AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ
310 320 330 340 350
MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA
360 370 380 390 400
ITDEERAPTA TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | Y → C in AAL04162 (Ref. 1) Curated | 1 | |
Sequence conflicti | 197 | G → E in AAL04162 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411978 mRNA. Translation: AAL04162.1. AL136525 Genomic DNA. No translation available. AL139183 Genomic DNA. No translation available. CH471075 Genomic DNA. Translation: EAX08883.1. BC014004 mRNA. Translation: AAH14004.1. |
CCDSi | CCDS9429.1. |
RefSeqi | NP_443182.1. NM_052950.3. |
UniGenei | Hs.208550. Hs.46506. |
Genome annotation databases
Ensembli | ENST00000298125; ENSP00000298125; ENSG00000139668. |
GeneIDi | 115825. |
KEGGi | hsa:115825. |
UCSCi | uc001vfp.4. human. |
Similar proteinsi
Entry informationi
Entry namei | WDFY2_HUMAN | |
Accessioni | Q96P53Primary (citable) accession number: Q96P53 Secondary accession number(s): B1AL86, Q96CS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 28, 2018 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |