Q96P53 (WDFY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat and FYVE domain-containing protein 2

Alternative name(s):
WD40- and FYVE domain-containing protein 2
Zinc finger FYVE domain-containing protein 22

Gene names

Name:	WDFY2
Synonyms:	WDF2, ZFYVE22

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FYVE-type zinc finger. Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	WD repeat and FYVE domain-containing protein 2		PRO_0000051336
Regions
	Repeat	22 – 61	40	WD 1
	Repeat	66 – 105	40	WD 2
	Repeat	112 – 150	39	WD 3
	Repeat	153 – 192	40	WD 4
	Repeat	197 – 236	40	WD 5
	Repeat	240 – 279	40	WD 6
	Repeat	364 – 399	36	WD 7
	Zinc finger	281 – 352	72	FYVE-type
Experimental info
	Sequence conflict	110	1	Y → C in AAL04162. Ref.1
	Sequence conflict	197	1	G → E in AAL04162. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96P53 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: 57868799A6C3C7C7	FASTA	400	45,154
	10 20 30 40 50 60 MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV WLKRDSGQYW 70 80 90 100 110 120 PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED YNKMTPVKNY QAHQSRVTMI 130 140 150 160 170 180 LFVLELEWVL STGQDKQFAW HCSESGQRLG GYRTSAVASG LQFDVETRHV FIGDHSGQVT 190 200 210 220 230 240 ILKLEQENCT LVTTFRGHTG GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG 250 260 270 280 290 300 HNDRVQALSY AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ 310 320 330 340 350 360 MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA ITDEERAPTA 370 380 390 400 TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"WD40- and FYVE-domain containing protein 2 (WDF2)." Hong W. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF411978 mRNA. Translation: AAL04162.1. AL136525, AL139183 Genomic DNA. Translation: CAH70585.1. AL139183, AL136525 Genomic DNA. Translation: CAH73431.1. CH471075 Genomic DNA. Translation: EAX08883.1. BC014004 mRNA. Translation: AAH14004.1.
IPI	IPI00073577.
RefSeq	NP_443182.1. NM_052950.3.
UniGene	Hs.208550.
3D structure databases
ProteinModelPortal	Q96P53.
SMR	Q96P53. Positions 18-100, 202-308, 369-395.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96P53.
Polymorphism databases
DMDM	51316902.
Proteomic databases
PRIDE	Q96P53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298125; ENSP00000298125; ENSG00000139668.
GeneID	115825.
KEGG	hsa:115825.
UCSC	uc001vfp.1. human.
Organism-specific databases
CTD	115825.
GeneCards	GC13P052158.
HGNC	HGNC:20482. WDFY2.
MIM	610418. gene.
neXtProt	NX_Q96P53.
PharmGKB	PA134870231.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15052.
GeneTree	ENSGT00550000074629.
HOGENOM	HBG380283.
HOVERGEN	HBG054128.
InParanoid	Q96P53.
OMA	FVLEMEW.
OrthoDB	EOG441QBF.
PhylomeDB	Q96P53.
Gene expression databases
ArrayExpress	Q96P53.
Bgee	Q96P53.
CleanEx	HS_WDFY2.
Genevestigator	Q96P53.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF01363. FYVE. 1 hit. PF00400. WD40. 4 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00064. FYVE. 1 hit. SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 2 hits. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79694.
SOURCE	Search...

Entry information

Entry name

WDFY2_HUMAN

Accession

Primary (citable) accession number: Q96P53
Secondary accession number(s): B1AL86, Q96CS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.