WDFY2

Functionⁱ

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	281 – 352	FYVE-typePROSITE-ProRule annotationAdd BLAST		72

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of fat cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18388859
positive regulation of protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 17313651

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q96P53.

SignaLinkⁱ

Q96P53.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat and FYVE domain-containing protein 2 Alternative name(s): Propeller-FYVE protein1 Publication Short name: Prof WD40- and FYVE domain-containing protein 2 Zinc finger FYVE domain-containing protein 22
Gene namesⁱ	Name:WDFY2 Synonyms:WDF2, ZFYVE22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139668.8.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20482. WDFY2.
MIMⁱ	610418. gene.
neXtProtⁱ	NX_Q96P53.

Keywords - Cellular componentⁱ

Cytoplasm, Endosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	115825.
Open Targets More...OpenTargetsⁱ	ENSG00000139668.
PharmGKBⁱ	PA134870231.

Polymorphism and mutation databases

BioMutaⁱ	WDFY2.
DMDMⁱ	51316902.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051336	1 – 400	WD repeat and FYVE domain-containing protein 2Add BLAST		400

Proteomic databases

EPDⁱ	Q96P53.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96P53.
PaxDbⁱ	Q96P53.
PeptideAtlas More...PeptideAtlasⁱ	Q96P53.
PRIDEⁱ	Q96P53.

PTM databases

iPTMnetⁱ	Q96P53.
PhosphoSitePlusⁱ	Q96P53.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139668.
CleanExⁱ	HS_WDFY2.
ExpressionAtlasⁱ	Q96P53. baseline and differential.
Genevisibleⁱ	Q96P53. HS.

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	125458. 27 interactors.
IntActⁱ	Q96P53. 4 interactors.
STRINGⁱ	9606.ENSP00000298125.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96P53.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	22 – 61	WD 1Add BLAST	40
Repeatⁱ	66 – 105	WD 2Add BLAST	40
Repeatⁱ	112 – 150	WD 3Add BLAST	39
Repeatⁱ	153 – 192	WD 4Add BLAST	40
Repeatⁱ	197 – 236	WD 5Add BLAST	40
Repeatⁱ	240 – 279	WD 6Add BLAST	40
Repeatⁱ	364 – 399	WD 7Add BLAST	36

Domainⁱ

The FYVE-type zinc finger is essential for its vesicular localization.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	281 – 352	FYVE-typePROSITE-ProRule annotationAdd BLAST		72

Keywords - Domainⁱ

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1409. Eukaryota. COG2319. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000098022.
HOGENOMⁱ	HOG000007835.
HOVERGENⁱ	HBG054128.
InParanoidⁱ	Q96P53.
OMAⁱ	TWHCSES.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ANN.
PhylomeDBⁱ	Q96P53.
TreeFamⁱ	TF314470.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit. 3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01363. FYVE. 1 hit. PF00400. WD40. 3 hits.
PRINTSⁱ	PR00320. GPROTEINBRPT.
SMARTⁱ	View protein in SMART SM00064. FYVE. 1 hit. SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit. SSF57903. SSF57903. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 2 hits. PS50178. ZF_FYVE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96P53-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV 
        60         70         80         90        100
WLKRDSGQYW PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED 
       110        120        130        140        150
YNKMTPVKNY QAHQSRVTMI LFVLELEWVL STGQDKQFAW HCSESGQRLG 
       160        170        180        190        200
GYRTSAVASG LQFDVETRHV FIGDHSGQVT ILKLEQENCT LVTTFRGHTG 
       210        220        230        240        250
GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG HNDRVQALSY 
       260        270        280        290        300
AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ 
       310        320        330        340        350
MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA 
       360        370        380        390        400
ITDEERAPTA TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS

Length:400

Mass (Da):45,154

Last modified:August 16, 2004 - v2

Checksum:ⁱ57868799A6C3C7C7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	110	Y → C in AAL04162 (Ref. 1) Curated		1
Sequence conflictⁱ	197	G → E in AAL04162 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411978 mRNA. Translation: AAL04162.1. AL136525 Genomic DNA. No translation available. AL139183 Genomic DNA. No translation available. CH471075 Genomic DNA. Translation: EAX08883.1. BC014004 mRNA. Translation: AAH14004.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9429.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_443182.1. NM_052950.3.
UniGeneⁱ	Hs.208550. Hs.46506.

Genome annotation databases

Ensemblⁱ	ENST00000298125; ENSP00000298125; ENSG00000139668.
GeneIDⁱ	115825.
KEGGⁱ	hsa:115825.
UCSC genome browser More...UCSCⁱ	uc001vfp.4. human.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q96P53	UPI00033411BC UPI000C9EEEAE UPI000698FC7E UPI00053F9465 UPI00038EFF0F A0A287A552 UPI000B5436D0 UPI000B54833D G3WIR4 A0A250Y043 +86	Octodon degus (Degu) (Sciurus degus) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Sus scrofa (Pig) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Castor canadensis (Beaver) Bos indicus (Zebu) Trichechus manatus latirostris (Florida manatee) Odobenus rosmarus divergens (Pacific walrus) And more	400	UniRef90_Q96P53	Cluster: WD repeat and FYVE domain-containing protein 2	97

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q96P53	Q8IWB7 A0A024R488 A0A1S3EPM6 UPI000642C0D8 UPI00046BDDEC UPI000BB48BC8 UPI00042C8BA1 G3SSE9 UPI000C812CCD UPI0002233760 +485	Homo sapiens (Human) Dipodomys ordii (Ord's kangaroo rat) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Enhydra lutris kenyoni Physeter catodon (Sperm whale) (Physeter macrocephalus) Loxodonta africana (African elephant) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Heterocephalus glaber (Naked mole rat) Equus caballus (Horse) And more	410	UniRef50_Q8IWB7	Cluster: WD repeat and FYVE domain-containing protein 1	496

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411978 mRNA. Translation: AAL04162.1. AL136525 Genomic DNA. No translation available. AL139183 Genomic DNA. No translation available. CH471075 Genomic DNA. Translation: EAX08883.1. BC014004 mRNA. Translation: AAH14004.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9429.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_443182.1. NM_052950.3.
UniGeneⁱ	Hs.208550. Hs.46506.

3D structure databases

ProteinModelPortalⁱ	Q96P53.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125458. 27 interactors.
IntActⁱ	Q96P53. 4 interactors.
STRINGⁱ	9606.ENSP00000298125.

PTM databases

iPTMnetⁱ	Q96P53.
PhosphoSitePlusⁱ	Q96P53.

Polymorphism and mutation databases

BioMutaⁱ	WDFY2.
DMDMⁱ	51316902.

Proteomic databases

EPDⁱ	Q96P53.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96P53.
PaxDbⁱ	Q96P53.
PeptideAtlas More...PeptideAtlasⁱ	Q96P53.
PRIDEⁱ	Q96P53.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	115825.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000298125; ENSP00000298125; ENSG00000139668.
GeneIDⁱ	115825.
KEGGⁱ	hsa:115825.
UCSC genome browser More...UCSCⁱ	uc001vfp.4. human.

Organism-specific databases

CTDⁱ	115825.
DisGeNET More...DisGeNETⁱ	115825.
EuPathDBⁱ	HostDB:ENSG00000139668.8.
GeneCardsⁱ	WDFY2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20482. WDFY2.
MIMⁱ	610418. gene.
neXtProtⁱ	NX_Q96P53.
Open Targets More...OpenTargetsⁱ	ENSG00000139668.
PharmGKBⁱ	PA134870231.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1409. Eukaryota. COG2319. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000098022.
HOGENOMⁱ	HOG000007835.
HOVERGENⁱ	HBG054128.
InParanoidⁱ	Q96P53.
OMAⁱ	TWHCSES.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ANN.
PhylomeDBⁱ	Q96P53.
TreeFamⁱ	TF314470.

Enzyme and pathway databases

SignaLinkⁱ	Q96P53.

SignaLinkⁱ

Q96P53.

Miscellaneous databases

ChiTaRSⁱ	WDFY2. human.
GenomeRNAiⁱ	115825.
Protein Ontology More...PROⁱ	PR:Q96P53.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139668.
CleanExⁱ	HS_WDFY2.
ExpressionAtlasⁱ	Q96P53. baseline and differential.
Genevisibleⁱ	Q96P53. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit. 3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01363. FYVE. 1 hit. PF00400. WD40. 3 hits.
PRINTSⁱ	PR00320. GPROTEINBRPT.
SMARTⁱ	View protein in SMART SM00064. FYVE. 1 hit. SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit. SSF57903. SSF57903. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 2 hits. PS50178. ZF_FYVE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDFY2_HUMAN
Accessionⁱ	Q96P53Primary (citable) accession number: Q96P53 Secondary accession number(s): B1AL86, Q96CS1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	August 16, 2004
	Last modified:	February 28, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96P53 (WDFY2_HUMAN)

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WD repeat and FYVE domain-containing protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Endosome

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ