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Q96P50

- ACAP3_HUMAN

UniProt

Q96P50 - ACAP3_HUMAN

Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Gene

ACAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    GTPase-activating protein for the ADP ribosylation factor family.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri418 – 44124C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
    Alternative name(s):
    Centaurin-beta-5
    Short name:
    Cnt-b5
    Gene namesi
    Name:ACAP3
    Synonyms:CENTB5, KIAA1716
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16754. ACAP3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26408.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3PRO_0000356159Add
    BLAST

    Proteomic databases

    MaxQBiQ96P50.
    PaxDbiQ96P50.
    PRIDEiQ96P50.

    PTM databases

    PhosphoSiteiQ96P50.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96P50.
    BgeeiQ96P50.
    CleanExiHS_ACAP3.
    GenevestigatoriQ96P50.

    Organism-specific databases

    HPAiHPA049317.

    Interactioni

    Protein-protein interaction databases

    BioGridi125546. 3 interactions.
    IntActiQ96P50. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P50.
    SMRiQ96P50. Positions 6-358, 405-522, 660-808.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini268 – 36396PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 525123Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati702 – 73130ANK 1Add
    BLAST
    Repeati735 – 76430ANK 2Add
    BLAST
    Repeati768 – 79730ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri418 – 44124C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000220815.
    HOVERGENiHBG050889.
    KOiK12489.
    OMAiVNWADAE.
    OrthoDBiEOG7PVWNT.
    PhylomeDBiQ96P50.
    TreeFamiTF318315.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    1.25.40.20. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96P50-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY    50
    VSTSRLFVSG VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ 100
    RSVRQQLQSF VKEDVRKFKE TKKQFDKVRE DLELSLVRNA QAPRHRPHEV 150
    EEATGALTLT RKCFRHLALD YVLQINVLQA KKKFEILDSM LSFMHAQSSF 200
    FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH AAIQQRTLLQ 250
    DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY 300
    QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL 350
    RQAWVQAVQA SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV 400
    KGESVLQRVQ SVAGNSQCGD CGQPDPRWAS INLGVLLCIE CSGIHRSLGV 450
    HCSKVRSLTL DSWEPELLKL MCELGNSAVN QIYEAQCEGA GSRKPTASSS 500
    RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR PHSSPRAPTA 550
    RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG 600
    AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD 650
    GDTEAEAWGL ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE 700
    DEGKTPLVQA VLGGSLIVCE FLLQNGADVN QRDSRGRAPL HHATLLGRTG 750
    QVCLFLKRGA DQHALDQEQR DPLAIAVQAA NADIVTLLRL ARMAEEMREA 800
    EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES 834
    Length:834
    Mass (Da):92,495
    Last modified:December 16, 2008 - v2
    Checksum:iD4C00A06EDB72F68
    GO
    Isoform 2 (identifier: Q96P50-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         605-638: SLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEE → K

    Show »
    Length:759
    Mass (Da):84,664
    Checksum:i9FC816F48DC78EAA
    GO
    Isoform 3 (identifier: Q96P50-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-270: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:564
    Mass (Da):61,395
    Checksum:iE0CDD1C80A9A13C1
    GO

    Sequence cautioni

    The sequence BAB21807.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941I → N in AAH51194. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 270270Missing in isoform 3. CuratedVSP_035992Add
    BLAST
    Alternative sequencei1 – 4242Missing in isoform 2. 2 PublicationsVSP_035993Add
    BLAST
    Alternative sequencei605 – 63834SLSSD…VTEEE → K in isoform 2. 2 PublicationsVSP_035994Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411981 mRNA. Translation: AAL04165.1.
    AB051503 mRNA. Translation: BAB21807.1. Different initiation.
    AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
    AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
    AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
    AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
    AL162741 Genomic DNA. Translation: CAI23264.1.
    CH471183 Genomic DNA. Translation: EAW56248.1.
    CH471183 Genomic DNA. Translation: EAW56249.1.
    BC004874 mRNA. Translation: AAH04874.2.
    BC051194 mRNA. Translation: AAH51194.2.
    CCDSiCCDS19.2. [Q96P50-3]
    RefSeqiNP_085152.2. NM_030649.2. [Q96P50-3]
    UniGeneiHs.535257.

    Genome annotation databases

    EnsembliENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
    ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
    GeneIDi116983.
    KEGGihsa:116983.
    UCSCiuc001ady.2. human. [Q96P50-3]
    uc001aea.2. human. [Q96P50-1]

    Polymorphism databases

    DMDMi218511905.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411981 mRNA. Translation: AAL04165.1 .
    AB051503 mRNA. Translation: BAB21807.1 . Different initiation.
    AL139287 , AL162741 Genomic DNA. Translation: CAI23170.1 .
    AL139287 , AL162741 Genomic DNA. Translation: CAI23171.1 .
    AL162741 , AL139287 Genomic DNA. Translation: CAI23243.1 .
    AL162741 , AL139287 Genomic DNA. Translation: CAI23244.1 .
    AL162741 Genomic DNA. Translation: CAI23264.1 .
    CH471183 Genomic DNA. Translation: EAW56248.1 .
    CH471183 Genomic DNA. Translation: EAW56249.1 .
    BC004874 mRNA. Translation: AAH04874.2 .
    BC051194 mRNA. Translation: AAH51194.2 .
    CCDSi CCDS19.2. [Q96P50-3 ]
    RefSeqi NP_085152.2. NM_030649.2. [Q96P50-3 ]
    UniGenei Hs.535257.

    3D structure databases

    ProteinModelPortali Q96P50.
    SMRi Q96P50. Positions 6-358, 405-522, 660-808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125546. 3 interactions.
    IntActi Q96P50. 3 interactions.

    PTM databases

    PhosphoSitei Q96P50.

    Polymorphism databases

    DMDMi 218511905.

    Proteomic databases

    MaxQBi Q96P50.
    PaxDbi Q96P50.
    PRIDEi Q96P50.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353662 ; ENSP00000321139 ; ENSG00000131584 . [Q96P50-1 ]
    ENST00000354700 ; ENSP00000346733 ; ENSG00000131584 . [Q96P50-3 ]
    GeneIDi 116983.
    KEGGi hsa:116983.
    UCSCi uc001ady.2. human. [Q96P50-3 ]
    uc001aea.2. human. [Q96P50-1 ]

    Organism-specific databases

    CTDi 116983.
    GeneCardsi GC01M001220.
    H-InvDB HIX0000019.
    HGNCi HGNC:16754. ACAP3.
    HPAi HPA049317.
    neXtProti NX_Q96P50.
    PharmGKBi PA26408.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000220815.
    HOVERGENi HBG050889.
    KOi K12489.
    OMAi VNWADAE.
    OrthoDBi EOG7PVWNT.
    PhylomeDBi Q96P50.
    TreeFami TF318315.

    Miscellaneous databases

    ChiTaRSi ACAP3. human.
    GenomeRNAii 116983.
    NextBioi 80052.
    PROi Q96P50.

    Gene expression databases

    ArrayExpressi Q96P50.
    Bgeei Q96P50.
    CleanExi HS_ACAP3.
    Genevestigatori Q96P50.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    1.25.40.20. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Centaurin beta5, a new member of centaurin family."
      Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus and Lymph.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiACAP3_HUMAN
    AccessioniPrimary (citable) accession number: Q96P50
    Secondary accession number(s): B1AMF5
    , Q5TA42, Q5TA43, Q86UT3, Q9BSR9, Q9C0E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3