Reviewed, UniProtKB/Swiss-Prot Q96P50 (ACAP3_HUMAN)

Names and origin

Protein names

Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Alternative name(s):
    Centaurin-beta-5
      Short name=Cnt-b5

Gene names

Name:	ACAP3
Synonyms:	CENTB5, KIAA1716

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	834 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	GTPase-activating protein for the ADP ribosylation factor family Potential.
Sequence similarities	Contains 3 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96P50-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96P50-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     605-638: SLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEE → K

Isoform 3 (identifier: Q96P50-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 834	834	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3		PRO_0000356159
Regions
	Domain	268 – 363	96	PH
	Domain	403 – 525	123	Arf-GAP
	Repeat	702 – 731	30	ANK 1
	Repeat	735 – 764	30	ANK 2
	Repeat	768 – 797	30	ANK 3
	Zinc finger	418 – 441	24	C4-type
Natural variations
	Alternative sequence	1 – 270	270	Missing in isoform 3.		VSP_035992
	Alternative sequence	1 – 42	42	Missing in isoform 2.		VSP_035993
	Alternative sequence	605 – 638	34	SLSSD…VTEEE → K in isoform 2.		VSP_035994
Experimental info
	Sequence conflict	94	1	I → N in AAH51194. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: D4C00A06EDB72F68	FASTA	834	92,495
	10 20 30 40 50 60 MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY VSTSRLFVSG 70 80 90 100 110 120 VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ RSVRQQLQSF VKEDVRKFKE 130 140 150 160 170 180 TKKQFDKVRE DLELSLVRNA QAPRHRPHEV EEATGALTLT RKCFRHLALD YVLQINVLQA 190 200 210 220 230 240 KKKFEILDSM LSFMHAQSSF FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH 250 260 270 280 290 300 AAIQQRTLLQ DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY 310 320 330 340 350 360 QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL RQAWVQAVQA 370 380 390 400 410 420 SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV KGESVLQRVQ SVAGNSQCGD 430 440 450 460 470 480 CGQPDPRWAS INLGVLLCIE CSGIHRSLGV HCSKVRSLTL DSWEPELLKL MCELGNSAVN 490 500 510 520 530 540 QIYEAQCEGA GSRKPTASSS RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR 550 560 570 580 590 600 PHSSPRAPTA RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG 610 620 630 640 650 660 AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD GDTEAEAWGL 670 680 690 700 710 720 ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE DEGKTPLVQA VLGGSLIVCE 730 740 750 760 770 780 FLLQNGADVN QRDSRGRAPL HHATLLGRTG QVCLFLKRGA DQHALDQEQR DPLAIAVQAA 790 800 810 820 830 NADIVTLLRL ARMAEEMREA EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES
	Isoform 2. Checksum: 9FC816F48DC78EAA	FASTA	759	84,664
	10 20 30 40 50 60 MVEAGKAYVS TSRLFVSGVR DLSQQCQGDT VISECLQRFA DSLQEVVNYH MILFDQAQRS 70 80 90 100 110 120 VRQQLQSFVK EDVRKFKETK KQFDKVREDL ELSLVRNAQA PRHRPHEVEE ATGALTLTRK 130 140 150 160 170 180 CFRHLALDYV LQINVLQAKK KFEILDSMLS FMHAQSSFFQ QGYSLLHQLD PYMKKLAAEL 190 200 210 220 230 240 DQLVIDSAVE KREMERKHAA IQQRTLLQDF SYDESKVEFD VDAPSGVVME GYLFKRASNA 250 260 270 280 290 300 FKTWNRRWFS IQNSQLVYQK KLKDALTVVV DDLRLCSVKP CEDIERRFCF EVLSPTKSCM 310 320 330 340 350 360 LQADSEKLRQ AWVQAVQASI ASAYRESPDS CYSERLDRTA SPSTSSIDSA TDTRERGVKG 370 380 390 400 410 420 ESVLQRVQSV AGNSQCGDCG QPDPRWASIN LGVLLCIECS GIHRSLGVHC SKVRSLTLDS 430 440 450 460 470 480 WEPELLKLMC ELGNSAVNQI YEAQCEGAGS RKPTASSSRQ DKEAWIKDKY VEKKFLRKAP 490 500 510 520 530 540 MAPALEAPRR WRVQKCLRPH SSPRAPTARR KVRLEPVLPC VAALSSVGTL DRKFRRDSLF 550 560 570 580 590 600 CPDELDSLFS YFDAGAAGAG PRKGAESEES SGEADGDTEA EAWGLADVRE LHPGLLAHRA 610 620 630 640 650 660 ARARDLPALA AALAHGAEVN WADAEDEGKT PLVQAVLGGS LIVCEFLLQN GADVNQRDSR 670 680 690 700 710 720 GRAPLHHATL LGRTGQVCLF LKRGADQHAL DQEQRDPLAI AVQAANADIV TLLRLARMAE 730 740 750 EMREAEAAPG PPGALAGSPT ELQFRRCIQE FISLHLEES
	Isoform 3. Checksum: E0CDD1C80A9A13C1	FASTA	564	61,395
	10 20 30 40 50 60 MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY QKKLKDALTV VVDDLRLCSV KPCEDIERRF 70 80 90 100 110 120 CFEVLSPTKS CMLQADSEKL RQAWVQAVQA SIASAYRESP DSCYSERLDR TASPSTSSID 130 140 150 160 170 180 SATDTRERGV KGESVLQRVQ SVAGNSQCGD CGQPDPRWAS INLGVLLCIE CSGIHRSLGV 190 200 210 220 230 240 HCSKVRSLTL DSWEPELLKL MCELGNSAVN QIYEAQCEGA GSRKPTASSS RQDKEAWIKD 250 260 270 280 290 300 KYVEKKFLRK APMAPALEAP RRWRVQKCLR PHSSPRAPTA RRKVRLEPVL PCVAALSSVG 310 320 330 340 350 360 TLDRKFRRDS LFCPDELDSL FSYFDAGAAG AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV 370 380 390 400 410 420 VDSVTEEEGA ESEESSGEAD GDTEAEAWGL ADVRELHPGL LAHRAARARD LPALAAALAH 430 440 450 460 470 480 GAEVNWADAE DEGKTPLVQA VLGGSLIVCE FLLQNGADVN QRDSRGRAPL HHATLLGRTG 490 500 510 520 530 540 QVCLFLKRGA DQHALDQEQR DPLAIAVQAA NADIVTLLRL ARMAEEMREA EAAPGPPGAL 550 560 AGSPTELQFR RCIQEFISLH LEES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Centaurin beta5, a new member of centaurin family." Hong W. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Hippocampus and Lymph.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF411981 mRNA. Translation: AAL04165.1. AB051503 mRNA. Translation: BAB21807.1. Different initiation. AL139287, AL162741 Genomic DNA. Translation: CAI23170.1. AL139287, AL162741 Genomic DNA. Translation: CAI23171.1. AL162741, AL139287 Genomic DNA. Translation: CAI23243.1. AL162741, AL139287 Genomic DNA. Translation: CAI23244.1. AL162741 Genomic DNA. Translation: CAI23264.1. CH471183 Genomic DNA. Translation: EAW56248.1. CH471183 Genomic DNA. Translation: EAW56249.1. BC004874 mRNA. Translation: AAH04874.2. BC051194 mRNA. Translation: AAH51194.2.
IPI	IPI00465167. IPI00550459. IPI00643360.
RefSeq	NP_085152.2.
UniGene	Hs.535257
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96P50. 2 interactions.
PTM databases
PhosphoSite	Q96P50.
Genome annotation databases
Ensembl	ENST00000354700; ENSP00000346733; ENSG00000131584; Homo sapiens. [Genome view]
GeneID	116983.
KEGG	hsa:116983.
UCSC	uc001adz.1. human.
Organism-specific databases
CTD	116983.
GeneCards	GC01M001220.
H-InvDB	HIX0000019.
HGNC	HGNC:16754. ACAP3.
PharmGKB	PA26408.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96P50.
OMA	LLQDFSY
OrthoDB	EOG9CVJSW
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000009856-MON.
Gene expression databases
ArrayExpress	Q96P50.
Bgee	Q96P50.
CleanEx	HS_ACAP3.
Genevestigator	Q96P50.
GermOnline	ENSG00000131584. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00023. Ank. 4 hits. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	80052.

Entry information

Entry name

ACAP3_HUMAN

Accession

Primary (citable) accession number: Q96P50
Secondary accession number(s): B1AMF5 , Q5TA42, Q5TA43, Q86UT3, Q9BSR9, Q9C0E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	December 16, 2008
Last modified:	November 24, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.