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Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Gene

ACAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri418 – 44124C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-beta-5
Short name:
Cnt-b5
Gene namesi
Name:ACAP3
Synonyms:CENTB5, KIAA1716
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16754. ACAP3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26408.

Polymorphism and mutation databases

BioMutaiACAP3.
DMDMi218511905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3PRO_0000356159Add
BLAST

Proteomic databases

MaxQBiQ96P50.
PaxDbiQ96P50.
PRIDEiQ96P50.

PTM databases

PhosphoSiteiQ96P50.

Expressioni

Gene expression databases

BgeeiQ96P50.
CleanExiHS_ACAP3.
ExpressionAtlasiQ96P50. baseline and differential.
GenevisibleiQ96P50. HS.

Organism-specific databases

HPAiHPA049317.
HPA058381.

Interactioni

Protein-protein interaction databases

BioGridi125546. 2 interactions.
IntActiQ96P50. 3 interactions.
STRINGi9606.ENSP00000346733.

Structurei

3D structure databases

ProteinModelPortaliQ96P50.
SMRiQ96P50. Positions 1-366, 405-522, 660-808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 36396PHPROSITE-ProRule annotationAdd
BLAST
Domaini403 – 525123Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati702 – 73130ANK 1Add
BLAST
Repeati735 – 76430ANK 2Add
BLAST
Repeati768 – 79730ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri418 – 44124C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ96P50.
KOiK12489.
OMAiAVEKRDM.
OrthoDBiEOG7PVWNT.
PhylomeDBiQ96P50.
TreeFamiTF318315.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P50-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY
60 70 80 90 100
VSTSRLFVSG VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ
110 120 130 140 150
RSVRQQLQSF VKEDVRKFKE TKKQFDKVRE DLELSLVRNA QAPRHRPHEV
160 170 180 190 200
EEATGALTLT RKCFRHLALD YVLQINVLQA KKKFEILDSM LSFMHAQSSF
210 220 230 240 250
FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH AAIQQRTLLQ
260 270 280 290 300
DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY
310 320 330 340 350
QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL
360 370 380 390 400
RQAWVQAVQA SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV
410 420 430 440 450
KGESVLQRVQ SVAGNSQCGD CGQPDPRWAS INLGVLLCIE CSGIHRSLGV
460 470 480 490 500
HCSKVRSLTL DSWEPELLKL MCELGNSAVN QIYEAQCEGA GSRKPTASSS
510 520 530 540 550
RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR PHSSPRAPTA
560 570 580 590 600
RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG
610 620 630 640 650
AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD
660 670 680 690 700
GDTEAEAWGL ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE
710 720 730 740 750
DEGKTPLVQA VLGGSLIVCE FLLQNGADVN QRDSRGRAPL HHATLLGRTG
760 770 780 790 800
QVCLFLKRGA DQHALDQEQR DPLAIAVQAA NADIVTLLRL ARMAEEMREA
810 820 830
EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES
Length:834
Mass (Da):92,495
Last modified:December 16, 2008 - v2
Checksum:iD4C00A06EDB72F68
GO
Isoform 2 (identifier: Q96P50-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     605-638: SLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEE → K

Show »
Length:759
Mass (Da):84,664
Checksum:i9FC816F48DC78EAA
GO
Isoform 3 (identifier: Q96P50-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):61,395
Checksum:iE0CDD1C80A9A13C1
GO

Sequence cautioni

The sequence BAB21807.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941I → N in AAH51194 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 270270Missing in isoform 3. CuratedVSP_035992Add
BLAST
Alternative sequencei1 – 4242Missing in isoform 2. 2 PublicationsVSP_035993Add
BLAST
Alternative sequencei605 – 63834SLSSD…VTEEE → K in isoform 2. 2 PublicationsVSP_035994Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411981 mRNA. Translation: AAL04165.1.
AB051503 mRNA. Translation: BAB21807.1. Different initiation.
AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
AL162741 Genomic DNA. Translation: CAI23264.1.
CH471183 Genomic DNA. Translation: EAW56248.1.
CH471183 Genomic DNA. Translation: EAW56249.1.
BC004874 mRNA. Translation: AAH04874.2.
BC051194 mRNA. Translation: AAH51194.2.
CCDSiCCDS19.2. [Q96P50-3]
RefSeqiNP_085152.2. NM_030649.2. [Q96P50-3]
UniGeneiHs.535257.

Genome annotation databases

EnsembliENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
GeneIDi116983.
KEGGihsa:116983.
UCSCiuc001ady.2. human. [Q96P50-3]
uc001aea.2. human. [Q96P50-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411981 mRNA. Translation: AAL04165.1.
AB051503 mRNA. Translation: BAB21807.1. Different initiation.
AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
AL162741 Genomic DNA. Translation: CAI23264.1.
CH471183 Genomic DNA. Translation: EAW56248.1.
CH471183 Genomic DNA. Translation: EAW56249.1.
BC004874 mRNA. Translation: AAH04874.2.
BC051194 mRNA. Translation: AAH51194.2.
CCDSiCCDS19.2. [Q96P50-3]
RefSeqiNP_085152.2. NM_030649.2. [Q96P50-3]
UniGeneiHs.535257.

3D structure databases

ProteinModelPortaliQ96P50.
SMRiQ96P50. Positions 1-366, 405-522, 660-808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125546. 2 interactions.
IntActiQ96P50. 3 interactions.
STRINGi9606.ENSP00000346733.

PTM databases

PhosphoSiteiQ96P50.

Polymorphism and mutation databases

BioMutaiACAP3.
DMDMi218511905.

Proteomic databases

MaxQBiQ96P50.
PaxDbiQ96P50.
PRIDEiQ96P50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
GeneIDi116983.
KEGGihsa:116983.
UCSCiuc001ady.2. human. [Q96P50-3]
uc001aea.2. human. [Q96P50-1]

Organism-specific databases

CTDi116983.
GeneCardsiGC01M001220.
H-InvDBHIX0000019.
HGNCiHGNC:16754. ACAP3.
HPAiHPA049317.
HPA058381.
neXtProtiNX_Q96P50.
PharmGKBiPA26408.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ96P50.
KOiK12489.
OMAiAVEKRDM.
OrthoDBiEOG7PVWNT.
PhylomeDBiQ96P50.
TreeFamiTF318315.

Miscellaneous databases

ChiTaRSiACAP3. human.
GenomeRNAii116983.
NextBioi80052.
PROiQ96P50.

Gene expression databases

BgeeiQ96P50.
CleanExiHS_ACAP3.
ExpressionAtlasiQ96P50. baseline and differential.
GenevisibleiQ96P50. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Centaurin beta5, a new member of centaurin family."
    Hong W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus and Lymph.
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiACAP3_HUMAN
AccessioniPrimary (citable) accession number: Q96P50
Secondary accession number(s): B1AMF5
, Q5TA42, Q5TA43, Q86UT3, Q9BSR9, Q9C0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.