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Q96P50 (ACAP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-beta-5
Short name=Cnt-b5
Gene names
Name:ACAP3
Synonyms:CENTB5, KIAA1716
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GTPase-activating protein for the ADP ribosylation factor family Potential.

Sequence similarities

Contains 3 ANK repeats.

Contains 1 Arf-GAP domain.

Contains 1 PH domain.

Sequence caution

The sequence BAB21807.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of ARF GTPase activity

Inferred from electronic annotation. Source: InterPro

   Molecular_functionARF GTPase activator activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96P50-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96P50-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     605-638: SLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEE → K
Isoform 3 (identifier: Q96P50-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
PRO_0000356159

Regions

Domain268 – 36396PH
Domain403 – 525123Arf-GAP
Repeat702 – 73130ANK 1
Repeat735 – 76430ANK 2
Repeat768 – 79730ANK 3
Zinc finger418 – 44124C4-type

Natural variations

Alternative sequence1 – 270270Missing in isoform 3.
VSP_035992
Alternative sequence1 – 4242Missing in isoform 2.
VSP_035993
Alternative sequence605 – 63834SLSSD…VTEEE → K in isoform 2.
VSP_035994

Experimental info

Sequence conflict941I → N in AAH51194. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: D4C00A06EDB72F68

FASTA83492,495
        10         20         30         40         50         60 
MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY VSTSRLFVSG 

        70         80         90        100        110        120 
VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ RSVRQQLQSF VKEDVRKFKE 

       130        140        150        160        170        180 
TKKQFDKVRE DLELSLVRNA QAPRHRPHEV EEATGALTLT RKCFRHLALD YVLQINVLQA 

       190        200        210        220        230        240 
KKKFEILDSM LSFMHAQSSF FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH 

       250        260        270        280        290        300 
AAIQQRTLLQ DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY 

       310        320        330        340        350        360 
QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL RQAWVQAVQA 

       370        380        390        400        410        420 
SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV KGESVLQRVQ SVAGNSQCGD 

       430        440        450        460        470        480 
CGQPDPRWAS INLGVLLCIE CSGIHRSLGV HCSKVRSLTL DSWEPELLKL MCELGNSAVN 

       490        500        510        520        530        540 
QIYEAQCEGA GSRKPTASSS RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR 

       550        560        570        580        590        600 
PHSSPRAPTA RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG 

       610        620        630        640        650        660 
AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD GDTEAEAWGL 

       670        680        690        700        710        720 
ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE DEGKTPLVQA VLGGSLIVCE 

       730        740        750        760        770        780 
FLLQNGADVN QRDSRGRAPL HHATLLGRTG QVCLFLKRGA DQHALDQEQR DPLAIAVQAA 

       790        800        810        820        830 
NADIVTLLRL ARMAEEMREA EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES 

« Hide

Isoform 2 [UniParc].

Checksum: 9FC816F48DC78EAA
Show »

FASTA75984,664
Isoform 3 [UniParc].

Checksum: E0CDD1C80A9A13C1
Show »

FASTA56461,395

References

« Hide 'large scale' references
[1]"Centaurin beta5, a new member of centaurin family."
Hong W.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hippocampus and Lymph.
[6]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411981 mRNA. Translation: AAL04165.1.
AB051503 mRNA. Translation: BAB21807.1. Different initiation.
AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
AL162741 Genomic DNA. Translation: CAI23264.1.
CH471183 Genomic DNA. Translation: EAW56248.1.
CH471183 Genomic DNA. Translation: EAW56249.1.
BC004874 mRNA. Translation: AAH04874.2.
BC051194 mRNA. Translation: AAH51194.2.
RefSeqNP_085152.2. NM_030649.2.
UniGeneHs.535257.

3D structure databases

ProteinModelPortalQ96P50.
SMRQ96P50. Positions 6-358, 404-828.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125546. 3 interactions.
IntActQ96P50. 3 interactions.

PTM databases

PhosphoSiteQ96P50.

Polymorphism databases

DMDM218511905.

Proteomic databases

PaxDbQ96P50.
PRIDEQ96P50.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
GeneID116983.
KEGGhsa:116983.
UCSCuc001ady.2. human. [Q96P50-3]
uc001aea.2. human. [Q96P50-1]

Organism-specific databases

CTD116983.
GeneCardsGC01M001220.
H-InvDBHIX0000019.
HGNCHGNC:16754. ACAP3.
HPAHPA049317.
neXtProtNX_Q96P50.
PharmGKBPA26408.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5347.
HOGENOMHOG000220815.
HOVERGENHBG050889.
KOK12489.
OMASYDEPKV.
OrthoDBEOG7PVWNT.
PhylomeDBQ96P50.
TreeFamTF318315.

Gene expression databases

ArrayExpressQ96P50.
BgeeQ96P50.
CleanExHS_ACAP3.
GenevestigatorQ96P50.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00405. REVINTRACTNG.
SMARTSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSACAP3. human.
GenomeRNAi116983.
NextBio80052.
PROQ96P50.

Entry information

Entry nameACAP3_HUMAN
AccessionPrimary (citable) accession number: Q96P50
Secondary accession number(s): B1AMF5 expand/collapse secondary AC list , Q5TA42, Q5TA43, Q86UT3, Q9BSR9, Q9C0E7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM