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Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Gene

ACAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 441C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-beta-5
Short name:
Cnt-b5
Gene namesi
Name:ACAP3
Synonyms:CENTB5, KIAA1716
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16754. ACAP3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131584.
PharmGKBiPA26408.

Polymorphism and mutation databases

BioMutaiACAP3.
DMDMi218511905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561591 – 834Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3Add BLAST834

Proteomic databases

EPDiQ96P50.
MaxQBiQ96P50.
PaxDbiQ96P50.
PeptideAtlasiQ96P50.
PRIDEiQ96P50.

PTM databases

iPTMnetiQ96P50.
PhosphoSitePlusiQ96P50.

Expressioni

Gene expression databases

BgeeiENSG00000131584.
CleanExiHS_ACAP3.
ExpressionAtlasiQ96P50. baseline and differential.
GenevisibleiQ96P50. HS.

Organism-specific databases

HPAiHPA049317.
HPA058381.

Interactioni

Protein-protein interaction databases

BioGridi125546. 3 interactors.
IntActiQ96P50. 4 interactors.
STRINGi9606.ENSP00000346733.

Structurei

3D structure databases

ProteinModelPortaliQ96P50.
SMRiQ96P50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 363PHPROSITE-ProRule annotationAdd BLAST96
Domaini403 – 525Arf-GAPPROSITE-ProRule annotationAdd BLAST123
Repeati702 – 731ANK 1Add BLAST30
Repeati735 – 764ANK 2Add BLAST30
Repeati768 – 797ANK 3Add BLAST30

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 441C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ96P50.
KOiK12489.
OMAiNTIWEDM.
OrthoDBiEOG091G029F.
PhylomeDBiQ96P50.
TreeFamiTF318315.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P50-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY
60 70 80 90 100
VSTSRLFVSG VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ
110 120 130 140 150
RSVRQQLQSF VKEDVRKFKE TKKQFDKVRE DLELSLVRNA QAPRHRPHEV
160 170 180 190 200
EEATGALTLT RKCFRHLALD YVLQINVLQA KKKFEILDSM LSFMHAQSSF
210 220 230 240 250
FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH AAIQQRTLLQ
260 270 280 290 300
DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY
310 320 330 340 350
QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL
360 370 380 390 400
RQAWVQAVQA SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV
410 420 430 440 450
KGESVLQRVQ SVAGNSQCGD CGQPDPRWAS INLGVLLCIE CSGIHRSLGV
460 470 480 490 500
HCSKVRSLTL DSWEPELLKL MCELGNSAVN QIYEAQCEGA GSRKPTASSS
510 520 530 540 550
RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR PHSSPRAPTA
560 570 580 590 600
RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG
610 620 630 640 650
AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD
660 670 680 690 700
GDTEAEAWGL ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE
710 720 730 740 750
DEGKTPLVQA VLGGSLIVCE FLLQNGADVN QRDSRGRAPL HHATLLGRTG
760 770 780 790 800
QVCLFLKRGA DQHALDQEQR DPLAIAVQAA NADIVTLLRL ARMAEEMREA
810 820 830
EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES
Length:834
Mass (Da):92,495
Last modified:December 16, 2008 - v2
Checksum:iD4C00A06EDB72F68
GO
Isoform 2 (identifier: Q96P50-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     605-638: SLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEE → K

Show »
Length:759
Mass (Da):84,664
Checksum:i9FC816F48DC78EAA
GO
Isoform 3 (identifier: Q96P50-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):61,395
Checksum:iE0CDD1C80A9A13C1
GO

Sequence cautioni

The sequence BAB21807 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94I → N in AAH51194 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0359921 – 270Missing in isoform 3. CuratedAdd BLAST270
Alternative sequenceiVSP_0359931 – 42Missing in isoform 2. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_035994605 – 638SLSSD…VTEEE → K in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411981 mRNA. Translation: AAL04165.1.
AB051503 mRNA. Translation: BAB21807.1. Different initiation.
AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
AL162741 Genomic DNA. Translation: CAI23264.1.
CH471183 Genomic DNA. Translation: EAW56248.1.
CH471183 Genomic DNA. Translation: EAW56249.1.
BC004874 mRNA. Translation: AAH04874.2.
BC051194 mRNA. Translation: AAH51194.2.
CCDSiCCDS19.2. [Q96P50-3]
RefSeqiNP_085152.2. NM_030649.2. [Q96P50-3]
UniGeneiHs.535257.

Genome annotation databases

EnsembliENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
GeneIDi116983.
KEGGihsa:116983.
UCSCiuc001aeb.3. human. [Q96P50-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411981 mRNA. Translation: AAL04165.1.
AB051503 mRNA. Translation: BAB21807.1. Different initiation.
AL139287, AL162741 Genomic DNA. Translation: CAI23170.1.
AL139287, AL162741 Genomic DNA. Translation: CAI23171.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23243.1.
AL162741, AL139287 Genomic DNA. Translation: CAI23244.1.
AL162741 Genomic DNA. Translation: CAI23264.1.
CH471183 Genomic DNA. Translation: EAW56248.1.
CH471183 Genomic DNA. Translation: EAW56249.1.
BC004874 mRNA. Translation: AAH04874.2.
BC051194 mRNA. Translation: AAH51194.2.
CCDSiCCDS19.2. [Q96P50-3]
RefSeqiNP_085152.2. NM_030649.2. [Q96P50-3]
UniGeneiHs.535257.

3D structure databases

ProteinModelPortaliQ96P50.
SMRiQ96P50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125546. 3 interactors.
IntActiQ96P50. 4 interactors.
STRINGi9606.ENSP00000346733.

PTM databases

iPTMnetiQ96P50.
PhosphoSitePlusiQ96P50.

Polymorphism and mutation databases

BioMutaiACAP3.
DMDMi218511905.

Proteomic databases

EPDiQ96P50.
MaxQBiQ96P50.
PaxDbiQ96P50.
PeptideAtlasiQ96P50.
PRIDEiQ96P50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353662; ENSP00000321139; ENSG00000131584. [Q96P50-1]
ENST00000354700; ENSP00000346733; ENSG00000131584. [Q96P50-3]
GeneIDi116983.
KEGGihsa:116983.
UCSCiuc001aeb.3. human. [Q96P50-3]

Organism-specific databases

CTDi116983.
GeneCardsiACAP3.
H-InvDBHIX0000019.
HGNCiHGNC:16754. ACAP3.
HPAiHPA049317.
HPA058381.
neXtProtiNX_Q96P50.
OpenTargetsiENSG00000131584.
PharmGKBiPA26408.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ96P50.
KOiK12489.
OMAiNTIWEDM.
OrthoDBiEOG091G029F.
PhylomeDBiQ96P50.
TreeFamiTF318315.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131584-MONOMER.

Miscellaneous databases

ChiTaRSiACAP3. human.
GenomeRNAii116983.
PROiQ96P50.

Gene expression databases

BgeeiENSG00000131584.
CleanExiHS_ACAP3.
ExpressionAtlasiQ96P50. baseline and differential.
GenevisibleiQ96P50. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACAP3_HUMAN
AccessioniPrimary (citable) accession number: Q96P50
Secondary accession number(s): B1AMF5
, Q5TA42, Q5TA43, Q86UT3, Q9BSR9, Q9C0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.