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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri550 – 576C4-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB

GO - Biological processi

  • actin filament reorganization involved in cell cycle Source: UniProtKB
  • negative regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  • positive regulation of filopodium assembly Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of receptor recycling Source: Ensembl
  • regulation of cell shape Source: UniProtKB
  • regulation of cellular component movement Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32741-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2
Short name:
Cnt-d2
Gene namesi
Name:ARAP1
Synonyms:CENTD2, KIAA0782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16925. ARAP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116985.
OpenTargetsiENSG00000186635.
PharmGKBiPA164715867.

Polymorphism and mutation databases

BioMutaiARAP1.
DMDMi226694321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742141 – 1450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphoserineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei431PhosphotyrosineCombined sources1
Modified residuei504PhosphotyrosineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei1428PhosphoserineCombined sources1
Modified residuei1435PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96P48.
PaxDbiQ96P48.
PeptideAtlasiQ96P48.
PRIDEiQ96P48.

PTM databases

iPTMnetiQ96P48.
PhosphoSitePlusiQ96P48.

Expressioni

Tissue specificityi

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.1 Publication

Gene expression databases

BgeeiENSG00000186635.
CleanExiHS_ARAP1.
ExpressionAtlasiQ96P48. baseline and differential.
GenevisibleiQ96P48. HS.

Organism-specific databases

HPAiCAB020703.

Interactioni

Subunit structurei

Interacts with TNFRSF10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-710003,EBI-8753518From a different organism.
TNFRSF10AO002204EBI-710003,EBI-518861
XRCC6P129562EBI-710003,EBI-353208

Protein-protein interaction databases

BioGridi125548. 24 interactors.
IntActiQ96P48. 14 interactors.
MINTiMINT-1395507.
STRINGi9606.ENSP00000377233.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X1VX-ray1.58B76-91[»]
ProteinModelPortaliQ96P48.
SMRiQ96P48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini327 – 419PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini440 – 529PH 2PROSITE-ProRule annotationAdd BLAST90
Domaini535 – 660Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Domaini743 – 850PH 3PROSITE-ProRule annotationAdd BLAST108
Domaini954 – 1139Rho-GAPPROSITE-ProRule annotationAdd BLAST186
Domaini1172 – 1261Ras-associatingPROSITE-ProRule annotationAdd BLAST90
Domaini1274 – 1396PH 4PROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 4 PH domains.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri550 – 576C4-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1117. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00860000133715.
HOGENOMiHOG000246988.
HOVERGENiHBG106625.
InParanoidiQ96P48.
KOiK18439.
OMAiGAPETSH.
OrthoDBiEOG091G00AN.
PhylomeDBiQ96P48.
TreeFamiTF105769.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 6 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 6 (identifier: Q96P48-6) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG
60 70 80 90 100
MLLPGHRRRI LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE
110 120 130 140 150
PLPTTTEDEG LPAAPPIPPR RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL
160 170 180 190 200
AELSVPPVPP RTGPPRLLVS LPTKEEESLL PSLSSPPQPQ SEEPLSTLPQ
210 220 230 240 250
GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG APARVMTKKE
260 270 280 290 300
EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS
310 320 330 340 350
LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV
360 370 380 390 400
RLDTDHLRYF DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR
410 420 430 440 450
AESDVERKEW MQALQQAMAE QRARARLSSA YLLGVPGSEQ PDRAGSLELR
460 470 480 490 500
GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI TFIDMSVGNV KEVDRRSFDL
510 520 530 540 550
TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER IWAAAPNRFC
560 570 580 590 600
ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET
610 620 630 640 650
LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR
660 670 680 690 700
RYHPLFGNQE ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP
710 720 730 740 750
LALAEQAGQT LQMEFLRNNR TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL
760 770 780 790 800
YKTASAGKLL QDRRAREEFS RRWCVLGDGV LSYFENERAV TPNGEIRASE
810 820 830 840 850
IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE WVKCIAKAFV
860 870 880 890 900
PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC
910 920 930 940 950
EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ
960 970 980 990 1000
KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK
1010 1020 1030 1040 1050
TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT
1060 1070 1080 1090 1100
WLEASEIEDE EEKVSRYREL LVRLPPVNRA TVKALISHLY CVQCFSDTNQ
1110 1120 1130 1140 1150
MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS VDEEELRKQR
1160 1170 1180 1190 1200
EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE
1210 1220 1230 1240 1250
ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT
1260 1270 1280 1290 1300
DSHLVVKKHQ AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH
1310 1320 1330 1340 1350
DRYFILNSSC LRLYKEVRSQ RPWSGAPETS HRPEKEWPIK SLKVYLGVKK
1360 1370 1380 1390 1400
KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV
1410 1420 1430 1440 1450
WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV
Length:1,450
Mass (Da):162,192
Last modified:March 24, 2009 - v3
Checksum:iA4B6CCC28EC4CD0D
GO
Isoform 1 (identifier: Q96P48-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ

Show »
Length:1,210
Mass (Da):136,264
Checksum:i31486141B6648495
GO
Isoform 2 (identifier: Q96P48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
     1320-1330: Missing.

Show »
Length:1,199
Mass (Da):135,066
Checksum:i95873FE63A8C3320
GO
Isoform 3 (identifier: Q96P48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1330: Missing.

Show »
Length:1,439
Mass (Da):160,994
Checksum:iA46A522E287CC2C3
GO
Isoform 4 (identifier: Q96P48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.
Show »
Length:1,205
Mass (Da):135,834
Checksum:iA679C6A273660197
GO
Isoform 5 (identifier: Q96P48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: Missing.
     761-767: QDRRARE → MDASGKG
     1320-1330: Missing.

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):77,550
Checksum:i2F50EB6053978B37
GO
Isoform 7 (identifier: Q96P48-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
     604-664: Missing.
     1320-1330: Missing.

Note: No experimental confirmation available.
Show »
Length:1,133
Mass (Da):127,665
Checksum:i69A2D13CDDA77185
GO

Sequence cautioni

The sequence BAA34502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92710 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1408V → M in AAH56401 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055529358R → Q.Corresponds to variant rs34976830dbSNPEnsembl.1
Natural variantiVAR_0610231047Q → E.1 PublicationCorresponds to variant rs56200889dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0149981 – 760Missing in isoform 5. 1 PublicationAdd BLAST760
Alternative sequenceiVSP_0150001 – 245Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST245
Alternative sequenceiVSP_0366071 – 240Missing in isoform 1 and isoform 2. 3 PublicationsAdd BLAST240
Alternative sequenceiVSP_036608241 – 249APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2. 3 Publications9
Alternative sequenceiVSP_043530604 – 664Missing in isoform 7. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_015001761 – 767QDRRARE → MDASGKG in isoform 5. 1 Publication7
Alternative sequenceiVSP_0003111320 – 1330Missing in isoform 2, isoform 3, isoform 5 and isoform 7. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSiCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRiC59431.
RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneiHs.503165.

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
GeneIDi116985.
KEGGihsa:116985.
UCSCiuc001osr.4. human. [Q96P48-6]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSiCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRiC59431.
RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneiHs.503165.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X1VX-ray1.58B76-91[»]
ProteinModelPortaliQ96P48.
SMRiQ96P48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125548. 24 interactors.
IntActiQ96P48. 14 interactors.
MINTiMINT-1395507.
STRINGi9606.ENSP00000377233.

PTM databases

iPTMnetiQ96P48.
PhosphoSitePlusiQ96P48.

Polymorphism and mutation databases

BioMutaiARAP1.
DMDMi226694321.

Proteomic databases

EPDiQ96P48.
PaxDbiQ96P48.
PeptideAtlasiQ96P48.
PRIDEiQ96P48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
GeneIDi116985.
KEGGihsa:116985.
UCSCiuc001osr.4. human. [Q96P48-6]

Organism-specific databases

CTDi116985.
DisGeNETi116985.
GeneCardsiARAP1.
H-InvDBHIX0079401.
HIX0171326.
HGNCiHGNC:16925. ARAP1.
HPAiCAB020703.
MIMi606646. gene.
neXtProtiNX_Q96P48.
OpenTargetsiENSG00000186635.
PharmGKBiPA164715867.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1117. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00860000133715.
HOGENOMiHOG000246988.
HOVERGENiHBG106625.
InParanoidiQ96P48.
KOiK18439.
OMAiGAPETSH.
OrthoDBiEOG091G00AN.
PhylomeDBiQ96P48.
TreeFamiTF105769.

Enzyme and pathway databases

BioCyciZFISH:G66-32741-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.

Miscellaneous databases

ChiTaRSiARAP1. human.
GeneWikiiCENTD2.
GenomeRNAii116985.
PROiQ96P48.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186635.
CleanExiHS_ARAP1.
ExpressionAtlasiQ96P48. baseline and differential.
GenevisibleiQ96P48. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 6 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96P48
Secondary accession number(s): A3KLL7
, B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.