Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96P48

- ARAP1_HUMAN

UniProt

Q96P48 - ARAP1_HUMAN

Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (24 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri550 – 57627C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: UniProtKB
    2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. Rho GTPase activator activity Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. actin filament reorganization involved in cell cycle Source: UniProtKB
    2. negative regulation of stress fiber assembly Source: UniProtKB
    3. positive regulation of Cdc42 GTPase activity Source: UniProtKB
    4. positive regulation of filopodium assembly Source: UniProtKB
    5. positive regulation of receptor recycling Source: Ensembl
    6. regulation of ARF GTPase activity Source: InterPro
    7. regulation of cell shape Source: UniProtKB
    8. regulation of cellular component movement Source: UniProtKB
    9. regulation of small GTPase mediated signal transduction Source: Reactome
    10. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
    Alternative name(s):
    Centaurin-delta-2
    Short name:
    Cnt-d2
    Gene namesi
    Name:ARAP1
    Synonyms:CENTD2, KIAA0782
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16925. ARAP1.

    Subcellular locationi

    Cytoplasm. Golgi apparatusGolgi stack membrane; Peripheral membrane protein. Cell membrane
    Note: Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. cytosol Source: Reactome
    3. Golgi apparatus Source: UniProtKB
    4. Golgi cisterna membrane Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB-SubCell
    6. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164715867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14501450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1PRO_0000074214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291Phosphoserine1 Publication
    Modified residuei354 – 3541Phosphothreonine1 Publication
    Modified residuei428 – 4281Phosphoserine1 Publication
    Modified residuei431 – 4311Phosphotyrosine1 Publication
    Modified residuei738 – 7381Phosphoserine1 Publication
    Modified residuei1435 – 14351Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96P48.
    PaxDbiQ96P48.
    PRIDEiQ96P48.

    Expressioni

    Tissue specificityi

    Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.1 Publication

    Gene expression databases

    ArrayExpressiQ96P48.
    BgeeiQ96P48.
    CleanExiHS_ARAP1.
    GenevestigatoriQ96P48.

    Organism-specific databases

    HPAiCAB020703.
    HPA038456.

    Interactioni

    Subunit structurei

    Interacts with TNFRSF10A.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P279583EBI-710003,EBI-8753518From a different organism.
    TNFRSF10AO002204EBI-710003,EBI-518861
    XRCC6P129562EBI-710003,EBI-353208

    Protein-protein interaction databases

    BioGridi125548. 19 interactions.
    IntActiQ96P48. 12 interactions.
    MINTiMINT-1395507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P48.
    SMRiQ96P48. Positions 4-61, 333-421, 537-853, 970-1114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7065SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini327 – 41993PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 52990PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini535 – 660126Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini743 – 850108PH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini954 – 1139186Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1172 – 126190Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1274 – 1396123PH 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 4 PH domains.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri550 – 57627C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000246988.
    HOVERGENiHBG106625.
    KOiK12490.
    OMAiCIAKAFV.
    OrthoDBiEOG7F24T4.
    PhylomeDBiQ96P48.
    TreeFamiTF105769.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProiIPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF01412. ArfGap. 1 hit.
    PF00169. PH. 3 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEiPS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 6 (identifier: Q96P48-6) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG     50
    MLLPGHRRRI LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE 100
    PLPTTTEDEG LPAAPPIPPR RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL 150
    AELSVPPVPP RTGPPRLLVS LPTKEEESLL PSLSSPPQPQ SEEPLSTLPQ 200
    GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG APARVMTKKE 250
    EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS 300
    LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV 350
    RLDTDHLRYF DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR 400
    AESDVERKEW MQALQQAMAE QRARARLSSA YLLGVPGSEQ PDRAGSLELR 450
    GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI TFIDMSVGNV KEVDRRSFDL 500
    TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER IWAAAPNRFC 550
    ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET 600
    LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR 650
    RYHPLFGNQE ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP 700
    LALAEQAGQT LQMEFLRNNR TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL 750
    YKTASAGKLL QDRRAREEFS RRWCVLGDGV LSYFENERAV TPNGEIRASE 800
    IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE WVKCIAKAFV 850
    PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC 900
    EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ 950
    KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK 1000
    TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT 1050
    WLEASEIEDE EEKVSRYREL LVRLPPVNRA TVKALISHLY CVQCFSDTNQ 1100
    MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS VDEEELRKQR 1150
    EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE 1200
    ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT 1250
    DSHLVVKKHQ AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH 1300
    DRYFILNSSC LRLYKEVRSQ RPWSGAPETS HRPEKEWPIK SLKVYLGVKK 1350
    KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV 1400
    WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV 1450
    Length:1,450
    Mass (Da):162,192
    Last modified:March 24, 2009 - v3
    Checksum:iA4B6CCC28EC4CD0D
    GO
    Isoform 1 (identifier: Q96P48-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-249: APARVMTKK → MTLSGSRGQ

    Show »
    Length:1,210
    Mass (Da):136,264
    Checksum:i31486141B6648495
    GO
    Isoform 2 (identifier: Q96P48-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-249: APARVMTKK → MTLSGSRGQ
         1320-1330: Missing.

    Show »
    Length:1,199
    Mass (Da):135,066
    Checksum:i95873FE63A8C3320
    GO
    Isoform 3 (identifier: Q96P48-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1320-1330: Missing.

    Show »
    Length:1,439
    Mass (Da):160,994
    Checksum:iA46A522E287CC2C3
    GO
    Isoform 4 (identifier: Q96P48-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-245: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,205
    Mass (Da):135,834
    Checksum:iA679C6A273660197
    GO
    Isoform 5 (identifier: Q96P48-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-760: Missing.
         761-767: QDRRARE → MDASGKG
         1320-1330: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:679
    Mass (Da):77,550
    Checksum:i2F50EB6053978B37
    GO
    Isoform 7 (identifier: Q96P48-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-245: Missing.
         604-664: Missing.
         1320-1330: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,133
    Mass (Da):127,665
    Checksum:i69A2D13CDDA77185
    GO

    Sequence cautioni

    The sequence BAA34502.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD92710.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1408 – 14081V → M in AAH56401. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti358 – 3581R → Q.
    Corresponds to variant rs34976830 [ dbSNP | Ensembl ].
    VAR_055529
    Natural varianti1047 – 10471Q → E.1 Publication
    Corresponds to variant rs56200889 [ dbSNP | Ensembl ].
    VAR_061023

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 760760Missing in isoform 5. 1 PublicationVSP_014998Add
    BLAST
    Alternative sequencei1 – 245245Missing in isoform 4 and isoform 7. 2 PublicationsVSP_015000Add
    BLAST
    Alternative sequencei1 – 240240Missing in isoform 1 and isoform 2. 3 PublicationsVSP_036607Add
    BLAST
    Alternative sequencei241 – 2499APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2. 3 PublicationsVSP_036608
    Alternative sequencei604 – 66461Missing in isoform 7. 1 PublicationVSP_043530Add
    BLAST
    Alternative sequencei761 – 7677QDRRARE → MDASGKG in isoform 5. 1 PublicationVSP_015001
    Alternative sequencei1320 – 133011Missing in isoform 2, isoform 3, isoform 5 and isoform 7. 2 PublicationsVSP_000311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049732 mRNA. Translation: AAL12169.1.
    AJ621557 mRNA. Translation: CAF21317.1.
    AB018325 mRNA. Translation: BAA34502.2. Different initiation.
    AY553630 mRNA. Translation: AAT36325.1.
    AB209473 mRNA. Translation: BAD92710.1. Different initiation.
    AP002381 Genomic DNA. No translation available.
    AP003065 Genomic DNA. No translation available.
    BC008315 mRNA. Translation: AAH08315.1.
    BC021244 mRNA. No translation available.
    BC056401 mRNA. Translation: AAH56401.1.
    BC140792 mRNA. Translation: AAI40793.1.
    AF411983 mRNA. Translation: AAL04167.1.
    CCDSiCCDS41687.1. [Q96P48-6]
    CCDS44671.1. [Q96P48-7]
    CCDS8217.2. [Q96P48-4]
    PIRiC59431.
    RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
    NP_001128662.1. NM_001135190.1. [Q96P48-7]
    NP_056057.2. NM_015242.4. [Q96P48-4]
    UniGeneiHs.503165.

    Genome annotation databases

    EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
    ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
    ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
    ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
    ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
    ENST00000455638; ENSP00000390461; ENSG00000186635. [Q96P48-3]
    GeneIDi116985.
    KEGGihsa:116985.
    UCSCiuc001osr.3. human. [Q96P48-1]
    uc001oss.3. human. [Q96P48-6]
    uc001osv.3. human. [Q96P48-3]
    uc009yth.3. human. [Q96P48-7]

    Polymorphism databases

    DMDMi226694321.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049732 mRNA. Translation: AAL12169.1 .
    AJ621557 mRNA. Translation: CAF21317.1 .
    AB018325 mRNA. Translation: BAA34502.2 . Different initiation.
    AY553630 mRNA. Translation: AAT36325.1 .
    AB209473 mRNA. Translation: BAD92710.1 . Different initiation.
    AP002381 Genomic DNA. No translation available.
    AP003065 Genomic DNA. No translation available.
    BC008315 mRNA. Translation: AAH08315.1 .
    BC021244 mRNA. No translation available.
    BC056401 mRNA. Translation: AAH56401.1 .
    BC140792 mRNA. Translation: AAI40793.1 .
    AF411983 mRNA. Translation: AAL04167.1 .
    CCDSi CCDS41687.1. [Q96P48-6 ]
    CCDS44671.1. [Q96P48-7 ]
    CCDS8217.2. [Q96P48-4 ]
    PIRi C59431.
    RefSeqi NP_001035207.1. NM_001040118.2. [Q96P48-6 ]
    NP_001128662.1. NM_001135190.1. [Q96P48-7 ]
    NP_056057.2. NM_015242.4. [Q96P48-4 ]
    UniGenei Hs.503165.

    3D structure databases

    ProteinModelPortali Q96P48.
    SMRi Q96P48. Positions 4-61, 333-421, 537-853, 970-1114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125548. 19 interactions.
    IntActi Q96P48. 12 interactions.
    MINTi MINT-1395507.

    Polymorphism databases

    DMDMi 226694321.

    Proteomic databases

    MaxQBi Q96P48.
    PaxDbi Q96P48.
    PRIDEi Q96P48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334211 ; ENSP00000335506 ; ENSG00000186635 . [Q96P48-4 ]
    ENST00000359373 ; ENSP00000352332 ; ENSG00000186635 . [Q96P48-3 ]
    ENST00000393605 ; ENSP00000377230 ; ENSG00000186635 . [Q96P48-1 ]
    ENST00000393609 ; ENSP00000377233 ; ENSG00000186635 . [Q96P48-6 ]
    ENST00000429686 ; ENSP00000403127 ; ENSG00000186635 . [Q96P48-7 ]
    ENST00000455638 ; ENSP00000390461 ; ENSG00000186635 . [Q96P48-3 ]
    GeneIDi 116985.
    KEGGi hsa:116985.
    UCSCi uc001osr.3. human. [Q96P48-1 ]
    uc001oss.3. human. [Q96P48-6 ]
    uc001osv.3. human. [Q96P48-3 ]
    uc009yth.3. human. [Q96P48-7 ]

    Organism-specific databases

    CTDi 116985.
    GeneCardsi GC11M072396.
    H-InvDB HIX0079401.
    HIX0171326.
    HGNCi HGNC:16925. ARAP1.
    HPAi CAB020703.
    HPA038456.
    MIMi 606646. gene.
    neXtProti NX_Q96P48.
    PharmGKBi PA164715867.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000246988.
    HOVERGENi HBG106625.
    KOi K12490.
    OMAi CIAKAFV.
    OrthoDBi EOG7F24T4.
    PhylomeDBi Q96P48.
    TreeFami TF105769.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi ARAP1. human.
    GeneWikii CENTD2.
    GenomeRNAii 116985.
    NextBioi 80062.
    PROi Q96P48.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96P48.
    Bgeei Q96P48.
    CleanExi HS_ARAP1.
    Genevestigatori Q96P48.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProi IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF01412. ArfGap. 1 hit.
    PF00169. PH. 3 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEi PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "ARAP1 splice variants in man and mouse."
      Krugmann S., Coadwell J., Stephens L.R., Hawkins P.T.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "Human ARAP1b."
      Randazzo P.A., Yoon H.-Y., Miura K.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-1047.
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 792-1450 (ISOFORMS 2/3/5).
      Tissue: Brain and Pancreas.
    9. "KIAA0782 as a member (centaurin delta2) of the ArfGAP centaurin family."
      Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 315-1450 (ISOFORM 1).
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
      Simova S., Klima M., Cermak L., Sourkova V., Andera L.
      Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TNFRSF10A, SUBCELLULAR LOCATION.
    12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; TYR-431 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARAP1_HUMAN
    AccessioniPrimary (citable) accession number: Q96P48
    Secondary accession number(s): A3KLL7
    , B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3