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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57627C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: UniProtKB
  2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  3. Rho GTPase activator activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. actin filament reorganization involved in cell cycle Source: UniProtKB
  2. negative regulation of stress fiber assembly Source: UniProtKB
  3. positive regulation of Cdc42 GTPase activity Source: UniProtKB
  4. positive regulation of filopodium assembly Source: UniProtKB
  5. positive regulation of receptor recycling Source: Ensembl
  6. regulation of ARF GTPase activity Source: InterPro
  7. regulation of cell shape Source: UniProtKB
  8. regulation of cellular component movement Source: UniProtKB
  9. regulation of small GTPase mediated signal transduction Source: Reactome
  10. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2
Short name:
Cnt-d2
Gene namesi
Name:ARAP1
Synonyms:CENTD2, KIAA0782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16925. ARAP1.

Subcellular locationi

Cytoplasm. Golgi apparatusGolgi stack membrane; Peripheral membrane protein. Cell membrane
Note: Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. cytosol Source: Reactome
  3. Golgi apparatus Source: UniProtKB
  4. Golgi cisterna membrane Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB-SubCell
  6. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14501450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1PRO_0000074214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291Phosphoserine1 Publication
Modified residuei354 – 3541Phosphothreonine1 Publication
Modified residuei428 – 4281Phosphoserine1 Publication
Modified residuei431 – 4311Phosphotyrosine1 Publication
Modified residuei738 – 7381Phosphoserine1 Publication
Modified residuei1435 – 14351Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96P48.
PaxDbiQ96P48.
PRIDEiQ96P48.

Expressioni

Tissue specificityi

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.1 Publication

Gene expression databases

BgeeiQ96P48.
CleanExiHS_ARAP1.
ExpressionAtlasiQ96P48. baseline and differential.
GenevestigatoriQ96P48.

Organism-specific databases

HPAiCAB020703.
HPA038456.

Interactioni

Subunit structurei

Interacts with TNFRSF10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-710003,EBI-8753518From a different organism.
TNFRSF10AO002204EBI-710003,EBI-518861
XRCC6P129562EBI-710003,EBI-353208

Protein-protein interaction databases

BioGridi125548. 21 interactions.
IntActiQ96P48. 12 interactions.
MINTiMINT-1395507.

Structurei

3D structure databases

ProteinModelPortaliQ96P48.
SMRiQ96P48. Positions 4-61, 333-421, 537-853, 970-1114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065SAMPROSITE-ProRule annotationAdd
BLAST
Domaini327 – 41993PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini440 – 52990PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini535 – 660126Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini743 – 850108PH 3PROSITE-ProRule annotationAdd
BLAST
Domaini954 – 1139186Rho-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini1172 – 126190Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini1274 – 1396123PH 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 4 PH domains.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57627C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000246988.
HOVERGENiHBG106625.
InParanoidiQ96P48.
KOiK18439.
OMAiATECQGL.
OrthoDBiEOG7F24T4.
PhylomeDBiQ96P48.
TreeFamiTF105769.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 6 (identifier: Q96P48-6) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG
60 70 80 90 100
MLLPGHRRRI LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE
110 120 130 140 150
PLPTTTEDEG LPAAPPIPPR RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL
160 170 180 190 200
AELSVPPVPP RTGPPRLLVS LPTKEEESLL PSLSSPPQPQ SEEPLSTLPQ
210 220 230 240 250
GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG APARVMTKKE
260 270 280 290 300
EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS
310 320 330 340 350
LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV
360 370 380 390 400
RLDTDHLRYF DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR
410 420 430 440 450
AESDVERKEW MQALQQAMAE QRARARLSSA YLLGVPGSEQ PDRAGSLELR
460 470 480 490 500
GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI TFIDMSVGNV KEVDRRSFDL
510 520 530 540 550
TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER IWAAAPNRFC
560 570 580 590 600
ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET
610 620 630 640 650
LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR
660 670 680 690 700
RYHPLFGNQE ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP
710 720 730 740 750
LALAEQAGQT LQMEFLRNNR TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL
760 770 780 790 800
YKTASAGKLL QDRRAREEFS RRWCVLGDGV LSYFENERAV TPNGEIRASE
810 820 830 840 850
IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE WVKCIAKAFV
860 870 880 890 900
PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC
910 920 930 940 950
EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ
960 970 980 990 1000
KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK
1010 1020 1030 1040 1050
TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT
1060 1070 1080 1090 1100
WLEASEIEDE EEKVSRYREL LVRLPPVNRA TVKALISHLY CVQCFSDTNQ
1110 1120 1130 1140 1150
MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS VDEEELRKQR
1160 1170 1180 1190 1200
EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE
1210 1220 1230 1240 1250
ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT
1260 1270 1280 1290 1300
DSHLVVKKHQ AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH
1310 1320 1330 1340 1350
DRYFILNSSC LRLYKEVRSQ RPWSGAPETS HRPEKEWPIK SLKVYLGVKK
1360 1370 1380 1390 1400
KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV
1410 1420 1430 1440 1450
WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV
Length:1,450
Mass (Da):162,192
Last modified:March 24, 2009 - v3
Checksum:iA4B6CCC28EC4CD0D
GO
Isoform 1 (identifier: Q96P48-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ

Show »
Length:1,210
Mass (Da):136,264
Checksum:i31486141B6648495
GO
Isoform 2 (identifier: Q96P48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
     1320-1330: Missing.

Show »
Length:1,199
Mass (Da):135,066
Checksum:i95873FE63A8C3320
GO
Isoform 3 (identifier: Q96P48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1330: Missing.

Show »
Length:1,439
Mass (Da):160,994
Checksum:iA46A522E287CC2C3
GO
Isoform 4 (identifier: Q96P48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.

Show »
Length:1,205
Mass (Da):135,834
Checksum:iA679C6A273660197
GO
Isoform 5 (identifier: Q96P48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: Missing.
     761-767: QDRRARE → MDASGKG
     1320-1330: Missing.

Note: No experimental confirmation available.

Show »
Length:679
Mass (Da):77,550
Checksum:i2F50EB6053978B37
GO
Isoform 7 (identifier: Q96P48-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
     604-664: Missing.
     1320-1330: Missing.

Note: No experimental confirmation available.

Show »
Length:1,133
Mass (Da):127,665
Checksum:i69A2D13CDDA77185
GO

Sequence cautioni

The sequence BAA34502.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD92710.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1408 – 14081V → M in AAH56401 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581R → Q.
Corresponds to variant rs34976830 [ dbSNP | Ensembl ].
VAR_055529
Natural varianti1047 – 10471Q → E.1 Publication
Corresponds to variant rs56200889 [ dbSNP | Ensembl ].
VAR_061023

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 760760Missing in isoform 5. 1 PublicationVSP_014998Add
BLAST
Alternative sequencei1 – 245245Missing in isoform 4 and isoform 7. 2 PublicationsVSP_015000Add
BLAST
Alternative sequencei1 – 240240Missing in isoform 1 and isoform 2. 3 PublicationsVSP_036607Add
BLAST
Alternative sequencei241 – 2499APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2. 3 PublicationsVSP_036608
Alternative sequencei604 – 66461Missing in isoform 7. 1 PublicationVSP_043530Add
BLAST
Alternative sequencei761 – 7677QDRRARE → MDASGKG in isoform 5. 1 PublicationVSP_015001
Alternative sequencei1320 – 133011Missing in isoform 2, isoform 3, isoform 5 and isoform 7. 2 PublicationsVSP_000311Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSiCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRiC59431.
RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneiHs.503165.

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
GeneIDi116985.
KEGGihsa:116985.
UCSCiuc001osr.3. human. [Q96P48-1]
uc001oss.3. human. [Q96P48-6]
uc001osv.3. human. [Q96P48-3]
uc009yth.3. human. [Q96P48-7]

Polymorphism databases

DMDMi226694321.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSiCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRiC59431.
RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneiHs.503165.

3D structure databases

ProteinModelPortaliQ96P48.
SMRiQ96P48. Positions 4-61, 333-421, 537-853, 970-1114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125548. 21 interactions.
IntActiQ96P48. 12 interactions.
MINTiMINT-1395507.

Polymorphism databases

DMDMi226694321.

Proteomic databases

MaxQBiQ96P48.
PaxDbiQ96P48.
PRIDEiQ96P48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
GeneIDi116985.
KEGGihsa:116985.
UCSCiuc001osr.3. human. [Q96P48-1]
uc001oss.3. human. [Q96P48-6]
uc001osv.3. human. [Q96P48-3]
uc009yth.3. human. [Q96P48-7]

Organism-specific databases

CTDi116985.
GeneCardsiGC11M072396.
H-InvDBHIX0079401.
HIX0171326.
HGNCiHGNC:16925. ARAP1.
HPAiCAB020703.
HPA038456.
MIMi606646. gene.
neXtProtiNX_Q96P48.
PharmGKBiPA164715867.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000246988.
HOVERGENiHBG106625.
InParanoidiQ96P48.
KOiK18439.
OMAiATECQGL.
OrthoDBiEOG7F24T4.
PhylomeDBiQ96P48.
TreeFamiTF105769.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARAP1. human.
GeneWikiiCENTD2.
GenomeRNAii116985.
NextBioi80062.
PROiQ96P48.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P48.
CleanExiHS_ARAP1.
ExpressionAtlasiQ96P48. baseline and differential.
GenevestigatoriQ96P48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "ARAP1 splice variants in man and mouse."
    Krugmann S., Coadwell J., Stephens L.R., Hawkins P.T.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Human ARAP1b."
    Randazzo P.A., Yoon H.-Y., Miura K.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-1047.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 792-1450 (ISOFORMS 2/3/5).
    Tissue: Brain and Pancreas.
  9. "KIAA0782 as a member (centaurin delta2) of the ArfGAP centaurin family."
    Hong W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 315-1450 (ISOFORM 1).
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
    Simova S., Klima M., Cermak L., Sourkova V., Andera L.
    Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TNFRSF10A, SUBCELLULAR LOCATION.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; TYR-431 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96P48
Secondary accession number(s): A3KLL7
, B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 24, 2009
Last modified: January 7, 2015
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.