Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96P48 (ARAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2
Short name=Cnt-d2
Gene names
Name:ARAP1
Synonyms:CENTD2, KIAA0782
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1450 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 By similarity. Ref.1

Subunit structure

Interacts with TNFRSF10A. Ref.11

Subcellular location

Cytoplasm. Golgi apparatusGolgi stack membrane; Peripheral membrane protein. Cell membrane. Note: Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading. Ref.1 Ref.11

Tissue specificity

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. Ref.1

Sequence similarities

Contains 1 Arf-GAP domain.

Contains 4 PH domains.

Contains 1 Ras-associating domain.

Contains 1 Rho-GAP domain.

Contains 1 SAM (sterile alpha motif) domain.

Sequence caution

The sequence BAA34502.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAD92710.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament reorganization involved in cell cycle

Traceable author statement Ref.1. Source: UniProtKB

negative regulation of stress fiber assembly

Inferred from mutant phenotype Ref.1. Source: UniProtKB

positive regulation of Cdc42 GTPase activity

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of filopodium assembly

Inferred from mutant phenotype Ref.1. Source: UniProtKB

positive regulation of receptor recycling

Inferred from electronic annotation. Source: Ensembl

regulation of ARF GTPase activity

Inferred from electronic annotation. Source: InterPro

regulation of cell shape

Inferred from mutant phenotype Ref.1. Source: UniProtKB

regulation of cellular component movement

Inferred from mutant phenotype Ref.1. Source: UniProtKB

regulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentGolgi apparatus

Inferred from direct assay Ref.1. Source: UniProtKB

Golgi cisterna membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

cytosol

Traceable author statement. Source: Reactome

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

trans-Golgi network

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionARF GTPase activator activity

Inferred from direct assay Ref.1. Source: UniProtKB

Rho GTPase activator activity

Inferred from direct assay Ref.1. Source: UniProtKB

phosphatidylinositol-3,4,5-trisphosphate binding

Inferred from direct assay PubMed 11804589. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 15607035PubMed 16169070Ref.11. Source: IntAct

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P279583EBI-710003,EBI-8753518From a different organism.
TNFRSF10AO002204EBI-710003,EBI-518861
XRCC6P129562EBI-710003,EBI-353208

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 6 (identifier: Q96P48-6)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q96P48-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
Isoform 2 (identifier: Q96P48-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
     1320-1330: Missing.
Isoform 3 (identifier: Q96P48-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1330: Missing.
Isoform 4 (identifier: Q96P48-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q96P48-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: Missing.
     761-767: QDRRARE → MDASGKG
     1320-1330: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q96P48-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
     604-664: Missing.
     1320-1330: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14501450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
PRO_0000074214

Regions

Domain6 – 7065SAM
Domain327 – 41993PH 1
Domain440 – 52990PH 2
Domain535 – 660126Arf-GAP
Domain743 – 850108PH 3
Domain954 – 1139186Rho-GAP
Domain1172 – 126190Ras-associating
Domain1274 – 1396123PH 4
Zinc finger550 – 57627C4-type

Amino acid modifications

Modified residue2291Phosphoserine Ref.13
Modified residue3541Phosphothreonine Ref.10
Modified residue4281Phosphoserine Ref.15
Modified residue4311Phosphotyrosine Ref.13
Modified residue7381Phosphoserine Ref.14
Modified residue14351Phosphoserine Ref.13 Ref.14

Natural variations

Alternative sequence1 – 760760Missing in isoform 5.
VSP_014998
Alternative sequence1 – 245245Missing in isoform 4 and isoform 7.
VSP_015000
Alternative sequence1 – 240240Missing in isoform 1 and isoform 2.
VSP_036607
Alternative sequence241 – 2499APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2.
VSP_036608
Alternative sequence604 – 66461Missing in isoform 7.
VSP_043530
Alternative sequence761 – 7677QDRRARE → MDASGKG in isoform 5.
VSP_015001
Alternative sequence1320 – 133011Missing in isoform 2, isoform 3, isoform 5 and isoform 7.
VSP_000311
Natural variant3581R → Q.
Corresponds to variant rs34976830 [ dbSNP | Ensembl ].
VAR_055529
Natural variant10471Q → E. Ref.6
Corresponds to variant rs56200889 [ dbSNP | Ensembl ].
VAR_061023

Experimental info

Sequence conflict14081V → M in AAH56401. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 6 [UniParc].

Last modified March 24, 2009. Version 3.
Checksum: A4B6CCC28EC4CD0D

FASTA1,450162,192
        10         20         30         40         50         60 
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG MLLPGHRRRI 

        70         80         90        100        110        120 
LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE PLPTTTEDEG LPAAPPIPPR 

       130        140        150        160        170        180 
RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL AELSVPPVPP RTGPPRLLVS LPTKEEESLL 

       190        200        210        220        230        240 
PSLSSPPQPQ SEEPLSTLPQ GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG 

       250        260        270        280        290        300 
APARVMTKKE EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS 

       310        320        330        340        350        360 
LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV RLDTDHLRYF 

       370        380        390        400        410        420 
DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR AESDVERKEW MQALQQAMAE 

       430        440        450        460        470        480 
QRARARLSSA YLLGVPGSEQ PDRAGSLELR GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI 

       490        500        510        520        530        540 
TFIDMSVGNV KEVDRRSFDL TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER 

       550        560        570        580        590        600 
IWAAAPNRFC ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET 

       610        620        630        640        650        660 
LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR RYHPLFGNQE 

       670        680        690        700        710        720 
ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP LALAEQAGQT LQMEFLRNNR 

       730        740        750        760        770        780 
TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL YKTASAGKLL QDRRAREEFS RRWCVLGDGV 

       790        800        810        820        830        840 
LSYFENERAV TPNGEIRASE IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE 

       850        860        870        880        890        900 
WVKCIAKAFV PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC 

       910        920        930        940        950        960 
EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ KAAASMGDTL 

       970        980        990       1000       1010       1020 
SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK TQRLLESLRQ DARSVHLKEG 

      1030       1040       1050       1060       1070       1080 
EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT WLEASEIEDE EEKVSRYREL LVRLPPVNRA 

      1090       1100       1110       1120       1130       1140 
TVKALISHLY CVQCFSDTNQ MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS 

      1150       1160       1170       1180       1190       1200 
VDEEELRKQR EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE 

      1210       1220       1230       1240       1250       1260 
ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT DSHLVVKKHQ 

      1270       1280       1290       1300       1310       1320 
AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH DRYFILNSSC LRLYKEVRSQ 

      1330       1340       1350       1360       1370       1380 
RPWSGAPETS HRPEKEWPIK SLKVYLGVKK KLRPPTCWGF TVVHETEKHE KQQWYLCCDT 

      1390       1400       1410       1420       1430       1440 
QMELREWFAT FLFVQHDGLV WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT 

      1450 
ADPLSLLRNV 

« Hide

Isoform 1 [UniParc].

Checksum: 31486141B6648495
Show »

FASTA1,210136,264
Isoform 2 [UniParc].

Checksum: 95873FE63A8C3320
Show »

FASTA1,199135,066
Isoform 3 [UniParc].

Checksum: A46A522E287CC2C3
Show »

FASTA1,439160,994
Isoform 4 [UniParc].

Checksum: A679C6A273660197
Show »

FASTA1,205135,834
Isoform 5 [UniParc].

Checksum: 2F50EB6053978B37
Show »

FASTA67977,550
Isoform 7 [UniParc].

Checksum: 69A2D13CDDA77185
Show »

FASTA1,133127,665

References

« Hide 'large scale' references
[1]"ARAP1: a point of convergence for Arf and Rho signaling."
Miura K., Jacques K.M., Stauffer S., Kubosaki A., Zhu K., Hirsch D.S., Resau J., Zheng Y., Randazzo P.A.
Mol. Cell 9:109-119(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"ARAP1 splice variants in man and mouse."
Krugmann S., Coadwell J., Stephens L.R., Hawkins P.T.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[3]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Human ARAP1b."
Randazzo P.A., Yoon H.-Y., Miura K.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-1047.
Tissue: Brain.
[7]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 792-1450 (ISOFORMS 2/3/5).
Tissue: Brain and Pancreas.
[9]"KIAA0782 as a member (centaurin delta2) of the ArfGAP centaurin family."
Hong W.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 315-1450 (ISOFORM 1).
[10]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
Simova S., Klima M., Cermak L., Sourkova V., Andera L.
Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TNFRSF10A, SUBCELLULAR LOCATION.
[12]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; TYR-431 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRC59431.
RefSeqNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneHs.503165.

3D structure databases

ProteinModelPortalQ96P48.
SMRQ96P48. Positions 4-61, 333-421, 537-853, 970-1114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125548. 19 interactions.
IntActQ96P48. 12 interactions.
MINTMINT-1395507.

Polymorphism databases

DMDM226694321.

Proteomic databases

MaxQBQ96P48.
PaxDbQ96P48.
PRIDEQ96P48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
ENST00000455638; ENSP00000390461; ENSG00000186635. [Q96P48-3]
GeneID116985.
KEGGhsa:116985.
UCSCuc001osr.3. human. [Q96P48-1]
uc001oss.3. human. [Q96P48-6]
uc001osv.3. human. [Q96P48-3]
uc009yth.3. human. [Q96P48-7]

Organism-specific databases

CTD116985.
GeneCardsGC11M072396.
H-InvDBHIX0079401.
HIX0171326.
HGNCHGNC:16925. ARAP1.
HPACAB020703.
HPA038456.
MIM606646. gene.
neXtProtNX_Q96P48.
PharmGKBPA164715867.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5347.
HOGENOMHOG000246988.
HOVERGENHBG106625.
KOK12490.
OMACIAKAFV.
OrthoDBEOG7F24T4.
PhylomeDBQ96P48.
TreeFamTF105769.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ96P48.
BgeeQ96P48.
CleanExHS_ARAP1.
GenevestigatorQ96P48.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProIPR001164. ArfGAP.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSPR00405. REVINTRACTNG.
SMARTSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSARAP1. human.
GeneWikiCENTD2.
GenomeRNAi116985.
NextBio80062.
PROQ96P48.
SOURCESearch...

Entry information

Entry nameARAP1_HUMAN
AccessionPrimary (citable) accession number: Q96P48
Secondary accession number(s): A3KLL7 expand/collapse secondary AC list , B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 24, 2009
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM