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Q96P48

- ARAP1_HUMAN

UniProt

Q96P48 - ARAP1_HUMAN

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Protein
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Gene
ARAP1, CENTD2, KIAA0782
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57627C4-type
Add
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: UniProtKB
  2. Rho GTPase activator activity Source: UniProtKB
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  4. protein binding Source: IntAct
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. actin filament reorganization involved in cell cycle Source: UniProtKB
  2. negative regulation of stress fiber assembly Source: UniProtKB
  3. positive regulation of Cdc42 GTPase activity Source: UniProtKB
  4. positive regulation of filopodium assembly Source: UniProtKB
  5. positive regulation of receptor recycling Source: Ensembl
  6. regulation of ARF GTPase activity Source: InterPro
  7. regulation of cell shape Source: UniProtKB
  8. regulation of cellular component movement Source: UniProtKB
  9. regulation of small GTPase mediated signal transduction Source: Reactome
  10. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2
Short name:
Cnt-d2
Gene namesi
Name:ARAP1
Synonyms:CENTD2, KIAA0782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16925. ARAP1.

Subcellular locationi

Cytoplasm. Golgi apparatusGolgi stack membrane; Peripheral membrane protein. Cell membrane
Note: Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.2 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. cytoplasmic vesicle Source: Ensembl
  4. cytosol Source: Reactome
  5. plasma membrane Source: UniProtKB-SubCell
  6. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14501450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
PRO_0000074214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291Phosphoserine1 Publication
Modified residuei354 – 3541Phosphothreonine1 Publication
Modified residuei428 – 4281Phosphoserine1 Publication
Modified residuei431 – 4311Phosphotyrosine1 Publication
Modified residuei738 – 7381Phosphoserine1 Publication
Modified residuei1435 – 14351Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96P48.
PaxDbiQ96P48.
PRIDEiQ96P48.

Expressioni

Tissue specificityi

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.1 Publication

Gene expression databases

ArrayExpressiQ96P48.
BgeeiQ96P48.
CleanExiHS_ARAP1.
GenevestigatoriQ96P48.

Organism-specific databases

HPAiCAB020703.
HPA038456.

Interactioni

Subunit structurei

Interacts with TNFRSF10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-710003,EBI-8753518From a different organism.
TNFRSF10AO002204EBI-710003,EBI-518861
XRCC6P129562EBI-710003,EBI-353208

Protein-protein interaction databases

BioGridi125548. 19 interactions.
IntActiQ96P48. 12 interactions.
MINTiMINT-1395507.

Structurei

3D structure databases

ProteinModelPortaliQ96P48.
SMRiQ96P48. Positions 4-61, 333-421, 537-853, 970-1114.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065SAM
Add
BLAST
Domaini327 – 41993PH 1
Add
BLAST
Domaini440 – 52990PH 2
Add
BLAST
Domaini535 – 660126Arf-GAP
Add
BLAST
Domaini743 – 850108PH 3
Add
BLAST
Domaini954 – 1139186Rho-GAP
Add
BLAST
Domaini1172 – 126190Ras-associating
Add
BLAST
Domaini1274 – 1396123PH 4
Add
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.
Contains 4 PH domains.
Contains 1 Rho-GAP domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
HOGENOMiHOG000246988.
HOVERGENiHBG106625.
KOiK12490.
OMAiCIAKAFV.
OrthoDBiEOG7F24T4.
PhylomeDBiQ96P48.
TreeFamiTF105769.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 6 (identifier: Q96P48-6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG     50
MLLPGHRRRI LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE 100
PLPTTTEDEG LPAAPPIPPR RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL 150
AELSVPPVPP RTGPPRLLVS LPTKEEESLL PSLSSPPQPQ SEEPLSTLPQ 200
GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG APARVMTKKE 250
EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS 300
LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV 350
RLDTDHLRYF DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR 400
AESDVERKEW MQALQQAMAE QRARARLSSA YLLGVPGSEQ PDRAGSLELR 450
GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI TFIDMSVGNV KEVDRRSFDL 500
TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER IWAAAPNRFC 550
ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET 600
LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR 650
RYHPLFGNQE ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP 700
LALAEQAGQT LQMEFLRNNR TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL 750
YKTASAGKLL QDRRAREEFS RRWCVLGDGV LSYFENERAV TPNGEIRASE 800
IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE WVKCIAKAFV 850
PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC 900
EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ 950
KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK 1000
TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT 1050
WLEASEIEDE EEKVSRYREL LVRLPPVNRA TVKALISHLY CVQCFSDTNQ 1100
MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS VDEEELRKQR 1150
EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE 1200
ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT 1250
DSHLVVKKHQ AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH 1300
DRYFILNSSC LRLYKEVRSQ RPWSGAPETS HRPEKEWPIK SLKVYLGVKK 1350
KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV 1400
WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV 1450
Length:1,450
Mass (Da):162,192
Last modified:March 24, 2009 - v3
Checksum:iA4B6CCC28EC4CD0D
GO
Isoform 1 (identifier: Q96P48-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ

Show »
Length:1,210
Mass (Da):136,264
Checksum:i31486141B6648495
GO
Isoform 2 (identifier: Q96P48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
     1320-1330: Missing.

Show »
Length:1,199
Mass (Da):135,066
Checksum:i95873FE63A8C3320
GO
Isoform 3 (identifier: Q96P48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1330: Missing.

Show »
Length:1,439
Mass (Da):160,994
Checksum:iA46A522E287CC2C3
GO
Isoform 4 (identifier: Q96P48-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.

Show »
Length:1,205
Mass (Da):135,834
Checksum:iA679C6A273660197
GO
Isoform 5 (identifier: Q96P48-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: Missing.
     761-767: QDRRARE → MDASGKG
     1320-1330: Missing.

Note: No experimental confirmation available.

Show »
Length:679
Mass (Da):77,550
Checksum:i2F50EB6053978B37
GO
Isoform 7 (identifier: Q96P48-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
     604-664: Missing.
     1320-1330: Missing.

Note: No experimental confirmation available.

Show »
Length:1,133
Mass (Da):127,665
Checksum:i69A2D13CDDA77185
GO

Sequence cautioni

The sequence BAA34502.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAD92710.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581R → Q.
Corresponds to variant rs34976830 [ dbSNP | Ensembl ].
VAR_055529
Natural varianti1047 – 10471Q → E.1 Publication
Corresponds to variant rs56200889 [ dbSNP | Ensembl ].
VAR_061023

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 760760Missing in isoform 5.
VSP_014998Add
BLAST
Alternative sequencei1 – 245245Missing in isoform 4 and isoform 7.
VSP_015000Add
BLAST
Alternative sequencei1 – 240240Missing in isoform 1 and isoform 2.
VSP_036607Add
BLAST
Alternative sequencei241 – 2499APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2.
VSP_036608
Alternative sequencei604 – 66461Missing in isoform 7.
VSP_043530Add
BLAST
Alternative sequencei761 – 7677QDRRARE → MDASGKG in isoform 5.
VSP_015001
Alternative sequencei1320 – 133011Missing in isoform 2, isoform 3, isoform 5 and isoform 7.
VSP_000311Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1408 – 14081V → M in AAH56401. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049732 mRNA. Translation: AAL12169.1.
AJ621557 mRNA. Translation: CAF21317.1.
AB018325 mRNA. Translation: BAA34502.2. Different initiation.
AY553630 mRNA. Translation: AAT36325.1.
AB209473 mRNA. Translation: BAD92710.1. Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1.
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1.
BC140792 mRNA. Translation: AAI40793.1.
AF411983 mRNA. Translation: AAL04167.1.
CCDSiCCDS41687.1. [Q96P48-6]
CCDS44671.1. [Q96P48-7]
CCDS8217.2. [Q96P48-4]
PIRiC59431.
RefSeqiNP_001035207.1. NM_001040118.2. [Q96P48-6]
NP_001128662.1. NM_001135190.1. [Q96P48-7]
NP_056057.2. NM_015242.4. [Q96P48-4]
UniGeneiHs.503165.

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635. [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635. [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635. [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635. [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635. [Q96P48-7]
ENST00000455638; ENSP00000390461; ENSG00000186635. [Q96P48-3]
GeneIDi116985.
KEGGihsa:116985.
UCSCiuc001osr.3. human. [Q96P48-1]
uc001oss.3. human. [Q96P48-6]
uc001osv.3. human. [Q96P48-3]
uc009yth.3. human. [Q96P48-7]

Polymorphism databases

DMDMi226694321.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049732 mRNA. Translation: AAL12169.1 .
AJ621557 mRNA. Translation: CAF21317.1 .
AB018325 mRNA. Translation: BAA34502.2 . Different initiation.
AY553630 mRNA. Translation: AAT36325.1 .
AB209473 mRNA. Translation: BAD92710.1 . Different initiation.
AP002381 Genomic DNA. No translation available.
AP003065 Genomic DNA. No translation available.
BC008315 mRNA. Translation: AAH08315.1 .
BC021244 mRNA. No translation available.
BC056401 mRNA. Translation: AAH56401.1 .
BC140792 mRNA. Translation: AAI40793.1 .
AF411983 mRNA. Translation: AAL04167.1 .
CCDSi CCDS41687.1. [Q96P48-6 ]
CCDS44671.1. [Q96P48-7 ]
CCDS8217.2. [Q96P48-4 ]
PIRi C59431.
RefSeqi NP_001035207.1. NM_001040118.2. [Q96P48-6 ]
NP_001128662.1. NM_001135190.1. [Q96P48-7 ]
NP_056057.2. NM_015242.4. [Q96P48-4 ]
UniGenei Hs.503165.

3D structure databases

ProteinModelPortali Q96P48.
SMRi Q96P48. Positions 4-61, 333-421, 537-853, 970-1114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125548. 19 interactions.
IntActi Q96P48. 12 interactions.
MINTi MINT-1395507.

Polymorphism databases

DMDMi 226694321.

Proteomic databases

MaxQBi Q96P48.
PaxDbi Q96P48.
PRIDEi Q96P48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334211 ; ENSP00000335506 ; ENSG00000186635 . [Q96P48-4 ]
ENST00000359373 ; ENSP00000352332 ; ENSG00000186635 . [Q96P48-3 ]
ENST00000393605 ; ENSP00000377230 ; ENSG00000186635 . [Q96P48-1 ]
ENST00000393609 ; ENSP00000377233 ; ENSG00000186635 . [Q96P48-6 ]
ENST00000429686 ; ENSP00000403127 ; ENSG00000186635 . [Q96P48-7 ]
ENST00000455638 ; ENSP00000390461 ; ENSG00000186635 . [Q96P48-3 ]
GeneIDi 116985.
KEGGi hsa:116985.
UCSCi uc001osr.3. human. [Q96P48-1 ]
uc001oss.3. human. [Q96P48-6 ]
uc001osv.3. human. [Q96P48-3 ]
uc009yth.3. human. [Q96P48-7 ]

Organism-specific databases

CTDi 116985.
GeneCardsi GC11M072396.
H-InvDB HIX0079401.
HIX0171326.
HGNCi HGNC:16925. ARAP1.
HPAi CAB020703.
HPA038456.
MIMi 606646. gene.
neXtProti NX_Q96P48.
PharmGKBi PA164715867.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5347.
HOGENOMi HOG000246988.
HOVERGENi HBG106625.
KOi K12490.
OMAi CIAKAFV.
OrthoDBi EOG7F24T4.
PhylomeDBi Q96P48.
TreeFami TF105769.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ARAP1. human.
GeneWikii CENTD2.
GenomeRNAii 116985.
NextBioi 80062.
PROi Q96P48.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96P48.
Bgeei Q96P48.
CleanExi HS_ARAP1.
Genevestigatori Q96P48.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProi IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
PRINTSi PR00405. REVINTRACTNG.
SMARTi SM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEi PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "ARAP1 splice variants in man and mouse."
    Krugmann S., Coadwell J., Stephens L.R., Hawkins P.T.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Human ARAP1b."
    Randazzo P.A., Yoon H.-Y., Miura K.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-1047.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 792-1450 (ISOFORMS 2/3/5).
    Tissue: Brain and Pancreas.
  9. "KIAA0782 as a member (centaurin delta2) of the ArfGAP centaurin family."
    Hong W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 315-1450 (ISOFORM 1).
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-354, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
    Simova S., Klima M., Cermak L., Sourkova V., Andera L.
    Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TNFRSF10A, SUBCELLULAR LOCATION.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; TYR-431 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738 AND SER-1435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96P48
Secondary accession number(s): A3KLL7
, B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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