Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XXI) chain

Gene

COL21A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-1650814. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXI) chain
Gene namesi
Name:COL21A1
Synonyms:COL1AL
ORF Names:FP633
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17025. COL21A1.

Subcellular locationi

  • Secretedextracellular spaceextracellular matrix 1 Publication
  • Cytoplasm 1 Publication

  • Note: Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26714.

Polymorphism and mutation databases

BioMutaiCOL21A1.
DMDMi74752071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 957935Collagen alpha-1(XXI) chainPRO_0000317613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96P44.
PaxDbiQ96P44.
PRIDEiQ96P44.

PTM databases

iPTMnetiQ96P44.

Expressioni

Tissue specificityi

Highly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes. Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium.2 Publications

Developmental stagei

Highest expression observed at the fetal stage. Expressed by smooth-muscle cells in the artery wall in a PDGF-dependent way.1 Publication

Inductioni

Stimulated by PDGF/platelet-derived growth factor.1 Publication

Gene expression databases

BgeeiQ96P44.
CleanExiHS_COL21A1.
ExpressionAtlasiQ96P44. baseline and differential.
GenevisibleiQ96P44. HS.

Organism-specific databases

HPAiHPA031210.
HPA031212.
HPA031213.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000244728.

Structurei

3D structure databases

ProteinModelPortaliQ96P44.
SMRiQ96P44. Positions 4-211, 227-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 211175VWFAPROSITE-ProRule annotationAdd
BLAST
Domaini230 – 412183Laminin G-likeAdd
BLAST
Domaini448 – 50053Collagen-like 1Add
BLAST
Domaini501 – 54242Collagen-like 2Add
BLAST
Domaini543 – 59452Collagen-like 3Add
BLAST
Domaini681 – 73353Collagen-like 4Add
BLAST
Domaini734 – 78754Collagen-like 5Add
BLAST
Domaini825 – 88258Collagen-like 6Add
BLAST
Domaini884 – 93451Collagen-like 7Add
BLAST

Sequence similaritiesi

Contains 7 collagen-like domains.Curated
Contains 1 laminin G-like domain.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS78. Eukaryota.
ENOG41100RI. LUCA.
GeneTreeiENSGT00840000129701.
HOVERGENiHBG106599.
InParanoidiQ96P44.
KOiK16629.
OMAiDGLMGPA.
OrthoDBiEOG7F7W8F.
PhylomeDBiQ96P44.
TreeFamiTF332934.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 6 hits.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHYITFLCM VLVLLLQNSV LAEDGEVRSS CRTAPTDLVF ILDGSYSVGP
60 70 80 90 100
ENFEIVKKWL VNITKNFDIG PKFIQVGVVQ YSDYPVLEIP LGSYDSGEHL
110 120 130 140 150
TAAVESILYL GGNTKTGKAI QFALDYLFAK SSRFLTKIAV VLTDGKSQDD
160 170 180 190 200
VKDAAQAARD SKITLFAIGV GSETEDAELR AIANKPSSTY VFYVEDYIAI
210 220 230 240 250
SKIREVMKQK LCEESVCPTR IPVAARDERG FDILLGLDVN KKVKKRIQLS
260 270 280 290 300
PKKIKGYEVT SKVDLSELTS NVFPEGLPPS YVFVSTQRFK VKKIWDLWRI
310 320 330 340 350
LTIDGRPQIA VTLNGVDKIL LFTTTSVING SQVVTFANPQ VKTLFDEGWH
360 370 380 390 400
QIRLLVTEQD VTLYIDDQQI ENKPLHPVLG ILINGQTQIG KYSGKEETVQ
410 420 430 440 450
FDVQKLRIYC DPEQNNRETA CEIPGFNGEC LNGPSDVGST PAPCICPPGK
460 470 480 490 500
PGLQGPKGDP GLPGNPGYPG QPGQDGKPGY QGIAGTPGVP GSPGIQGARG
510 520 530 540 550
LPGYKGEPGR DGDKGDRGLP GFPGLHGMPG SKGEMGAKGD KGSPGFYGKK
560 570 580 590 600
GAKGEKGNAG FPGLPGPAGE PGRHGKDGLM GSPGFKGEAG SPGAPGQDGT
610 620 630 640 650
RGEPGIPGFP GNRGLMGQKG EIGPPGQQGK KGAPGMPGLM GSNGSPGQPG
660 670 680 690 700
TPGSKGSKGE PGIQGMPGAS GLKGEPGATG SPGEPGYMGL PGIQGKKGDK
710 720 730 740 750
GNQGEKGIQG QKGENGRQGI PGQQGIQGHH GAKGERGEKG EPGVRGAIGS
760 770 780 790 800
KGESGVDGLM GPAGPKGQPG DPGPQGPPGL DGKPGREFSE QFIRQVCTDV
810 820 830 840 850
IRAQLPVLLQ SGRIRNCDHC LSQHGSPGIP GPPGPIGPEG PRGLPGLPGR
860 870 880 890 900
DGVPGLVGVP GRPGVRGLKG LPGRNGEKGS QGFGYPGEQG PPGPPGPEGP
910 920 930 940 950
PGISKEGPPG DPGLPGKDGD HGKPGIQGQP GPPGICDPSL CFSVIARRDP

FRKGPNY
Length:957
Mass (Da):99,369
Last modified:December 1, 2001 - v1
Checksum:i4C5CDF5E6656A675
GO
Isoform 2 (identifier: Q96P44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-600: Missing.
     601-604: RGEP → MIAS
     803-836: Missing.

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):31,650
Checksum:i71FB0C48E750734C
GO
Isoform 3 (identifier: Q96P44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-429: Missing.

Note: No experimental confirmation available.
Show »
Length:954
Mass (Da):99,068
Checksum:iC3514675DDACDF23
GO

Sequence cautioni

The sequence AAH45597.1 differs from that shown. Reason: Frameshift at position 478. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291A → D in CAB66559 (PubMed:11230166).Curated
Sequence conflicti780 – 7801L → W in AAH45597 (PubMed:15489334).Curated
Sequence conflicti802 – 8021R → K in AAH45597 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771L → P.
Corresponds to variant rs2764043 [ dbSNP | Ensembl ].
VAR_038555
Natural varianti343 – 3431T → M.1 Publication
Corresponds to variant rs35471617 [ dbSNP | Ensembl ].
VAR_038556
Natural varianti495 – 4951I → T.
Corresponds to variant rs35583895 [ dbSNP | Ensembl ].
VAR_038557
Natural varianti560 – 5601G → S.
Corresponds to variant rs9382581 [ dbSNP | Ensembl ].
VAR_038558
Natural varianti747 – 7471A → D.
Corresponds to variant rs9464337 [ dbSNP | Ensembl ].
VAR_038559
Natural varianti821 – 8211L → P.
Corresponds to variant rs12209452 [ dbSNP | Ensembl ].
VAR_038560
Natural varianti827 – 8271P → A.
Corresponds to variant rs1555131 [ dbSNP | Ensembl ].
VAR_038561

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 600600Missing in isoform 2. 1 PublicationVSP_031083Add
BLAST
Alternative sequencei427 – 4293Missing in isoform 3. 1 PublicationVSP_031084
Alternative sequencei601 – 6044RGEP → MIAS in isoform 2. 1 PublicationVSP_031085
Alternative sequencei803 – 83634Missing in isoform 2. 1 PublicationVSP_031086Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414088 mRNA. Translation: AAL02227.1.
AF330693 mRNA. Translation: AAL50033.1.
AF438327 Genomic DNA. Translation: AAL86699.1.
AL136624 mRNA. Translation: CAB66559.1.
AF370383 mRNA. Translation: AAQ15219.1.
AK313398 mRNA. Translation: BAG36196.1.
AL513530, AL031782, AL034452 Genomic DNA. Translation: CAH73912.1.
AL513530, AL031782, AL034452 Genomic DNA. Translation: CAH73913.1.
AL034452, AL031782, AL513530 Genomic DNA. Translation: CAI22395.1.
AL034452, AL031782, AL513530 Genomic DNA. Translation: CAI22396.1.
AL031782, AL034452, AL513530 Genomic DNA. Translation: CAI22496.1.
AL031782, AL034452, AL513530 Genomic DNA. Translation: CAI22497.1.
BC045597 mRNA. Translation: AAH45597.1. Frameshift.
BC126108 mRNA. Translation: AAI26109.1.
CCDSiCCDS55025.1. [Q96P44-1]
RefSeqiNP_001305680.1. NM_001318751.1. [Q96P44-1]
NP_001305681.1. NM_001318752.1. [Q96P44-3]
NP_001305682.1. NM_001318753.1.
NP_001305683.1. NM_001318754.1.
NP_110447.2. NM_030820.3. [Q96P44-1]
XP_011513226.1. XM_011514924.1. [Q96P44-1]
XP_011513227.1. XM_011514925.1. [Q96P44-1]
XP_011513228.1. XM_011514926.1. [Q96P44-1]
XP_011513229.1. XM_011514927.1. [Q96P44-1]
UniGeneiHs.47629.

Genome annotation databases

EnsembliENST00000244728; ENSP00000244728; ENSG00000124749. [Q96P44-1]
ENST00000370819; ENSP00000359855; ENSG00000124749. [Q96P44-3]
GeneIDi81578.
KEGGihsa:81578.
UCSCiuc003pcs.4. human. [Q96P44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414088 mRNA. Translation: AAL02227.1.
AF330693 mRNA. Translation: AAL50033.1.
AF438327 Genomic DNA. Translation: AAL86699.1.
AL136624 mRNA. Translation: CAB66559.1.
AF370383 mRNA. Translation: AAQ15219.1.
AK313398 mRNA. Translation: BAG36196.1.
AL513530, AL031782, AL034452 Genomic DNA. Translation: CAH73912.1.
AL513530, AL031782, AL034452 Genomic DNA. Translation: CAH73913.1.
AL034452, AL031782, AL513530 Genomic DNA. Translation: CAI22395.1.
AL034452, AL031782, AL513530 Genomic DNA. Translation: CAI22396.1.
AL031782, AL034452, AL513530 Genomic DNA. Translation: CAI22496.1.
AL031782, AL034452, AL513530 Genomic DNA. Translation: CAI22497.1.
BC045597 mRNA. Translation: AAH45597.1. Frameshift.
BC126108 mRNA. Translation: AAI26109.1.
CCDSiCCDS55025.1. [Q96P44-1]
RefSeqiNP_001305680.1. NM_001318751.1. [Q96P44-1]
NP_001305681.1. NM_001318752.1. [Q96P44-3]
NP_001305682.1. NM_001318753.1.
NP_001305683.1. NM_001318754.1.
NP_110447.2. NM_030820.3. [Q96P44-1]
XP_011513226.1. XM_011514924.1. [Q96P44-1]
XP_011513227.1. XM_011514925.1. [Q96P44-1]
XP_011513228.1. XM_011514926.1. [Q96P44-1]
XP_011513229.1. XM_011514927.1. [Q96P44-1]
UniGeneiHs.47629.

3D structure databases

ProteinModelPortaliQ96P44.
SMRiQ96P44. Positions 4-211, 227-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000244728.

PTM databases

iPTMnetiQ96P44.

Polymorphism and mutation databases

BioMutaiCOL21A1.
DMDMi74752071.

Proteomic databases

EPDiQ96P44.
PaxDbiQ96P44.
PRIDEiQ96P44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244728; ENSP00000244728; ENSG00000124749. [Q96P44-1]
ENST00000370819; ENSP00000359855; ENSG00000124749. [Q96P44-3]
GeneIDi81578.
KEGGihsa:81578.
UCSCiuc003pcs.4. human. [Q96P44-1]

Organism-specific databases

CTDi81578.
GeneCardsiCOL21A1.
HGNCiHGNC:17025. COL21A1.
HPAiHPA031210.
HPA031212.
HPA031213.
MIMi610002. gene.
neXtProtiNX_Q96P44.
PharmGKBiPA26714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS78. Eukaryota.
ENOG41100RI. LUCA.
GeneTreeiENSGT00840000129701.
HOVERGENiHBG106599.
InParanoidiQ96P44.
KOiK16629.
OMAiDGLMGPA.
OrthoDBiEOG7F7W8F.
PhylomeDBiQ96P44.
TreeFamiTF332934.

Enzyme and pathway databases

ReactomeiR-HSA-1650814. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

GenomeRNAii81578.
PROiQ96P44.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P44.
CleanExiHS_COL21A1.
ExpressionAtlasiQ96P44. baseline and differential.
GenevisibleiQ96P44. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 6 hits.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new FACIT of the collagen family: COL21A1."
    Fitzgerald J., Bateman J.F.
    FEBS Lett. 505:275-280(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Genomic organization and characterization of the human type XXI collagen (COL21A1) gene."
    Chou M.-Y., Li H.-C.
    Genomics 79:395-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION BY PDGF.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-343.
    Tissue: Trachea.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCOLA1_HUMAN
AccessioniPrimary (citable) accession number: Q96P44
Secondary accession number(s): A6NIX5
, B2R8J9, Q49A51, Q71RF4, Q8WXV8, Q9H0V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.