##gff-version 3 Q96P31 UniProtKB Signal peptide 1 17 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96P31 UniProtKB Chain 18 734 . . . ID=PRO_0000331640;Note=Fc receptor-like protein 3 Q96P31 UniProtKB Topological domain 18 573 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96P31 UniProtKB Transmembrane 574 594 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96P31 UniProtKB Topological domain 595 734 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96P31 UniProtKB Domain 21 98 . . . Note=Ig-like C2-type 1 Q96P31 UniProtKB Domain 99 182 . . . Note=Ig-like C2-type 2 Q96P31 UniProtKB Domain 192 270 . . . Note=Ig-like C2-type 3 Q96P31 UniProtKB Domain 284 369 . . . Note=Ig-like C2-type 4 Q96P31 UniProtKB Domain 383 470 . . . Note=Ig-like C2-type 5 Q96P31 UniProtKB Domain 476 563 . . . Note=Ig-like C2-type 6 Q96P31 UniProtKB Region 603 655 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96P31 UniProtKB Region 695 734 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96P31 UniProtKB Motif 648 653 . . . Note=ITIM motif 1 Q96P31 UniProtKB Motif 660 665 . . . Note=ITIM motif 2 Q96P31 UniProtKB Motif 690 695 . . . Note=ITIM motif 3 Q96P31 UniProtKB Motif 720 725 . . . Note=ITIM motif 4 Q96P31 UniProtKB Compositional bias 606 631 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96P31 UniProtKB Compositional bias 695 724 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96P31 UniProtKB Modified residue 650 650 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19843936;Dbxref=PMID:19843936 Q96P31 UniProtKB Modified residue 662 662 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19843936;Dbxref=PMID:19843936 Q96P31 UniProtKB Modified residue 692 692 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19843936;Dbxref=PMID:19843936 Q96P31 UniProtKB Modified residue 722 722 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:19843936;Dbxref=PMID:19843936 Q96P31 UniProtKB Glycosylation 561 561 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96P31 UniProtKB Disulfide bond 44 82 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Disulfide bond 120 163 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Disulfide bond 211 260 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Disulfide bond 309 358 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Disulfide bond 404 451 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Disulfide bond 497 544 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q96P31 UniProtKB Alternative sequence 187 282 . . . ID=VSP_033300;Note=In isoform 2. ELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQR->G;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 187 189 . . . ID=VSP_033301;Note=In isoform 4. ELF->GNG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 188 199 . . . ID=VSP_033302;Note=In isoform 5. LFLHPVLRASSS->ARCPAAILPLQR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 190 734 . . . ID=VSP_033303;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 200 734 . . . ID=VSP_033304;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 378 378 . . . ID=VSP_033305;Note=In isoform 3. I->TLLSPSV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12051764;Dbxref=PMID:12051764 Q96P31 UniProtKB Alternative sequence 698 707 . . . ID=VSP_033306;Note=In isoform 7. THPDDSAGEA->EQSSRFSMSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q96P31 UniProtKB Alternative sequence 708 734 . . . ID=VSP_033307;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q96P31 UniProtKB Alternative sequence 725 734 . . . ID=VSP_033308;Note=In isoform 6. VPRVLLASDH->ILNPRKNKVQDFPCLCNT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q96P31 UniProtKB Natural variant 28 28 . . . ID=VAR_042924;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|Ref.3,ECO:0000269|Ref.6;Dbxref=dbSNP:rs7522061 Q96P31 UniProtKB Natural variant 307 307 . . . ID=VAR_042925;Note=L->F;Dbxref=dbSNP:rs12041673 Q96P31 UniProtKB Natural variant 445 445 . . . ID=VAR_042926;Note=In a breast cancer sample%3B somatic mutation. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q96P31 UniProtKB Natural variant 660 660 . . . ID=VAR_042927;Note=P->L;Dbxref=dbSNP:rs944627 Q96P31 UniProtKB Natural variant 721 721 . . . ID=VAR_042928;Note=N->S;Dbxref=dbSNP:rs2282284 Q96P31 UniProtKB Mutagenesis 650 650 . . . Note=No effect on inhibition of cell death. No effect on interaction with INPP5D%2C PTPN6 and PTPN11. Loss of phosphorylation%2C calcium influx inhibition and interaction with INPP5D%2C PTPN6 and PTPN11%3B when associated with F-662%3B F-692 and F-722. Alters binding with SYK and ZAP70%3B when associated with F-662. Decreases calcium influx inhibition%3B when associated with F-662 and F-722. Decreases calcium influx inhibition%3B when associated with F-692 and F-722. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051764,ECO:0000269|PubMed:19843936;Dbxref=PMID:12051764,PMID:19843936 Q96P31 UniProtKB Mutagenesis 662 662 . . . Note=Reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN6. No effect on interaction with PTPN11. Loss of phosphorylation%2C calcium influx inhibition and interaction with INPP5D%2C PTPN6 and PTPN11%3B when associated with F-650%3B F-692 and F-722. Alters binding with SYK and ZAP70%3B when associated with F-650. Decreases calcium influx inhibition%3B when associated with F-650 and F-722. Increases calcium influx inhibition%3B when associated with F-650 and F-722. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051764,ECO:0000269|PubMed:19843936;Dbxref=PMID:12051764,PMID:19843936 Q96P31 UniProtKB Mutagenesis 692 692 . . . Note=Partially reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN11. No effect on interaction with PTPN6. Loss of phosphorylation%2C calcium influx inhibition and interaction with INPP5D%2C PTPN6 and PTPN11%3B when associated with F-650%3B F-662 and F-722. Alters binding with PTPN6 and PTPN11%3B when associated with F-772. Decreases calcium influx inhibition%3B when associated with F-650 and F-722. Increases calcium influx inhibition%3B when associated with F-650 and F-662. Decreases calcium influx inhibition%3B when associated with F-722. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051764,ECO:0000269|PubMed:19843936;Dbxref=PMID:12051764,PMID:19843936 Q96P31 UniProtKB Mutagenesis 722 722 . . . Note=No effect on inhibition of cell death. No effect on interaction with INPP5D%2C PTPN6 and PTPN11. Loss of phosphorylation%2C calcium influx inhibition and interaction with INPP5D%2C PTPN6 and PTPN11%3B when associated with F-650%3B F-662 and F-692. Alters binding with PTPN6 and PTPN11%3B when associated with F-692. Decreases calcium influx inhibition%3B when associated with F-650 and F-662. Decreases calcium influx inhibition%3B when associated with F-650 and F-692. Decreases calcium influx inhibition%3B when associated with F-692. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12051764,ECO:0000269|PubMed:19843936;Dbxref=PMID:12051764,PMID:19843936 Q96P31 UniProtKB Sequence conflict 244 244 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96P31 UniProtKB Sequence conflict 653 653 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305