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Q96P31

- FCRL3_HUMAN

UniProt

Q96P31 - FCRL3_HUMAN

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Protein
Fc receptor-like protein 3
Gene
FCRL3, FCRH3, IFGP3, IRTA3, SPAP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 3
Short name:
FcR-like protein 3
Short name:
FcRL3
Alternative name(s):
Fc receptor homolog 3
Short name:
FcRH3
IFGP family protein 3
Short name:
hIFGP3
Immune receptor translocation-associated protein 3
SH2 domain-containing phosphatase anchor protein 2
CD_antigen: CD307c
Gene namesi
Name:FCRL3
Synonyms:FCRH3, IFGP3, IRTA3, SPAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18506. FCRL3.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 573556Extracellular Reviewed prediction
Add
BLAST
Transmembranei574 – 59421Helical; Reviewed prediction
Add
BLAST
Topological domaini595 – 734140Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.3 Publications
Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi650 – 6501Y → F: Loss of phosphorylation; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. 1 Publication
Mutagenesisi662 – 6621Y → F: Loss of phosphorylation; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. 1 Publication
Mutagenesisi692 – 6921Y → F: Loss of phosphorylation; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. 1 Publication
Mutagenesisi722 – 7221Y → F: Loss of phosphorylation; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. 1 Publication

Organism-specific databases

MIMi180300. phenotype.
PharmGKBiPA142671767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 734717Fc receptor-like protein 3
PRO_0000331640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 82 By similarity
Disulfide bondi120 ↔ 163 By similarity
Disulfide bondi211 ↔ 260 By similarity
Disulfide bondi309 ↔ 358 By similarity
Disulfide bondi404 ↔ 451 By similarity
Disulfide bondi497 ↔ 544 By similarity
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96P31.
PRIDEiQ96P31.

PTM databases

PhosphoSiteiQ96P31.

Expressioni

Tissue specificityi

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).5 Publications

Gene expression databases

BgeeiQ96P31.
GenevestigatoriQ96P31.

Organism-specific databases

HPAiHPA015508.

Interactioni

Subunit structurei

Interacts with PTPN6, PTPN11, SYK and ZAP70.1 Publication

Protein-protein interaction databases

BioGridi125428. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96P31.
SMRiQ96P31. Positions 22-562.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 9878Ig-like C2-type 1
Add
BLAST
Domaini99 – 18284Ig-like C2-type 2
Add
BLAST
Domaini192 – 27079Ig-like C2-type 3
Add
BLAST
Domaini284 – 36986Ig-like C2-type 4
Add
BLAST
Domaini383 – 47088Ig-like C2-type 5
Add
BLAST
Domaini476 – 56388Ig-like C2-type 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi648 – 6536ITIM motif 1
Motifi660 – 6656ITIM motif 2
Motifi690 – 6956ITIM motif 3
Motifi720 – 7256ITIM motif 4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151212.
HOVERGENiHBG074073.
OMAiENSANCP.
OrthoDBiEOG7BP81V.
PhylomeDBiQ96P31.
TreeFamiTF351107.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96P31-1) [UniParc]FASTAAdd to Basket

Also known as: Spap2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS    50
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 100
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 150
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 200
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 250
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 300
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 350
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 400
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 450
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 500
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 550
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 600
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 650
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP 700
DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH 734
Length:734
Mass (Da):80,856
Last modified:December 1, 2001 - v1
Checksum:iB3411B73A35EC668
GO
Isoform 2 (identifier: Q96P31-2) [UniParc]FASTAAdd to Basket

Also known as: Spap2b

The sequence of this isoform differs from the canonical sequence as follows:
     187-282: ELFLHPVLRA...SLRSQIRVQR → G

Show »
Length:639
Mass (Da):69,929
Checksum:iDEAD7AD4E64CA984
GO
Isoform 3 (identifier: Q96P31-3) [UniParc]FASTAAdd to Basket

Also known as: Spap2c

The sequence of this isoform differs from the canonical sequence as follows:
     378-378: I → TLLSPSV

Show »
Length:740
Mass (Da):81,441
Checksum:i038AFA83A2909E46
GO
Isoform 4 (identifier: Q96P31-4) [UniParc]FASTAAdd to Basket

Also known as: Spap2d

The sequence of this isoform differs from the canonical sequence as follows:
     187-189: ELF → GNG
     190-734: Missing.

Show »
Length:189
Mass (Da):21,441
Checksum:iE4A4CC249EBC65C9
GO
Isoform 5 (identifier: Q96P31-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-199: LFLHPVLRASSS → ARCPAAILPLQR
     200-734: Missing.

Show »
Length:199
Mass (Da):22,632
Checksum:iD51D6112E9DA5603
GO
Isoform 6 (identifier: Q96P31-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-734: VPRVLLASDH → ILNPRKNKVQDFPCLCNT

Note: No experimental confirmation available.

Show »
Length:742
Mass (Da):81,853
Checksum:iB0650200E7CA19B8
GO
Isoform 7 (identifier: Q96P31-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-707: THPDDSAGEA → EQSSRFSMSL
     708-734: Missing.

Show »
Length:707
Mass (Da):77,921
Checksum:iAC6D131F97359E8E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281N → D.2 Publications
Corresponds to variant rs7522061 [ dbSNP | Ensembl ].
VAR_042924
Natural varianti307 – 3071L → F.
Corresponds to variant rs12041673 [ dbSNP | Ensembl ].
VAR_042925
Natural varianti445 – 4451H → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_042926
Natural varianti660 – 6601P → L.
Corresponds to variant rs944627 [ dbSNP | Ensembl ].
VAR_042927
Natural varianti721 – 7211N → S.
Corresponds to variant rs2282284 [ dbSNP | Ensembl ].
VAR_042928

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 28296ELFLH…IRVQR → G in isoform 2.
VSP_033300Add
BLAST
Alternative sequencei187 – 1893ELF → GNG in isoform 4.
VSP_033301
Alternative sequencei188 – 19912LFLHP…RASSS → ARCPAAILPLQR in isoform 5.
VSP_033302Add
BLAST
Alternative sequencei190 – 734545Missing in isoform 4.
VSP_033303Add
BLAST
Alternative sequencei200 – 734535Missing in isoform 5.
VSP_033304Add
BLAST
Alternative sequencei378 – 3781I → TLLSPSV in isoform 3.
VSP_033305
Alternative sequencei698 – 70710THPDDSAGEA → EQSSRFSMSL in isoform 7.
VSP_033306
Alternative sequencei708 – 73427Missing in isoform 7.
VSP_033307Add
BLAST
Alternative sequencei725 – 73410VPRVLLASDH → ILNPRKNKVQDFPCLCNT in isoform 6.
VSP_033308

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441R → K in AK098122. 1 Publication
Sequence conflicti653 – 6531V → A in AAK91779. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY043466 mRNA. Translation: AAK91779.1.
AF416901 mRNA. Translation: AAL13290.1.
AF416902 mRNA. Translation: AAL13291.1.
AF416903 mRNA. Translation: AAL13292.1.
AF416904 mRNA. Translation: AAL13293.1.
AF416905 mRNA. Translation: AAL13294.1.
EF064732 Genomic DNA. Translation: ABK41915.1.
AK098122 mRNA. No translation available.
AL356276 Genomic DNA. Translation: CAH73055.1.
AL356276 Genomic DNA. Translation: CAH73056.1.
AL356276 Genomic DNA. Translation: CAH73058.1.
CH471121 Genomic DNA. Translation: EAW52872.1.
CH471121 Genomic DNA. Translation: EAW52876.1.
CH471121 Genomic DNA. Translation: EAW52877.1.
BC028933 mRNA. Translation: AAH28933.1.
CCDSiCCDS1167.1. [Q96P31-1]
RefSeqiNP_443171.2. NM_052939.3. [Q96P31-1]
XP_006711208.1. XM_006711145.1. [Q96P31-1]
UniGeneiHs.292449.

Genome annotation databases

EnsembliENST00000368184; ENSP00000357167; ENSG00000160856. [Q96P31-1]
ENST00000368186; ENSP00000357169; ENSG00000160856. [Q96P31-6]
ENST00000477837; ENSP00000433430; ENSG00000160856. [Q96P31-2]
ENST00000485028; ENSP00000434331; ENSG00000160856. [Q96P31-1]
ENST00000492769; ENSP00000435487; ENSG00000160856. [Q96P31-3]
GeneIDi115352.
KEGGihsa:115352.
UCSCiuc001fqz.4. human. [Q96P31-6]
uc001frb.3. human. [Q96P31-1]

Polymorphism databases

DMDMi74761021.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY043466 mRNA. Translation: AAK91779.1 .
AF416901 mRNA. Translation: AAL13290.1 .
AF416902 mRNA. Translation: AAL13291.1 .
AF416903 mRNA. Translation: AAL13292.1 .
AF416904 mRNA. Translation: AAL13293.1 .
AF416905 mRNA. Translation: AAL13294.1 .
EF064732 Genomic DNA. Translation: ABK41915.1 .
AK098122 mRNA. No translation available.
AL356276 Genomic DNA. Translation: CAH73055.1 .
AL356276 Genomic DNA. Translation: CAH73056.1 .
AL356276 Genomic DNA. Translation: CAH73058.1 .
CH471121 Genomic DNA. Translation: EAW52872.1 .
CH471121 Genomic DNA. Translation: EAW52876.1 .
CH471121 Genomic DNA. Translation: EAW52877.1 .
BC028933 mRNA. Translation: AAH28933.1 .
CCDSi CCDS1167.1. [Q96P31-1 ]
RefSeqi NP_443171.2. NM_052939.3. [Q96P31-1 ]
XP_006711208.1. XM_006711145.1. [Q96P31-1 ]
UniGenei Hs.292449.

3D structure databases

ProteinModelPortali Q96P31.
SMRi Q96P31. Positions 22-562.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125428. 4 interactions.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q96P31.

Polymorphism databases

DMDMi 74761021.

Proteomic databases

PaxDbi Q96P31.
PRIDEi Q96P31.

Protocols and materials databases

DNASUi 115352.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368184 ; ENSP00000357167 ; ENSG00000160856 . [Q96P31-1 ]
ENST00000368186 ; ENSP00000357169 ; ENSG00000160856 . [Q96P31-6 ]
ENST00000477837 ; ENSP00000433430 ; ENSG00000160856 . [Q96P31-2 ]
ENST00000485028 ; ENSP00000434331 ; ENSG00000160856 . [Q96P31-1 ]
ENST00000492769 ; ENSP00000435487 ; ENSG00000160856 . [Q96P31-3 ]
GeneIDi 115352.
KEGGi hsa:115352.
UCSCi uc001fqz.4. human. [Q96P31-6 ]
uc001frb.3. human. [Q96P31-1 ]

Organism-specific databases

CTDi 115352.
GeneCardsi GC01M157646.
HGNCi HGNC:18506. FCRL3.
HPAi HPA015508.
MIMi 180300. phenotype.
606510. gene.
neXtProti NX_Q96P31.
PharmGKBi PA142671767.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151212.
HOVERGENi HBG074073.
OMAi ENSANCP.
OrthoDBi EOG7BP81V.
PhylomeDBi Q96P31.
TreeFami TF351107.

Miscellaneous databases

GeneWikii FCRL3.
GenomeRNAii 115352.
NextBioi 79574.
PROi Q96P31.
SOURCEi Search...

Gene expression databases

Bgeei Q96P31.
Genevestigatori Q96P31.

Family and domain databases

Gene3Di 2.60.40.10. 6 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
SMARTi SM00409. IG. 4 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of Fc receptor homologs with preferential B cell expression."
    Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Lymph node.
  2. "SPAP2, an Ig family receptor containing both ITIMs and ITAMs."
    Xu M.-J., Zhao R., Cao H., Zhao Z.J.
    Biochem. Biophys. Res. Commun. 293:1037-1046(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), PHOSPHORYLATION, INTERACTION WITH PTPN6; PTPN11; SYK AND ZAP70, MUTAGENESIS OF TYR-650; TYR-662; TYR-692 AND TYR-722, TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASP-28.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Trachea.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-28.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Lymph.
  8. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
    Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
    Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
  9. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS AND GRAVES DISEASE, TISSUE SPECIFICITY.
  10. "Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis."
    Ikari K., Momohara S., Nakamura T., Hara M., Yamanaka H., Tomatsu T., Kamatani N.
    Ann. Rheum. Dis. 65:671-673(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  11. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  12. "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?"
    Eyre S., Bowes J., Potter C., Worthington J., Barton A.
    Arthritis Res. Ther. 8:R117-R117(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  13. "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population."
    Newman W.G., Zhang Q., Liu X., Walker E., Ternan H., Owen J., Johnson B., Greer W., Mosher D.P., Maksymowych W.P., Bykerk V.P., Keystone E.C., Amos C.I., Siminovitch K.A.
    Arthritis Rheum. 54:3820-3827(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  14. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
    Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
    Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  15. "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease."
    Simmonds M.J., Heward J.M., Carr-Smith J., Foxall H., Franklyn J.A., Gough S.C.L.
    J. Clin. Endocrinol. Metab. 91:1056-1061(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN GRAVES DISEASE.
  16. "FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians."
    Thabet M.M., Wesoly J., Slagboom P.E., Toes R.E.M., Huizinga T.W.J.
    Ann. Rheum. Dis. 66:803-806(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  17. "Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients."
    Begovich A.B., Chang M., Schrodi S.J.
    Arthritis Rheum. 56:3168-3171(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
  18. "Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants."
    The Wellcome Trust case control consortium, The Australo-Anglo-American spondylitis consortium
    Nat. Genet. 39:1329-1337(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN GRAVES DISEASE.
  19. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.

Entry informationi

Entry nameiFCRL3_HUMAN
AccessioniPrimary (citable) accession number: Q96P31
Secondary accession number(s): A0N0M4
, A8MTH7, D3DVD2, Q5VXZ8, Q8N6S2, Q96LA4, Q96P27, Q96P28, Q96P29, Q96P30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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