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Q96P31

- FCRL3_HUMAN

UniProt

Q96P31 - FCRL3_HUMAN

Protein

Fc receptor-like protein 3

Gene

FCRL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Receptor

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fc receptor-like protein 3
    Short name:
    FcR-like protein 3
    Short name:
    FcRL3
    Alternative name(s):
    Fc receptor homolog 3
    Short name:
    FcRH3
    IFGP family protein 3
    Short name:
    hIFGP3
    Immune receptor translocation-associated protein 3
    SH2 domain-containing phosphatase anchor protein 2
    CD_antigen: CD307c
    Gene namesi
    Name:FCRL3
    Synonyms:FCRH3, IFGP3, IRTA3, SPAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18506. FCRL3.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.7 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi650 – 6501Y → F: Loss of phosphorylation; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. 1 Publication
    Mutagenesisi662 – 6621Y → F: Loss of phosphorylation; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. 1 Publication
    Mutagenesisi692 – 6921Y → F: Loss of phosphorylation; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. 1 Publication
    Mutagenesisi722 – 7221Y → F: Loss of phosphorylation; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. 1 Publication

    Organism-specific databases

    MIMi180300. phenotype.
    PharmGKBiPA142671767.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 734717Fc receptor-like protein 3PRO_0000331640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 82PROSITE-ProRule annotation
    Disulfide bondi120 ↔ 163PROSITE-ProRule annotation
    Disulfide bondi211 ↔ 260PROSITE-ProRule annotation
    Disulfide bondi309 ↔ 358PROSITE-ProRule annotation
    Disulfide bondi404 ↔ 451PROSITE-ProRule annotation
    Disulfide bondi497 ↔ 544PROSITE-ProRule annotation
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ96P31.
    PRIDEiQ96P31.

    PTM databases

    PhosphoSiteiQ96P31.

    Expressioni

    Tissue specificityi

    Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).5 Publications

    Gene expression databases

    BgeeiQ96P31.
    GenevestigatoriQ96P31.

    Organism-specific databases

    HPAiHPA015508.

    Interactioni

    Subunit structurei

    Interacts with PTPN6, PTPN11, SYK and ZAP70.1 Publication

    Protein-protein interaction databases

    BioGridi125428. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P31.
    SMRiQ96P31. Positions 22-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 573556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini595 – 734140CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei574 – 59421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 9878Ig-like C2-type 1Add
    BLAST
    Domaini99 – 18284Ig-like C2-type 2Add
    BLAST
    Domaini192 – 27079Ig-like C2-type 3Add
    BLAST
    Domaini284 – 36986Ig-like C2-type 4Add
    BLAST
    Domaini383 – 47088Ig-like C2-type 5Add
    BLAST
    Domaini476 – 56388Ig-like C2-type 6Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi648 – 6536ITIM motif 1
    Motifi660 – 6656ITIM motif 2
    Motifi690 – 6956ITIM motif 3
    Motifi720 – 7256ITIM motif 4

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151212.
    HOVERGENiHBG074073.
    OMAiENSANCP.
    OrthoDBiEOG7BP81V.
    PhylomeDBiQ96P31.
    TreeFamiTF351107.

    Family and domain databases

    Gene3Di2.60.40.10. 6 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    SMARTiSM00409. IG. 4 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96P31-1) [UniParc]FASTAAdd to Basket

    Also known as: Spap2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS    50
    LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 100
    WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 150
    VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 200
    PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 250
    WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 300
    EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 350
    SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 400
    ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 450
    CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 500
    RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 550
    GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 600
    RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 650
    SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP 700
    DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH 734
    Length:734
    Mass (Da):80,856
    Last modified:December 1, 2001 - v1
    Checksum:iB3411B73A35EC668
    GO
    Isoform 2 (identifier: Q96P31-2) [UniParc]FASTAAdd to Basket

    Also known as: Spap2b

    The sequence of this isoform differs from the canonical sequence as follows:
         187-282: ELFLHPVLRA...SLRSQIRVQR → G

    Show »
    Length:639
    Mass (Da):69,929
    Checksum:iDEAD7AD4E64CA984
    GO
    Isoform 3 (identifier: Q96P31-3) [UniParc]FASTAAdd to Basket

    Also known as: Spap2c

    The sequence of this isoform differs from the canonical sequence as follows:
         378-378: I → TLLSPSV

    Show »
    Length:740
    Mass (Da):81,441
    Checksum:i038AFA83A2909E46
    GO
    Isoform 4 (identifier: Q96P31-4) [UniParc]FASTAAdd to Basket

    Also known as: Spap2d

    The sequence of this isoform differs from the canonical sequence as follows:
         187-189: ELF → GNG
         190-734: Missing.

    Show »
    Length:189
    Mass (Da):21,441
    Checksum:iE4A4CC249EBC65C9
    GO
    Isoform 5 (identifier: Q96P31-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         188-199: LFLHPVLRASSS → ARCPAAILPLQR
         200-734: Missing.

    Show »
    Length:199
    Mass (Da):22,632
    Checksum:iD51D6112E9DA5603
    GO
    Isoform 6 (identifier: Q96P31-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         725-734: VPRVLLASDH → ILNPRKNKVQDFPCLCNT

    Note: No experimental confirmation available.

    Show »
    Length:742
    Mass (Da):81,853
    Checksum:iB0650200E7CA19B8
    GO
    Isoform 7 (identifier: Q96P31-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         698-707: THPDDSAGEA → EQSSRFSMSL
         708-734: Missing.

    Show »
    Length:707
    Mass (Da):77,921
    Checksum:iAC6D131F97359E8E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441R → K in AK098122. (PubMed:14702039)Curated
    Sequence conflicti653 – 6531V → A in AAK91779. (PubMed:11493702)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281N → D.2 Publications
    Corresponds to variant rs7522061 [ dbSNP | Ensembl ].
    VAR_042924
    Natural varianti307 – 3071L → F.
    Corresponds to variant rs12041673 [ dbSNP | Ensembl ].
    VAR_042925
    Natural varianti445 – 4451H → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_042926
    Natural varianti660 – 6601P → L.
    Corresponds to variant rs944627 [ dbSNP | Ensembl ].
    VAR_042927
    Natural varianti721 – 7211N → S.
    Corresponds to variant rs2282284 [ dbSNP | Ensembl ].
    VAR_042928

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 28296ELFLH…IRVQR → G in isoform 2. 1 PublicationVSP_033300Add
    BLAST
    Alternative sequencei187 – 1893ELF → GNG in isoform 4. 1 PublicationVSP_033301
    Alternative sequencei188 – 19912LFLHP…RASSS → ARCPAAILPLQR in isoform 5. 1 PublicationVSP_033302Add
    BLAST
    Alternative sequencei190 – 734545Missing in isoform 4. 1 PublicationVSP_033303Add
    BLAST
    Alternative sequencei200 – 734535Missing in isoform 5. 1 PublicationVSP_033304Add
    BLAST
    Alternative sequencei378 – 3781I → TLLSPSV in isoform 3. 1 PublicationVSP_033305
    Alternative sequencei698 – 70710THPDDSAGEA → EQSSRFSMSL in isoform 7. 1 PublicationVSP_033306
    Alternative sequencei708 – 73427Missing in isoform 7. 1 PublicationVSP_033307Add
    BLAST
    Alternative sequencei725 – 73410VPRVLLASDH → ILNPRKNKVQDFPCLCNT in isoform 6. 1 PublicationVSP_033308

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY043466 mRNA. Translation: AAK91779.1.
    AF416901 mRNA. Translation: AAL13290.1.
    AF416902 mRNA. Translation: AAL13291.1.
    AF416903 mRNA. Translation: AAL13292.1.
    AF416904 mRNA. Translation: AAL13293.1.
    AF416905 mRNA. Translation: AAL13294.1.
    EF064732 Genomic DNA. Translation: ABK41915.1.
    AK098122 mRNA. No translation available.
    AL356276 Genomic DNA. Translation: CAH73055.1.
    AL356276 Genomic DNA. Translation: CAH73056.1.
    AL356276 Genomic DNA. Translation: CAH73058.1.
    CH471121 Genomic DNA. Translation: EAW52872.1.
    CH471121 Genomic DNA. Translation: EAW52876.1.
    CH471121 Genomic DNA. Translation: EAW52877.1.
    BC028933 mRNA. Translation: AAH28933.1.
    CCDSiCCDS1167.1. [Q96P31-1]
    RefSeqiNP_443171.2. NM_052939.3. [Q96P31-1]
    XP_006711208.1. XM_006711145.1. [Q96P31-1]
    UniGeneiHs.292449.

    Genome annotation databases

    EnsembliENST00000368184; ENSP00000357167; ENSG00000160856. [Q96P31-1]
    ENST00000368186; ENSP00000357169; ENSG00000160856. [Q96P31-6]
    ENST00000477837; ENSP00000433430; ENSG00000160856. [Q96P31-2]
    ENST00000485028; ENSP00000434331; ENSG00000160856. [Q96P31-1]
    ENST00000492769; ENSP00000435487; ENSG00000160856. [Q96P31-3]
    GeneIDi115352.
    KEGGihsa:115352.
    UCSCiuc001fqz.4. human. [Q96P31-6]
    uc001frb.3. human. [Q96P31-1]

    Polymorphism databases

    DMDMi74761021.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY043466 mRNA. Translation: AAK91779.1 .
    AF416901 mRNA. Translation: AAL13290.1 .
    AF416902 mRNA. Translation: AAL13291.1 .
    AF416903 mRNA. Translation: AAL13292.1 .
    AF416904 mRNA. Translation: AAL13293.1 .
    AF416905 mRNA. Translation: AAL13294.1 .
    EF064732 Genomic DNA. Translation: ABK41915.1 .
    AK098122 mRNA. No translation available.
    AL356276 Genomic DNA. Translation: CAH73055.1 .
    AL356276 Genomic DNA. Translation: CAH73056.1 .
    AL356276 Genomic DNA. Translation: CAH73058.1 .
    CH471121 Genomic DNA. Translation: EAW52872.1 .
    CH471121 Genomic DNA. Translation: EAW52876.1 .
    CH471121 Genomic DNA. Translation: EAW52877.1 .
    BC028933 mRNA. Translation: AAH28933.1 .
    CCDSi CCDS1167.1. [Q96P31-1 ]
    RefSeqi NP_443171.2. NM_052939.3. [Q96P31-1 ]
    XP_006711208.1. XM_006711145.1. [Q96P31-1 ]
    UniGenei Hs.292449.

    3D structure databases

    ProteinModelPortali Q96P31.
    SMRi Q96P31. Positions 22-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125428. 4 interactions.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q96P31.

    Polymorphism databases

    DMDMi 74761021.

    Proteomic databases

    PaxDbi Q96P31.
    PRIDEi Q96P31.

    Protocols and materials databases

    DNASUi 115352.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368184 ; ENSP00000357167 ; ENSG00000160856 . [Q96P31-1 ]
    ENST00000368186 ; ENSP00000357169 ; ENSG00000160856 . [Q96P31-6 ]
    ENST00000477837 ; ENSP00000433430 ; ENSG00000160856 . [Q96P31-2 ]
    ENST00000485028 ; ENSP00000434331 ; ENSG00000160856 . [Q96P31-1 ]
    ENST00000492769 ; ENSP00000435487 ; ENSG00000160856 . [Q96P31-3 ]
    GeneIDi 115352.
    KEGGi hsa:115352.
    UCSCi uc001fqz.4. human. [Q96P31-6 ]
    uc001frb.3. human. [Q96P31-1 ]

    Organism-specific databases

    CTDi 115352.
    GeneCardsi GC01M157646.
    HGNCi HGNC:18506. FCRL3.
    HPAi HPA015508.
    MIMi 180300. phenotype.
    606510. gene.
    neXtProti NX_Q96P31.
    PharmGKBi PA142671767.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151212.
    HOVERGENi HBG074073.
    OMAi ENSANCP.
    OrthoDBi EOG7BP81V.
    PhylomeDBi Q96P31.
    TreeFami TF351107.

    Miscellaneous databases

    GeneWikii FCRL3.
    GenomeRNAii 115352.
    NextBioi 79574.
    PROi Q96P31.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96P31.
    Genevestigatori Q96P31.

    Family and domain databases

    Gene3Di 2.60.40.10. 6 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    SMARTi SM00409. IG. 4 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a family of Fc receptor homologs with preferential B cell expression."
      Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
      Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Lymph node.
    2. "SPAP2, an Ig family receptor containing both ITIMs and ITAMs."
      Xu M.-J., Zhao R., Cao H., Zhao Z.J.
      Biochem. Biophys. Res. Commun. 293:1037-1046(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), PHOSPHORYLATION, INTERACTION WITH PTPN6; PTPN11; SYK AND ZAP70, MUTAGENESIS OF TYR-650; TYR-662; TYR-692 AND TYR-722, TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASP-28.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Trachea.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-28.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Lymph.
    8. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
      Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
      Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
    9. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS AND GRAVES DISEASE, TISSUE SPECIFICITY.
    10. "Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis."
      Ikari K., Momohara S., Nakamura T., Hara M., Yamanaka H., Tomatsu T., Kamatani N.
      Ann. Rheum. Dis. 65:671-673(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    11. Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    12. "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?"
      Eyre S., Bowes J., Potter C., Worthington J., Barton A.
      Arthritis Res. Ther. 8:R117-R117(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    13. "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population."
      Newman W.G., Zhang Q., Liu X., Walker E., Ternan H., Owen J., Johnson B., Greer W., Mosher D.P., Maksymowych W.P., Bykerk V.P., Keystone E.C., Amos C.I., Siminovitch K.A.
      Arthritis Rheum. 54:3820-3827(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    14. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
      Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
      Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    15. "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease."
      Simmonds M.J., Heward J.M., Carr-Smith J., Foxall H., Franklyn J.A., Gough S.C.L.
      J. Clin. Endocrinol. Metab. 91:1056-1061(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN GRAVES DISEASE.
    16. "FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians."
      Thabet M.M., Wesoly J., Slagboom P.E., Toes R.E.M., Huizinga T.W.J.
      Ann. Rheum. Dis. 66:803-806(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    17. "Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients."
      Begovich A.B., Chang M., Schrodi S.J.
      Arthritis Rheum. 56:3168-3171(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RHEUMATOID ARTHRITIS.
    18. "Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants."
      The Wellcome Trust case control consortium, The Australo-Anglo-American spondylitis consortium
      Nat. Genet. 39:1329-1337(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN GRAVES DISEASE.
    19. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.

    Entry informationi

    Entry nameiFCRL3_HUMAN
    AccessioniPrimary (citable) accession number: Q96P31
    Secondary accession number(s): A0N0M4
    , A8MTH7, D3DVD2, Q5VXZ8, Q8N6S2, Q96LA4, Q96P27, Q96P28, Q96P29, Q96P30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3