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Protein

Serpin B11

Gene

SERPINB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3582Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B11
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:14221. SERPINB11.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Serpin B11PRO_0000094117Add
BLAST

Proteomic databases

PaxDbiQ96P15.
PRIDEiQ96P15.

PTM databases

PhosphoSiteiQ96P15.

Expressioni

Tissue specificityi

Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.1 Publication

Gene expression databases

BgeeiQ96P15.
ExpressionAtlasiQ96P15. baseline and differential.
GenevestigatoriQ96P15.

Interactioni

Protein-protein interaction databases

BioGridi124598. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96P15.
SMRiQ96P15. Positions 1-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni341 – 36525RCLBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiQ96P15.
KOiK13966.
PhylomeDBiQ96P15.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P15-1) [UniParc]FASTAAdd to basket

Also known as: SERPINB11a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET
60 70 80 90 100
AEQLEKVLHF SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN
110 120 130 140 150
CTLSIANRLY GTKTMAFHQQ YLSCSEKWYQ ARLQTVDFEQ STEETRKMIN
160 170 180 190 200
AWVENKTNGK VANLFGKSTI DPSSVMVLVN IIYFKGQRQN KFQVRETVKS
210 220 230 240 250
PFQLSEGKNV TVEMMYQIGT FKLAFVKEPQ MQVLELPYVN NKLSMIILLP
260 270 280 290 300
VGIANLKQIE KQLNSGTFHE WTSSSNMMER EVEVHLPRFK LEIKYELNSL
310 320 330 340 350
LKPLGVTDLF NQVKADLSGM SPTKGLYLSK AIHKSYLDVS EEGTEAAAAT
360 370 380 390
GDSIAVKSLP MRAQFKANHP FLFFIRHTHT NTILFCGKLA SP
Length:392
Mass (Da):44,099
Last modified:December 1, 2001 - v1
Checksum:i906F6DD412BCD756
GO
Isoform 2 (identifier: Q96P15-2) [UniParc]FASTAAdd to basket

Also known as: SERPINB11e

The sequence of this isoform differs from the canonical sequence as follows:
     120-206: Missing.

Show »
Length:305
Mass (Da):33,948
Checksum:iD04B70566400DA88
GO
Isoform 3 (identifier: Q96P15-3) [UniParc]FASTAAdd to basket

Also known as: SERPINB11g

The sequence of this isoform differs from the canonical sequence as follows:
     57-258: Missing.

Show »
Length:190
Mass (Da):21,080
Checksum:iB19413131524D37F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121C → R in AAV73921 (PubMed:17562709).Curated
Sequence conflicti43 – 431L → P in AAV73923 (PubMed:17562709).Curated
Sequence conflicti91 – 911F → S in AAV73920 (PubMed:17562709).Curated
Sequence conflicti267 – 2671T → A in AAV73920 (PubMed:17562709).Curated
Sequence conflicti356 – 3561V → A in AAV73921 (PubMed:17562709).Curated

Polymorphismi

According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511A → E.2 Publications
Corresponds to variant rs1395268 [ dbSNP | Ensembl ].
VAR_060331
Natural varianti148 – 1481M → T in allele B and allele D. 1 Publication
Corresponds to variant rs17071550 [ dbSNP | Ensembl ].
VAR_012472
Natural varianti181 – 1811I → A in allele D; requires 2 nucleotide substitutions. 1 Publication
VAR_064572
Natural varianti181 – 1811I → T in allele B and allele C. 3 Publications
VAR_012473
Natural varianti188 – 1881R → W in allele D. 1 Publication
Corresponds to variant rs1506419 [ dbSNP | Ensembl ].
VAR_060332
Natural varianti293 – 2931I → T.1 Publication
Corresponds to variant rs1395266 [ dbSNP | Ensembl ].
VAR_060333
Natural varianti303 – 3031P → S.1 Publication
Corresponds to variant rs1395267 [ dbSNP | Ensembl ].
VAR_060334
Natural varianti354 – 3541I → T.
Corresponds to variant rs34811964 [ dbSNP | Ensembl ].
VAR_057177

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 258202Missing in isoform 3. CuratedVSP_040670Add
BLAST
Alternative sequencei120 – 20687Missing in isoform 2. CuratedVSP_040671Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419953 mRNA. Translation: AAL16056.1.
AF419954 mRNA. Translation: AAL16057.1.
AF419955 mRNA. Translation: AAL16058.1.
AY792323 mRNA. Translation: AAV73920.1.
AY792324 mRNA. Translation: AAV73921.1.
AY792325 mRNA. Translation: AAV73922.1.
AY792326 mRNA. Translation: AAV73923.1.
AK292775 mRNA. Translation: BAF85464.1.
AC069356 Genomic DNA. No translation available.
BC069596 mRNA. Translation: AAH69596.1.
RefSeqiNP_001278207.1. NM_001291278.1.
NP_536723.2. NM_080475.3.
UniGeneiHs.350958.

Genome annotation databases

EnsembliENST00000382749; ENSP00000421854; ENSG00000206072.
GeneIDi89778.
KEGGihsa:89778.

Polymorphism databases

DMDMi20140144.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419953 mRNA. Translation: AAL16056.1.
AF419954 mRNA. Translation: AAL16057.1.
AF419955 mRNA. Translation: AAL16058.1.
AY792323 mRNA. Translation: AAV73920.1.
AY792324 mRNA. Translation: AAV73921.1.
AY792325 mRNA. Translation: AAV73922.1.
AY792326 mRNA. Translation: AAV73923.1.
AK292775 mRNA. Translation: BAF85464.1.
AC069356 Genomic DNA. No translation available.
BC069596 mRNA. Translation: AAH69596.1.
RefSeqiNP_001278207.1. NM_001291278.1.
NP_536723.2. NM_080475.3.
UniGeneiHs.350958.

3D structure databases

ProteinModelPortaliQ96P15.
SMRiQ96P15. Positions 1-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124598. 7 interactions.

Protein family/group databases

MEROPSiI04.956.

PTM databases

PhosphoSiteiQ96P15.

Polymorphism databases

DMDMi20140144.

Proteomic databases

PaxDbiQ96P15.
PRIDEiQ96P15.

Protocols and materials databases

DNASUi89778.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382749; ENSP00000421854; ENSG00000206072.
GeneIDi89778.
KEGGihsa:89778.

Organism-specific databases

CTDi89778.
GeneCardsiGC18P061350.
H-InvDBHIX0039713.
HGNCiHGNC:14221. SERPINB11.
MIMi615682. gene.
neXtProtiNX_Q96P15.
PharmGKBiPA37860.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiQ96P15.
KOiK13966.
PhylomeDBiQ96P15.

Miscellaneous databases

GenomeRNAii89778.
NextBioi76259.
PROiQ96P15.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P15.
ExpressionAtlasiQ96P15. baseline and differential.
GenevestigatoriQ96P15.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change."
    Askew D.J., Cataltepe S., Kumar V., Edwards C., Pace S.M., Howarth R.N., Pak S.C., Askew Y.S., Bromme D., Luke C.J., Whisstock J.C., Silverman G.A.
    J. Biol. Chem. 282:24948-24960(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-51; THR-148; ALA-181; THR-181; TRP-188; THR-293 AND SER-303.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-51.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.

Entry informationi

Entry nameiSPB11_HUMAN
AccessioniPrimary (citable) accession number: Q96P15
Secondary accession number(s): A8K9R0
, Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.