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Q96P15 (SPB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B11
Gene names
Name:SERPINB11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. Ref.1

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil. Ref.1

Polymorphism

According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (Ref.1). The sequence displayed here corresponds to SERPINB11a.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Caution

Mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96P15-1)

Also known as: SERPINB11a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96P15-2)

Also known as: SERPINB11e;

The sequence of this isoform differs from the canonical sequence as follows:
     120-206: Missing.
Isoform 3 (identifier: Q96P15-3)

Also known as: SERPINB11g;

The sequence of this isoform differs from the canonical sequence as follows:
     57-258: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Serpin B11
PRO_0000094117

Regions

Region341 – 36525RCL By similarity

Sites

Site357 – 3582Reactive bond By similarity

Natural variations

Alternative sequence57 – 258202Missing in isoform 3.
VSP_040670
Alternative sequence120 – 20687Missing in isoform 2.
VSP_040671
Natural variant511A → E. Ref.1 Ref.3
Corresponds to variant rs1395268 [ dbSNP | Ensembl ].
VAR_060331
Natural variant1481M → T in allele B and allele D. Ref.1
Corresponds to variant rs17071550 [ dbSNP | Ensembl ].
VAR_012472
Natural variant1811I → A in allele D; requires 2 nucleotide substitutions. Ref.1
VAR_064572
Natural variant1811I → T in allele B and allele C. Ref.1 Ref.2 Ref.4
VAR_012473
Natural variant1881R → W in allele D. Ref.1
Corresponds to variant rs1506419 [ dbSNP | Ensembl ].
VAR_060332
Natural variant2931I → T. Ref.1
Corresponds to variant rs1395266 [ dbSNP | Ensembl ].
VAR_060333
Natural variant3031P → S. Ref.1
Corresponds to variant rs1395267 [ dbSNP | Ensembl ].
VAR_060334
Natural variant3541I → T.
Corresponds to variant rs34811964 [ dbSNP | Ensembl ].
VAR_057177

Experimental info

Sequence conflict121C → R in AAV73921. Ref.1
Sequence conflict431L → P in AAV73923. Ref.1
Sequence conflict911F → S in AAV73920. Ref.1
Sequence conflict2671T → A in AAV73920. Ref.1
Sequence conflict3561V → A in AAV73921. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (SERPINB11a) [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 906F6DD412BCD756

FASTA39244,099
        10         20         30         40         50         60 
MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET AEQLEKVLHF 

        70         80         90        100        110        120 
SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN CTLSIANRLY GTKTMAFHQQ 

       130        140        150        160        170        180 
YLSCSEKWYQ ARLQTVDFEQ STEETRKMIN AWVENKTNGK VANLFGKSTI DPSSVMVLVN 

       190        200        210        220        230        240 
IIYFKGQRQN KFQVRETVKS PFQLSEGKNV TVEMMYQIGT FKLAFVKEPQ MQVLELPYVN 

       250        260        270        280        290        300 
NKLSMIILLP VGIANLKQIE KQLNSGTFHE WTSSSNMMER EVEVHLPRFK LEIKYELNSL 

       310        320        330        340        350        360 
LKPLGVTDLF NQVKADLSGM SPTKGLYLSK AIHKSYLDVS EEGTEAAAAT GDSIAVKSLP 

       370        380        390 
MRAQFKANHP FLFFIRHTHT NTILFCGKLA SP 

« Hide

Isoform 2 (SERPINB11e) [UniParc].

Checksum: D04B70566400DA88
Show »

FASTA30533,948
Isoform 3 (SERPINB11g) [UniParc].

Checksum: B19413131524D37F
Show »

FASTA19021,080

References

« Hide 'large scale' references
[1]"SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change."
Askew D.J., Cataltepe S., Kumar V., Edwards C., Pace S.M., Howarth R.N., Pak S.C., Askew Y.S., Bromme D., Luke C.J., Whisstock J.C., Silverman G.A.
J. Biol. Chem. 282:24948-24960(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-51; THR-148; ALA-181; THR-181; TRP-188; THR-293 AND SER-303.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.
Tissue: Trachea.
[3]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-51.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF419953 mRNA. Translation: AAL16056.1.
AF419954 mRNA. Translation: AAL16057.1.
AF419955 mRNA. Translation: AAL16058.1.
AY792323 mRNA. Translation: AAV73920.1.
AY792324 mRNA. Translation: AAV73921.1.
AY792325 mRNA. Translation: AAV73922.1.
AY792326 mRNA. Translation: AAV73923.1.
AK292775 mRNA. Translation: BAF85464.1.
AC069356 Genomic DNA. No translation available.
BC069596 mRNA. Translation: AAH69596.1.
RefSeqNP_001278207.1. NM_001291278.1.
NP_536723.2. NM_080475.3.
UniGeneHs.350958.

3D structure databases

ProteinModelPortalQ96P15.
SMRQ96P15. Positions 1-392.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.012.

PTM databases

PhosphoSiteQ96P15.

Polymorphism databases

DMDM20140144.

Proteomic databases

PaxDbQ96P15.
PRIDEQ96P15.

Protocols and materials databases

DNASU89778.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382749; ENSP00000421854; ENSG00000206072.
GeneID89778.
KEGGhsa:89778.

Organism-specific databases

CTD89778.
GeneCardsGC18P061350.
H-InvDBHIX0039713.
HGNCHGNC:14221. SERPINB11.
neXtProtNX_Q96P15.
PharmGKBPA37860.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
KOK13966.
PhylomeDBQ96P15.

Gene expression databases

ArrayExpressQ96P15.
BgeeQ96P15.
GenevestigatorQ96P15.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINB11. human.
GenomeRNAi89778.
NextBio76259.
PROQ96P15.

Entry information

Entry nameSPB11_HUMAN
AccessionPrimary (citable) accession number: Q96P15
Secondary accession number(s): A8K9R0 expand/collapse secondary AC list , Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM