Q96P15 (SPB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin B11

Gene names

Name:

SERPINB11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. Ref.1
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil. Ref.1
Polymorphism	According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (Ref.1). The sequence displayed here corresponds to SERPINB11a.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.
Caution	Mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Protease inhibitor Serine protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96P15-1)

Also known as: SERPINB11a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96P15-2)

Also known as: SERPINB11e;

The sequence of this isoform differs from the canonical sequence as follows:
     120-206: Missing.

Isoform 3 (identifier: Q96P15-3)

Also known as: SERPINB11g;

The sequence of this isoform differs from the canonical sequence as follows:
     57-258: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Serpin B11		PRO_0000094117
Regions
	Region	341 – 365	25	RCL By similarity
Sites
	Site	357 – 358	2	Reactive bond By similarity
Natural variations
	Alternative sequence	57 – 258	202	Missing in isoform 3.		VSP_040670
	Alternative sequence	120 – 206	87	Missing in isoform 2.		VSP_040671
	Natural variant	51	1	A → E. Ref.1 Ref.3 Corresponds to variant rs1395268 [ dbSNP | Ensembl ].		VAR_060331
	Natural variant	148	1	M → T in allele B and allele D. Ref.1 Corresponds to variant rs17071550 [ dbSNP | Ensembl ].		VAR_012472
	Natural variant	181	1	I → A in allele D; requires 2 nucleotide substitutions. Ref.1		VAR_064572
	Natural variant	181	1	I → T in allele B and allele C. Ref.1 Ref.2 Ref.4		VAR_012473
	Natural variant	188	1	R → W in allele D. Ref.1 Corresponds to variant rs1506419 [ dbSNP | Ensembl ].		VAR_060332
	Natural variant	293	1	I → T. Ref.1 Corresponds to variant rs1395266 [ dbSNP | Ensembl ].		VAR_060333
	Natural variant	303	1	P → S. Ref.1 Corresponds to variant rs1395267 [ dbSNP | Ensembl ].		VAR_060334
	Natural variant	354	1	I → T. Corresponds to variant rs34811964 [ dbSNP | Ensembl ].		VAR_057177
Experimental info
	Sequence conflict	12	1	C → R in AAV73921. Ref.1
	Sequence conflict	43	1	L → P in AAV73923. Ref.1
	Sequence conflict	91	1	F → S in AAV73920. Ref.1
	Sequence conflict	267	1	T → A in AAV73920. Ref.1
	Sequence conflict	356	1	V → A in AAV73921. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SERPINB11a) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 906F6DD412BCD756	FASTA	392	44,099
	10 20 30 40 50 60 MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET AEQLEKVLHF 70 80 90 100 110 120 SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN CTLSIANRLY GTKTMAFHQQ 130 140 150 160 170 180 YLSCSEKWYQ ARLQTVDFEQ STEETRKMIN AWVENKTNGK VANLFGKSTI DPSSVMVLVN 190 200 210 220 230 240 IIYFKGQRQN KFQVRETVKS PFQLSEGKNV TVEMMYQIGT FKLAFVKEPQ MQVLELPYVN 250 260 270 280 290 300 NKLSMIILLP VGIANLKQIE KQLNSGTFHE WTSSSNMMER EVEVHLPRFK LEIKYELNSL 310 320 330 340 350 360 LKPLGVTDLF NQVKADLSGM SPTKGLYLSK AIHKSYLDVS EEGTEAAAAT GDSIAVKSLP 370 380 390 MRAQFKANHP FLFFIRHTHT NTILFCGKLA SP
	Isoform 2 (SERPINB11e) [UniParc]. Checksum: D04B70566400DA88	FASTA	305	33,948
	10 20 30 40 50 60 MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET AEQLEKVLHF 70 80 90 100 110 120 SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN CTLSIANRLY GTKTMAFHQG 130 140 150 160 170 180 KNVTVEMMYQ IGTFKLAFVK EPQMQVLELP YVNNKLSMII LLPVGIANLK QIEKQLNSGT 190 200 210 220 230 240 FHEWTSSSNM MEREVEVHLP RFKLEIKYEL NSLLKPLGVT DLFNQVKADL SGMSPTKGLY 250 260 270 280 290 300 LSKAIHKSYL DVSEEGTEAA AATGDSIAVK SLPMRAQFKA NHPFLFFIRH THTNTILFCG KLASP
	Isoform 3 (SERPINB11g) [UniParc]. Checksum: B19413131524D37F	FASTA	190	21,080
	10 20 30 40 50 60 MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET AEQLEKIEKQ 70 80 90 100 110 120 LNSGTFHEWT SSSNMMEREV EVHLPRFKLE IKYELNSLLK PLGVTDLFNQ VKADLSGMSP 130 140 150 160 170 180 TKGLYLSKAI HKSYLDVSEE GTEAAAATGD SIAVKSLPMR AQFKANHPFL FFIRHTHTNT 190 ILFCGKLASP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change." Askew D.J., Cataltepe S., Kumar V., Edwards C., Pace S.M., Howarth R.N., Pak S.C., Askew Y.S., Bromme D., Luke C.J., Whisstock J.C., Silverman G.A. J. Biol. Chem. 282:24948-24960(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-51; THR-148; ALA-181; THR-181; TRP-188; THR-293 AND SER-303.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181. Tissue: Trachea.
[3]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-51.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF419953 mRNA. Translation: AAL16056.1. AF419954 mRNA. Translation: AAL16057.1. AF419955 mRNA. Translation: AAL16058.1. AY792323 mRNA. Translation: AAV73920.1. AY792324 mRNA. Translation: AAV73921.1. AY792325 mRNA. Translation: AAV73922.1. AY792326 mRNA. Translation: AAV73923.1. AK292775 mRNA. Translation: BAF85464.1. AC069356 Genomic DNA. No translation available. BC069596 mRNA. Translation: AAH69596.1.
IPI	IPI00289606. IPI00979204. IPI00982372.
RefSeq	NP_536723.2. NM_080475.2.
UniGene	Hs.350958.
3D structure databases
ProteinModelPortal	Q96P15.
ModBase	Search...
Protein family/group databases
MEROPS	I04.956.
PTM databases
PhosphoSite	Q96P15.
Polymorphism databases
DMDM	20140144.
Proteomic databases
PaxDb	Q96P15.
PRIDE	Q96P15.
Protocols and materials databases
DNASU	89778.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382749; ENSP00000421854; ENSG00000206072.
GeneID	89778.
KEGG	hsa:89778.
Organism-specific databases
CTD	89778.
GeneCards	GC18P061350.
H-InvDB	HIX0039713.
HGNC	HGNC:14221. SERPINB11.
neXtProt	NX_Q96P15.
PharmGKB	PA37860.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOVERGEN	HBG005957.
KO	K13966.
Gene expression databases
ArrayExpress	Q96P15.
Bgee	Q96P15.
Genevestigator	Q96P15.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SERPINB11. human.
GenomeRNAi	89778.
NextBio	76259.

Entry information

Entry name

SPB11_HUMAN

Accession

Primary (citable) accession number: Q96P15
Secondary accession number(s): A8K9R0 , Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.