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Q96P15

- SPB11_HUMAN

UniProt

Q96P15 - SPB11_HUMAN

Protein

Serpin B11

Gene

SERPINB11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei357 – 3582Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B11
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:14221. SERPINB11.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37860.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Serpin B11PRO_0000094117Add
    BLAST

    Proteomic databases

    PaxDbiQ96P15.
    PRIDEiQ96P15.

    PTM databases

    PhosphoSiteiQ96P15.

    Expressioni

    Tissue specificityi

    Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.1 Publication

    Gene expression databases

    ArrayExpressiQ96P15.
    BgeeiQ96P15.
    GenevestigatoriQ96P15.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96P15.
    SMRiQ96P15. Positions 1-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni341 – 36525RCLBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    KOiK13966.
    PhylomeDBiQ96P15.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96P15-1) [UniParc]FASTAAdd to Basket

    Also known as: SERPINB11a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET    50
    AEQLEKVLHF SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN 100
    CTLSIANRLY GTKTMAFHQQ YLSCSEKWYQ ARLQTVDFEQ STEETRKMIN 150
    AWVENKTNGK VANLFGKSTI DPSSVMVLVN IIYFKGQRQN KFQVRETVKS 200
    PFQLSEGKNV TVEMMYQIGT FKLAFVKEPQ MQVLELPYVN NKLSMIILLP 250
    VGIANLKQIE KQLNSGTFHE WTSSSNMMER EVEVHLPRFK LEIKYELNSL 300
    LKPLGVTDLF NQVKADLSGM SPTKGLYLSK AIHKSYLDVS EEGTEAAAAT 350
    GDSIAVKSLP MRAQFKANHP FLFFIRHTHT NTILFCGKLA SP 392
    Length:392
    Mass (Da):44,099
    Last modified:December 1, 2001 - v1
    Checksum:i906F6DD412BCD756
    GO
    Isoform 2 (identifier: Q96P15-2) [UniParc]FASTAAdd to Basket

    Also known as: SERPINB11e

    The sequence of this isoform differs from the canonical sequence as follows:
         120-206: Missing.

    Show »
    Length:305
    Mass (Da):33,948
    Checksum:iD04B70566400DA88
    GO
    Isoform 3 (identifier: Q96P15-3) [UniParc]FASTAAdd to Basket

    Also known as: SERPINB11g

    The sequence of this isoform differs from the canonical sequence as follows:
         57-258: Missing.

    Show »
    Length:190
    Mass (Da):21,080
    Checksum:iB19413131524D37F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121C → R in AAV73921. (PubMed:17562709)Curated
    Sequence conflicti43 – 431L → P in AAV73923. (PubMed:17562709)Curated
    Sequence conflicti91 – 911F → S in AAV73920. (PubMed:17562709)Curated
    Sequence conflicti267 – 2671T → A in AAV73920. (PubMed:17562709)Curated
    Sequence conflicti356 – 3561V → A in AAV73921. (PubMed:17562709)Curated

    Polymorphismi

    According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511A → E.2 Publications
    Corresponds to variant rs1395268 [ dbSNP | Ensembl ].
    VAR_060331
    Natural varianti148 – 1481M → T in allele B and allele D. 1 Publication
    Corresponds to variant rs17071550 [ dbSNP | Ensembl ].
    VAR_012472
    Natural varianti181 – 1811I → A in allele D; requires 2 nucleotide substitutions. 1 Publication
    VAR_064572
    Natural varianti181 – 1811I → T in allele B and allele C. 3 Publications
    VAR_012473
    Natural varianti188 – 1881R → W in allele D. 1 Publication
    Corresponds to variant rs1506419 [ dbSNP | Ensembl ].
    VAR_060332
    Natural varianti293 – 2931I → T.1 Publication
    Corresponds to variant rs1395266 [ dbSNP | Ensembl ].
    VAR_060333
    Natural varianti303 – 3031P → S.1 Publication
    Corresponds to variant rs1395267 [ dbSNP | Ensembl ].
    VAR_060334
    Natural varianti354 – 3541I → T.
    Corresponds to variant rs34811964 [ dbSNP | Ensembl ].
    VAR_057177

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei57 – 258202Missing in isoform 3. CuratedVSP_040670Add
    BLAST
    Alternative sequencei120 – 20687Missing in isoform 2. CuratedVSP_040671Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF419953 mRNA. Translation: AAL16056.1.
    AF419954 mRNA. Translation: AAL16057.1.
    AF419955 mRNA. Translation: AAL16058.1.
    AY792323 mRNA. Translation: AAV73920.1.
    AY792324 mRNA. Translation: AAV73921.1.
    AY792325 mRNA. Translation: AAV73922.1.
    AY792326 mRNA. Translation: AAV73923.1.
    AK292775 mRNA. Translation: BAF85464.1.
    AC069356 Genomic DNA. No translation available.
    BC069596 mRNA. Translation: AAH69596.1.
    RefSeqiNP_001278207.1. NM_001291278.1.
    NP_536723.2. NM_080475.3.
    UniGeneiHs.350958.

    Genome annotation databases

    EnsembliENST00000382749; ENSP00000421854; ENSG00000206072.
    GeneIDi89778.
    KEGGihsa:89778.

    Polymorphism databases

    DMDMi20140144.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF419953 mRNA. Translation: AAL16056.1 .
    AF419954 mRNA. Translation: AAL16057.1 .
    AF419955 mRNA. Translation: AAL16058.1 .
    AY792323 mRNA. Translation: AAV73920.1 .
    AY792324 mRNA. Translation: AAV73921.1 .
    AY792325 mRNA. Translation: AAV73922.1 .
    AY792326 mRNA. Translation: AAV73923.1 .
    AK292775 mRNA. Translation: BAF85464.1 .
    AC069356 Genomic DNA. No translation available.
    BC069596 mRNA. Translation: AAH69596.1 .
    RefSeqi NP_001278207.1. NM_001291278.1.
    NP_536723.2. NM_080475.3.
    UniGenei Hs.350958.

    3D structure databases

    ProteinModelPortali Q96P15.
    SMRi Q96P15. Positions 1-392.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.012.

    PTM databases

    PhosphoSitei Q96P15.

    Polymorphism databases

    DMDMi 20140144.

    Proteomic databases

    PaxDbi Q96P15.
    PRIDEi Q96P15.

    Protocols and materials databases

    DNASUi 89778.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382749 ; ENSP00000421854 ; ENSG00000206072 .
    GeneIDi 89778.
    KEGGi hsa:89778.

    Organism-specific databases

    GeneCardsi GC18P061350.
    H-InvDB HIX0039713.
    HGNCi HGNC:14221. SERPINB11.
    MIMi 615682. gene.
    neXtProti NX_Q96P15.
    PharmGKBi PA37860.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    KOi K13966.
    PhylomeDBi Q96P15.

    Miscellaneous databases

    ChiTaRSi SERPINB11. human.
    GenomeRNAii 89778.
    NextBioi 76259.
    PROi Q96P15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96P15.
    Bgeei Q96P15.
    Genevestigatori Q96P15.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change."
      Askew D.J., Cataltepe S., Kumar V., Edwards C., Pace S.M., Howarth R.N., Pak S.C., Askew Y.S., Bromme D., Luke C.J., Whisstock J.C., Silverman G.A.
      J. Biol. Chem. 282:24948-24960(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-51; THR-148; ALA-181; THR-181; TRP-188; THR-293 AND SER-303.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-51.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-181.

    Entry informationi

    Entry nameiSPB11_HUMAN
    AccessioniPrimary (citable) accession number: Q96P15
    Secondary accession number(s): A8K9R0
    , Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3