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Protein

Probable 28S rRNA (cytosine-C(5))-methyltransferase

Gene

NSUN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 3782 in 28S rRNA.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + cytosine(3782) in 28S rRNA = S-adenosyl-L-homocysteine + C(5)-methylcytosine(3782) in 28S rRNA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei258 – 2581S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication
Binding sitei263 – 2631S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication
Binding sitei305 – 3051S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication
Active sitei359 – 3591NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  • methyltransferase activity Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC:2.1.1.-1 Publication)
Alternative name(s):
NOL1-related protein
Short name:
NOL1R
NOL1/NOP2/Sun domain family member 5
Williams-Beuren syndrome chromosomal region 20A protein
Gene namesi
Name:NSUN5
Synonyms:NSUN5A, WBSCR20, WBSCR20A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16385. NSUN5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

NSUN5 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

PharmGKBiPA134993779.

Polymorphism and mutation databases

BioMutaiNSUN5.
DMDMi118573085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 429428Probable 28S rRNA (cytosine-C(5))-methyltransferasePRO_0000261669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei167 – 1671PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96P11.
MaxQBiQ96P11.
PaxDbiQ96P11.
PeptideAtlasiQ96P11.
PRIDEiQ96P11.

PTM databases

iPTMnetiQ96P11.

Expressioni

Tissue specificityi

Ubiquitous. Detected in placenta, heart and skeletal muscle.2 Publications

Gene expression databases

BgeeiQ96P11.
CleanExiHS_NSUN5.
ExpressionAtlasiQ96P11. baseline and differential.
GenevisibleiQ96P11. HS.

Organism-specific databases

HPAiHPA020536.
HPA045590.
HPA046867.

Interactioni

Protein-protein interaction databases

BioGridi120820. 14 interactions.
IntActiQ96P11. 5 interactions.
MINTiMINT-5009481.
STRINGi9606.ENSP00000309126.

Structurei

Secondary structure

1
429
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi136 – 1405Combined sources
Turni142 – 1443Combined sources
Helixi147 – 15610Combined sources
Beta strandi160 – 1645Combined sources
Helixi168 – 1725Combined sources
Beta strandi178 – 1814Combined sources
Beta strandi183 – 1853Combined sources
Beta strandi188 – 1914Combined sources
Helixi201 – 2044Combined sources
Beta strandi207 – 2104Combined sources
Helixi214 – 2163Combined sources
Helixi217 – 2226Combined sources
Beta strandi229 – 2346Combined sources
Helixi239 – 24810Combined sources
Beta strandi252 – 2598Combined sources
Helixi261 – 27313Combined sources
Beta strandi278 – 2836Combined sources
Helixi286 – 2883Combined sources
Helixi294 – 2963Combined sources
Beta strandi299 – 3046Combined sources
Helixi331 – 34515Combined sources
Beta strandi353 – 3597Combined sources
Helixi363 – 3653Combined sources
Helixi367 – 3748Combined sources
Turni378 – 3803Combined sources
Beta strandi381 – 3833Combined sources
Beta strandi396 – 3983Combined sources
Helixi401 – 4033Combined sources
Beta strandi404 – 4074Combined sources
Helixi409 – 4124Combined sources
Beta strandi416 – 4249Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B9EX-ray1.65A127-429[»]
ProteinModelPortaliQ96P11.
SMRiQ96P11. Positions 133-425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96P11.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 2407S-adenosyl-L-methionine binding

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2360. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00550000074709.
HOGENOMiHOG000203203.
HOVERGENiHBG062278.
InParanoidiQ96P11.
KOiK15264.
OMAiLVYDSKF.
PhylomeDBiQ96P11.
TreeFamiTF314285.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001678. MeTrfase_RsmB/NOP2.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Methyltr_RsmB-F. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96P11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL
60 70 80 90 100
DAVIASAGLL RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA
110 120 130 140 150
RLKAELARLK VHRGVSRNED LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV
160 170 180 190 200
VDYFKRQGFS YQGRASSLDD LRALKGKHFL LDPLMPELLV FPAQTDLHEH
210 220 230 240 250
PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK TSHLAALLKN
260 270 280 290 300
QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
310 320 330 340 350
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS
360 370 380 390 400
LQRLVYSTCS LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG
410 420
AEHCLRASPE TTLSSGFFVA VIERVEVPR
Length:429
Mass (Da):46,692
Last modified:November 28, 2006 - v2
Checksum:iE4DA635C6135298B
GO
Isoform 2 (identifier: Q96P11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-429: R → SSASQAKASAPERTPSPAPKRKKRQQRAAAGACTPPCT

Show »
Length:466
Mass (Da):50,411
Checksum:i6AB933A70607C4B9
GO
Isoform 3 (identifier: Q96P11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     58-72: GLLRAEKKLRPHLAK → MLRAFLFLSLFPHSQ
     253-381: KIFAFDLDAK...DALQQNPGAF → SLPLTWMPSG...RCSRTRAPSG
     382-429: Missing.

Show »
Length:324
Mass (Da):36,075
Checksum:i045EDB19E1A7CAA5
GO
Isoform 4 (identifier: Q96P11-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-429: R → SLTGQSISTRTHTQPSPKEKEETAKSRSRCLHTALHIAEAPG

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):51,061
Checksum:i946D7FC8E1768174
GO
Isoform 5 (identifier: Q96P11-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-109: Missing.

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):42,478
Checksum:i21C93D90C15F9D30
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421E → G in AAL16067 (PubMed:11978965).Curated
Sequence conflicti100 – 1001A → P in AAL16067 (PubMed:11978965).Curated
Sequence conflicti425 – 4251V → A in BAG54316 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831P → S.
Corresponds to variant rs34913552 [ dbSNP | Ensembl ].
VAR_051889

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 3. CuratedVSP_021752Add
BLAST
Alternative sequencei58 – 7215GLLRA…PHLAK → MLRAFLFLSLFPHSQ in isoform 3. CuratedVSP_021753Add
BLAST
Alternative sequencei72 – 10938Missing in isoform 5. 1 PublicationVSP_045492Add
BLAST
Alternative sequencei253 – 381129KIFAF…NPGAF → SLPLTWMPSGWHPWPRCWPG LASLAVNWLRRTSWRSPPRI HATMRSTTSCWILPAVARVC RADSWRSPGQAHLARCVCMP WQGSSSEPCATRSLSLPCSG SSTPRAPSARRRMKTWCEMR CSRTRAPSG in isoform 3. CuratedVSP_021754Add
BLAST
Alternative sequencei382 – 42948Missing in isoform 3. CuratedVSP_021755Add
BLAST
Alternative sequencei429 – 4291R → SSASQAKASAPERTPSPAPK RKKRQQRAAAGACTPPCT in isoform 2. 3 PublicationsVSP_021756
Alternative sequencei429 – 4291R → SLTGQSISTRTHTQPSPKEK EETAKSRSRCLHTALHIAEA PG in isoform 4. 1 PublicationVSP_043352

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420249 mRNA. Translation: AAL16067.1.
AF412028 mRNA. Translation: AAM62310.1.
AK001129 mRNA. Translation: BAA91515.1.
AK125667 mRNA. No translation available.
AK126375 mRNA. Translation: BAG54316.1.
AK298221 mRNA. Translation: BAG60491.1.
AC073841 Genomic DNA. Translation: AAQ96838.1.
AC073841 Genomic DNA. Translation: AAQ96839.1.
CH471200 Genomic DNA. Translation: EAW69694.1.
BC008084 mRNA. Translation: AAH08084.1.
CCDSiCCDS55118.1. [Q96P11-5]
CCDS55119.1. [Q96P11-4]
CCDS5546.1. [Q96P11-2]
CCDS5547.1. [Q96P11-1]
RefSeqiNP_001161819.1. NM_001168347.2. [Q96P11-4]
NP_001161820.1. NM_001168348.2. [Q96P11-5]
NP_060514.1. NM_018044.4. [Q96P11-1]
NP_683759.1. NM_148956.3. [Q96P11-2]
UniGeneiHs.510927.
Hs.647060.
Hs.655217.

Genome annotation databases

EnsembliENST00000252594; ENSP00000252594; ENSG00000130305. [Q96P11-1]
ENST00000310326; ENSP00000309126; ENSG00000130305. [Q96P11-4]
ENST00000428206; ENSP00000393081; ENSG00000130305. [Q96P11-5]
ENST00000438747; ENSP00000388464; ENSG00000130305. [Q96P11-2]
GeneIDi55695.
KEGGihsa:55695.
UCSCiuc003txv.5. human. [Q96P11-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420249 mRNA. Translation: AAL16067.1.
AF412028 mRNA. Translation: AAM62310.1.
AK001129 mRNA. Translation: BAA91515.1.
AK125667 mRNA. No translation available.
AK126375 mRNA. Translation: BAG54316.1.
AK298221 mRNA. Translation: BAG60491.1.
AC073841 Genomic DNA. Translation: AAQ96838.1.
AC073841 Genomic DNA. Translation: AAQ96839.1.
CH471200 Genomic DNA. Translation: EAW69694.1.
BC008084 mRNA. Translation: AAH08084.1.
CCDSiCCDS55118.1. [Q96P11-5]
CCDS55119.1. [Q96P11-4]
CCDS5546.1. [Q96P11-2]
CCDS5547.1. [Q96P11-1]
RefSeqiNP_001161819.1. NM_001168347.2. [Q96P11-4]
NP_001161820.1. NM_001168348.2. [Q96P11-5]
NP_060514.1. NM_018044.4. [Q96P11-1]
NP_683759.1. NM_148956.3. [Q96P11-2]
UniGeneiHs.510927.
Hs.647060.
Hs.655217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B9EX-ray1.65A127-429[»]
ProteinModelPortaliQ96P11.
SMRiQ96P11. Positions 133-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120820. 14 interactions.
IntActiQ96P11. 5 interactions.
MINTiMINT-5009481.
STRINGi9606.ENSP00000309126.

PTM databases

iPTMnetiQ96P11.

Polymorphism and mutation databases

BioMutaiNSUN5.
DMDMi118573085.

Proteomic databases

EPDiQ96P11.
MaxQBiQ96P11.
PaxDbiQ96P11.
PeptideAtlasiQ96P11.
PRIDEiQ96P11.

Protocols and materials databases

DNASUi55695.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252594; ENSP00000252594; ENSG00000130305. [Q96P11-1]
ENST00000310326; ENSP00000309126; ENSG00000130305. [Q96P11-4]
ENST00000428206; ENSP00000393081; ENSG00000130305. [Q96P11-5]
ENST00000438747; ENSP00000388464; ENSG00000130305. [Q96P11-2]
GeneIDi55695.
KEGGihsa:55695.
UCSCiuc003txv.5. human. [Q96P11-1]

Organism-specific databases

CTDi55695.
GeneCardsiNSUN5.
HGNCiHGNC:16385. NSUN5.
HPAiHPA020536.
HPA045590.
HPA046867.
MIMi615732. gene.
neXtProtiNX_Q96P11.
PharmGKBiPA134993779.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2360. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00550000074709.
HOGENOMiHOG000203203.
HOVERGENiHBG062278.
InParanoidiQ96P11.
KOiK15264.
OMAiLVYDSKF.
PhylomeDBiQ96P11.
TreeFamiTF314285.

Miscellaneous databases

EvolutionaryTraceiQ96P11.
GeneWikiiNSUN5.
GenomeRNAii55695.
PROiQ96P11.
SOURCEiSearch...

Gene expression databases

BgeeiQ96P11.
CleanExiHS_NSUN5.
ExpressionAtlasiQ96P11. baseline and differential.
GenevisibleiQ96P11. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001678. MeTrfase_RsmB/NOP2.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Methyltr_RsmB-F. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome."
    Doll A., Grzeschik K.-H.
    Cytogenet. Cell Genet. 95:20-27(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Identification of additional transcripts in the Williams-Beuren syndrome critical region."
    Merla G., Ucla C., Guipponi M., Reymond A.
    Hum. Genet. 110:429-438(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5).
    Tissue: Embryo, Mammary tumor and Uterus.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  7. Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-17; 46-61 AND 73-82, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  11. "Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively."
    Sharma S., Yang J., Watzinger P., Kotter P., Entian K.D.
    Nucleic Acids Res. 41:9062-9076(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION, CATALYTIC ACTIVITY.
  12. "The crystal structure of human NSUN5 protein in complex with S-adenosyl-L-methionine."
    Structural genomics consortium (SGC)
    Submitted (MAR-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 127-429 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE.

Entry informationi

Entry nameiNSUN5_HUMAN
AccessioniPrimary (citable) accession number: Q96P11
Secondary accession number(s): B3KX04
, B4DP79, G3V0G9, Q6ZUI8, Q96HT9, Q9NW70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.