Q96P09 (BIRC8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Baculoviral IAP repeat-containing protein 8

Alternative name(s):
Inhibitor of apoptosis-like protein 2
Short name=IAP-like protein 2
Short name=ILP-2
Testis-specific inhibitor of apoptosis

Gene names

Name:	BIRC8
Synonyms:	ILP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protects against apoptosis mediated by BAX.
Subunit structure	Binds to caspase-9.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Testis specific in normal tissues.
Sequence similarities	Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 236

236

Baculoviral IAP repeat-containing protein 8

PRO_0000122363

Regions

Repeat

7 – 70

64

BIR

Zinc finger

189 – 224

36

RING-type

Sites

Metal binding

39

1

Zinc By similarity

Metal binding

42

1

Zinc By similarity

Metal binding

59

1

Zinc By similarity

Metal binding

66

1

Zinc By similarity

Natural variations

Natural variant

156

1

A → T.
Corresponds to variant rs35880972 [ dbSNP | Ensembl ].

VAR_055944

Natural variant

165

1

L → S.
Corresponds to variant rs34092035 [ dbSNP | Ensembl ].

VAR_055945

Natural variant

196

1

H → Y. Ref.1 Ref.4
Corresponds to variant rs8109165 [ dbSNP | Ensembl ].

VAR_028282

Natural variant

225

1

A → T.
Corresponds to variant rs35700345 [ dbSNP | Ensembl ].

VAR_055946

Natural variant

225

1

A → V.
Corresponds to variant rs34683072 [ dbSNP | Ensembl ].

VAR_055947

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

236

Helix Strand Turn

Details...

Helix

4 – 8

5

Helix

9 – 11

3

Beta strand

16 – 18

3

Helix

20 – 25

6

Beta strand

28 – 30

3

Beta strand

37 – 39

3

Turn

40 – 42

3

Beta strand

45 – 48

4

Helix

55 – 62

8

Helix

67 – 73

7

Helix

75 – 81

7

Sequences

	Sequence		Length	Mass (Da)
	Q96P09 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: DF3A170E0DDFAD9D	FASTA	236	27,089
	10 20 30 40 50 60 MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK PKEDPWEQHA 70 80 90 100 110 120 KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS LTKRISDTIF PNPMLQEAIR 130 140 150 160 170 180 MGFDFKDVKK IMEERIQTSG SNYKTLEVLV ADLVSAQKDT TENELNQTSL QREISPEEPL 190 200 210 220 230 RRLQEEKLCK ICMDRHIAVV FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript." Lagace M., Xuan J.-Y., Young S.S., McRoberts C., Maier J., Rajcan-Separovic E., Korneluk R.G. Genomics 77:181-188(2001) [PubMed: 11597143] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-196. Tissue: Testis.
[2]	"Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family." Richter B.W.M., Mir S.S., Eiben L.J., Lewis J., Reffey S.B., Frattini A., Tian L., Frank S., Youle R.J., Nelson D.L., Notarangelo L.D., Vezzoni P., Fearnhead H.O., Duckett C.S. Mol. Cell. Biol. 21:4292-4301(2001) [PubMed: 11390657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-196. Tissue: Brain.
[5]	"The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition." Shin H., Renatus M., Eckelman B.P., Nunes V.A., Sampaio C.A., Salvesen G.S. Biochem. J. 385:1-10(2005) [PubMed: 15485395] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-95.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF420440 mRNA. Translation: AAL30369.1.
AF164682 Genomic DNA. Translation: AAK81892.1.
AC092070 Genomic DNA. No translation available.
BC071665 mRNA. Translation: AAH71665.2.

IPI

IPI00102423.

RefSeq

NP_203127.3. NM_033341.4.

UniGene

Hs.348263.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XB0	X-ray	2.20	A/B/C/D/E/F	1-95	[»]
1XB1	X-ray	2.70	A/B/C/D/E/F	1-95	[»]

ProteinModelPortal

Q96P09.

SMR

Q96P09. Positions 1-236.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96P09. 9 interactions.

STRING

Q96P09.

Protein family/group databases

MEROPS

I32.008.

PTM databases

PhosphoSite

Q96P09.

Polymorphism databases

DMDM

311033354.

Proteomic databases

PRIDE

Q96P09.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000426466; ENSP00000412957; ENSG00000163098.

GeneID

112401.

KEGG

hsa:112401.

Organism-specific databases

CTD

112401.

GeneCards

GC19M053792.

H-InvDB

HIX0040006.

HGNC

HGNC:14878. BIRC8.

neXtProt

NX_Q96P09.

GenAtlas

Search...

Phylogenomic databases

eggNOG

maNOG06078.

GeneTree

ENSGT00500000044782.

HOVERGEN

HBG104450.

InParanoid

Q96P09.

OMA

HCGGGLA.

OrthoDB

EOG45TCMX.

PhylomeDB

Q96P09.

Gene expression databases

ArrayExpress

Q96P09.

Bgee

Q96P09.

CleanEx

HS_BIRC8.

Genevestigator

Q96P09.

Family and domain databases

InterPro

IPR001370. BIR.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:1.10.1170.10. BIR. 2 hits.
G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

Pfam

PF00653. BIR. 1 hit.
[Graphical view]

SMART

SM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]

PROSITE

PS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

78582.

Entry information

Entry name

BIRC8_HUMAN

Accession

Primary (citable) accession number: Q96P09
Secondary accession number(s): Q6IPY1, Q96RW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	November 2, 2010
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.