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Protein

Baculoviral IAP repeat-containing protein 8

Gene

BIRC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protects against apoptosis mediated by BAX.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391ZincPROSITE-ProRule annotation
Metal bindingi42 – 421ZincPROSITE-ProRule annotation
Metal bindingi59 – 591ZincPROSITE-ProRule annotation
Metal bindingi66 – 661ZincPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 22436RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96P09.

Protein family/group databases

MEROPSiI32.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 8
Alternative name(s):
Inhibitor of apoptosis-like protein 2
Short name:
IAP-like protein 2
Short name:
ILP-2
Testis-specific inhibitor of apoptosis
Gene namesi
Name:BIRC8
Synonyms:ILP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14878. BIRC8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25365.

Chemistry

ChEMBLiCHEMBL5851.

Polymorphism and mutation databases

BioMutaiBIRC8.
DMDMi311033354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Baculoviral IAP repeat-containing protein 8PRO_0000122363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891S-nitrosocysteineBy similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiQ96P09.
PRIDEiQ96P09.

PTM databases

iPTMnetiQ96P09.
PhosphoSiteiQ96P09.

Expressioni

Tissue specificityi

Testis specific in normal tissues.

Gene expression databases

BgeeiQ96P09.
CleanExiHS_BIRC8.

Organism-specific databases

HPAiHPA042129.
HPA042521.

Interactioni

Subunit structurei

Binds to caspase-9.

Protein-protein interaction databases

BioGridi125186. 17 interactions.
IntActiQ96P09. 9 interactions.
MINTiMINT-201655.
STRINGi9606.ENSP00000412957.

Chemistry

BindingDBiQ96P09.

Structurei

Secondary structure

1
236
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85Combined sources
Helixi9 – 113Combined sources
Beta strandi16 – 183Combined sources
Helixi20 – 256Combined sources
Beta strandi28 – 303Combined sources
Beta strandi37 – 393Combined sources
Turni40 – 423Combined sources
Beta strandi45 – 484Combined sources
Helixi55 – 628Combined sources
Helixi67 – 737Combined sources
Helixi75 – 817Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XB0X-ray2.20A/B/C/D/E/F1-95[»]
1XB1X-ray2.70A/B/C/D/E/F1-95[»]
ProteinModelPortaliQ96P09.
SMRiQ96P09. Positions 1-236.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96P09.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 7064BIRAdd
BLAST

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 22436RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG104450.
InParanoidiQ96P09.
KOiK16061.
OMAiHCGGGLA.
OrthoDBiEOG78H3TF.
PhylomeDBiQ96P09.
TreeFamiTF105356.

Family and domain databases

Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK
60 70 80 90 100
PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS
110 120 130 140 150
LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLEVLV
160 170 180 190 200
ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV
210 220 230
FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS
Length:236
Mass (Da):27,089
Last modified:November 2, 2010 - v2
Checksum:iDF3A170E0DDFAD9D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561A → T.
Corresponds to variant rs35880972 [ dbSNP | Ensembl ].
VAR_055944
Natural varianti165 – 1651L → S.
Corresponds to variant rs34092035 [ dbSNP | Ensembl ].
VAR_055945
Natural varianti196 – 1961H → Y.2 Publications
Corresponds to variant rs8109165 [ dbSNP | Ensembl ].
VAR_028282
Natural varianti225 – 2251A → T.
Corresponds to variant rs35700345 [ dbSNP | Ensembl ].
VAR_055946
Natural varianti225 – 2251A → V.
Corresponds to variant rs34683072 [ dbSNP | Ensembl ].
VAR_055947

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420440 mRNA. Translation: AAL30369.1.
AF164682 Genomic DNA. Translation: AAK81892.1.
AC092070 Genomic DNA. No translation available.
BC071665 mRNA. Translation: AAH71665.2.
CCDSiCCDS12863.1.
RefSeqiNP_203127.3. NM_033341.4.
UniGeneiHs.348263.

Genome annotation databases

EnsembliENST00000426466; ENSP00000412957; ENSG00000163098.
GeneIDi112401.
KEGGihsa:112401.
UCSCiuc002qbk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420440 mRNA. Translation: AAL30369.1.
AF164682 Genomic DNA. Translation: AAK81892.1.
AC092070 Genomic DNA. No translation available.
BC071665 mRNA. Translation: AAH71665.2.
CCDSiCCDS12863.1.
RefSeqiNP_203127.3. NM_033341.4.
UniGeneiHs.348263.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XB0X-ray2.20A/B/C/D/E/F1-95[»]
1XB1X-ray2.70A/B/C/D/E/F1-95[»]
ProteinModelPortaliQ96P09.
SMRiQ96P09. Positions 1-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125186. 17 interactions.
IntActiQ96P09. 9 interactions.
MINTiMINT-201655.
STRINGi9606.ENSP00000412957.

Chemistry

BindingDBiQ96P09.
ChEMBLiCHEMBL5851.

Protein family/group databases

MEROPSiI32.008.

PTM databases

iPTMnetiQ96P09.
PhosphoSiteiQ96P09.

Polymorphism and mutation databases

BioMutaiBIRC8.
DMDMi311033354.

Proteomic databases

PaxDbiQ96P09.
PRIDEiQ96P09.

Protocols and materials databases

DNASUi112401.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426466; ENSP00000412957; ENSG00000163098.
GeneIDi112401.
KEGGihsa:112401.
UCSCiuc002qbk.4. human.

Organism-specific databases

CTDi112401.
GeneCardsiBIRC8.
H-InvDBHIX0040006.
HGNCiHGNC:14878. BIRC8.
HPAiHPA042129.
HPA042521.
neXtProtiNX_Q96P09.
PharmGKBiPA25365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG104450.
InParanoidiQ96P09.
KOiK16061.
OMAiHCGGGLA.
OrthoDBiEOG78H3TF.
PhylomeDBiQ96P09.
TreeFamiTF105356.

Enzyme and pathway databases

SignaLinkiQ96P09.

Miscellaneous databases

EvolutionaryTraceiQ96P09.
GenomeRNAii112401.
PROiQ96P09.

Gene expression databases

BgeeiQ96P09.
CleanExiHS_BIRC8.

Family and domain databases

Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript."
    Lagace M., Xuan J.-Y., Young S.S., McRoberts C., Maier J., Rajcan-Separovic E., Korneluk R.G.
    Genomics 77:181-188(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-196.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-196.
    Tissue: Brain.
  5. "The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition."
    Shin H., Renatus M., Eckelman B.P., Nunes V.A., Sampaio C.A., Salvesen G.S.
    Biochem. J. 385:1-10(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-95.

Entry informationi

Entry nameiBIRC8_HUMAN
AccessioniPrimary (citable) accession number: Q96P09
Secondary accession number(s): Q6IPY1, Q96RW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.