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Protein

Baculoviral IAP repeat-containing protein 8

Gene

BIRC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects against apoptosis mediated by BAX.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39ZincPROSITE-ProRule annotation1
Metal bindingi42ZincPROSITE-ProRule annotation1
Metal bindingi59ZincPROSITE-ProRule annotation1
Metal bindingi66ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 224RING-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96P09

Protein family/group databases

MEROPSiI32.008

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 8
Alternative name(s):
Inhibitor of apoptosis-like protein 2
Short name:
IAP-like protein 2
Short name:
ILP-2
Testis-specific inhibitor of apoptosis
Gene namesi
Name:BIRC8
Synonyms:ILP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000163098.4
HGNCiHGNC:14878 BIRC8
neXtProtiNX_Q96P09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi112401
OpenTargetsiENSG00000163098
PharmGKBiPA25365

Chemistry databases

ChEMBLiCHEMBL5851

Polymorphism and mutation databases

BioMutaiBIRC8
DMDMi311033354

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223631 – 236Baculoviral IAP repeat-containing protein 8Add BLAST236

Proteomic databases

PaxDbiQ96P09
PeptideAtlasiQ96P09
PRIDEiQ96P09

PTM databases

iPTMnetiQ96P09
PhosphoSitePlusiQ96P09

Expressioni

Tissue specificityi

Testis specific in normal tissues.

Gene expression databases

BgeeiENSG00000163098
CleanExiHS_BIRC8

Interactioni

Subunit structurei

Binds to caspase-9.

Protein-protein interaction databases

BioGridi125186, 18 interactors
IntActiQ96P09, 9 interactors
STRINGi9606.ENSP00000412957

Chemistry databases

BindingDBiQ96P09

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 8Combined sources5
Helixi9 – 11Combined sources3
Beta strandi16 – 18Combined sources3
Helixi20 – 25Combined sources6
Beta strandi28 – 30Combined sources3
Beta strandi37 – 39Combined sources3
Turni40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi55 – 62Combined sources8
Helixi67 – 73Combined sources7
Helixi75 – 81Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB0X-ray2.20A/B/C/D/E/F1-95[»]
1XB1X-ray2.70A/B/C/D/E/F1-95[»]
ProteinModelPortaliQ96P09
SMRiQ96P09
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96P09

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 70BIRAdd BLAST64

Sequence similaritiesi

Belongs to the IAP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 224RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00500000044782
HOGENOMiHOG000232059
HOVERGENiHBG104450
InParanoidiQ96P09
KOiK16061
OMAiHCGGGLA
OrthoDBiEOG091G0CXH
PhylomeDBiQ96P09
TreeFamiTF105356

Family and domain databases

CDDicd00022 BIR, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00653 BIR, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 1 hit
PS50143 BIR_REPEAT_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK
60 70 80 90 100
PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS
110 120 130 140 150
LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLEVLV
160 170 180 190 200
ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV
210 220 230
FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS
Length:236
Mass (Da):27,089
Last modified:November 2, 2010 - v2
Checksum:iDF3A170E0DDFAD9D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055944156A → T. Corresponds to variant dbSNP:rs35880972Ensembl.1
Natural variantiVAR_055945165L → S. Corresponds to variant dbSNP:rs34092035Ensembl.1
Natural variantiVAR_028282196H → Y2 PublicationsCorresponds to variant dbSNP:rs8109165Ensembl.1
Natural variantiVAR_055946225A → T. Corresponds to variant dbSNP:rs35700345Ensembl.1
Natural variantiVAR_055947225A → V. Corresponds to variant dbSNP:rs34683072Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420440 mRNA Translation: AAL30369.1
AF164682 Genomic DNA Translation: AAK81892.1
AC092070 Genomic DNA No translation available.
BC071665 mRNA Translation: AAH71665.2
CCDSiCCDS12863.1
RefSeqiNP_203127.3, NM_033341.4
UniGeneiHs.348263

Genome annotation databases

EnsembliENST00000426466; ENSP00000412957; ENSG00000163098
GeneIDi112401
KEGGihsa:112401
UCSCiuc002qbk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBIRC8_HUMAN
AccessioniPrimary (citable) accession number: Q96P09
Secondary accession number(s): Q6IPY1, Q96RW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 2, 2010
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health