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Protein

Baculoviral IAP repeat-containing protein 8

Gene

BIRC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protects against apoptosis mediated by BAX.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39ZincPROSITE-ProRule annotation1
Metal bindingi42ZincPROSITE-ProRule annotation1
Metal bindingi59ZincPROSITE-ProRule annotation1
Metal bindingi66ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 224RING-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180152-MONOMER.
SignaLinkiQ96P09.

Protein family/group databases

MEROPSiI32.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 8
Alternative name(s):
Inhibitor of apoptosis-like protein 2
Short name:
IAP-like protein 2
Short name:
ILP-2
Testis-specific inhibitor of apoptosis
Gene namesi
Name:BIRC8
Synonyms:ILP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14878. BIRC8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi112401.
OpenTargetsiENSG00000163098.
PharmGKBiPA25365.

Chemistry databases

ChEMBLiCHEMBL5851.

Polymorphism and mutation databases

BioMutaiBIRC8.
DMDMi311033354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223631 – 236Baculoviral IAP repeat-containing protein 8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei189S-nitrosocysteineBy similarity1

Keywords - PTMi

Isopeptide bond, S-nitrosylation, Ubl conjugation

Proteomic databases

PaxDbiQ96P09.
PeptideAtlasiQ96P09.
PRIDEiQ96P09.

PTM databases

iPTMnetiQ96P09.
PhosphoSitePlusiQ96P09.

Expressioni

Tissue specificityi

Testis specific in normal tissues.

Gene expression databases

BgeeiENSG00000163098.
CleanExiHS_BIRC8.

Organism-specific databases

HPAiHPA042129.
HPA042521.

Interactioni

Subunit structurei

Binds to caspase-9.

Protein-protein interaction databases

BioGridi125186. 17 interactors.
IntActiQ96P09. 9 interactors.
MINTiMINT-201655.
STRINGi9606.ENSP00000412957.

Chemistry databases

BindingDBiQ96P09.

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 8Combined sources5
Helixi9 – 11Combined sources3
Beta strandi16 – 18Combined sources3
Helixi20 – 25Combined sources6
Beta strandi28 – 30Combined sources3
Beta strandi37 – 39Combined sources3
Turni40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi55 – 62Combined sources8
Helixi67 – 73Combined sources7
Helixi75 – 81Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB0X-ray2.20A/B/C/D/E/F1-95[»]
1XB1X-ray2.70A/B/C/D/E/F1-95[»]
ProteinModelPortaliQ96P09.
SMRiQ96P09.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96P09.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 70BIRAdd BLAST64

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 224RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG104450.
InParanoidiQ96P09.
KOiK16061.
OMAiHCGGGLA.
OrthoDBiEOG091G0CXH.
PhylomeDBiQ96P09.
TreeFamiTF105356.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96P09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK
60 70 80 90 100
PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS
110 120 130 140 150
LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLEVLV
160 170 180 190 200
ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV
210 220 230
FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS
Length:236
Mass (Da):27,089
Last modified:November 2, 2010 - v2
Checksum:iDF3A170E0DDFAD9D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055944156A → T.Corresponds to variant rs35880972dbSNPEnsembl.1
Natural variantiVAR_055945165L → S.Corresponds to variant rs34092035dbSNPEnsembl.1
Natural variantiVAR_028282196H → Y.2 PublicationsCorresponds to variant rs8109165dbSNPEnsembl.1
Natural variantiVAR_055946225A → T.Corresponds to variant rs35700345dbSNPEnsembl.1
Natural variantiVAR_055947225A → V.Corresponds to variant rs34683072dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420440 mRNA. Translation: AAL30369.1.
AF164682 Genomic DNA. Translation: AAK81892.1.
AC092070 Genomic DNA. No translation available.
BC071665 mRNA. Translation: AAH71665.2.
CCDSiCCDS12863.1.
RefSeqiNP_203127.3. NM_033341.4.
UniGeneiHs.348263.

Genome annotation databases

EnsembliENST00000426466; ENSP00000412957; ENSG00000163098.
GeneIDi112401.
KEGGihsa:112401.
UCSCiuc002qbk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420440 mRNA. Translation: AAL30369.1.
AF164682 Genomic DNA. Translation: AAK81892.1.
AC092070 Genomic DNA. No translation available.
BC071665 mRNA. Translation: AAH71665.2.
CCDSiCCDS12863.1.
RefSeqiNP_203127.3. NM_033341.4.
UniGeneiHs.348263.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB0X-ray2.20A/B/C/D/E/F1-95[»]
1XB1X-ray2.70A/B/C/D/E/F1-95[»]
ProteinModelPortaliQ96P09.
SMRiQ96P09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125186. 17 interactors.
IntActiQ96P09. 9 interactors.
MINTiMINT-201655.
STRINGi9606.ENSP00000412957.

Chemistry databases

BindingDBiQ96P09.
ChEMBLiCHEMBL5851.

Protein family/group databases

MEROPSiI32.008.

PTM databases

iPTMnetiQ96P09.
PhosphoSitePlusiQ96P09.

Polymorphism and mutation databases

BioMutaiBIRC8.
DMDMi311033354.

Proteomic databases

PaxDbiQ96P09.
PeptideAtlasiQ96P09.
PRIDEiQ96P09.

Protocols and materials databases

DNASUi112401.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426466; ENSP00000412957; ENSG00000163098.
GeneIDi112401.
KEGGihsa:112401.
UCSCiuc002qbk.4. human.

Organism-specific databases

CTDi112401.
DisGeNETi112401.
GeneCardsiBIRC8.
H-InvDBHIX0040006.
HGNCiHGNC:14878. BIRC8.
HPAiHPA042129.
HPA042521.
neXtProtiNX_Q96P09.
OpenTargetsiENSG00000163098.
PharmGKBiPA25365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG104450.
InParanoidiQ96P09.
KOiK16061.
OMAiHCGGGLA.
OrthoDBiEOG091G0CXH.
PhylomeDBiQ96P09.
TreeFamiTF105356.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180152-MONOMER.
SignaLinkiQ96P09.

Miscellaneous databases

EvolutionaryTraceiQ96P09.
GenomeRNAii112401.
PROiQ96P09.

Gene expression databases

BgeeiENSG00000163098.
CleanExiHS_BIRC8.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIRC8_HUMAN
AccessioniPrimary (citable) accession number: Q96P09
Secondary accession number(s): Q6IPY1, Q96RW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.