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Protein

Forkhead box protein N4

Gene

FOXN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).By similarity

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi193 – 289Fork-headPROSITE-ProRule annotationAdd BLAST97

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N4
Gene namesi
Name:FOXN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139445.17
HGNCiHGNC:21399 FOXN4
MIMi609429 gene
neXtProtiNX_Q96NZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139445
PharmGKBiPA134982965

Polymorphism and mutation databases

BioMutaiFOXN4
DMDMi71153520

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918701 – 517Forkhead box protein N4Add BLAST517

Proteomic databases

MaxQBiQ96NZ1
PaxDbiQ96NZ1
PeptideAtlasiQ96NZ1
PRIDEiQ96NZ1

PTM databases

iPTMnetiQ96NZ1
PhosphoSitePlusiQ96NZ1

Expressioni

Gene expression databases

BgeeiENSG00000139445
CleanExiHS_FOXN4
ExpressionAtlasiQ96NZ1 baseline and differential
GenevisibleiQ96NZ1 HS

Organism-specific databases

HPAiHPA050018

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1257422 interactors.
IntActiQ96NZ1 4 interactors.
STRINGi9606.ENSP00000299162

Structurei

3D structure databases

ProteinModelPortaliQ96NZ1
SMRiQ96NZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 176Pro-richAdd BLAST107

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144055
HOGENOMiHOG000232153
HOVERGENiHBG051655
InParanoidiQ96NZ1
KOiK09407
OMAiMAVHSSQ
OrthoDBiEOG091G0678
PhylomeDBiQ96NZ1
TreeFamiTF329867

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIESDTSSIM SGIIRNSGQN HHPSPQEYRL LATTSDDDLP GDLQSLSWLT
60 70 80 90 100
AVDVPRLQQM ASGRVDLGGP CVPHPHPGAL AGVADLHVGA TPSPLLHGPA
110 120 130 140 150
GMAPRGMPGL GPITGHRDSM SQFPVGGQPS SGLQDPPHLY SPATQPQFPL
160 170 180 190 200
PPGAQQCPPV GLYGPPFGVR PPYPQPHVAV HSSQELHPKH YPKPIYSYSC
210 220 230 240 250
LIAMALKNSK TGSLPVSEIY SFMKEHFPYF KTAPDGWKNS VRHNLSLNKC
260 270 280 290 300
FEKVENKMSG SSRKGCLWAL NLARIDKMEE EMHKWKRKDL AAIHRSMANP
310 320 330 340 350
EELDKLISDR PESCRRPGKP GEPEAPVLTH ATTVAVAHGC LAVSQLPPQP
360 370 380 390 400
LMTLSLQSVP LHHQVQPQAH LAPDSPAPAQ TPPLHALPDL SPSPLPHPAM
410 420 430 440 450
GRAPVDFINI STDMNTEVDA LDPSIMDFAL QGNLWEEMKD EGFSLDTLGA
460 470 480 490 500
FADSPLGCDL GASGLTPASG GSDQSFPDLQ VTGLYTAYST PDSVAASGTS
510
SSSQYLGAQG NKPIALL
Length:517
Mass (Da):55,215
Last modified:July 19, 2005 - v2
Checksum:iD4150E6C4F1363EF
GO
Isoform 2 (identifier: Q96NZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: S → SQ
     157-257: CPPVGLYGPP...NKCFEKVENK → LSDRHGPEEQ...GCHPPEYGQP
     258-517: Missing.

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):27,246
Checksum:iF1814B58222A4813
GO
Isoform 3 (identifier: Q96NZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: MIESDTSSIM...KHYPKPIYSY → MPGLPCPALPCPAPPPAP

Show »
Length:337
Mass (Da):36,025
Checksum:i607EE81653B89992
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059300137P → L. Corresponds to variant dbSNP:rs11609341Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0543251 – 198MIESD…PIYSY → MPGLPCPALPCPAPPPAP in isoform 3. 1 PublicationAdd BLAST198
Alternative sequenceiVSP_017227119S → SQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_017228157 – 257CPPVG…KVENK → LSDRHGPEEQQDRQPACERD LQLHEGALPLLQDGPRRVEE LGAAQPVSEQVLREGGEQDE RLLPQGLPVGSEPGPHRQDG GGDAQVEEEGPGCHPPEYGQ P in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_017229258 – 517Missing in isoform 2. 1 PublicationAdd BLAST260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012384 Genomic DNA No translation available.
AF425596 mRNA Translation: AAL23949.1
AF425597 mRNA Translation: AAL23950.1
AK131519 mRNA Translation: BAD18661.1
CCDSiCCDS9126.2 [Q96NZ1-1]
RefSeqiNP_998761.2, NM_213596.2 [Q96NZ1-1]
UniGeneiHs.528316

Genome annotation databases

EnsembliENST00000299162; ENSP00000299162; ENSG00000139445 [Q96NZ1-1]
ENST00000355216; ENSP00000347354; ENSG00000139445 [Q96NZ1-3]
GeneIDi121643
KEGGihsa:121643
UCSCiuc001toe.5 human [Q96NZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXN4_HUMAN
AccessioniPrimary (citable) accession number: Q96NZ1
Secondary accession number(s): Q6ZMR4, Q96NZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome