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Protein

Nectin-4

Gene

PVRL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-4
Alternative name(s):
Ig superfamily receptor LNIR
Poliovirus receptor-related protein 4
Cleaved into the following chain:
Gene namesi
Name:PVRL4
Synonyms:LNIR, PRR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19688. PVRL4.

Subcellular locationi

Processed poliovirus receptor-related protein 4 :
  • Secreted

  • Note: The secreted form is found in breast tumor patients.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 349318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Topological domaini371 – 510140CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.

See also OMIM:613573
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851T → M in EDSS1. 1 Publication
VAR_064189

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia

Organism-specific databases

MIMi613573. phenotype.
Orphaneti247820. Ectodermal dysplasia - syndactyly syndrome.
PharmGKBiPA134991624.

Polymorphism and mutation databases

BioMutaiPVRL4.
DMDMi74761016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 510479Nectin-4PRO_0000297673Add
BLAST
Chaini32 – ?Processed poliovirus receptor-related protein 4PRO_0000311086

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 127
Disulfide bondi171 ↔ 223
Disulfide bondi270 ↔ 315PROSITE-ProRule annotation
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96NY8.
PaxDbiQ96NY8.
PRIDEiQ96NY8.

PTM databases

PhosphoSiteiQ96NY8.

Expressioni

Tissue specificityi

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.2 Publications

Gene expression databases

BgeeiQ96NY8.
CleanExiHS_PRR4.
HS_PVRL4.
ExpressionAtlasiQ96NY8. baseline and differential.
GenevisibleiQ96NY8. HS.

Organism-specific databases

HPAiHPA010775.

Interactioni

Subunit structurei

Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HQ786F22EBI-4314784,EBI-5323300From a different organism.
PVRL1Q152232EBI-4314784,EBI-1771314
TIGITQ495A12EBI-4314784,EBI-4314807

Protein-protein interaction databases

BioGridi123544. 16 interactions.
DIPiDIP-41492N.
IntActiQ96NY8. 4 interactions.
MINTiMINT-237395.
STRINGi9606.ENSP00000356991.

Structurei

Secondary structure

1
510
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 436Combined sources
Beta strandi48 – 503Combined sources
Beta strandi62 – 698Combined sources
Beta strandi72 – 743Combined sources
Beta strandi77 – 837Combined sources
Turni84 – 863Combined sources
Beta strandi87 – 904Combined sources
Helixi92 – 943Combined sources
Turni95 – 973Combined sources
Beta strandi112 – 1143Combined sources
Helixi119 – 1213Combined sources
Beta strandi123 – 13412Combined sources
Beta strandi136 – 14611Combined sources
Beta strandi152 – 1554Combined sources
Beta strandi165 – 17713Combined sources
Beta strandi180 – 1878Combined sources
Beta strandi190 – 1978Combined sources
Beta strandi199 – 21012Combined sources
Helixi214 – 2163Combined sources
Beta strandi220 – 2267Combined sources
Beta strandi234 – 2396Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FRWX-ray3.50A/B/C/D/E/F32-243[»]
4GJTX-ray3.10B/C32-146[»]
4JJHX-ray2.25A/B32-153[»]
ProteinModelPortaliQ96NY8.
SMRiQ96NY8. Positions 32-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 144113Ig-like V-type 1Add
BLAST
Domaini148 – 23790Ig-like C2-type 1Add
BLAST
Domaini248 – 33184Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149403.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000115806.
HOVERGENiHBG108310.
InParanoidiQ96NY8.
KOiK06593.
OMAiQDEGIKQ.
OrthoDBiEOG73RBB5.
PhylomeDBiQ96NY8.
TreeFamiTF338610.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSLGAEMW GPEAWLLLLL LLASFTGRCP AGELETSDVV TVVLGQDAKL
60 70 80 90 100
PCFYRGDSGE QVGQVAWARV DAGEGAQELA LLHSKYGLHV SPAYEGRVEQ
110 120 130 140 150
PPPPRNPLDG SVLLRNAVQA DEGEYECRVS TFPAGSFQAR LRLRVLVPPL
160 170 180 190 200
PSLNPGPALE EGQGLTLAAS CTAEGSPAPS VTWDTEVKGT TSSRSFKHSR
210 220 230 240 250
SAAVTSEFHL VPSRSMNGQP LTCVVSHPGL LQDQRITHIL HVSFLAEASV
260 270 280 290 300
RGLEDQNLWH IGREGAMLKC LSEGQPPPSY NWTRLDGPLP SGVRVDGDTL
310 320 330 340 350
GFPPLTTEHS GIYVCHVSNE FSSRDSQVTV DVLDPQEDSG KQVDLVSASV
360 370 380 390 400
VVVGVIAALL FCLLVVVVVL MSRYHRRKAQ QMTQKYEEEL TLTRENSIRR
410 420 430 440 450
LHSHHTDPRS QPEESVGLRA EGHPDSLKDN SSCSVMSEEP EGRSYSTLTT
460 470 480 490 500
VREIETQTEL LSPGSGRAEE EEDQDEGIKQ AMNHFVQENG TLRAKPTGNG
510
IYINGRGHLV
Length:510
Mass (Da):55,454
Last modified:December 1, 2001 - v1
Checksum:iDCF5E1D794F227FA
GO
Isoform 2 (identifier: Q96NY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-266: Missing.
     412-436: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,341
Checksum:i3E306C32386C5C5A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351E → G in BAB55344 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531F → L.
Corresponds to variant rs3737786 [ dbSNP | Ensembl ].
VAR_034669
Natural varianti185 – 1851T → M in EDSS1. 1 Publication
VAR_064189

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 266266Missing in isoform 2. 1 PublicationVSP_056819Add
BLAST
Alternative sequencei412 – 43625Missing in isoform 2. 1 PublicationVSP_056820Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426163 mRNA. Translation: AAL23958.1.
AK027753 mRNA. Translation: BAB55344.1.
AK298981 mRNA. Translation: BAG61075.1.
AL591806 Genomic DNA. Translation: CAI15376.1.
CH471121 Genomic DNA. Translation: EAW52665.1.
BC010423 mRNA. Translation: AAH10423.1.
CCDSiCCDS1216.1. [Q96NY8-1]
RefSeqiNP_112178.2. NM_030916.2. [Q96NY8-1]
UniGeneiHs.492490.
Hs.732297.

Genome annotation databases

EnsembliENST00000368012; ENSP00000356991; ENSG00000143217. [Q96NY8-1]
GeneIDi81607.
KEGGihsa:81607.
UCSCiuc001fxo.2. human. [Q96NY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426163 mRNA. Translation: AAL23958.1.
AK027753 mRNA. Translation: BAB55344.1.
AK298981 mRNA. Translation: BAG61075.1.
AL591806 Genomic DNA. Translation: CAI15376.1.
CH471121 Genomic DNA. Translation: EAW52665.1.
BC010423 mRNA. Translation: AAH10423.1.
CCDSiCCDS1216.1. [Q96NY8-1]
RefSeqiNP_112178.2. NM_030916.2. [Q96NY8-1]
UniGeneiHs.492490.
Hs.732297.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FRWX-ray3.50A/B/C/D/E/F32-243[»]
4GJTX-ray3.10B/C32-146[»]
4JJHX-ray2.25A/B32-153[»]
ProteinModelPortaliQ96NY8.
SMRiQ96NY8. Positions 32-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123544. 16 interactions.
DIPiDIP-41492N.
IntActiQ96NY8. 4 interactions.
MINTiMINT-237395.
STRINGi9606.ENSP00000356991.

PTM databases

PhosphoSiteiQ96NY8.

Polymorphism and mutation databases

BioMutaiPVRL4.
DMDMi74761016.

Proteomic databases

MaxQBiQ96NY8.
PaxDbiQ96NY8.
PRIDEiQ96NY8.

Protocols and materials databases

DNASUi81607.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368012; ENSP00000356991; ENSG00000143217. [Q96NY8-1]
GeneIDi81607.
KEGGihsa:81607.
UCSCiuc001fxo.2. human. [Q96NY8-1]

Organism-specific databases

CTDi81607.
GeneCardsiGC01M161040.
H-InvDBHIX0001228.
HGNCiHGNC:19688. PVRL4.
HPAiHPA010775.
MIMi609607. gene.
613573. phenotype.
neXtProtiNX_Q96NY8.
Orphaneti247820. Ectodermal dysplasia - syndactyly syndrome.
PharmGKBiPA134991624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149403.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000115806.
HOVERGENiHBG108310.
InParanoidiQ96NY8.
KOiK06593.
OMAiQDEGIKQ.
OrthoDBiEOG73RBB5.
PhylomeDBiQ96NY8.
TreeFamiTF338610.

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Miscellaneous databases

GenomeRNAii81607.
NextBioi35474234.
PROiQ96NY8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NY8.
CleanExiHS_PRR4.
HS_PVRL4.
ExpressionAtlasiQ96NY8. baseline and differential.
GenevisibleiQ96NY8. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."
    Reymond N., Fabre S., Lecocq E., Adelaide J., Dubreuil P., Lopez M.
    J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH MLLT4 AND PVRL1.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  6. "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C'-D beta-strands of the nectin1 V domain."
    Fabre S., Reymond N., Cocchi F., Menotti L., Dubreuil P., Campadelli-Fiume G., Lopez M.
    J. Biol. Chem. 277:27006-27013(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PVLR1.
  7. "Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17."
    Fabre-Lafay S., Garrido-Urbani S., Reymond N., Goncalves A., Dubreuil P., Lopez M.
    J. Biol. Chem. 280:19543-19550(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  8. Cited for: TISSUE SPECIFICITY.
  9. Cited for: INTERACTION WITH MEASLES VIRUS PROTEIN H.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 32-243, SUBUNIT, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4."
    Zhang X., Lu G., Qi J., Li Y., He Y., Xu X., Shi J., Zhang C.W., Yan J., Gao G.F.
    Nat. Struct. Mol. Biol. 20:67-72(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 32-146 IN COMPLEX WITH WITH MEASLES VIRUS HEMAGGLUTININ, SUBUNIT, DISULFIDE BOND.
  12. Cited for: VARIANT EDSS1 MET-185.

Entry informationi

Entry nameiPVRL4_HUMAN
AccessioniPrimary (citable) accession number: Q96NY8
Secondary accession number(s): B4DQW3, Q96K15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.