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Protein

Dachshund homolog 2

Gene

DACH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. development of primary female sexual characteristics Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dachshund homolog 2
Short name:
Dach2
Gene namesi
Name:DACH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16814. DACH2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Dachshund homolog 2PRO_0000095599Add
BLAST

Proteomic databases

PaxDbiQ96NX9.
PRIDEiQ96NX9.

PTM databases

PhosphoSiteiQ96NX9.

Expressioni

Gene expression databases

BgeeiQ96NX9.
CleanExiHS_DACH2.
ExpressionAtlasiQ96NX9. baseline and differential.
GenevestigatoriQ96NX9.

Organism-specific databases

HPAiHPA000258.

Interactioni

Subunit structurei

Interacts with SIX6 and EYA2.By similarity

Protein-protein interaction databases

BioGridi125560. 1 interaction.
STRINGi9606.ENSP00000362217.

Structurei

3D structure databases

ProteinModelPortaliQ96NX9.
SMRiQ96NX9. Positions 66-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 15587DACHbox-NAdd
BLAST
Regioni453 – 53381DACHbox-CAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili459 – 55496Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 616Poly-Gly
Compositional biasi350 – 3534Poly-Ala

Domaini

The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.By similarity

Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG279124.
GeneTreeiENSGT00390000001134.
HOGENOMiHOG000293309.
HOVERGENiHBG065810.
InParanoidiQ96NX9.
OMAiDCTNARR.
OrthoDBiEOG7ZKSCN.
PhylomeDBiQ96NX9.
TreeFamiTF316697.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR003380. Transform_Ski.
[Graphical view]
PfamiPF02437. Ski_Sno. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSASPVIS ATSSGAGVPG GLFRAEPLYS TPREPPRLTP NMINSFVVNN
60 70 80 90 100
HSNSAGGGGR GNTNTNECRM VDMHGMKVAS FLMDGQELIC LPQVFDLFLK
110 120 130 140 150
HLVGGLHTVY TKLKRLDISP VVCTVEQVRI LRGLGAIQPG VNRCKLITRK
160 170 180 190 200
DFETLFTDCT NARRKRQMTR KQAVNSSRPG RPPKRSLGVL QENARLLTHA
210 220 230 240 250
VPGLLSPGLI TPTGITAAAM AEAMKLQKMK LMAMNTLQGN GSQNGTESEP
260 270 280 290 300
DDLNSNTGGS ESSWDKDKMQ SPFAAPGPQH GIAHAALAGQ PGIGGAPTLN
310 320 330 340 350
PLQQNHLLTN RLDLPFMMMP HPLLPVSLPP ASVAMAMNQM NHLNTIANMA
360 370 380 390 400
AAAQIHSPLS RAGTSVIKER IPESPSPAPS LEENHRPGSQ TSSHTSSSVS
410 420 430 440 450
SSPSQMDHHL ERMEEVPVQI PIMKSPLDKI QLTPGQALPA GFPGPFIFAD
460 470 480 490 500
SLSSVETLLT NIQGLLKVAL DNARIQEKQI QQEKKELRLE LYREREIREN
510 520 530 540 550
LERQLAVELQ SRTTMQKRLK KEKKTKRKLQ EALEFESKRR EQVEQALKQA
560 570 580 590
TTSDSGLRML KDTGIPDIEI ENNGTPHDSA AMQGGNYYCL EMAQQLYSA
Length:599
Mass (Da):65,323
Last modified:December 1, 2001 - v1
Checksum:i4EE435720A83BAA0
GO
Isoform 2 (identifier: Q96NX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-175: Missing.
     584-599: GGNYYCLEMAQQLYSA → A

Show »
Length:571
Mass (Da):61,947
Checksum:i9594DA631D3DA2A7
GO
Isoform 3 (identifier: Q96NX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.

Note: No experimental confirmation available.

Show »
Length:380
Mass (Da):41,772
Checksum:i1EB661514C165A0D
GO
Isoform 4 (identifier: Q96NX9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:432
Mass (Da):47,156
Checksum:i6A57F75AAE9BE15D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 219219Missing in isoform 3. 1 PublicationVSP_009492Add
BLAST
Alternative sequencei1 – 167167Missing in isoform 4. 1 PublicationVSP_044275Add
BLAST
Alternative sequencei163 – 17513Missing in isoform 2. 1 PublicationVSP_009490Add
BLAST
Alternative sequencei584 – 59916GGNYY…QLYSA → A in isoform 2. 1 PublicationVSP_009491Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF428101 mRNA. Translation: AAL26561.1.
AK055953 mRNA. Translation: BAB71054.1.
AK091842 mRNA. Translation: BAC03761.1.
AK298787 mRNA. Translation: BAG60925.1.
AL390058
, AL023095, AL034406, AL109752 Genomic DNA. Translation: CAI40274.1.
AL023095
, AL034406, AL109752, AL390058 Genomic DNA. Translation: CAI42168.1.
AL109752
, AL023095, AL034406, AL390058 Genomic DNA. Translation: CAI42587.1.
AL034406
, AL023095, AL109752, AL390058 Genomic DNA. Translation: CAI42954.1.
AL138747 Genomic DNA. No translation available.
AL157381 Genomic DNA. No translation available.
AL591465 Genomic DNA. No translation available.
Z95124 Genomic DNA. No translation available.
Z95325 Genomic DNA. No translation available.
AL834456 mRNA. Translation: CAD39116.1.
CCDSiCCDS14455.1. [Q96NX9-1]
CCDS48140.1. [Q96NX9-2]
CCDS55457.1. [Q96NX9-4]
RefSeqiNP_001132986.1. NM_001139514.1. [Q96NX9-2]
NP_001132987.1. NM_001139515.1. [Q96NX9-4]
NP_444511.1. NM_053281.3. [Q96NX9-1]
UniGeneiHs.86603.

Genome annotation databases

EnsembliENST00000373125; ENSP00000362217; ENSG00000126733. [Q96NX9-1]
ENST00000373131; ENSP00000362223; ENSG00000126733. [Q96NX9-2]
ENST00000508860; ENSP00000420896; ENSG00000126733. [Q96NX9-4]
ENST00000510272; ENSP00000421919; ENSG00000126733. [Q96NX9-3]
GeneIDi117154.
KEGGihsa:117154.
UCSCiuc004eew.2. human. [Q96NX9-1]
uc004eex.2. human. [Q96NX9-2]
uc004eez.3. human. [Q96NX9-3]

Polymorphism databases

DMDMi44887818.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF428101 mRNA. Translation: AAL26561.1.
AK055953 mRNA. Translation: BAB71054.1.
AK091842 mRNA. Translation: BAC03761.1.
AK298787 mRNA. Translation: BAG60925.1.
AL390058
, AL023095, AL034406, AL109752 Genomic DNA. Translation: CAI40274.1.
AL023095
, AL034406, AL109752, AL390058 Genomic DNA. Translation: CAI42168.1.
AL109752
, AL023095, AL034406, AL390058 Genomic DNA. Translation: CAI42587.1.
AL034406
, AL023095, AL109752, AL390058 Genomic DNA. Translation: CAI42954.1.
AL138747 Genomic DNA. No translation available.
AL157381 Genomic DNA. No translation available.
AL591465 Genomic DNA. No translation available.
Z95124 Genomic DNA. No translation available.
Z95325 Genomic DNA. No translation available.
AL834456 mRNA. Translation: CAD39116.1.
CCDSiCCDS14455.1. [Q96NX9-1]
CCDS48140.1. [Q96NX9-2]
CCDS55457.1. [Q96NX9-4]
RefSeqiNP_001132986.1. NM_001139514.1. [Q96NX9-2]
NP_001132987.1. NM_001139515.1. [Q96NX9-4]
NP_444511.1. NM_053281.3. [Q96NX9-1]
UniGeneiHs.86603.

3D structure databases

ProteinModelPortaliQ96NX9.
SMRiQ96NX9. Positions 66-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125560. 1 interaction.
STRINGi9606.ENSP00000362217.

PTM databases

PhosphoSiteiQ96NX9.

Polymorphism databases

DMDMi44887818.

Proteomic databases

PaxDbiQ96NX9.
PRIDEiQ96NX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373125; ENSP00000362217; ENSG00000126733. [Q96NX9-1]
ENST00000373131; ENSP00000362223; ENSG00000126733. [Q96NX9-2]
ENST00000508860; ENSP00000420896; ENSG00000126733. [Q96NX9-4]
ENST00000510272; ENSP00000421919; ENSG00000126733. [Q96NX9-3]
GeneIDi117154.
KEGGihsa:117154.
UCSCiuc004eew.2. human. [Q96NX9-1]
uc004eex.2. human. [Q96NX9-2]
uc004eez.3. human. [Q96NX9-3]

Organism-specific databases

CTDi117154.
GeneCardsiGC0XP085403.
HGNCiHGNC:16814. DACH2.
HPAiHPA000258.
MIMi300608. gene.
neXtProtiNX_Q96NX9.
PharmGKBiPA27135.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279124.
GeneTreeiENSGT00390000001134.
HOGENOMiHOG000293309.
HOVERGENiHBG065810.
InParanoidiQ96NX9.
OMAiDCTNARR.
OrthoDBiEOG7ZKSCN.
PhylomeDBiQ96NX9.
TreeFamiTF316697.

Miscellaneous databases

ChiTaRSiDACH2. human.
GeneWikiiDACH2.
GenomeRNAii117154.
NextBioi80105.
PROiQ96NX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NX9.
CleanExiHS_DACH2.
ExpressionAtlasiQ96NX9. baseline and differential.
GenevestigatoriQ96NX9.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR003380. Transform_Ski.
[Graphical view]
PfamiPF02437. Ski_Sno. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human Dachshund 2."
    Prueitt R.L., Barnes R., Zinn A.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Lung and Neuron.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 414-599 (ISOFORMS 1/3/4).
    Tissue: Brain.

Entry informationi

Entry nameiDACH2_HUMAN
AccessioniPrimary (citable) accession number: Q96NX9
Secondary accession number(s): B1AJV3
, B4DQG3, Q8NAY3, Q8ND17, Q96N55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.