Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96NX9

- DACH2_HUMAN

UniProt

Q96NX9 - DACH2_HUMAN

Protein

Dachshund homolog 2

Gene

DACH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression By similarity. Probably binds to DNA via its DACHbox-N domain.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. development of primary female sexual characteristics Source: Ensembl
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dachshund homolog 2
    Short name:
    Dach2
    Gene namesi
    Name:DACH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:16814. DACH2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27135.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Dachshund homolog 2PRO_0000095599Add
    BLAST

    Proteomic databases

    PaxDbiQ96NX9.
    PRIDEiQ96NX9.

    PTM databases

    PhosphoSiteiQ96NX9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96NX9.
    BgeeiQ96NX9.
    CleanExiHS_DACH2.
    GenevestigatoriQ96NX9.

    Organism-specific databases

    HPAiHPA000258.

    Interactioni

    Subunit structurei

    Interacts with SIX6 and EYA2.By similarity

    Protein-protein interaction databases

    BioGridi125560. 1 interaction.
    STRINGi9606.ENSP00000362217.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NX9.
    SMRiQ96NX9. Positions 66-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 15587DACHbox-NAdd
    BLAST
    Regioni453 – 53381DACHbox-CAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili459 – 55496Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 616Poly-Gly
    Compositional biasi350 – 3534Poly-Ala

    Domaini

    The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.By similarity

    Sequence similaritiesi

    Belongs to the DACH/dachshund family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG279124.
    HOGENOMiHOG000293309.
    HOVERGENiHBG065810.
    InParanoidiQ96NX9.
    OMAiDCTNARR.
    OrthoDBiEOG7ZKSCN.
    PhylomeDBiQ96NX9.
    TreeFamiTF316697.

    Family and domain databases

    Gene3Di3.10.260.20. 1 hit.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR003380. Transform_Ski.
    [Graphical view]
    PfamiPF02437. Ski_Sno. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96NX9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVSASPVIS ATSSGAGVPG GLFRAEPLYS TPREPPRLTP NMINSFVVNN    50
    HSNSAGGGGR GNTNTNECRM VDMHGMKVAS FLMDGQELIC LPQVFDLFLK 100
    HLVGGLHTVY TKLKRLDISP VVCTVEQVRI LRGLGAIQPG VNRCKLITRK 150
    DFETLFTDCT NARRKRQMTR KQAVNSSRPG RPPKRSLGVL QENARLLTHA 200
    VPGLLSPGLI TPTGITAAAM AEAMKLQKMK LMAMNTLQGN GSQNGTESEP 250
    DDLNSNTGGS ESSWDKDKMQ SPFAAPGPQH GIAHAALAGQ PGIGGAPTLN 300
    PLQQNHLLTN RLDLPFMMMP HPLLPVSLPP ASVAMAMNQM NHLNTIANMA 350
    AAAQIHSPLS RAGTSVIKER IPESPSPAPS LEENHRPGSQ TSSHTSSSVS 400
    SSPSQMDHHL ERMEEVPVQI PIMKSPLDKI QLTPGQALPA GFPGPFIFAD 450
    SLSSVETLLT NIQGLLKVAL DNARIQEKQI QQEKKELRLE LYREREIREN 500
    LERQLAVELQ SRTTMQKRLK KEKKTKRKLQ EALEFESKRR EQVEQALKQA 550
    TTSDSGLRML KDTGIPDIEI ENNGTPHDSA AMQGGNYYCL EMAQQLYSA 599
    Length:599
    Mass (Da):65,323
    Last modified:December 1, 2001 - v1
    Checksum:i4EE435720A83BAA0
    GO
    Isoform 2 (identifier: Q96NX9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         163-175: Missing.
         584-599: GGNYYCLEMAQQLYSA → A

    Show »
    Length:571
    Mass (Da):61,947
    Checksum:i9594DA631D3DA2A7
    GO
    Isoform 3 (identifier: Q96NX9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-219: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:380
    Mass (Da):41,772
    Checksum:i1EB661514C165A0D
    GO
    Isoform 4 (identifier: Q96NX9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-167: Missing.

    Show »
    Length:432
    Mass (Da):47,156
    Checksum:i6A57F75AAE9BE15D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 219219Missing in isoform 3. 1 PublicationVSP_009492Add
    BLAST
    Alternative sequencei1 – 167167Missing in isoform 4. 1 PublicationVSP_044275Add
    BLAST
    Alternative sequencei163 – 17513Missing in isoform 2. 1 PublicationVSP_009490Add
    BLAST
    Alternative sequencei584 – 59916GGNYY…QLYSA → A in isoform 2. 1 PublicationVSP_009491Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF428101 mRNA. Translation: AAL26561.1.
    AK055953 mRNA. Translation: BAB71054.1.
    AK091842 mRNA. Translation: BAC03761.1.
    AK298787 mRNA. Translation: BAG60925.1.
    AL390058
    , AL023095, AL034406, AL109752 Genomic DNA. Translation: CAI40274.1.
    AL023095
    , AL034406, AL109752, AL390058 Genomic DNA. Translation: CAI42168.1.
    AL109752
    , AL023095, AL034406, AL390058 Genomic DNA. Translation: CAI42587.1.
    AL034406
    , AL023095, AL109752, AL390058 Genomic DNA. Translation: CAI42954.1.
    AL138747 Genomic DNA. No translation available.
    AL157381 Genomic DNA. No translation available.
    AL591465 Genomic DNA. No translation available.
    Z95124 Genomic DNA. No translation available.
    Z95325 Genomic DNA. No translation available.
    AL834456 mRNA. Translation: CAD39116.1.
    CCDSiCCDS14455.1. [Q96NX9-1]
    CCDS48140.1. [Q96NX9-2]
    CCDS55457.1. [Q96NX9-4]
    RefSeqiNP_001132986.1. NM_001139514.1. [Q96NX9-2]
    NP_001132987.1. NM_001139515.1. [Q96NX9-4]
    NP_444511.1. NM_053281.3. [Q96NX9-1]
    UniGeneiHs.86603.

    Genome annotation databases

    EnsembliENST00000373125; ENSP00000362217; ENSG00000126733. [Q96NX9-1]
    ENST00000373131; ENSP00000362223; ENSG00000126733. [Q96NX9-2]
    ENST00000508860; ENSP00000420896; ENSG00000126733. [Q96NX9-4]
    ENST00000510272; ENSP00000421919; ENSG00000126733. [Q96NX9-3]
    GeneIDi117154.
    KEGGihsa:117154.
    UCSCiuc004eew.2. human. [Q96NX9-1]
    uc004eex.2. human. [Q96NX9-2]
    uc004eez.3. human. [Q96NX9-3]

    Polymorphism databases

    DMDMi44887818.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF428101 mRNA. Translation: AAL26561.1 .
    AK055953 mRNA. Translation: BAB71054.1 .
    AK091842 mRNA. Translation: BAC03761.1 .
    AK298787 mRNA. Translation: BAG60925.1 .
    AL390058
    , AL023095 , AL034406 , AL109752 Genomic DNA. Translation: CAI40274.1 .
    AL023095
    , AL034406 , AL109752 , AL390058 Genomic DNA. Translation: CAI42168.1 .
    AL109752
    , AL023095 , AL034406 , AL390058 Genomic DNA. Translation: CAI42587.1 .
    AL034406
    , AL023095 , AL109752 , AL390058 Genomic DNA. Translation: CAI42954.1 .
    AL138747 Genomic DNA. No translation available.
    AL157381 Genomic DNA. No translation available.
    AL591465 Genomic DNA. No translation available.
    Z95124 Genomic DNA. No translation available.
    Z95325 Genomic DNA. No translation available.
    AL834456 mRNA. Translation: CAD39116.1 .
    CCDSi CCDS14455.1. [Q96NX9-1 ]
    CCDS48140.1. [Q96NX9-2 ]
    CCDS55457.1. [Q96NX9-4 ]
    RefSeqi NP_001132986.1. NM_001139514.1. [Q96NX9-2 ]
    NP_001132987.1. NM_001139515.1. [Q96NX9-4 ]
    NP_444511.1. NM_053281.3. [Q96NX9-1 ]
    UniGenei Hs.86603.

    3D structure databases

    ProteinModelPortali Q96NX9.
    SMRi Q96NX9. Positions 66-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125560. 1 interaction.
    STRINGi 9606.ENSP00000362217.

    PTM databases

    PhosphoSitei Q96NX9.

    Polymorphism databases

    DMDMi 44887818.

    Proteomic databases

    PaxDbi Q96NX9.
    PRIDEi Q96NX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373125 ; ENSP00000362217 ; ENSG00000126733 . [Q96NX9-1 ]
    ENST00000373131 ; ENSP00000362223 ; ENSG00000126733 . [Q96NX9-2 ]
    ENST00000508860 ; ENSP00000420896 ; ENSG00000126733 . [Q96NX9-4 ]
    ENST00000510272 ; ENSP00000421919 ; ENSG00000126733 . [Q96NX9-3 ]
    GeneIDi 117154.
    KEGGi hsa:117154.
    UCSCi uc004eew.2. human. [Q96NX9-1 ]
    uc004eex.2. human. [Q96NX9-2 ]
    uc004eez.3. human. [Q96NX9-3 ]

    Organism-specific databases

    CTDi 117154.
    GeneCardsi GC0XP085403.
    HGNCi HGNC:16814. DACH2.
    HPAi HPA000258.
    MIMi 300608. gene.
    neXtProti NX_Q96NX9.
    PharmGKBi PA27135.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279124.
    HOGENOMi HOG000293309.
    HOVERGENi HBG065810.
    InParanoidi Q96NX9.
    OMAi DCTNARR.
    OrthoDBi EOG7ZKSCN.
    PhylomeDBi Q96NX9.
    TreeFami TF316697.

    Miscellaneous databases

    GeneWikii DACH2.
    GenomeRNAii 117154.
    NextBioi 80105.
    PROi Q96NX9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96NX9.
    Bgeei Q96NX9.
    CleanExi HS_DACH2.
    Genevestigatori Q96NX9.

    Family and domain databases

    Gene3Di 3.10.260.20. 1 hit.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR003380. Transform_Ski.
    [Graphical view ]
    Pfami PF02437. Ski_Sno. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human Dachshund 2."
      Prueitt R.L., Barnes R., Zinn A.R.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Lung and Neuron.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 414-599 (ISOFORMS 1/3/4).
      Tissue: Brain.

    Entry informationi

    Entry nameiDACH2_HUMAN
    AccessioniPrimary (citable) accession number: Q96NX9
    Secondary accession number(s): B1AJV3
    , B4DQG3, Q8NAY3, Q8ND17, Q96N55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3