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Protein

Probable imidazolonepropionase

Gene

AMDHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.

Cofactori

Zn2+By similarity, Fe2+By similarityNote: Binds 1 zinc or iron ion per subunit.By similarity

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (HAL), Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (UROC1)
  3. Probable imidazolonepropionase (AMDHD1)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Zinc or ironBy similarity1
Metal bindingi89Zinc or ironBy similarity1
Binding sitei96SubstrateBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei159SubstrateBy similarity1
Binding sitei192SubstrateBy similarity1
Metal bindingi260Zinc or ironBy similarity1
Binding sitei263SubstrateBy similarity1
Metal bindingi334Zinc or ironBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-70921 Histidine catabolism
UniPathwayiUPA00379; UER00551

Protein family/group databases

MEROPSiM38.980

Names & Taxonomyi

Protein namesi
Recommended name:
Probable imidazolonepropionase (EC:3.5.2.7)
Alternative name(s):
Amidohydrolase domain-containing protein 1
Gene namesi
Name:AMDHD1
ORF Names:HMFT1272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139344.7
HGNCiHGNC:28577 AMDHD1
neXtProtiNX_Q96NU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi144193
OpenTargetsiENSG00000139344
PharmGKBiPA143485297

Polymorphism and mutation databases

BioMutaiAMDHD1
DMDMi311033395

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825821 – 426Probable imidazolonepropionaseAdd BLAST426

Proteomic databases

MaxQBiQ96NU7
PaxDbiQ96NU7
PeptideAtlasiQ96NU7
PRIDEiQ96NU7
ProteomicsDBi77565

PTM databases

iPTMnetiQ96NU7
PhosphoSitePlusiQ96NU7

Expressioni

Gene expression databases

BgeeiENSG00000139344
CleanExiHS_AMDHD1
ExpressionAtlasiQ96NU7 baseline and differential
GenevisibleiQ96NU7 HS

Organism-specific databases

HPAiHPA039720

Interactioni

Protein-protein interaction databases

BioGridi126836, 3 interactors
STRINGi9606.ENSP00000266736

Structurei

3D structure databases

ProteinModelPortaliQ96NU7
SMRiQ96NU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410ITQS Eukaryota
COG1228 LUCA
GeneTreeiENSGT00390000008645
HOGENOMiHOG000218460
HOVERGENiHBG054263
InParanoidiQ96NU7
KOiK01468
OMAiCMMRAGT
OrthoDBiEOG091G0ART
PhylomeDBiQ96NU7
TreeFamiTF312878

Family and domain databases

CDDicd01296 Imidazolone-5PH, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR005920 HutI
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR42752 PTHR42752, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01224 hutI, 1 hit

Sequencei

Sequence statusi: Complete.

Q96NU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGHSLLLE NAQQVVLVCA RGERFLARDA LRSLAVLEGA SLVVGKDGFI
60 70 80 90 100
KAIGPADVIQ RQFSGETFEE IIDCSGKCIL PGLVDAHTHP VWAGERVHEF
110 120 130 140 150
AMKLAGATYM EIHQAGGGIH FTVERTRQAT EEELFRSLQQ RLQCMMRAGT
160 170 180 190 200
TLVECKSGYG LDLETELKML RVIERARREL DIGISATYCG AHSVPKGKTA
210 220 230 240 250
TEAADDIINN HLPKLKELGR NGEIHVDNID VFCEKGVFDL DSTRRILQRG
260 270 280 290 300
KDIGLQINFH GDELHPMKAA ELGAELGAQA ISHLEEVSDE GIVAMATARC
310 320 330 340 350
SAILLPTTAY MLRLKQPRAR KMLDEGVIVA LGSDFNPNAY CFSMPMVMHL
360 370 380 390 400
ACVNMRMSMP EALAAATINA AYALGKSHTH GSLEVGKQGD LIIINSSRWE
410 420
HLIYQFGGHH ELIEYVIAKG KLIYKT
Length:426
Mass (Da):46,743
Last modified:November 2, 2010 - v2
Checksum:iAD747F82BD00ACD3
GO

Sequence cautioni

The sequence BAD38660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0314193S → G4 PublicationsCorresponds to variant dbSNP:rs7955450Ensembl.1
Natural variantiVAR_031420360P → H. Corresponds to variant dbSNP:rs17024904Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054617 mRNA Translation: BAB70775.1
AK290828 mRNA Translation: BAF83517.1
AB075878 mRNA Translation: BAD38660.1 Different initiation.
AC126174 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97552.1
BC029146 mRNA Translation: AAH29146.1
CCDSiCCDS9057.1
RefSeqiNP_689648.2, NM_152435.2
UniGeneiHs.424907

Genome annotation databases

EnsembliENST00000266736; ENSP00000266736; ENSG00000139344
GeneIDi144193
KEGGihsa:144193
UCSCiuc001tel.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHUTI_HUMAN
AccessioniPrimary (citable) accession number: Q96NU7
Secondary accession number(s): A8K463, Q68CI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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