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Protein

Contactin-associated protein-like 3B

Gene

CNTNAP3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

The gene encoding CNTNAP3B is the result of a pericentromeric duplication of the genomic region encoding CNTNAP3 on chromosome 9.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 3B
Alternative name(s):
Cell recognition molecule Caspr3b
Gene namesi
Name:CNTNAP3B
Synonyms:CASPR3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000154529.14
HGNCiHGNC:32035 CNTNAP3B
neXtProtiNX_Q96NU0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1245ExtracellularSequence analysisAdd BLAST1220
Transmembranei1246 – 1266HelicalSequence analysisAdd BLAST21
Topological domaini1267 – 1288CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154529

Polymorphism and mutation databases

BioMutaiCNTNAP3B
DMDMi190358858

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000033935326 – 1288Contactin-associated protein-like 3BAdd BLAST1263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 177By similarity
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 545By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 571By similarity
Disulfide bondi573 ↔ 583By similarity
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Disulfide bondi1167 ↔ 1203By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96NU0
PaxDbiQ96NU0
PeptideAtlasiQ96NU0
PRIDEiQ96NU0
TopDownProteomicsiQ96NU0-2 [Q96NU0-2]

PTM databases

iPTMnetiQ96NU0
PhosphoSitePlusiQ96NU0

Expressioni

Gene expression databases

BgeeiENSG00000154529
CleanExiHS_CNTNAP3B
ExpressionAtlasiQ96NU0 baseline and differential
GenevisibleiQ96NU0 HS

Organism-specific databases

HPAiHPA015604
HPA047731

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366787

Structurei

3D structure databases

ProteinModelPortaliQ96NU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini183 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini370 – 545Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini547 – 584EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini585 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST208
Domaini793 – 958Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini959 – 997EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini1016 – 1203Laminin G-like 4PROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00760000118991
HOVERGENiHBG057718
InParanoidiQ96NU0
OMAiDRLEWTE
OrthoDBiEOG091G00LF
PhylomeDBiQ96NU0
TreeFamiTF321823

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF6 PTHR43925:SF6, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDSPLASALP RSSFSSSSEL
60 70 80 90 100
SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF
160 170 180 190 200
EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYTLDKKP
210 220 230 240 250
LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA
260 270 280 290 300
KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
310 320 330 340 350
SSNLDLNFEI SFGGILSPGR SRAFTRKSFH GCLENLYYNG VDVTELAKKH
360 370 380 390 400
KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT
410 420 430 440 450
WNRAGHLLFG ELQRGSGSFV LFLKDGKLKL SLFQAGQSPR NVTAGAGLND
460 470 480 490 500
GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLGNSSG
510 520 530 540 550
SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR
560 570 580 590 600
CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
610 620 630 640 650
PSGLYYIDAD GSGPLGPFLV YCNMTADSAW TVVRHGGPDA VTLRGAPSGH
660 670 680 690 700
PLSAVSFAYA AGAGQLRAAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW
710 720 730 740 750
WVGRTNETHT SWGGSLPDAQ KCTCGLEGNC IDSQYYCNCD AGQNEWTSDT
760 770 780 790 800
IVLSQKEHLP VTQIVMTDTG QPHSEADYTL GPLLCRGDKS FWNSASFNTE
810 820 830 840 850
TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI RIELRAPTEV
860 870 880 890 900
TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
910 920 930 940 950
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV
960 970 980 990 1000
TPGVEPGCAG HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI
1010 1020 1030 1040 1050
SAYFATGSSM TYHFQEHYTL SENSSSLVSS LHRDVTLTRE MITLSFRTTR
1060 1070 1080 1090 1100
TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY KLDRHQNPDA FTFDFKNMAD
1110 1120 1130 1140 1150
GQLHQVKINR EEAVVMVEVN QSAKKQVILS SGTEFNAVKS LILGKVLEAA
1160 1170 1180 1190 1200
GADPDTRRAA TSGFTGCLSA VRFGCAAPLK AALRPSGPSR VTVRGHVAPM
1210 1220 1230 1240 1250
ARCAAGAASG SPARELAPRL AGGAGRSGPV DEGEPLVNAD RRDSAVIGGV
1260 1270 1280
IAVEIFILLC ITAIAIRIYQ QRKLRKENES KVSKKEEC
Note: No experimental confirmation available. Gene prediction based on EST data.Curated
Length:1,288
Mass (Da):140,415
Last modified:March 28, 2018 - v3
Checksum:i11852910E1338C58
GO
Isoform 2 (identifier: Q96NU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-586: GCLGNSSGSG...GYTGETCHSS → A
     626-626: Missing.
     694-698: DGTPL → GLVTQ
     699-1288: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:604
Mass (Da):66,292
Checksum:iA7C0AFC5F3E660F1
GO

Sequence cautioni

The sequence CAI16324 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16325 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95321 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33S → A in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti316 – 317LS → PT in BAB70782 (PubMed:14702039).Curated2
Sequence conflicti414R → S in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti420V → I in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti439P → L in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti652L → R in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti1032H → Y in CAI16324 (PubMed:15164053).Curated1
Sequence conflicti1032H → Y in CAI16326 (PubMed:15164053).Curated1
Sequence conflicti1051T → S in CAI16324 (PubMed:15164053).Curated1
Sequence conflicti1051T → S in CAI16326 (PubMed:15164053).Curated1
Sequence conflicti1175C → R in CAI16326 (PubMed:15164053).Curated1
Sequence conflicti1247I → M in CAI16326 (PubMed:15164053).Curated1
Sequence conflicti1254E → V in CAI16326 (PubMed:15164053).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034153493 – 586GCLGN…TCHSS → A in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_034154626Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_034155694 – 698DGTPL → GLVTQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_034156699 – 1288Missing in isoform 2. 1 PublicationAdd BLAST590

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054645 mRNA Translation: BAB70782.1
AL953854 Genomic DNA No translation available.
BX664735, BX649569, CR788268 Genomic DNA Translation: CAI16324.1 Sequence problems.
BX664735, BX649569, CR788268 Genomic DNA Translation: CAI16325.1 Sequence problems.
BX664735, BX649569, CR788268 Genomic DNA Translation: CAI16326.1
BX664735, BX649569, CR788268 Genomic DNA Translation: CAI95321.1 Sequence problems.
CCDSiCCDS75836.1 [Q96NU0-1]
RefSeqiNP_001188309.2, NM_001201380.2 [Q96NU0-1]
UniGeneiHs.521495
Hs.722375

Genome annotation databases

EnsembliENST00000377561; ENSP00000478671; ENSG00000154529 [Q96NU0-1]
GeneIDi728577
KEGGihsa:728577
UCSCiuc064thx.1 human [Q96NU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNT3B_HUMAN
AccessioniPrimary (citable) accession number: Q96NU0
Secondary accession number(s): A0A087WUH3
, B1B0V7, B1B0V8, B1B0V9, B1B0W0, B1B0X8, B1B162, Q4VXF0, Q9H7W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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