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Protein

Contactin-associated protein-like 3B

Gene

CNTNAP3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154529-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 3B
Alternative name(s):
Cell recognition molecule Caspr3b
Gene namesi
Name:CNTNAP3B
Synonyms:CASPR3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:32035. CNTNAP3B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1245ExtracellularSequence analysisAdd BLAST1220
Transmembranei1246 – 1266HelicalSequence analysisAdd BLAST21
Topological domaini1267 – 1288CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154529.

Polymorphism and mutation databases

BioMutaiCNTNAP3B.
DMDMi190358858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000033935326 – 1288Contactin-associated protein-like 3BAdd BLAST1263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 177By similarity
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi513 ↔ 545By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 571By similarity
Disulfide bondi573 ↔ 583By similarity
Glycosylationi706N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Disulfide bondi1167 ↔ 1203By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ96NU0.
MaxQBiQ96NU0.
PaxDbiQ96NU0.
PeptideAtlasiQ96NU0.
PRIDEiQ96NU0.
TopDownProteomicsiQ96NU0-2. [Q96NU0-2]

PTM databases

iPTMnetiQ96NU0.
PhosphoSitePlusiQ96NU0.

Expressioni

Gene expression databases

BgeeiENSG00000154529.
CleanExiHS_CNTNAP3B.
ExpressionAtlasiQ96NU0. baseline and differential.
GenevisibleiQ96NU0. HS.

Organism-specific databases

HPAiHPA015604.
HPA047731.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366787.

Structurei

3D structure databases

ProteinModelPortaliQ96NU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini183 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini370 – 545Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini547 – 584EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini585 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST208
Domaini793 – 958Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini959 – 997EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini1016 – 1203Laminin G-like 4PROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOVERGENiHBG057718.
InParanoidiQ96NU0.
PhylomeDBiQ96NU0.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028873. CASPR3.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF605. PTHR10127:SF605. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDSPLASALP RSSFSSSSEL
60 70 80 90 100
SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF
160 170 180 190 200
EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYTLDKKP
210 220 230 240 250
LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA
260 270 280 290 300
KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
310 320 330 340 350
SSNLDLNFEI SFGGILSPGR SRAFTRKSFH GCLENLYYNG VDVTELAKKH
360 370 380 390 400
KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT
410 420 430 440 450
WNRAGHLLFG ELQRGSGSFV LFLKDGKLKL SLFQAGQSPR NVTAGAGLND
460 470 480 490 500
GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLGNSSG
510 520 530 540 550
SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR
560 570 580 590 600
CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
610 620 630 640 650
PSGLYYIDAD GSGPLGPFLV YCNMTADSAW TVVRHGGPDA VTLRGAPSGH
660 670 680 690 700
PLSAVSFAYA AGAGQLRAAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW
710 720 730 740 750
WVGRTNETHT SWGGSLPDAQ KCTCGLEGNC IDSQYYCNCD AGQNEWTSDT
760 770 780 790 800
IVLSQKEHLP VTQIVMTDTG QPHSEADYTL GPLLCRGDKS FWNSASFNTE
810 820 830 840 850
TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI RIELRAPTEV
860 870 880 890 900
TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
910 920 930 940 950
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV
960 970 980 990 1000
TPGVEPGCAG HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI
1010 1020 1030 1040 1050
SAYFATGSSM TYHFQEHYTL SENSSSLVSS LYRDVTLTRE MITLSFRTTR
1060 1070 1080 1090 1100
SPSLLLYVSS FYEEYLSVIL ANNGSLQIRY KLDRHQNPDA FTFDFKNMAD
1110 1120 1130 1140 1150
GQLHQVKINR EEAVVMVEVN QSAKKQVILS SGTEFNAVKS LILGKVLEAA
1160 1170 1180 1190 1200
GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM
1210 1220 1230 1240 1250
ARCAAGAASG SPARELAPRL AGGAGRSGPV DEGEPLVNAD RRDSAVMGGV
1260 1270 1280
IAVVIFILLC ITAIAIRIYQ QRKLRKENES KVSKKEEC
Length:1,288
Mass (Da):140,468
Last modified:June 10, 2008 - v2
Checksum:iB207B28EE52A8AF5
GO
Isoform 2 (identifier: Q96NU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-586: GCLGNSSGSG...GYTGETCHSS → A
     626-626: Missing.
     694-698: DGTPL → GLVTQ
     699-1288: Missing.

Note: No experimental confirmation available.
Show »
Length:604
Mass (Da):66,292
Checksum:iA7C0AFC5F3E660F1
GO
Isoform 3 (identifier: Q96NU0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-380: GNVSFSCPQPQTVPVTFLSSRSY → ELAHGLQDQNLKISLTVCHQTTQ
     381-1288: Missing.

Note: No experimental confirmation available.
Show »
Length:380
Mass (Da):42,401
Checksum:i0FD314D9C94FBD55
GO
Isoform 4 (identifier: Q96NU0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     358-380: GNVSFSCPQPQTVPVTFLSSRSY → ELAHGLQDQNLKISLTVCHQTTQ
     381-1288: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):33,038
Checksum:i8BD87436D9DCCE46
GO

Sequence cautioni

The sequence CAI12626 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16324 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95046 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95048 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95321 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33S → A in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti204I → L in BAB14861 (PubMed:14702039).Curated1
Sequence conflicti316 – 317LS → PT in BAB14861 (PubMed:14702039).Curated2
Sequence conflicti316 – 317LS → PT in BAB70782 (PubMed:14702039).Curated2
Sequence conflicti414R → S in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti420V → I in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti439P → L in BAB70782 (PubMed:14702039).Curated1
Sequence conflicti652L → R in BAB70782 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0341501 – 88Missing in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_034151358 – 380GNVSF…SSRSY → ELAHGLQDQNLKISLTVCHQ TTQ in isoform 3 and isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_034152381 – 1288Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST908
Alternative sequenceiVSP_034153493 – 586GCLGN…TCHSS → A in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_034154626Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_034155694 – 698DGTPL → GLVTQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_034156699 – 1288Missing in isoform 2. 1 PublicationAdd BLAST590

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024257 mRNA. Translation: BAB14861.1.
AK054645 mRNA. Translation: BAB70782.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12626.1. Sequence problems.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12627.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12628.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16324.1. Sequence problems.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16325.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16326.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI94998.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95046.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95047.1.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95048.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95050.1.
AL353791 Genomic DNA. Translation: CAI95288.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI95321.1. Sequence problems.
CCDSiCCDS75836.1. [Q96NU0-1]
UniGeneiHs.521495.
Hs.604441.
Hs.722375.

Genome annotation databases

EnsembliENST00000276974; ENSP00000276974; ENSG00000154529. [Q96NU0-3]
UCSCiuc064thx.1. human. [Q96NU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024257 mRNA. Translation: BAB14861.1.
AK054645 mRNA. Translation: BAB70782.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12626.1. Sequence problems.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12627.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI12628.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16324.1. Sequence problems.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16325.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI16326.1.
BX649569, BX664735, CR788268 Genomic DNA. Translation: CAI94998.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95046.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95047.1.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95048.1. Sequence problems.
CR788268, BX649569, BX664735 Genomic DNA. Translation: CAI95050.1.
AL353791 Genomic DNA. Translation: CAI95288.1.
BX664735, BX649569, CR788268 Genomic DNA. Translation: CAI95321.1. Sequence problems.
CCDSiCCDS75836.1. [Q96NU0-1]
UniGeneiHs.521495.
Hs.604441.
Hs.722375.

3D structure databases

ProteinModelPortaliQ96NU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366787.

PTM databases

iPTMnetiQ96NU0.
PhosphoSitePlusiQ96NU0.

Polymorphism and mutation databases

BioMutaiCNTNAP3B.
DMDMi190358858.

Proteomic databases

EPDiQ96NU0.
MaxQBiQ96NU0.
PaxDbiQ96NU0.
PeptideAtlasiQ96NU0.
PRIDEiQ96NU0.
TopDownProteomicsiQ96NU0-2. [Q96NU0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276974; ENSP00000276974; ENSG00000154529. [Q96NU0-3]
UCSCiuc064thx.1. human. [Q96NU0-1]

Organism-specific databases

GeneCardsiCNTNAP3B.
H-InvDBHIX0034795.
HIX0035297.
HGNCiHGNC:32035. CNTNAP3B.
HPAiHPA015604.
HPA047731.
neXtProtiNX_Q96NU0.
OpenTargetsiENSG00000154529.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOVERGENiHBG057718.
InParanoidiQ96NU0.
PhylomeDBiQ96NU0.
TreeFamiTF321823.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154529-MONOMER.

Miscellaneous databases

PROiQ96NU0.

Gene expression databases

BgeeiENSG00000154529.
CleanExiHS_CNTNAP3B.
ExpressionAtlasiQ96NU0. baseline and differential.
GenevisibleiQ96NU0. HS.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028873. CASPR3.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF605. PTHR10127:SF605. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNT3B_HUMAN
AccessioniPrimary (citable) accession number: Q96NU0
Secondary accession number(s): B1B0V7
, B1B0V8, B1B0V9, B1B0W0, B1B0X8, B1B162, Q4VXF0, Q9H7W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene encoding CNTNAP3B is the result of a pericentromeric duplication of the genomic region encoding CNTNAP3 on chromosome 9.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.