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Q96NT3

- GUCD1_HUMAN

UniProt

Q96NT3 - GUCD1_HUMAN

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Protein

Protein GUCD1

Gene
GUCD1, C22orf13, LLN4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GUCD1
Alternative name(s):
Guanylyl cyclase domain-containing protein 1
Protein LLN4
Gene namesi
Name:GUCD1
Synonyms:C22orf13, LLN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:14237. GUCD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Protein GUCD1PRO_0000079574Add
BLAST

Proteomic databases

MaxQBiQ96NT3.
PaxDbiQ96NT3.
PRIDEiQ96NT3.

Expressioni

Gene expression databases

ArrayExpressiQ96NT3.
BgeeiQ96NT3.
CleanExiHS_C22orf13.
GenevestigatoriQ96NT3.

Organism-specific databases

HPAiHPA022786.

Interactioni

Protein-protein interaction databases

BioGridi123697. 10 interactions.
IntActiQ96NT3. 1 interaction.
MINTiMINT-8407176.
STRINGi9606.ENSP00000386076.

Structurei

3D structure databases

ProteinModelPortaliQ96NT3.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG284950.
HOGENOMiHOG000015782.
HOVERGENiHBG079875.
OrthoDBiEOG78D7KW.
PhylomeDBiQ96NT3.
TreeFamiTF324062.

Family and domain databases

InterProiIPR018616. Guanylyl_cyclase.
[Graphical view]
PfamiPF09778. Guanylate_cyc_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD    50
SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF 100
YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV 150
NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI 200
FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS 240
Length:240
Mass (Da):27,207
Last modified:April 3, 2007 - v2
Checksum:i164875E32F70D1E0
GO
Isoform 2 (identifier: Q96NT3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: PG → R

Show »
Length:239
Mass (Da):27,209
Checksum:i671CC5ABE4236335
GO
Isoform 3 (identifier: Q96NT3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRTEAEAAGPPLE → MTGPGGRRND...SQFHLLIPAP
     210-211: PG → R

Show »
Length:295
Mass (Da):33,476
Checksum:i0D00A1849B036EB4
GO

Sequence cautioni

The sequence BAB68411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. VSP_055753Add
BLAST
Alternative sequencei210 – 2112PG → R in isoform 2 and isoform 3. VSP_044730

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132LE → AP in AAH02924. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054681 mRNA. Translation: BAB70791.1.
AK098754 mRNA. No translation available.
AP000356 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59667.1.
BC002924 mRNA. Translation: AAH02924.2.
BC070109 mRNA. Translation: AAH70109.1.
AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
CCDSiCCDS33621.1. [Q96NT3-1]
CCDS63426.1. [Q96NT3-2]
RefSeqiNP_001271180.1. NM_001284251.1.
NP_001271183.1. NM_001284254.1. [Q96NT3-2]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1]
UniGeneiHs.9850.

Genome annotation databases

EnsembliENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867.
ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
GeneIDi83606.
KEGGihsa:83606.
UCSCiuc003aah.2. human. [Q96NT3-1]

Polymorphism databases

DMDMi143811383.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054681 mRNA. Translation: BAB70791.1 .
AK098754 mRNA. No translation available.
AP000356 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59667.1 .
BC002924 mRNA. Translation: AAH02924.2 .
BC070109 mRNA. Translation: AAH70109.1 .
AB049215 Genomic DNA. Translation: BAB68411.1 . Different initiation.
CCDSi CCDS33621.1. [Q96NT3-1 ]
CCDS63426.1. [Q96NT3-2 ]
RefSeqi NP_001271180.1. NM_001284251.1.
NP_001271183.1. NM_001284254.1. [Q96NT3-2 ]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1 ]
UniGenei Hs.9850.

3D structure databases

ProteinModelPortali Q96NT3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123697. 10 interactions.
IntActi Q96NT3. 1 interaction.
MINTi MINT-8407176.
STRINGi 9606.ENSP00000386076.

Polymorphism databases

DMDMi 143811383.

Proteomic databases

MaxQBi Q96NT3.
PaxDbi Q96NT3.
PRIDEi Q96NT3.

Protocols and materials databases

DNASUi 83606.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398245 ; ENSP00000381297 ; ENSG00000138867 . [Q96NT3-2 ]
ENST00000404664 ; ENSP00000384121 ; ENSG00000138867 .
ENST00000407471 ; ENSP00000386076 ; ENSG00000138867 . [Q96NT3-1 ]
ENST00000435822 ; ENSP00000405985 ; ENSG00000138867 . [Q96NT3-2 ]
GeneIDi 83606.
KEGGi hsa:83606.
UCSCi uc003aah.2. human. [Q96NT3-1 ]

Organism-specific databases

CTDi 83606.
GeneCardsi GC22M025034.
HGNCi HGNC:14237. GUCD1.
HPAi HPA022786.
neXtProti NX_Q96NT3.
PharmGKBi PA25882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284950.
HOGENOMi HOG000015782.
HOVERGENi HBG079875.
OrthoDBi EOG78D7KW.
PhylomeDBi Q96NT3.
TreeFami TF324062.

Miscellaneous databases

GenomeRNAii 83606.
NextBioi 72555.

Gene expression databases

ArrayExpressi Q96NT3.
Bgeei Q96NT3.
CleanExi HS_C22orf13.
Genevestigatori Q96NT3.

Family and domain databases

InterProi IPR018616. Guanylyl_cyclase.
[Graphical view ]
Pfami PF09778. Guanylate_cyc_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Cerebellum.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-240 (ISOFORM 1).
    Tissue: Placenta and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Molecular cloning of a novel gene."
    Shimizu N., Minosima S., Kawasaki K., Sasaki T.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-239 (ISOFORM 2).

Entry informationi

Entry nameiGUCD1_HUMAN
AccessioniPrimary (citable) accession number: Q96NT3
Secondary accession number(s): B5MCB8
, B5MCL7, Q96Q79, Q9BU32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM

External Data

Dasty 3

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