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Protein

Protein GUCD1

Gene

GUCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GUCD1
Alternative name(s):
Guanylyl cyclase domain-containing protein 1
Protein LLN4
Gene namesi
Name:GUCD1
Synonyms:C22orf13, LLN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14237. GUCD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Protein GUCD1PRO_0000079574Add
BLAST

Proteomic databases

MaxQBiQ96NT3.
PaxDbiQ96NT3.
PRIDEiQ96NT3.

Expressioni

Gene expression databases

BgeeiQ96NT3.
CleanExiHS_C22orf13.
ExpressionAtlasiQ96NT3. baseline and differential.
GenevestigatoriQ96NT3.

Organism-specific databases

HPAiHPA022786.

Interactioni

Protein-protein interaction databases

BioGridi123697. 15 interactions.
IntActiQ96NT3. 1 interaction.
MINTiMINT-8407176.
STRINGi9606.ENSP00000386076.

Structurei

3D structure databases

ProteinModelPortaliQ96NT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG284950.
GeneTreeiENSGT00390000000571.
HOGENOMiHOG000015782.
HOVERGENiHBG079875.
InParanoidiQ96NT3.
OMAiHLEQGHV.
OrthoDBiEOG78D7KW.
PhylomeDBiQ96NT3.
TreeFamiTF324062.

Family and domain databases

InterProiIPR018616. Guanylyl_cyclase.
[Graphical view]
PfamiPF09778. Guanylate_cyc_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD
60 70 80 90 100
SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF
110 120 130 140 150
YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV
160 170 180 190 200
NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI
210 220 230 240
FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS
Length:240
Mass (Da):27,207
Last modified:April 3, 2007 - v2
Checksum:i164875E32F70D1E0
GO
Isoform 2 (identifier: Q96NT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: PG → R

Show »
Length:239
Mass (Da):27,209
Checksum:i671CC5ABE4236335
GO
Isoform 3 (identifier: Q96NT3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRTEAEAAGPPLE → MTGPGGRRND...SQFHLLIPAP
     210-211: PG → R

Show »
Length:295
Mass (Da):33,476
Checksum:i0D00A1849B036EB4
GO

Sequence cautioni

The sequence BAB68411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132LE → AP in AAH02924 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. 1 PublicationVSP_055753Add
BLAST
Alternative sequencei210 – 2112PG → R in isoform 2 and isoform 3. 2 PublicationsVSP_044730

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054681 mRNA. Translation: BAB70791.1.
AK098754 mRNA. No translation available.
AP000356 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59667.1.
BC002924 mRNA. Translation: AAH02924.2.
BC070109 mRNA. Translation: AAH70109.1.
AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
CCDSiCCDS33621.1. [Q96NT3-1]
CCDS63426.1. [Q96NT3-2]
CCDS63427.1. [Q96NT3-3]
RefSeqiNP_001271180.1. NM_001284251.1.
NP_001271181.1. NM_001284252.1. [Q96NT3-3]
NP_001271183.1. NM_001284254.1. [Q96NT3-2]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1]
UniGeneiHs.9850.

Genome annotation databases

EnsembliENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867. [Q96NT3-3]
ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
GeneIDi83606.
KEGGihsa:83606.
UCSCiuc003aah.2. human. [Q96NT3-1]

Polymorphism databases

DMDMi143811383.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054681 mRNA. Translation: BAB70791.1.
AK098754 mRNA. No translation available.
AP000356 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59667.1.
BC002924 mRNA. Translation: AAH02924.2.
BC070109 mRNA. Translation: AAH70109.1.
AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
CCDSiCCDS33621.1. [Q96NT3-1]
CCDS63426.1. [Q96NT3-2]
CCDS63427.1. [Q96NT3-3]
RefSeqiNP_001271180.1. NM_001284251.1.
NP_001271181.1. NM_001284252.1. [Q96NT3-3]
NP_001271183.1. NM_001284254.1. [Q96NT3-2]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1]
UniGeneiHs.9850.

3D structure databases

ProteinModelPortaliQ96NT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123697. 15 interactions.
IntActiQ96NT3. 1 interaction.
MINTiMINT-8407176.
STRINGi9606.ENSP00000386076.

Polymorphism databases

DMDMi143811383.

Proteomic databases

MaxQBiQ96NT3.
PaxDbiQ96NT3.
PRIDEiQ96NT3.

Protocols and materials databases

DNASUi83606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867. [Q96NT3-3]
ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
GeneIDi83606.
KEGGihsa:83606.
UCSCiuc003aah.2. human. [Q96NT3-1]

Organism-specific databases

CTDi83606.
GeneCardsiGC22M025180.
HGNCiHGNC:14237. GUCD1.
HPAiHPA022786.
neXtProtiNX_Q96NT3.
PharmGKBiPA25882.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284950.
GeneTreeiENSGT00390000000571.
HOGENOMiHOG000015782.
HOVERGENiHBG079875.
InParanoidiQ96NT3.
OMAiHLEQGHV.
OrthoDBiEOG78D7KW.
PhylomeDBiQ96NT3.
TreeFamiTF324062.

Miscellaneous databases

GenomeRNAii83606.
NextBioi35478130.

Gene expression databases

BgeeiQ96NT3.
CleanExiHS_C22orf13.
ExpressionAtlasiQ96NT3. baseline and differential.
GenevestigatoriQ96NT3.

Family and domain databases

InterProiIPR018616. Guanylyl_cyclase.
[Graphical view]
PfamiPF09778. Guanylate_cyc_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Cerebellum.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-240 (ISOFORM 1).
    Tissue: Placenta and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Molecular cloning of a novel gene."
    Shimizu N., Minosima S., Kawasaki K., Sasaki T.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-239 (ISOFORM 2).

Entry informationi

Entry nameiGUCD1_HUMAN
AccessioniPrimary (citable) accession number: Q96NT3
Secondary accession number(s): B5MCB8
, B5MCL7, Q96Q79, Q9BU32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 3, 2007
Last modified: February 4, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.