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Q96NT3 (GUCD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GUCD1
Alternative name(s):
Guanylyl cyclase domain-containing protein 1
Protein LLN4
Gene names
Name:GUCD1
Synonyms:C22orf13, LLN4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAB68411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96NT3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96NT3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: PG → R

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Protein GUCD1
PRO_0000079574

Natural variations

Alternative sequence210 – 2112PG → R in isoform 2.
VSP_044730

Experimental info

Sequence conflict12 – 132LE → AP in AAH02924. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 164875E32F70D1E0

FASTA24027,207
        10         20         30         40         50         60 
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD SEFERALQKL 

        70         80         90        100        110        120 
QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF YRKHFDTEET RVNQLFAQAK 

       130        140        150        160        170        180 
ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT 

       190        200        210        220        230        240 
PDYQGHFIVL RGYNRATGCI FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS 

« Hide

Isoform 2 [UniParc].

Checksum: 671CC5ABE4236335
Show »

FASTA23927,209

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Cerebellum.
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-240 (ISOFORM 1).
Tissue: Placenta and Testis.
[4]"Molecular cloning of a novel gene."
Shimizu N., Minosima S., Kawasaki K., Sasaki T.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-239 (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK054681 mRNA. Translation: BAB70791.1.
AP000356 Genomic DNA. No translation available.
BC002924 mRNA. Translation: AAH02924.2.
BC070109 mRNA. Translation: AAH70109.1.
AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
CCDSCCDS33621.1. [Q96NT3-1]
CCDS63426.1. [Q96NT3-2]
RefSeqNP_001271180.1. NM_001284251.1.
NP_001271183.1. NM_001284254.1. [Q96NT3-2]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1]
UniGeneHs.9850.

3D structure databases

ProteinModelPortalQ96NT3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123697. 4 interactions.
IntActQ96NT3. 1 interaction.
MINTMINT-8407176.
STRING9606.ENSP00000386076.

Polymorphism databases

DMDM143811383.

Proteomic databases

MaxQBQ96NT3.
PaxDbQ96NT3.
PRIDEQ96NT3.

Protocols and materials databases

DNASU83606.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
GeneID83606.
KEGGhsa:83606.
UCSCuc003aah.2. human. [Q96NT3-1]

Organism-specific databases

CTD83606.
GeneCardsGC22M025034.
HGNCHGNC:14237. GUCD1.
HPAHPA022786.
neXtProtNX_Q96NT3.
PharmGKBPA25882.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284950.
HOGENOMHOG000015782.
HOVERGENHBG079875.
OrthoDBEOG78D7KW.
PhylomeDBQ96NT3.
TreeFamTF324062.

Gene expression databases

ArrayExpressQ96NT3.
BgeeQ96NT3.
CleanExHS_C22orf13.
GenevestigatorQ96NT3.

Family and domain databases

InterProIPR018616. Guanylyl_cyclase.
[Graphical view]
PfamPF09778. Guanylate_cyc_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83606.
NextBio72555.

Entry information

Entry nameGUCD1_HUMAN
AccessionPrimary (citable) accession number: Q96NT3
Secondary accession number(s): B5MCB8, Q96Q79, Q9BU32
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM