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Q96NT3

- GUCD1_HUMAN

UniProt

Q96NT3 - GUCD1_HUMAN

Protein

Protein GUCD1

Gene

GUCD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GUCD1
    Alternative name(s):
    Guanylyl cyclase domain-containing protein 1
    Protein LLN4
    Gene namesi
    Name:GUCD1
    Synonyms:C22orf13, LLN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:14237. GUCD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Protein GUCD1PRO_0000079574Add
    BLAST

    Proteomic databases

    MaxQBiQ96NT3.
    PaxDbiQ96NT3.
    PRIDEiQ96NT3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96NT3.
    BgeeiQ96NT3.
    CleanExiHS_C22orf13.
    GenevestigatoriQ96NT3.

    Organism-specific databases

    HPAiHPA022786.

    Interactioni

    Protein-protein interaction databases

    BioGridi123697. 10 interactions.
    IntActiQ96NT3. 1 interaction.
    MINTiMINT-8407176.
    STRINGi9606.ENSP00000386076.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NT3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG284950.
    HOGENOMiHOG000015782.
    HOVERGENiHBG079875.
    OrthoDBiEOG78D7KW.
    PhylomeDBiQ96NT3.
    TreeFamiTF324062.

    Family and domain databases

    InterProiIPR018616. Guanylyl_cyclase.
    [Graphical view]
    PfamiPF09778. Guanylate_cyc_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD    50
    SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF 100
    YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV 150
    NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI 200
    FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS 240
    Length:240
    Mass (Da):27,207
    Last modified:April 3, 2007 - v2
    Checksum:i164875E32F70D1E0
    GO
    Isoform 2 (identifier: Q96NT3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-211: PG → R

    Show »
    Length:239
    Mass (Da):27,209
    Checksum:i671CC5ABE4236335
    GO
    Isoform 3 (identifier: Q96NT3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MRTEAEAAGPPLE → MTGPGGRRND...SQFHLLIPAP
         210-211: PG → R

    Show »
    Length:295
    Mass (Da):33,476
    Checksum:i0D00A1849B036EB4
    GO

    Sequence cautioni

    The sequence BAB68411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 132LE → AP in AAH02924. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. 1 PublicationVSP_055753Add
    BLAST
    Alternative sequencei210 – 2112PG → R in isoform 2 and isoform 3. 2 PublicationsVSP_044730

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054681 mRNA. Translation: BAB70791.1.
    AK098754 mRNA. No translation available.
    AP000356 Genomic DNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW59667.1.
    BC002924 mRNA. Translation: AAH02924.2.
    BC070109 mRNA. Translation: AAH70109.1.
    AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
    CCDSiCCDS33621.1. [Q96NT3-1]
    CCDS63426.1. [Q96NT3-2]
    RefSeqiNP_001271180.1. NM_001284251.1.
    NP_001271183.1. NM_001284254.1. [Q96NT3-2]
    NP_001271184.1. NM_001284255.1.
    NP_001271185.1. NM_001284256.1.
    NP_001271186.1. NM_001284257.1.
    NP_113632.2. NM_031444.3. [Q96NT3-1]
    UniGeneiHs.9850.

    Genome annotation databases

    EnsembliENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
    ENST00000404664; ENSP00000384121; ENSG00000138867. [Q96NT3-3]
    ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
    ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
    GeneIDi83606.
    KEGGihsa:83606.
    UCSCiuc003aah.2. human. [Q96NT3-1]

    Polymorphism databases

    DMDMi143811383.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054681 mRNA. Translation: BAB70791.1 .
    AK098754 mRNA. No translation available.
    AP000356 Genomic DNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW59667.1 .
    BC002924 mRNA. Translation: AAH02924.2 .
    BC070109 mRNA. Translation: AAH70109.1 .
    AB049215 Genomic DNA. Translation: BAB68411.1 . Different initiation.
    CCDSi CCDS33621.1. [Q96NT3-1 ]
    CCDS63426.1. [Q96NT3-2 ]
    RefSeqi NP_001271180.1. NM_001284251.1.
    NP_001271183.1. NM_001284254.1. [Q96NT3-2 ]
    NP_001271184.1. NM_001284255.1.
    NP_001271185.1. NM_001284256.1.
    NP_001271186.1. NM_001284257.1.
    NP_113632.2. NM_031444.3. [Q96NT3-1 ]
    UniGenei Hs.9850.

    3D structure databases

    ProteinModelPortali Q96NT3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123697. 10 interactions.
    IntActi Q96NT3. 1 interaction.
    MINTi MINT-8407176.
    STRINGi 9606.ENSP00000386076.

    Polymorphism databases

    DMDMi 143811383.

    Proteomic databases

    MaxQBi Q96NT3.
    PaxDbi Q96NT3.
    PRIDEi Q96NT3.

    Protocols and materials databases

    DNASUi 83606.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398245 ; ENSP00000381297 ; ENSG00000138867 . [Q96NT3-2 ]
    ENST00000404664 ; ENSP00000384121 ; ENSG00000138867 . [Q96NT3-3 ]
    ENST00000407471 ; ENSP00000386076 ; ENSG00000138867 . [Q96NT3-1 ]
    ENST00000435822 ; ENSP00000405985 ; ENSG00000138867 . [Q96NT3-2 ]
    GeneIDi 83606.
    KEGGi hsa:83606.
    UCSCi uc003aah.2. human. [Q96NT3-1 ]

    Organism-specific databases

    CTDi 83606.
    GeneCardsi GC22M025034.
    HGNCi HGNC:14237. GUCD1.
    HPAi HPA022786.
    neXtProti NX_Q96NT3.
    PharmGKBi PA25882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284950.
    HOGENOMi HOG000015782.
    HOVERGENi HBG079875.
    OrthoDBi EOG78D7KW.
    PhylomeDBi Q96NT3.
    TreeFami TF324062.

    Miscellaneous databases

    GenomeRNAii 83606.
    NextBioi 72555.

    Gene expression databases

    ArrayExpressi Q96NT3.
    Bgeei Q96NT3.
    CleanExi HS_C22orf13.
    Genevestigatori Q96NT3.

    Family and domain databases

    InterProi IPR018616. Guanylyl_cyclase.
    [Graphical view ]
    Pfami PF09778. Guanylate_cyc_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Cerebellum.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-240 (ISOFORM 1).
      Tissue: Placenta and Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Molecular cloning of a novel gene."
      Shimizu N., Minosima S., Kawasaki K., Sasaki T.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-239 (ISOFORM 2).

    Entry informationi

    Entry nameiGUCD1_HUMAN
    AccessioniPrimary (citable) accession number: Q96NT3
    Secondary accession number(s): B5MCB8
    , B5MCL7, Q96Q79, Q9BU32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM

    External Data

    Dasty 3