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Protein

Protein GUCD1

Gene

GUCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GUCD1
Alternative name(s):
Guanylyl cyclase domain-containing protein 1
Protein LLN4
Gene namesi
Name:GUCD1
Synonyms:C22orf13, LLN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14237. GUCD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi83606.
OpenTargetsiENSG00000138867.
PharmGKBiPA25882.

Polymorphism and mutation databases

DMDMi143811383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795741 – 240Protein GUCD1Add BLAST240

Proteomic databases

MaxQBiQ96NT3.
PaxDbiQ96NT3.
PeptideAtlasiQ96NT3.
PRIDEiQ96NT3.

PTM databases

iPTMnetiQ96NT3.
PhosphoSitePlusiQ96NT3.

Expressioni

Gene expression databases

BgeeiENSG00000138867.
CleanExiHS_C22orf13.
ExpressionAtlasiQ96NT3. baseline and differential.
GenevisibleiQ96NT3. HS.

Organism-specific databases

HPAiHPA022786.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123697. 17 interactors.
IntActiQ96NT3. 70 interactors.
MINTiMINT-8407176.
STRINGi9606.ENSP00000386076.

Structurei

3D structure databases

ProteinModelPortaliQ96NT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4621. Eukaryota.
ENOG4111HS3. LUCA.
GeneTreeiENSGT00390000000571.
HOGENOMiHOG000015782.
HOVERGENiHBG079875.
InParanoidiQ96NT3.
PhylomeDBiQ96NT3.
TreeFamiTF324062.

Family and domain databases

InterProiView protein in InterPro
IPR018616. Guanylyl_cyclase.
PfamiView protein in Pfam
PF09778. Guanylate_cyc_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD
60 70 80 90 100
SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF
110 120 130 140 150
YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV
160 170 180 190 200
NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI
210 220 230 240
FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS
Length:240
Mass (Da):27,207
Last modified:April 3, 2007 - v2
Checksum:i164875E32F70D1E0
GO
Isoform 2 (identifier: Q96NT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: PG → R

Show »
Length:239
Mass (Da):27,209
Checksum:i671CC5ABE4236335
GO
Isoform 3 (identifier: Q96NT3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRTEAEAAGPPLE → MTGPGGRRND...SQFHLLIPAP
     210-211: PG → R

Show »
Length:295
Mass (Da):33,476
Checksum:i0D00A1849B036EB4
GO

Sequence cautioni

The sequence BAB68411 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13LE → AP in AAH02924 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557531 – 13MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_044730210 – 211PG → R in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054681 mRNA. Translation: BAB70791.1.
AK098754 mRNA. No translation available.
AP000356 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59667.1.
BC002924 mRNA. Translation: AAH02924.2.
BC070109 mRNA. Translation: AAH70109.1.
AB049215 Genomic DNA. Translation: BAB68411.1. Different initiation.
CCDSiCCDS33621.1. [Q96NT3-1]
CCDS63426.1. [Q96NT3-2]
CCDS63427.1. [Q96NT3-3]
RefSeqiNP_001271180.1. NM_001284251.1.
NP_001271181.1. NM_001284252.1. [Q96NT3-3]
NP_001271183.1. NM_001284254.1. [Q96NT3-2]
NP_001271184.1. NM_001284255.1.
NP_001271185.1. NM_001284256.1.
NP_001271186.1. NM_001284257.1.
NP_113632.2. NM_031444.3. [Q96NT3-1]
UniGeneiHs.9850.

Genome annotation databases

EnsembliENST00000398245; ENSP00000381297; ENSG00000138867. [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867. [Q96NT3-3]
ENST00000407471; ENSP00000386076; ENSG00000138867. [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867. [Q96NT3-2]
GeneIDi83606.
KEGGihsa:83606.
UCSCiuc003aah.4. human. [Q96NT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGUCD1_HUMAN
AccessioniPrimary (citable) accession number: Q96NT3
Secondary accession number(s): B5MCB8
, B5MCL7, Q96Q79, Q9BU32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 3, 2007
Last modified: August 30, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM