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Protein

Nucleosome assembly protein 1-like 5

Gene

NAP1L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 5
Alternative name(s):
Down-regulated in liver malignancy
Gene namesi
Name:NAP1L5
Synonyms:DRLM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19968. NAP1L5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921404.

Polymorphism and mutation databases

BioMutaiNAP1L5.
DMDMi74732635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Nucleosome assembly protein 1-like 5PRO_0000317142Add
BLAST

Proteomic databases

EPDiQ96NT1.
MaxQBiQ96NT1.
PaxDbiQ96NT1.
PeptideAtlasiQ96NT1.
PRIDEiQ96NT1.

PTM databases

iPTMnetiQ96NT1.
PhosphoSiteiQ96NT1.

Expressioni

Tissue specificityi

Predominantly expressed in brain.1 Publication

Gene expression databases

BgeeiQ96NT1.
CleanExiHS_NAP1L5.
GenevisibleiQ96NT1. HS.

Organism-specific databases

HPAiHPA038615.

Interactioni

Protein-protein interaction databases

BioGridi129344. 29 interactions.
IntActiQ96NT1. 9 interactions.
MINTiMINT-1369088.
STRINGi9606.ENSP00000320488.

Structurei

3D structure databases

ProteinModelPortaliQ96NT1.
SMRiQ96NT1. Positions 68-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili81 – 10727Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 239Poly-Ala
Compositional biasi122 – 16241Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00730000111564.
HOGENOMiHOG000113834.
HOVERGENiHBG056984.
InParanoidiQ96NT1.
KOiK11283.
OMAiCAWTLEG.
OrthoDBiEOG7BKCX2.
PhylomeDBiQ96NT1.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ
60 70 80 90 100
MAEEPQTPAE NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK
110 120 130 140 150
EFQALEKKYN DIYKPLLAKI QELTGEMEGC AWTLEGEEEE EEEYEDDEEE
160 170 180
GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA KK
Length:182
Mass (Da):19,593
Last modified:December 1, 2001 - v1
Checksum:i8774791B37F99986
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541E → Q.
Corresponds to variant rs13109442 [ dbSNP | Ensembl ].
VAR_050227

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054689 mRNA. Translation: BAB70793.1.
CH471057 Genomic DNA. Translation: EAX06025.1.
BC104883 mRNA. Translation: AAI04884.1.
CCDSiCCDS3632.1.
RefSeqiNP_715638.1. NM_153757.3.
UniGeneiHs.12554.

Genome annotation databases

EnsembliENST00000323061; ENSP00000320488; ENSG00000177432.
GeneIDi266812.
KEGGihsa:266812.
UCSCiuc003hrx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054689 mRNA. Translation: BAB70793.1.
CH471057 Genomic DNA. Translation: EAX06025.1.
BC104883 mRNA. Translation: AAI04884.1.
CCDSiCCDS3632.1.
RefSeqiNP_715638.1. NM_153757.3.
UniGeneiHs.12554.

3D structure databases

ProteinModelPortaliQ96NT1.
SMRiQ96NT1. Positions 68-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129344. 29 interactions.
IntActiQ96NT1. 9 interactions.
MINTiMINT-1369088.
STRINGi9606.ENSP00000320488.

PTM databases

iPTMnetiQ96NT1.
PhosphoSiteiQ96NT1.

Polymorphism and mutation databases

BioMutaiNAP1L5.
DMDMi74732635.

Proteomic databases

EPDiQ96NT1.
MaxQBiQ96NT1.
PaxDbiQ96NT1.
PeptideAtlasiQ96NT1.
PRIDEiQ96NT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323061; ENSP00000320488; ENSG00000177432.
GeneIDi266812.
KEGGihsa:266812.
UCSCiuc003hrx.4. human.

Organism-specific databases

CTDi266812.
GeneCardsiNAP1L5.
HGNCiHGNC:19968. NAP1L5.
HPAiHPA038615.
MIMi612203. gene.
neXtProtiNX_Q96NT1.
PharmGKBiPA134921404.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00730000111564.
HOGENOMiHOG000113834.
HOVERGENiHBG056984.
InParanoidiQ96NT1.
KOiK11283.
OMAiCAWTLEG.
OrthoDBiEOG7BKCX2.
PhylomeDBiQ96NT1.

Miscellaneous databases

GenomeRNAii266812.
PROiQ96NT1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NT1.
CleanExiHS_NAP1L5.
GenevisibleiQ96NT1. HS.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein."
    Harada H., Nagai H., Ezura Y., Yokota T., Ohsawa I., Yamaguchi K., Ohue C., Tsuneizumi M., Mikami I., Terada Y., Yabe A., Emi M.
    Gene 296:171-177(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNP1L5_HUMAN
AccessioniPrimary (citable) accession number: Q96NT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.