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Protein

Nucleosome assembly protein 1-like 5

Gene

NAP1L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 5
Alternative name(s):
Down-regulated in liver malignancy
Gene namesi
Name:NAP1L5
Synonyms:DRLM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000177432.6
HGNCiHGNC:19968 NAP1L5
MIMi612203 gene
neXtProtiNX_Q96NT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi266812
OpenTargetsiENSG00000177432
PharmGKBiPA134921404

Polymorphism and mutation databases

BioMutaiNAP1L5
DMDMi74732635

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171421 – 182Nucleosome assembly protein 1-like 5Add BLAST182

Proteomic databases

EPDiQ96NT1
MaxQBiQ96NT1
PaxDbiQ96NT1
PeptideAtlasiQ96NT1
PRIDEiQ96NT1

PTM databases

iPTMnetiQ96NT1
PhosphoSitePlusiQ96NT1

Expressioni

Tissue specificityi

Predominantly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000177432
CleanExiHS_NAP1L5
GenevisibleiQ96NT1 HS

Organism-specific databases

HPAiHPA058227

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WHAMMP3Q1A5X74EBI-713627,EBI-11956783

Protein-protein interaction databases

BioGridi129344, 30 interactors
IntActiQ96NT1, 14 interactors
STRINGi9606.ENSP00000320488

Structurei

3D structure databases

ProteinModelPortaliQ96NT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili81 – 107Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 23Poly-Ala9
Compositional biasi122 – 162Glu-richAdd BLAST41

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00730000111564
HOGENOMiHOG000113834
HOVERGENiHBG056984
InParanoidiQ96NT1
KOiK11283
OMAiEMEGCAW
OrthoDBiEOG091G10TW
PhylomeDBiQ96NT1

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

Q96NT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ
60 70 80 90 100
MAEEPQTPAE NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK
110 120 130 140 150
EFQALEKKYN DIYKPLLAKI QELTGEMEGC AWTLEGEEEE EEEYEDDEEE
160 170 180
GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA KK
Length:182
Mass (Da):19,593
Last modified:December 1, 2001 - v1
Checksum:i8774791B37F99986
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050227154E → Q. Corresponds to variant dbSNP:rs13109442Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054689 mRNA Translation: BAB70793.1
CH471057 Genomic DNA Translation: EAX06025.1
BC104883 mRNA Translation: AAI04884.1
CCDSiCCDS3632.1
RefSeqiNP_715638.1, NM_153757.3
UniGeneiHs.12554

Genome annotation databases

EnsembliENST00000323061; ENSP00000320488; ENSG00000177432
GeneIDi266812
KEGGihsa:266812
UCSCiuc003hrx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNP1L5_HUMAN
AccessioniPrimary (citable) accession number: Q96NT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health