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Protein

Ankyrin repeat and SOCS box protein 16

Gene

ASB16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ96NS5.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 16
Short name:
ASB-16
Gene namesi
Name:ASB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19768. ASB16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879678.

Polymorphism and mutation databases

BioMutaiASB16.
DMDMi296434399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Ankyrin repeat and SOCS box protein 16PRO_0000066956Add
BLAST

Proteomic databases

PaxDbiQ96NS5.
PeptideAtlasiQ96NS5.
PRIDEiQ96NS5.

PTM databases

iPTMnetiQ96NS5.
PhosphoSiteiQ96NS5.

Expressioni

Gene expression databases

BgeeiENSG00000161664.
CleanExiHS_ASB16.
ExpressionAtlasiQ96NS5. baseline and differential.
GenevisibleiQ96NS5. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1751918,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124958. 21 interactions.
IntActiQ96NS5. 5 interactions.
STRINGi9606.ENSP00000293414.

Structurei

3D structure databases

ProteinModelPortaliQ96NS5.
SMRiQ96NS5. Positions 57-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 8530ANK 1Add
BLAST
Repeati110 – 13930ANK 2Add
BLAST
Repeati142 – 17130ANK 3Add
BLAST
Repeati175 – 20430ANK 4Add
BLAST
Repeati209 – 23830ANK 5Add
BLAST
Repeati242 – 27938ANK 6Add
BLAST
Repeati283 – 31230ANK 7Add
BLAST
Domaini398 – 45053SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ96NS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG091G08N2.
PhylomeDBiQ96NS5.
TreeFamiTF333494.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARETFPFTS SMLRSLRLQQ EWLEWEDRRR AAAQQCRSRR CPSSPRARLT
60 70 80 90 100
RPHRSCRDPA VHQALFSGNL QQVQALFQDE EAANMIVETV SNQLAWSAEQ
110 120 130 140 150
GFWVLTPKTK QTAPLAIATA RGYTDCARHL IRQGAELDAR VGGRAALHEA
160 170 180 190 200
CARAQFDCVR LLLTFGAKAN VLTEEGTTPL HLCTIPESLQ CAKLLLEAGA
210 220 230 240 250
TVNLAAGESQ ETPLHVAAAR GLEQHVALYL EHGADVGLRT SQGETALNTA
260 270 280 290 300
CAGAEGPGSC RRHQAAARRL LEAGADARAA GRKRHTPLHN ACANGCGGLA
310 320 330 340 350
ELLLRYGARA EVPNGAGHTP MDCALQAVQD SPNWEPEVLF AALLDYGAQP
360 370 380 390 400
VRPEMLKHCA NFPRALEVLL NAYPCVPSCE TWVEAVLPEL WKEHEAFYSS
410 420 430 440 450
ALCMVNQPRQ LQHLARLAVR ARLGSRCRQG ATRLPLPPLL RDYLLLRVEG

CIQ
Length:453
Mass (Da):49,637
Last modified:May 18, 2010 - v2
Checksum:iCAF7A454F76F3A32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631Q → H in BAB70800 (PubMed:14702039).Curated
Sequence conflicti63 – 631Q → H in BAG37167 (PubMed:14702039).Curated
Sequence conflicti63 – 631Q → H in AAH75088 (PubMed:15489334).Curated
Sequence conflicti249 – 2491T → A in BAB70800 (PubMed:14702039).Curated
Sequence conflicti249 – 2491T → A in BAG37167 (PubMed:14702039).Curated
Sequence conflicti249 – 2491T → A in AAH75088 (PubMed:15489334).Curated
Sequence conflicti249 – 2491T → A in AAL57353 (Ref. 4) Curated
Sequence conflicti294 – 2941N → S in BAB70800 (PubMed:14702039).Curated
Sequence conflicti294 – 2941N → S in BAG37167 (PubMed:14702039).Curated
Sequence conflicti294 – 2941N → S in AAH75088 (PubMed:15489334).Curated
Sequence conflicti294 – 2941N → S in AAL57353 (Ref. 4) Curated
Sequence conflicti331 – 3311S → A in BAB70800 (PubMed:14702039).Curated
Sequence conflicti331 – 3311S → A in BAG37167 (PubMed:14702039).Curated
Sequence conflicti331 – 3311S → A in AAH75088 (PubMed:15489334).Curated
Sequence conflicti331 – 3311S → A in AAL57353 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731T → P Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication
VAR_064697
Natural varianti240 – 2401T → I.
Corresponds to variant rs7224330 [ dbSNP | Ensembl ].
VAR_059127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054727 mRNA. Translation: BAB70800.1.
AK314595 mRNA. Translation: BAG37167.1.
AC004596 Genomic DNA. No translation available.
BC075088 mRNA. Translation: AAH75088.1.
AF403034 mRNA. Translation: AAL57353.1.
CCDSiCCDS11478.1.
RefSeqiNP_543139.4. NM_080863.4.
UniGeneiHs.534517.

Genome annotation databases

EnsembliENST00000293414; ENSP00000293414; ENSG00000161664.
GeneIDi92591.
KEGGihsa:92591.
UCSCiuc002ifl.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054727 mRNA. Translation: BAB70800.1.
AK314595 mRNA. Translation: BAG37167.1.
AC004596 Genomic DNA. No translation available.
BC075088 mRNA. Translation: AAH75088.1.
AF403034 mRNA. Translation: AAL57353.1.
CCDSiCCDS11478.1.
RefSeqiNP_543139.4. NM_080863.4.
UniGeneiHs.534517.

3D structure databases

ProteinModelPortaliQ96NS5.
SMRiQ96NS5. Positions 57-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124958. 21 interactions.
IntActiQ96NS5. 5 interactions.
STRINGi9606.ENSP00000293414.

PTM databases

iPTMnetiQ96NS5.
PhosphoSiteiQ96NS5.

Polymorphism and mutation databases

BioMutaiASB16.
DMDMi296434399.

Proteomic databases

PaxDbiQ96NS5.
PeptideAtlasiQ96NS5.
PRIDEiQ96NS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293414; ENSP00000293414; ENSG00000161664.
GeneIDi92591.
KEGGihsa:92591.
UCSCiuc002ifl.1. human.

Organism-specific databases

CTDi92591.
GeneCardsiASB16.
H-InvDBHIX0202433.
HGNCiHGNC:19768. ASB16.
MIMi615056. gene.
neXtProtiNX_Q96NS5.
PharmGKBiPA134879678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ96NS5.
KOiK10338.
OMAiLHNACAN.
OrthoDBiEOG091G08N2.
PhylomeDBiQ96NS5.
TreeFamiTF333494.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ96NS5.

Miscellaneous databases

GenomeRNAii92591.
PROiQ96NS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161664.
CleanExiHS_ASB16.
ExpressionAtlasiQ96NS5. baseline and differential.
GenevisibleiQ96NS5. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB16_HUMAN
AccessioniPrimary (citable) accession number: Q96NS5
Secondary accession number(s): B2RBC0, Q8WXK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.