Q96NN9 (AIFM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 87.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Apoptosis-inducing factor 3 EC=1.-.-.- Alternative name(s): Apoptosis-inducing factor-like protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 605 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Ref.1 |
| Subcellular location | Mitochondrion. Note: Does not translocate to the nucleus upon induction of apoptosis. Ref.1 |
| Tissue specificity | Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). Ref.1 |
| Domain | The Rieske domain induces apoptosis. |
| Sequence similarities | Belongs to the FAD-dependent oxidoreductase family. Contains 1 Rieske domain. |
Ontologies
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96NN9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96NN9-2) The sequence of this isoform differs from the canonical sequence as follows: 10-10: P → PGAALPT 587-593: Missing. | ||||||
| Isoform 3 (identifier: Q96NN9-3) The sequence of this isoform differs from the canonical sequence as follows: 587-593: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 605 | 605 | Apoptosis-inducing factor 3 | PRO_0000255660 | |||||
Regions | |||||||||
| Domain | 70 – 165 | 96 | Rieske | ||||||
| Nucleotide binding | 201 – 205 | 5 | FAD Potential | ||||||
Sites | |||||||||
| Metal binding | 109 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 111 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen | ||||||
| Metal binding | 128 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 131 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen | ||||||
| Binding site | 235 | 1 | FAD Potential | ||||||
| Binding site | 240 | 1 | FAD Potential | ||||||
| Binding site | 270 | 1 | FAD; via amide nitrogen and carbonyl oxygen Potential | ||||||
| Binding site | 467 | 1 | FAD Potential | ||||||
| Binding site | 514 | 1 | FAD; via carbonyl oxygen Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 10 | 1 | P → PGAALPT in isoform 2. | VSP_021300 | |||||
| Alternative sequence | 587 – 593 | 7 | Missing in isoform 2 and isoform 3. | VSP_021303 | |||||
| Natural variant | 508 | 1 | S → T. Corresponds to variant rs61356271 [ dbSNP | Ensembl ]. | VAR_061553 | |||||
Experimental info | |||||||||
| Sequence conflict | 165 | 1 | V → A in BAC04434. Ref.3 | ||||||
Sequences
| ||||||||||||||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR456342 mRNA. Translation: CAG30228.1. AK055035 mRNA. Translation: BAB70841.1. AK094844 mRNA. Translation: BAC04434.1. AC002470 Genomic DNA. No translation available. CH471176 Genomic DNA. Translation: EAX02924.1. CH471176 Genomic DNA. Translation: EAX02925.1. CH471176 Genomic DNA. Translation: EAX02926.1. CH471176 Genomic DNA. Translation: EAX02927.1. CH471176 Genomic DNA. Translation: EAX02930.1. CH471176 Genomic DNA. Translation: EAX02931.1. BC032485 mRNA. Translation: AAH32485.1. |
| IPI | IPI00043760. IPI00384348. IPI00793477. |
| RefSeq | NP_001018070.1. NM_001018060.2. NP_001139760.1. NM_001146288.1. NP_653305.1. NM_144704.2. |
| UniGene | Hs.723246. |
3D structure databases | |
| ProteinModelPortal | Q96NN9. |
| SMR | Q96NN9. Positions 68-170, 193-593. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96NN9. 1 interaction. |
| STRING | Q96NN9. |
PTM databases | |
| PhosphoSite | Q96NN9. |
Polymorphism databases | |
| DMDM | 74732608. |
Proteomic databases | |
| PRIDE | Q96NN9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000335375; ENSP00000335369; ENSG00000183773. ENST00000399167; ENSP00000382120; ENSG00000183773. |
| GeneID | 150209. |
| KEGG | hsa:150209. |
| UCSC | uc002ztj.1. human. uc002ztk.1. human. uc002ztl.1. human. |
Organism-specific databases | |
| CTD | 150209. |
| GeneCards | GC22P021321. |
| HGNC | HGNC:26398. AIFM3. |
| HPA | HPA001271. |
| neXtProt | NX_Q96NN9. |
| PharmGKB | PA162376173. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG10819. |
| GeneTree | ENSGT00530000063416. |
| HOGENOM | HBG644911. |
| HOVERGEN | HBG052926. |
| InParanoid | Q96NN9. |
| OMA | CHVKDLE. |
| OrthoDB | EOG4STS46. |
| PhylomeDB | Q96NN9. |
Gene expression databases | |
| ArrayExpress | Q96NN9. |
| Bgee | Q96NN9. |
| CleanEx | HS_AIFM3. |
| Genevestigator | Q96NN9. |
| GermOnline | ENSG00000183773. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR017941. Rieske_2Fe-2S. [Graphical view] |
| Gene3D | G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit. G3DSA:2.102.10.10. Rieske_reg. 1 hit. |
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF00355. Rieske. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. PR00469. PNDRDTASEII. |
| SUPFAM | SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit. SSF50022. Rieske_dom. 1 hit. |
| PROSITE | PS51296. RIESKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 86362. |
Entry information
| Entry name | AIFM3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96NN9 Secondary accession number(s): B7WP37 Q8N5E0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with