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Protein

Sodium channel and clathrin linker 1

Gene

SCLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • clustering of voltage-gated sodium channels Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151466-MONOMER.
ReactomeiR-HSA-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel and clathrin linker 1
Alternative name(s):
Sodium channel-associated protein 1
Gene namesi
Name:SCLT1
Synonyms:SAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26406. SCLT1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • ciliary transition fiber Source: MGI
  • clathrin complex Source: Ensembl
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi132320.
OpenTargetsiENSG00000151466.
PharmGKBiPA147357369.

Polymorphism and mutation databases

BioMutaiSCLT1.
DMDMi300669665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003171272 – 688Sodium channel and clathrin linker 1Add BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei681PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96NL6.
MaxQBiQ96NL6.
PaxDbiQ96NL6.
PeptideAtlasiQ96NL6.
PRIDEiQ96NL6.

PTM databases

iPTMnetiQ96NL6.
PhosphoSitePlusiQ96NL6.

Expressioni

Gene expression databases

BgeeiENSG00000151466.
CleanExiHS_SCLT1.
ExpressionAtlasiQ96NL6. baseline and differential.
GenevisibleiQ96NL6. HS.

Organism-specific databases

HPAiHPA036560.
HPA036561.

Interactioni

Subunit structurei

Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi126318. 159 interactors.
IntActiQ96NL6. 159 interactors.
STRINGi9606.ENSP00000281142.

Structurei

3D structure databases

ProteinModelPortaliQ96NL6.
SMRiQ96NL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 673Sequence analysisAdd BLAST605

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE5K. Eukaryota.
ENOG4111QZJ. LUCA.
GeneTreeiENSGT00730000111168.
HOGENOMiHOG000154268.
HOVERGENiHBG098335.
InParanoidiQ96NL6.
OMAiQSVMIEQ.
OrthoDBiEOG091G03T6.
PhylomeDBiQ96NL6.
TreeFamiTF331372.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEIDFLRE QNRRLNEDFR RYQMESFSKY SSVQKAVCQG EGDDTFENLV
60 70 80 90 100
FDQSFLAPLV TEYDKHLGEL NGQLKYYQKQ VGEMKLQLEN VIKENERLHS
110 120 130 140 150
ELKDAVEKKL EAFPLGTEVG TDIYADDETV RNLQEQLQLA NQEKTQAVEL
160 170 180 190 200
WQTVSQELDR LHKLYQEHMT EAQIHVFESQ KQKDQLFDFQ QLTKQLHVTN
210 220 230 240 250
ENMEVTNQQF LKTVTEQSVI IEQLRKKLRQ AKLELRVAVA KVEELTNVTE
260 270 280 290 300
DLQGQMKKKE KDVVSAHGRE EASDRRLQQL QSSIKQLEIR LCVTIQEANQ
310 320 330 340 350
LRTENTHLEK QTRELQAKCN ELENERYEAI VRARNSMQLL EEANLQKSQA
360 370 380 390 400
LLEEKQKEED IEKMKETVSR FVQDATIRTK KEVANTKKQC NIQISRLTEE
410 420 430 440 450
LSALQMECAE KQGQIERVIK EKKAVEEELE KIYREGRGNE SDYRKLEEMH
460 470 480 490 500
QRFLVSERSK DDLQLRLTRA ENRIKQLETD SSEEISRYQE MIQKLQNVLE
510 520 530 540 550
SERENCGLVS EQRLKLQQEN KQLRKETESL RKIALEAQKK AKVKISTMEH
560 570 580 590 600
EFSIKERGFE VQLREMEDSN RNSIVELRHL LATQQKAANR WKEETKKLTE
610 620 630 640 650
SAEIRINNLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR
660 670 680
LQRRLSQAEE RAASASQQLS VITVQRRKAA SLMNLENI
Length:688
Mass (Da):80,910
Last modified:July 13, 2010 - v2
Checksum:i9432F258529C47D3
GO
Isoform 2 (identifier: Q96NL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-610: Missing.

Note: No experimental confirmation available.
Show »
Length:307
Mass (Da):36,042
Checksum:i4587B760E26E200D
GO
Isoform 3 (identifier: Q96NL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-610: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):20,468
Checksum:i282CB741C90CFC0A
GO
Isoform 4 (identifier: Q96NL6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: K → A
     80-688: Missing.

Note: No experimental confirmation available.
Show »
Length:79
Mass (Da):9,323
Checksum:iED2C20AEE54627E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038481441S → C.2 PublicationsCorresponds to variant rs10028124dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03090479K → A in isoform 4. 1 Publication1
Alternative sequenceiVSP_03090580 – 688Missing in isoform 4. 1 PublicationAdd BLAST609
Alternative sequenceiVSP_03090698 – 610Missing in isoform 3. 1 PublicationAdd BLAST513
Alternative sequenceiVSP_030907230 – 610Missing in isoform 2. 1 PublicationAdd BLAST381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055217 mRNA. Translation: BAB70876.1.
AC093783 Genomic DNA. No translation available.
AC093826 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05167.1.
BC064428 mRNA. Translation: AAH64428.1.
BC121057 mRNA. Translation: AAI21058.1.
BC121058 mRNA. Translation: AAI21059.1.
BC128051 mRNA. Translation: AAI28052.1.
CCDSiCCDS3740.1. [Q96NL6-1]
CCDS77958.1. [Q96NL6-4]
RefSeqiNP_001287826.1. NM_001300897.1. [Q96NL6-4]
NP_001287827.1. NM_001300898.1.
NP_653244.2. NM_144643.3. [Q96NL6-1]
UniGeneiHs.654690.

Genome annotation databases

EnsembliENST00000281142; ENSP00000281142; ENSG00000151466. [Q96NL6-1]
ENST00000439369; ENSP00000395292; ENSG00000151466. [Q96NL6-3]
ENST00000511426; ENSP00000420861; ENSG00000151466. [Q96NL6-4]
GeneIDi132320.
KEGGihsa:132320.
UCSCiuc003igp.3. human. [Q96NL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055217 mRNA. Translation: BAB70876.1.
AC093783 Genomic DNA. No translation available.
AC093826 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05167.1.
BC064428 mRNA. Translation: AAH64428.1.
BC121057 mRNA. Translation: AAI21058.1.
BC121058 mRNA. Translation: AAI21059.1.
BC128051 mRNA. Translation: AAI28052.1.
CCDSiCCDS3740.1. [Q96NL6-1]
CCDS77958.1. [Q96NL6-4]
RefSeqiNP_001287826.1. NM_001300897.1. [Q96NL6-4]
NP_001287827.1. NM_001300898.1.
NP_653244.2. NM_144643.3. [Q96NL6-1]
UniGeneiHs.654690.

3D structure databases

ProteinModelPortaliQ96NL6.
SMRiQ96NL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126318. 159 interactors.
IntActiQ96NL6. 159 interactors.
STRINGi9606.ENSP00000281142.

PTM databases

iPTMnetiQ96NL6.
PhosphoSitePlusiQ96NL6.

Polymorphism and mutation databases

BioMutaiSCLT1.
DMDMi300669665.

Proteomic databases

EPDiQ96NL6.
MaxQBiQ96NL6.
PaxDbiQ96NL6.
PeptideAtlasiQ96NL6.
PRIDEiQ96NL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281142; ENSP00000281142; ENSG00000151466. [Q96NL6-1]
ENST00000439369; ENSP00000395292; ENSG00000151466. [Q96NL6-3]
ENST00000511426; ENSP00000420861; ENSG00000151466. [Q96NL6-4]
GeneIDi132320.
KEGGihsa:132320.
UCSCiuc003igp.3. human. [Q96NL6-1]

Organism-specific databases

CTDi132320.
DisGeNETi132320.
GeneCardsiSCLT1.
H-InvDBHIX0004499.
HGNCiHGNC:26406. SCLT1.
HPAiHPA036560.
HPA036561.
MIMi611399. gene.
neXtProtiNX_Q96NL6.
OpenTargetsiENSG00000151466.
PharmGKBiPA147357369.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5K. Eukaryota.
ENOG4111QZJ. LUCA.
GeneTreeiENSGT00730000111168.
HOGENOMiHOG000154268.
HOVERGENiHBG098335.
InParanoidiQ96NL6.
OMAiQSVMIEQ.
OrthoDBiEOG091G03T6.
PhylomeDBiQ96NL6.
TreeFamiTF331372.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151466-MONOMER.
ReactomeiR-HSA-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

ChiTaRSiSCLT1. human.
GenomeRNAii132320.
PROiQ96NL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151466.
CleanExiHS_SCLT1.
ExpressionAtlasiQ96NL6. baseline and differential.
GenevisibleiQ96NL6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSCLT1_HUMAN
AccessioniPrimary (citable) accession number: Q96NL6
Secondary accession number(s): A4QN04, Q0VAH2, Q6P2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.