Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96NL6

- SCLT1_HUMAN

UniProt

Q96NL6 - SCLT1_HUMAN

Protein

Sodium channel and clathrin linker 1

Gene

SCLT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization By similarity.By similarity

    GO - Molecular functioni

    1. sodium channel regulator activity Source: Ensembl

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. clustering of voltage-gated sodium channels Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel and clathrin linker 1
    Alternative name(s):
    Sodium channel-associated protein 1
    Gene namesi
    Name:SCLT1
    Synonyms:SAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26406. SCLT1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication
    Note: Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. centrosome Source: UniProtKB
    3. ciliary transition fiber Source: MGI
    4. clathrin complex Source: Ensembl
    5. cytoplasm Source: HPA
    6. extracellular vesicular exosome Source: UniProt
    7. microtubule cytoskeleton Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147357369.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 688687Sodium channel and clathrin linker 1PRO_0000317127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96NL6.
    PaxDbiQ96NL6.
    PRIDEiQ96NL6.

    PTM databases

    PhosphoSiteiQ96NL6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96NL6.
    BgeeiQ96NL6.
    CleanExiHS_SCLT1.
    GenevestigatoriQ96NL6.

    Organism-specific databases

    HPAiHPA036561.

    Interactioni

    Subunit structurei

    Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi126318. 4 interactions.
    IntActiQ96NL6. 6 interactions.
    STRINGi9606.ENSP00000281142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili69 – 673605Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG121178.
    HOGENOMiHOG000154268.
    HOVERGENiHBG098335.
    InParanoidiQ96NL6.
    OMAiATIRTKK.
    OrthoDBiEOG74FF0G.
    PhylomeDBiQ96NL6.
    TreeFamiTF331372.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96NL6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEIDFLRE QNRRLNEDFR RYQMESFSKY SSVQKAVCQG EGDDTFENLV    50
    FDQSFLAPLV TEYDKHLGEL NGQLKYYQKQ VGEMKLQLEN VIKENERLHS 100
    ELKDAVEKKL EAFPLGTEVG TDIYADDETV RNLQEQLQLA NQEKTQAVEL 150
    WQTVSQELDR LHKLYQEHMT EAQIHVFESQ KQKDQLFDFQ QLTKQLHVTN 200
    ENMEVTNQQF LKTVTEQSVI IEQLRKKLRQ AKLELRVAVA KVEELTNVTE 250
    DLQGQMKKKE KDVVSAHGRE EASDRRLQQL QSSIKQLEIR LCVTIQEANQ 300
    LRTENTHLEK QTRELQAKCN ELENERYEAI VRARNSMQLL EEANLQKSQA 350
    LLEEKQKEED IEKMKETVSR FVQDATIRTK KEVANTKKQC NIQISRLTEE 400
    LSALQMECAE KQGQIERVIK EKKAVEEELE KIYREGRGNE SDYRKLEEMH 450
    QRFLVSERSK DDLQLRLTRA ENRIKQLETD SSEEISRYQE MIQKLQNVLE 500
    SERENCGLVS EQRLKLQQEN KQLRKETESL RKIALEAQKK AKVKISTMEH 550
    EFSIKERGFE VQLREMEDSN RNSIVELRHL LATQQKAANR WKEETKKLTE 600
    SAEIRINNLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR 650
    LQRRLSQAEE RAASASQQLS VITVQRRKAA SLMNLENI 688
    Length:688
    Mass (Da):80,910
    Last modified:July 13, 2010 - v2
    Checksum:i9432F258529C47D3
    GO
    Isoform 2 (identifier: Q96NL6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         230-610: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:307
    Mass (Da):36,042
    Checksum:i4587B760E26E200D
    GO
    Isoform 3 (identifier: Q96NL6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-610: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:175
    Mass (Da):20,468
    Checksum:i282CB741C90CFC0A
    GO
    Isoform 4 (identifier: Q96NL6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-79: K → A
         80-688: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:79
    Mass (Da):9,323
    Checksum:iED2C20AEE54627E8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti441 – 4411S → C.2 Publications
    Corresponds to variant rs10028124 [ dbSNP | Ensembl ].
    VAR_038481

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei79 – 791K → A in isoform 4. 1 PublicationVSP_030904
    Alternative sequencei80 – 688609Missing in isoform 4. 1 PublicationVSP_030905Add
    BLAST
    Alternative sequencei98 – 610513Missing in isoform 3. 1 PublicationVSP_030906Add
    BLAST
    Alternative sequencei230 – 610381Missing in isoform 2. 1 PublicationVSP_030907Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055217 mRNA. Translation: BAB70876.1.
    AC093783 Genomic DNA. No translation available.
    AC093826 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05167.1.
    BC064428 mRNA. Translation: AAH64428.1.
    BC121057 mRNA. Translation: AAI21058.1.
    BC121058 mRNA. Translation: AAI21059.1.
    BC128051 mRNA. Translation: AAI28052.1.
    CCDSiCCDS3740.1. [Q96NL6-1]
    RefSeqiNP_653244.2. NM_144643.2. [Q96NL6-1]
    UniGeneiHs.654690.

    Genome annotation databases

    EnsembliENST00000281142; ENSP00000281142; ENSG00000151466. [Q96NL6-1]
    ENST00000439369; ENSP00000395292; ENSG00000151466. [Q96NL6-3]
    ENST00000511426; ENSP00000420861; ENSG00000151466. [Q96NL6-4]
    GeneIDi132320.
    KEGGihsa:132320.
    UCSCiuc003ign.2. human. [Q96NL6-1]
    uc003igq.2. human. [Q96NL6-2]
    uc003igt.4. human. [Q96NL6-4]
    uc010iob.1. human. [Q96NL6-3]

    Polymorphism databases

    DMDMi300669665.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055217 mRNA. Translation: BAB70876.1 .
    AC093783 Genomic DNA. No translation available.
    AC093826 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05167.1 .
    BC064428 mRNA. Translation: AAH64428.1 .
    BC121057 mRNA. Translation: AAI21058.1 .
    BC121058 mRNA. Translation: AAI21059.1 .
    BC128051 mRNA. Translation: AAI28052.1 .
    CCDSi CCDS3740.1. [Q96NL6-1 ]
    RefSeqi NP_653244.2. NM_144643.2. [Q96NL6-1 ]
    UniGenei Hs.654690.

    3D structure databases

    ProteinModelPortali Q96NL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126318. 4 interactions.
    IntActi Q96NL6. 6 interactions.
    STRINGi 9606.ENSP00000281142.

    PTM databases

    PhosphoSitei Q96NL6.

    Polymorphism databases

    DMDMi 300669665.

    Proteomic databases

    MaxQBi Q96NL6.
    PaxDbi Q96NL6.
    PRIDEi Q96NL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281142 ; ENSP00000281142 ; ENSG00000151466 . [Q96NL6-1 ]
    ENST00000439369 ; ENSP00000395292 ; ENSG00000151466 . [Q96NL6-3 ]
    ENST00000511426 ; ENSP00000420861 ; ENSG00000151466 . [Q96NL6-4 ]
    GeneIDi 132320.
    KEGGi hsa:132320.
    UCSCi uc003ign.2. human. [Q96NL6-1 ]
    uc003igq.2. human. [Q96NL6-2 ]
    uc003igt.4. human. [Q96NL6-4 ]
    uc010iob.1. human. [Q96NL6-3 ]

    Organism-specific databases

    CTDi 132320.
    GeneCardsi GC04M129805.
    H-InvDB HIX0004499.
    HGNCi HGNC:26406. SCLT1.
    HPAi HPA036561.
    MIMi 611399. gene.
    neXtProti NX_Q96NL6.
    PharmGKBi PA147357369.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121178.
    HOGENOMi HOG000154268.
    HOVERGENi HBG098335.
    InParanoidi Q96NL6.
    OMAi ATIRTKK.
    OrthoDBi EOG74FF0G.
    PhylomeDBi Q96NL6.
    TreeFami TF331372.

    Miscellaneous databases

    ChiTaRSi SCLT1. human.
    GenomeRNAii 132320.
    NextBioi 83079.
    PROi Q96NL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96NL6.
    Bgeei Q96NL6.
    CleanExi HS_SCLT1.
    Genevestigatori Q96NL6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-441.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-441.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Lung.
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. "Centriole distal appendages promote membrane docking, leading to cilia initiation."
      Tanos B.E., Yang H.J., Soni R., Wang W.J., Macaluso F.P., Asara J.M., Tsou M.F.
      Genes Dev. 27:163-168(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSCLT1_HUMAN
    AccessioniPrimary (citable) accession number: Q96NL6
    Secondary accession number(s): A4QN04, Q0VAH2, Q6P2M4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3