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Q96NL6 (SCLT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium channel and clathrin linker 1
Alternative name(s):
Sodium channel-associated protein 1
Gene names
Name:SCLT1
Synonyms:SAP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization By similarity.

Subunit structure

Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Note: Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Ref.6

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96NL6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96NL6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-610: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96NL6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     98-610: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q96NL6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: K → A
     80-688: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 688687Sodium channel and clathrin linker 1
PRO_0000317127

Regions

Coiled coil69 – 673605 Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.5

Natural variations

Alternative sequence791K → A in isoform 4.
VSP_030904
Alternative sequence80 – 688609Missing in isoform 4.
VSP_030905
Alternative sequence98 – 610513Missing in isoform 3.
VSP_030906
Alternative sequence230 – 610381Missing in isoform 2.
VSP_030907
Natural variant4411S → C. Ref.1 Ref.3
Corresponds to variant rs10028124 [ dbSNP | Ensembl ].
VAR_038481

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 9432F258529C47D3

FASTA68880,910
        10         20         30         40         50         60 
MAAEIDFLRE QNRRLNEDFR RYQMESFSKY SSVQKAVCQG EGDDTFENLV FDQSFLAPLV 

        70         80         90        100        110        120 
TEYDKHLGEL NGQLKYYQKQ VGEMKLQLEN VIKENERLHS ELKDAVEKKL EAFPLGTEVG 

       130        140        150        160        170        180 
TDIYADDETV RNLQEQLQLA NQEKTQAVEL WQTVSQELDR LHKLYQEHMT EAQIHVFESQ 

       190        200        210        220        230        240 
KQKDQLFDFQ QLTKQLHVTN ENMEVTNQQF LKTVTEQSVI IEQLRKKLRQ AKLELRVAVA 

       250        260        270        280        290        300 
KVEELTNVTE DLQGQMKKKE KDVVSAHGRE EASDRRLQQL QSSIKQLEIR LCVTIQEANQ 

       310        320        330        340        350        360 
LRTENTHLEK QTRELQAKCN ELENERYEAI VRARNSMQLL EEANLQKSQA LLEEKQKEED 

       370        380        390        400        410        420 
IEKMKETVSR FVQDATIRTK KEVANTKKQC NIQISRLTEE LSALQMECAE KQGQIERVIK 

       430        440        450        460        470        480 
EKKAVEEELE KIYREGRGNE SDYRKLEEMH QRFLVSERSK DDLQLRLTRA ENRIKQLETD 

       490        500        510        520        530        540 
SSEEISRYQE MIQKLQNVLE SERENCGLVS EQRLKLQQEN KQLRKETESL RKIALEAQKK 

       550        560        570        580        590        600 
AKVKISTMEH EFSIKERGFE VQLREMEDSN RNSIVELRHL LATQQKAANR WKEETKKLTE 

       610        620        630        640        650        660 
SAEIRINNLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR LQRRLSQAEE 

       670        680 
RAASASQQLS VITVQRRKAA SLMNLENI 

« Hide

Isoform 2 [UniParc].

Checksum: 4587B760E26E200D
Show »

FASTA30736,042
Isoform 3 [UniParc].

Checksum: 282CB741C90CFC0A
Show »

FASTA17520,468
Isoform 4 [UniParc].

Checksum: ED2C20AEE54627E8
Show »

FASTA799,323

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-441.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-441.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Lung.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[6]"Centriole distal appendages promote membrane docking, leading to cilia initiation."
Tanos B.E., Yang H.J., Soni R., Wang W.J., Macaluso F.P., Asara J.M., Tsou M.F.
Genes Dev. 27:163-168(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055217 mRNA. Translation: BAB70876.1.
AC093783 Genomic DNA. No translation available.
AC093826 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05167.1.
BC064428 mRNA. Translation: AAH64428.1.
BC121057 mRNA. Translation: AAI21058.1.
BC121058 mRNA. Translation: AAI21059.1.
BC128051 mRNA. Translation: AAI28052.1.
CCDSCCDS3740.1. [Q96NL6-1]
RefSeqNP_653244.2. NM_144643.2. [Q96NL6-1]
UniGeneHs.654690.

3D structure databases

ProteinModelPortalQ96NL6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126318. 4 interactions.
IntActQ96NL6. 6 interactions.
STRING9606.ENSP00000281142.

PTM databases

PhosphoSiteQ96NL6.

Polymorphism databases

DMDM300669665.

Proteomic databases

MaxQBQ96NL6.
PaxDbQ96NL6.
PRIDEQ96NL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281142; ENSP00000281142; ENSG00000151466. [Q96NL6-1]
ENST00000434680; ENSP00000401539; ENSG00000151466. [Q96NL6-2]
ENST00000439369; ENSP00000395292; ENSG00000151466. [Q96NL6-3]
ENST00000511426; ENSP00000420861; ENSG00000151466. [Q96NL6-4]
GeneID132320.
KEGGhsa:132320.
UCSCuc003ign.2. human. [Q96NL6-1]
uc003igq.2. human. [Q96NL6-2]
uc003igt.4. human. [Q96NL6-4]
uc010iob.1. human. [Q96NL6-3]

Organism-specific databases

CTD132320.
GeneCardsGC04M129805.
H-InvDBHIX0004499.
HGNCHGNC:26406. SCLT1.
HPAHPA036561.
MIM611399. gene.
neXtProtNX_Q96NL6.
PharmGKBPA147357369.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG121178.
HOGENOMHOG000154268.
HOVERGENHBG098335.
InParanoidQ96NL6.
OMAATIRTKK.
OrthoDBEOG74FF0G.
PhylomeDBQ96NL6.
TreeFamTF331372.

Gene expression databases

ArrayExpressQ96NL6.
BgeeQ96NL6.
CleanExHS_SCLT1.
GenevestigatorQ96NL6.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSSCLT1. human.
GenomeRNAi132320.
NextBio83079.
PROQ96NL6.
SOURCESearch...

Entry information

Entry nameSCLT1_HUMAN
AccessionPrimary (citable) accession number: Q96NL6
Secondary accession number(s): A4QN04, Q0VAH2, Q6P2M4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM