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Q96NL6

- SCLT1_HUMAN

UniProt

Q96NL6 - SCLT1_HUMAN

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Protein
Sodium channel and clathrin linker 1
Gene
SCLT1, SAP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization By similarity.

GO - Molecular functioni

  1. sodium channel regulator activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. clustering of voltage-gated sodium channels Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel and clathrin linker 1
Alternative name(s):
Sodium channel-associated protein 1
Gene namesi
Name:SCLT1
Synonyms:SAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:26406. SCLT1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole
Note: Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.1 Publication

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. centrosome Source: UniProtKB
  3. ciliary transition fiber Source: MGI
  4. clathrin complex Source: Ensembl
  5. cytoplasm Source: HPA
  6. extracellular vesicular exosome Source: UniProt
  7. microtubule cytoskeleton Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 688687Sodium channel and clathrin linker 1
PRO_0000317127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96NL6.
PaxDbiQ96NL6.
PRIDEiQ96NL6.

PTM databases

PhosphoSiteiQ96NL6.

Expressioni

Gene expression databases

ArrayExpressiQ96NL6.
BgeeiQ96NL6.
CleanExiHS_SCLT1.
GenevestigatoriQ96NL6.

Organism-specific databases

HPAiHPA036561.

Interactioni

Subunit structurei

Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 By similarity.

Protein-protein interaction databases

BioGridi126318. 4 interactions.
IntActiQ96NL6. 6 interactions.
STRINGi9606.ENSP00000281142.

Structurei

3D structure databases

ProteinModelPortaliQ96NL6.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 673605 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG121178.
HOGENOMiHOG000154268.
HOVERGENiHBG098335.
InParanoidiQ96NL6.
OMAiATIRTKK.
OrthoDBiEOG74FF0G.
PhylomeDBiQ96NL6.
TreeFamiTF331372.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96NL6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAEIDFLRE QNRRLNEDFR RYQMESFSKY SSVQKAVCQG EGDDTFENLV    50
FDQSFLAPLV TEYDKHLGEL NGQLKYYQKQ VGEMKLQLEN VIKENERLHS 100
ELKDAVEKKL EAFPLGTEVG TDIYADDETV RNLQEQLQLA NQEKTQAVEL 150
WQTVSQELDR LHKLYQEHMT EAQIHVFESQ KQKDQLFDFQ QLTKQLHVTN 200
ENMEVTNQQF LKTVTEQSVI IEQLRKKLRQ AKLELRVAVA KVEELTNVTE 250
DLQGQMKKKE KDVVSAHGRE EASDRRLQQL QSSIKQLEIR LCVTIQEANQ 300
LRTENTHLEK QTRELQAKCN ELENERYEAI VRARNSMQLL EEANLQKSQA 350
LLEEKQKEED IEKMKETVSR FVQDATIRTK KEVANTKKQC NIQISRLTEE 400
LSALQMECAE KQGQIERVIK EKKAVEEELE KIYREGRGNE SDYRKLEEMH 450
QRFLVSERSK DDLQLRLTRA ENRIKQLETD SSEEISRYQE MIQKLQNVLE 500
SERENCGLVS EQRLKLQQEN KQLRKETESL RKIALEAQKK AKVKISTMEH 550
EFSIKERGFE VQLREMEDSN RNSIVELRHL LATQQKAANR WKEETKKLTE 600
SAEIRINNLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR 650
LQRRLSQAEE RAASASQQLS VITVQRRKAA SLMNLENI 688
Length:688
Mass (Da):80,910
Last modified:July 13, 2010 - v2
Checksum:i9432F258529C47D3
GO
Isoform 2 (identifier: Q96NL6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-610: Missing.

Note: No experimental confirmation available.

Show »
Length:307
Mass (Da):36,042
Checksum:i4587B760E26E200D
GO
Isoform 3 (identifier: Q96NL6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-610: Missing.

Note: No experimental confirmation available.

Show »
Length:175
Mass (Da):20,468
Checksum:i282CB741C90CFC0A
GO
Isoform 4 (identifier: Q96NL6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: K → A
     80-688: Missing.

Note: No experimental confirmation available.

Show »
Length:79
Mass (Da):9,323
Checksum:iED2C20AEE54627E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti441 – 4411S → C.2 Publications
Corresponds to variant rs10028124 [ dbSNP | Ensembl ].
VAR_038481

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 791K → A in isoform 4.
VSP_030904
Alternative sequencei80 – 688609Missing in isoform 4.
VSP_030905Add
BLAST
Alternative sequencei98 – 610513Missing in isoform 3.
VSP_030906Add
BLAST
Alternative sequencei230 – 610381Missing in isoform 2.
VSP_030907Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055217 mRNA. Translation: BAB70876.1.
AC093783 Genomic DNA. No translation available.
AC093826 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05167.1.
BC064428 mRNA. Translation: AAH64428.1.
BC121057 mRNA. Translation: AAI21058.1.
BC121058 mRNA. Translation: AAI21059.1.
BC128051 mRNA. Translation: AAI28052.1.
CCDSiCCDS3740.1. [Q96NL6-1]
RefSeqiNP_653244.2. NM_144643.2. [Q96NL6-1]
UniGeneiHs.654690.

Genome annotation databases

EnsembliENST00000281142; ENSP00000281142; ENSG00000151466. [Q96NL6-1]
ENST00000434680; ENSP00000401539; ENSG00000151466. [Q96NL6-2]
ENST00000439369; ENSP00000395292; ENSG00000151466. [Q96NL6-3]
ENST00000511426; ENSP00000420861; ENSG00000151466. [Q96NL6-4]
GeneIDi132320.
KEGGihsa:132320.
UCSCiuc003ign.2. human. [Q96NL6-1]
uc003igq.2. human. [Q96NL6-2]
uc003igt.4. human. [Q96NL6-4]
uc010iob.1. human. [Q96NL6-3]

Polymorphism databases

DMDMi300669665.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055217 mRNA. Translation: BAB70876.1 .
AC093783 Genomic DNA. No translation available.
AC093826 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05167.1 .
BC064428 mRNA. Translation: AAH64428.1 .
BC121057 mRNA. Translation: AAI21058.1 .
BC121058 mRNA. Translation: AAI21059.1 .
BC128051 mRNA. Translation: AAI28052.1 .
CCDSi CCDS3740.1. [Q96NL6-1 ]
RefSeqi NP_653244.2. NM_144643.2. [Q96NL6-1 ]
UniGenei Hs.654690.

3D structure databases

ProteinModelPortali Q96NL6.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126318. 4 interactions.
IntActi Q96NL6. 6 interactions.
STRINGi 9606.ENSP00000281142.

PTM databases

PhosphoSitei Q96NL6.

Polymorphism databases

DMDMi 300669665.

Proteomic databases

MaxQBi Q96NL6.
PaxDbi Q96NL6.
PRIDEi Q96NL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281142 ; ENSP00000281142 ; ENSG00000151466 . [Q96NL6-1 ]
ENST00000434680 ; ENSP00000401539 ; ENSG00000151466 . [Q96NL6-2 ]
ENST00000439369 ; ENSP00000395292 ; ENSG00000151466 . [Q96NL6-3 ]
ENST00000511426 ; ENSP00000420861 ; ENSG00000151466 . [Q96NL6-4 ]
GeneIDi 132320.
KEGGi hsa:132320.
UCSCi uc003ign.2. human. [Q96NL6-1 ]
uc003igq.2. human. [Q96NL6-2 ]
uc003igt.4. human. [Q96NL6-4 ]
uc010iob.1. human. [Q96NL6-3 ]

Organism-specific databases

CTDi 132320.
GeneCardsi GC04M129805.
H-InvDB HIX0004499.
HGNCi HGNC:26406. SCLT1.
HPAi HPA036561.
MIMi 611399. gene.
neXtProti NX_Q96NL6.
PharmGKBi PA147357369.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121178.
HOGENOMi HOG000154268.
HOVERGENi HBG098335.
InParanoidi Q96NL6.
OMAi ATIRTKK.
OrthoDBi EOG74FF0G.
PhylomeDBi Q96NL6.
TreeFami TF331372.

Miscellaneous databases

ChiTaRSi SCLT1. human.
GenomeRNAii 132320.
NextBioi 83079.
PROi Q96NL6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96NL6.
Bgeei Q96NL6.
CleanExi HS_SCLT1.
Genevestigatori Q96NL6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-441.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-441.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Lung.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "Centriole distal appendages promote membrane docking, leading to cilia initiation."
    Tanos B.E., Yang H.J., Soni R., Wang W.J., Macaluso F.P., Asara J.M., Tsou M.F.
    Genes Dev. 27:163-168(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSCLT1_HUMAN
AccessioniPrimary (citable) accession number: Q96NL6
Secondary accession number(s): A4QN04, Q0VAH2, Q6P2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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