Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96NL3

- ZN599_HUMAN

UniProt

Q96NL3 - ZN599_HUMAN

Protein

Zinc finger protein 599

Gene

ZNF599

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri199 – 22123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri227 – 24923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 27723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri283 – 30523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri339 – 36123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri367 – 38923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri395 – 41723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri479 – 50123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri507 – 52923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri535 – 55723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri563 – 58523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 599
    Gene namesi
    Name:ZNF599
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26408. ZNF599.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Zinc finger protein 599PRO_0000234592Add
    BLAST

    Proteomic databases

    PaxDbiQ96NL3.
    PRIDEiQ96NL3.

    PTM databases

    PhosphoSiteiQ96NL3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96NL3.
    BgeeiQ96NL3.
    CleanExiHS_ZNF599.
    GenevestigatoriQ96NL3.

    Organism-specific databases

    HPAiHPA014701.

    Interactioni

    Protein-protein interaction databases

    BioGridi127117. 1 interaction.
    IntActiQ96NL3. 1 interaction.
    STRINGi9606.ENSP00000333802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NL3.
    SMRiQ96NL3. Positions 198-587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 8072KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri199 – 22123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri227 – 24923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 27723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri283 – 30523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri339 – 36123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri367 – 38923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri395 – 41723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri479 – 50123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri507 – 52923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri535 – 55723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri563 – 58523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96NL3.
    KOiK09228.
    OMAiFCDNFAL.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96NL3.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 15 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96NL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPALALVS FEDVVVTFTG EEWGHLDLAQ RTLYQEVMLE TCRLLVSLGH    50
    PVPKPELIYL LEHGQELWTV KRGLSQSTCA GEKAKPKITE PTASQLAFSE 100
    ESSFQELLAQ RSSRDSRLGQ ARDEEKLIKI QEGNLRPGTN PHKEICPEKL 150
    SYKHDDLEPD DSLGLRVLQE RVTPQDALHE CDSQGPGKDP MTDARNNPYT 200
    CTECGKGFSK KWALVRHQQI HAGVKPYECN ECGKACRYMA DVIRHMRLHT 250
    GEKPYKCIEC GKAFKRRFHL TEHQRIHTGD KPYECKECGK AFTHRSSFIQ 300
    HNMTHTREKP FLCKECGKAF YYSSSFAQHM RIHTGKKLYE CGECGKAFTH 350
    RSTFIQHNVT HTGEKPFLCK ECGKTFCLNS SFTQHMRIHT GEKPYECGEC 400
    GKAFTHRSTF IRHKRTHTGE KPFECKECGK AFCDSSSLIQ HMRIHTGEKP 450
    YECSECGKAF THHSVFIRHN RTHSGQKPLE CKECAKAFYY SSSFTRHMRI 500
    HTGEKPYVCR ECGKAFTQPA NFVRHNRIHT GEKPFECKEC EKAFCDNFAL 550
    TQHMRTHTGE KPFECNECGK TFSHSSSFTH HRKIHTRV 588
    Length:588
    Mass (Da):67,492
    Last modified:December 1, 2001 - v1
    Checksum:i0A6E87DD0A817D57
    GO
    Isoform 2 (identifier: Q96NL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-95: GEKAKPKITEPTASQ → ASFSLLWKSYHPGHG
         96-588: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:95
    Mass (Da):10,606
    Checksum:iF9A4A7F085A0E1D9
    GO

    Sequence cautioni

    The sequence AAH44615.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti459 – 4591A → T in AAH44615. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti178 – 1781L → F De novo variant found in a patient with mental retardation. 1 Publication
    VAR_065087

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 9515GEKAK…PTASQ → ASFSLLWKSYHPGHG in isoform 2. 1 PublicationVSP_018385Add
    BLAST
    Alternative sequencei96 – 588493Missing in isoform 2. 1 PublicationVSP_018386Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055225 mRNA. Translation: BAB70879.1.
    BC044615 mRNA. Translation: AAH44615.1. Different initiation.
    BC092428 mRNA. Translation: AAH92428.1.
    CCDSiCCDS32991.1. [Q96NL3-1]
    RefSeqiNP_001007249.1. NM_001007248.2. [Q96NL3-1]
    UniGeneiHs.590961.

    Genome annotation databases

    EnsembliENST00000329285; ENSP00000333802; ENSG00000153896. [Q96NL3-1]
    ENST00000587354; ENSP00000468446; ENSG00000153896. [Q96NL3-2]
    GeneIDi148103.
    KEGGihsa:148103.
    UCSCiuc010edm.2. human. [Q96NL3-1]
    uc010edo.3. human. [Q96NL3-2]

    Polymorphism databases

    DMDMi74762682.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055225 mRNA. Translation: BAB70879.1 .
    BC044615 mRNA. Translation: AAH44615.1 . Different initiation.
    BC092428 mRNA. Translation: AAH92428.1 .
    CCDSi CCDS32991.1. [Q96NL3-1 ]
    RefSeqi NP_001007249.1. NM_001007248.2. [Q96NL3-1 ]
    UniGenei Hs.590961.

    3D structure databases

    ProteinModelPortali Q96NL3.
    SMRi Q96NL3. Positions 198-587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127117. 1 interaction.
    IntActi Q96NL3. 1 interaction.
    STRINGi 9606.ENSP00000333802.

    PTM databases

    PhosphoSitei Q96NL3.

    Polymorphism databases

    DMDMi 74762682.

    Proteomic databases

    PaxDbi Q96NL3.
    PRIDEi Q96NL3.

    Protocols and materials databases

    DNASUi 148103.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329285 ; ENSP00000333802 ; ENSG00000153896 . [Q96NL3-1 ]
    ENST00000587354 ; ENSP00000468446 ; ENSG00000153896 . [Q96NL3-2 ]
    GeneIDi 148103.
    KEGGi hsa:148103.
    UCSCi uc010edm.2. human. [Q96NL3-1 ]
    uc010edo.3. human. [Q96NL3-2 ]

    Organism-specific databases

    CTDi 148103.
    GeneCardsi GC19M035248.
    HGNCi HGNC:26408. ZNF599.
    HPAi HPA014701.
    neXtProti NX_Q96NL3.
    PharmGKBi PA134983786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96NL3.
    KOi K09228.
    OMAi FCDNFAL.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96NL3.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 148103.
    NextBioi 85827.
    PROi Q96NL3.

    Gene expression databases

    ArrayExpressi Q96NL3.
    Bgeei Q96NL3.
    CleanExi HS_ZNF599.
    Genevestigatori Q96NL3.

    Family and domain databases

    Gene3Di 3.30.160.60. 15 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-588 (ISOFORM 1).
      Tissue: Testis.
    3. Cited for: VARIANT PHE-178.

    Entry informationi

    Entry nameiZN599_HUMAN
    AccessioniPrimary (citable) accession number: Q96NL3
    Secondary accession number(s): Q569K0, Q5PRG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3