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Q96NL1

- TMM74_HUMAN

UniProt

Q96NL1 - TMM74_HUMAN

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Protein

Transmembrane protein 74

Gene

TMEM74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.2 Publications

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 74
Gene namesi
Name:TMEM74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:26409. TMEM74.

Subcellular locationi

Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic vesicleautophagosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Transmembrane protein 74PRO_0000259600Add
BLAST

Proteomic databases

PaxDbiQ96NL1.
PRIDEiQ96NL1.

PTM databases

PhosphoSiteiQ96NL1.

Expressioni

Tissue specificityi

Expressed in heart, lung, and placenta.1 Publication

Gene expression databases

BgeeiQ96NL1.
CleanExiHS_TMEM74.
GenevestigatoriQ96NL1.

Organism-specific databases

HPAiHPA015672.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297459.

Structurei

3D structure databases

ProteinModelPortaliQ96NL1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM74 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47300.
GeneTreeiENSGT00530000063880.
HOGENOMiHOG000112021.
HOVERGENiHBG094072.
InParanoidiQ96NL1.
OMAiNEWSHEA.
OrthoDBiEOG7HF1KD.
PhylomeDBiQ96NL1.
TreeFamiTF335735.

Family and domain databases

InterProiIPR029696. Tmem74.
[Graphical view]
PANTHERiPTHR16125:SF3. PTHR16125:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96NL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELHYLAKKS NQADLCDARD WSSRGLPGDQ ADTAATRAAL CCQKQCASTP
60 70 80 90 100
RATEMEGSKL SSSPASPSSS LQNSTLQPDA FPPGLLHSGN NQITAERKVC
110 120 130 140 150
NCCSQELETS FTYVDKNINL EQRNRSSPSA KGHNHPGELG WENPNEWSQE
160 170 180 190 200
AAISLISEEE DDTSSEATSS GKSIDYGFIS AILFLVTGIL LVIISYIVPR
210 220 230 240 250
EVTVDPNTVA AREMERLEKE SARLGAHLDR CVIAGLCLLT LGGVILSCLL
260 270 280 290 300
MMSMWKGELY RRNRFASSKE SAKLYGSFNF RMKTSTNENT LELSLVEEDA

LAVQS
Length:305
Mass (Da):33,338
Last modified:December 1, 2001 - v1
Checksum:i9521A382F126B683
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055230 mRNA. Translation: BAB70881.1.
BC030710 mRNA. Translation: AAH30710.1.
CCDSiCCDS6310.1.
RefSeqiNP_694560.1. NM_153015.1.
XP_005250862.1. XM_005250805.1.
UniGeneiHs.99439.

Genome annotation databases

EnsembliENST00000297459; ENSP00000297459; ENSG00000164841.
GeneIDi157753.
KEGGihsa:157753.
UCSCiuc003ymy.1. human.

Polymorphism databases

DMDMi74732587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055230 mRNA. Translation: BAB70881.1 .
BC030710 mRNA. Translation: AAH30710.1 .
CCDSi CCDS6310.1.
RefSeqi NP_694560.1. NM_153015.1.
XP_005250862.1. XM_005250805.1.
UniGenei Hs.99439.

3D structure databases

ProteinModelPortali Q96NL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000297459.

PTM databases

PhosphoSitei Q96NL1.

Polymorphism databases

DMDMi 74732587.

Proteomic databases

PaxDbi Q96NL1.
PRIDEi Q96NL1.

Protocols and materials databases

DNASUi 157753.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297459 ; ENSP00000297459 ; ENSG00000164841 .
GeneIDi 157753.
KEGGi hsa:157753.
UCSCi uc003ymy.1. human.

Organism-specific databases

CTDi 157753.
GeneCardsi GC08M109619.
HGNCi HGNC:26409. TMEM74.
HPAi HPA015672.
MIMi 613935. gene.
neXtProti NX_Q96NL1.
PharmGKBi PA142670785.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47300.
GeneTreei ENSGT00530000063880.
HOGENOMi HOG000112021.
HOVERGENi HBG094072.
InParanoidi Q96NL1.
OMAi NEWSHEA.
OrthoDBi EOG7HF1KD.
PhylomeDBi Q96NL1.
TreeFami TF335735.

Miscellaneous databases

GenomeRNAii 157753.
NextBioi 87542.
PROi Q96NL1.
SOURCEi Search...

Gene expression databases

Bgeei Q96NL1.
CleanExi HS_TMEM74.
Genevestigatori Q96NL1.

Family and domain databases

InterProi IPR029696. Tmem74.
[Graphical view ]
PANTHERi PTHR16125:SF3. PTHR16125:SF3. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "TMEM74, a lysosome and autophagosome protein, regulates autophagy."
    Yu C., Wang L., Lv B., Lu Y., Zeng L., Chen Y., Ma D., Shi T., Wang L.
    Biochem. Biophys. Res. Commun. 369:622-629(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene."
    He P., Peng Z., Luo Y., Wang L., Yu P., Deng W., An Y., Shi T., Ma D.
    Autophagy 5:52-60(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTMM74_HUMAN
AccessioniPrimary (citable) accession number: Q96NL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3