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Q96NL1 (TMM74_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 74
Gene names
Name:TMEM74
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. Ref.3 Ref.4

Subcellular location

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicleautophagosome membrane; Multi-pass membrane protein Ref.3.

Tissue specificity

Expressed in heart, lung, and placenta. Ref.3

Sequence similarities

Belongs to the TMEM74 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Transmembrane protein 74
PRO_0000259600

Regions

Transmembrane178 – 19821Helical; Potential
Transmembrane232 – 25221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q96NL1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9521A382F126B683

FASTA30533,338
        10         20         30         40         50         60 
MELHYLAKKS NQADLCDARD WSSRGLPGDQ ADTAATRAAL CCQKQCASTP RATEMEGSKL 

        70         80         90        100        110        120 
SSSPASPSSS LQNSTLQPDA FPPGLLHSGN NQITAERKVC NCCSQELETS FTYVDKNINL 

       130        140        150        160        170        180 
EQRNRSSPSA KGHNHPGELG WENPNEWSQE AAISLISEEE DDTSSEATSS GKSIDYGFIS 

       190        200        210        220        230        240 
AILFLVTGIL LVIISYIVPR EVTVDPNTVA AREMERLEKE SARLGAHLDR CVIAGLCLLT 

       250        260        270        280        290        300 
LGGVILSCLL MMSMWKGELY RRNRFASSKE SAKLYGSFNF RMKTSTNENT LELSLVEEDA 


LAVQS 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"TMEM74, a lysosome and autophagosome protein, regulates autophagy."
Yu C., Wang L., Lv B., Lu Y., Zeng L., Chen Y., Ma D., Shi T., Wang L.
Biochem. Biophys. Res. Commun. 369:622-629(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]"High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene."
He P., Peng Z., Luo Y., Wang L., Yu P., Deng W., An Y., Shi T., Ma D.
Autophagy 5:52-60(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055230 mRNA. Translation: BAB70881.1.
BC030710 mRNA. Translation: AAH30710.1.
RefSeqNP_694560.1. NM_153015.1.
XP_005250862.1. XM_005250805.1.
UniGeneHs.99439.

3D structure databases

ProteinModelPortalQ96NL1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000297459.

PTM databases

PhosphoSiteQ96NL1.

Polymorphism databases

DMDM74732587.

Proteomic databases

PaxDbQ96NL1.
PRIDEQ96NL1.

Protocols and materials databases

DNASU157753.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297459; ENSP00000297459; ENSG00000164841.
GeneID157753.
KEGGhsa:157753.
UCSCuc003ymy.1. human.

Organism-specific databases

CTD157753.
GeneCardsGC08M109619.
HGNCHGNC:26409. TMEM74.
HPAHPA015672.
MIM613935. gene.
neXtProtNX_Q96NL1.
PharmGKBPA142670785.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47300.
HOGENOMHOG000112021.
HOVERGENHBG094072.
InParanoidQ96NL1.
OMANEWSHEA.
OrthoDBEOG7HF1KD.
PhylomeDBQ96NL1.
TreeFamTF335735.

Gene expression databases

BgeeQ96NL1.
CleanExHS_TMEM74.
GenevestigatorQ96NL1.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi157753.
NextBio87542.
PROQ96NL1.
SOURCESearch...

Entry information

Entry nameTMM74_HUMAN
AccessionPrimary (citable) accession number: Q96NL1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM