Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96NL1

- TMM74_HUMAN

UniProt

Q96NL1 - TMM74_HUMAN

Protein

Transmembrane protein 74

Gene

TMEM74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.2 Publications

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 74
    Gene namesi
    Name:TMEM74
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26409. TMEM74.

    Subcellular locationi

    Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic vesicleautophagosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. autophagic vacuole membrane Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Transmembrane protein 74PRO_0000259600Add
    BLAST

    Proteomic databases

    PaxDbiQ96NL1.
    PRIDEiQ96NL1.

    PTM databases

    PhosphoSiteiQ96NL1.

    Expressioni

    Tissue specificityi

    Expressed in heart, lung, and placenta.1 Publication

    Gene expression databases

    BgeeiQ96NL1.
    CleanExiHS_TMEM74.
    GenevestigatoriQ96NL1.

    Organism-specific databases

    HPAiHPA015672.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000297459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM74 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47300.
    HOGENOMiHOG000112021.
    HOVERGENiHBG094072.
    InParanoidiQ96NL1.
    OMAiNEWSHEA.
    OrthoDBiEOG7HF1KD.
    PhylomeDBiQ96NL1.
    TreeFamiTF335735.

    Sequencei

    Sequence statusi: Complete.

    Q96NL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELHYLAKKS NQADLCDARD WSSRGLPGDQ ADTAATRAAL CCQKQCASTP    50
    RATEMEGSKL SSSPASPSSS LQNSTLQPDA FPPGLLHSGN NQITAERKVC 100
    NCCSQELETS FTYVDKNINL EQRNRSSPSA KGHNHPGELG WENPNEWSQE 150
    AAISLISEEE DDTSSEATSS GKSIDYGFIS AILFLVTGIL LVIISYIVPR 200
    EVTVDPNTVA AREMERLEKE SARLGAHLDR CVIAGLCLLT LGGVILSCLL 250
    MMSMWKGELY RRNRFASSKE SAKLYGSFNF RMKTSTNENT LELSLVEEDA 300
    LAVQS 305
    Length:305
    Mass (Da):33,338
    Last modified:December 1, 2001 - v1
    Checksum:i9521A382F126B683
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055230 mRNA. Translation: BAB70881.1.
    BC030710 mRNA. Translation: AAH30710.1.
    CCDSiCCDS6310.1.
    RefSeqiNP_694560.1. NM_153015.1.
    XP_005250862.1. XM_005250805.1.
    UniGeneiHs.99439.

    Genome annotation databases

    EnsembliENST00000297459; ENSP00000297459; ENSG00000164841.
    GeneIDi157753.
    KEGGihsa:157753.
    UCSCiuc003ymy.1. human.

    Polymorphism databases

    DMDMi74732587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055230 mRNA. Translation: BAB70881.1 .
    BC030710 mRNA. Translation: AAH30710.1 .
    CCDSi CCDS6310.1.
    RefSeqi NP_694560.1. NM_153015.1.
    XP_005250862.1. XM_005250805.1.
    UniGenei Hs.99439.

    3D structure databases

    ProteinModelPortali Q96NL1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000297459.

    PTM databases

    PhosphoSitei Q96NL1.

    Polymorphism databases

    DMDMi 74732587.

    Proteomic databases

    PaxDbi Q96NL1.
    PRIDEi Q96NL1.

    Protocols and materials databases

    DNASUi 157753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297459 ; ENSP00000297459 ; ENSG00000164841 .
    GeneIDi 157753.
    KEGGi hsa:157753.
    UCSCi uc003ymy.1. human.

    Organism-specific databases

    CTDi 157753.
    GeneCardsi GC08M109619.
    HGNCi HGNC:26409. TMEM74.
    HPAi HPA015672.
    MIMi 613935. gene.
    neXtProti NX_Q96NL1.
    PharmGKBi PA142670785.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47300.
    HOGENOMi HOG000112021.
    HOVERGENi HBG094072.
    InParanoidi Q96NL1.
    OMAi NEWSHEA.
    OrthoDBi EOG7HF1KD.
    PhylomeDBi Q96NL1.
    TreeFami TF335735.

    Miscellaneous databases

    GenomeRNAii 157753.
    NextBioi 87542.
    PROi Q96NL1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96NL1.
    CleanExi HS_TMEM74.
    Genevestigatori Q96NL1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "TMEM74, a lysosome and autophagosome protein, regulates autophagy."
      Yu C., Wang L., Lv B., Lu Y., Zeng L., Chen Y., Ma D., Shi T., Wang L.
      Biochem. Biophys. Res. Commun. 369:622-629(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene."
      He P., Peng Z., Luo Y., Wang L., Yu P., Deng W., An Y., Shi T., Ma D.
      Autophagy 5:52-60(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTMM74_HUMAN
    AccessioniPrimary (citable) accession number: Q96NL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3