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Protein

RUN domain-containing protein 3B

Gene

RUNDC3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RUN domain-containing protein 3B
Alternative name(s):
Rap2-binding protein 9
Rap2-interacting protein 9
Short name:
RPIP-9
Gene namesi
Name:RUNDC3B
Synonyms:RPIB9, RPIP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30286. RUNDC3B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi154661.
OpenTargetsiENSG00000105784.
PharmGKBiPA162402278.

Polymorphism and mutation databases

BioMutaiRUNDC3B.
DMDMi74732586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003360491 – 473RUN domain-containing protein 3BAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Omega-N-methylarginineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ96NL0.
PaxDbiQ96NL0.
PeptideAtlasiQ96NL0.
PRIDEiQ96NL0.

PTM databases

iPTMnetiQ96NL0.
PhosphoSitePlusiQ96NL0.

Expressioni

Tissue specificityi

Isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine and prostate. Isoform 1 is expressed in the brain, testis and adrenal gland. It is activated in tumorigenic breast cancer cell lines and in the primary tumor of breast cancer patients. Activation also correlates with metastatic lymph node invasion and can be detected in metastatic epithelial cells from the lymph nodes and in the bone marrow of patients.2 Publications

Gene expression databases

BgeeiENSG00000105784.
CleanExiHS_RUNDC3B.
GenevisibleiQ96NL0. HS.

Organism-specific databases

HPAiHPA056968.
HPA057155.

Interactioni

Subunit structurei

Interacts with RAP2A.By similarity

Protein-protein interaction databases

BioGridi127550. 5 interactors.
IntActiQ96NL0. 4 interactors.
MINTiMINT-8247421.
STRINGi9606.ENSP00000337732.

Structurei

3D structure databases

ProteinModelPortaliQ96NL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 206RUNPROSITE-ProRule annotationAdd BLAST150

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili317 – 342Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 20Poly-Gly7

Sequence similaritiesi

Belongs to the RUNDC3 family.Curated
Contains 1 RUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4381. Eukaryota.
ENOG410XRAX. LUCA.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000143407.
HOVERGENiHBG052747.
InParanoidiQ96NL0.
OMAiTHLTNQW.
OrthoDBiEOG091G06Y5.
PhylomeDBiQ96NL0.
TreeFamiTF323904.

Family and domain databases

InterProiIPR004012. Run_dom.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
PROSITEiPS50826. RUN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRSLGGLS GIRGGGGGGG KKSLSARNAA VERRNLITVC RFSVKTLIDR
60 70 80 90 100
SCFETIDDSS PEFNNFAAIL EQILSHRLKE ISQSCRWLAH LQIPLQGQVT
110 120 130 140 150
WFGYESPRSF WDYIRVACRK VSQNCICSIE NMENVSSSRA KGRAWIRVAL
160 170 180 190 200
MEKHLSEYIS TALRDFKTTR RFYEDGAIVL GEEANMLAGM LLGLNAIDFS
210 220 230 240 250
FCLKGEGLDG SFPAVIDYTP YLKYIQSSDS ISSDEEELRT LGSSGSESST
260 270 280 290 300
PENVGPPFLM DENSWFNKCK RVKQKYQLTL EQKGYLEELL RLRENQLSES
310 320 330 340 350
VSQNKILLQR IEDSDLAHKL EKEQLEYIIV ELQDQLTVLK NNDLRSRQEL
360 370 380 390 400
TAHLTNQWPS PGALDVNAVA LDTLLYRKHN KQWYEKSYQS LDQLSAEVSL
410 420 430 440 450
SQTSLDPGQS QEGDGKQDTL NVMSEGKEDT PSLLGLCGSL TSVASYKSLT
460 470
SLKSNDYLAS PTTEMTSPGL TPS
Length:473
Mass (Da):52,813
Last modified:December 1, 2001 - v1
Checksum:i1AC96C90379EEFB8
GO
Isoform 2 (identifier: Q96NL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.
     96-96: Q → M
     337-385: Missing.

Show »
Length:329
Mass (Da):36,817
Checksum:iF0604E003E38DAE5
GO
Isoform 3 (identifier: Q96NL0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.
     337-385: Missing.

Show »
Length:165
Mass (Da):18,525
Checksum:i21E9238CF09FE563
GO
Isoform 4 (identifier: Q96NL0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-96: Missing.
     337-385: Missing.

Show »
Length:407
Mass (Da):45,108
Checksum:i4DA471E37F431CCD
GO
Isoform 5 (identifier: Q96NL0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-96: Missing.

Note: No experimental confirmation available.
Show »
Length:456
Mass (Da):50,809
Checksum:i725B011B480C69B5
GO

Sequence cautioni

The sequence AAH22520 differs from that shown. Reason: Frameshift at position 444.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102F → V in AAK52313 (PubMed:12645870).Curated1
Sequence conflicti185N → S in AAK52313 (PubMed:12645870).Curated1
Sequence conflicti243S → G in AAK52313 (PubMed:12645870).Curated1
Sequence conflicti266F → L in BAG57391 (PubMed:14702039).Curated1
Sequence conflicti412E → G in AAK52313 (PubMed:12645870).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04347347L → M.1 PublicationCorresponds to variant rs17852065dbSNPEnsembl.1
Natural variantiVAR_043474206E → G.1 PublicationCorresponds to variant rs17852063dbSNPEnsembl.1
Natural variantiVAR_043475440L → P.1 PublicationCorresponds to variant rs17856673dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0338031 – 259Missing in isoform 3. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_0338041 – 95Missing in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_03380580 – 96Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_03380696Q → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_033807337 – 385Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033596 mRNA. Translation: AAK52313.1.
AK055233 mRNA. Translation: BAB70882.1.
AK091536 mRNA. Translation: BAC03686.1.
AK294039 mRNA. Translation: BAG57391.1.
AC002457 Genomic DNA. No translation available.
AC003083 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24172.1.
CH471091 Genomic DNA. Translation: EAW76937.1.
BC022520 mRNA. Translation: AAH22520.1. Frameshift.
CCDSiCCDS47635.1. [Q96NL0-5]
CCDS47636.1. [Q96NL0-4]
CCDS5609.1. [Q96NL0-1]
RefSeqiNP_001127877.1. NM_001134405.1. [Q96NL0-5]
NP_001127878.1. NM_001134406.1. [Q96NL0-4]
NP_612147.1. NM_138290.2. [Q96NL0-1]
UniGeneiHs.411488.

Genome annotation databases

EnsembliENST00000338056; ENSP00000337732; ENSG00000105784. [Q96NL0-1]
ENST00000394654; ENSP00000378149; ENSG00000105784. [Q96NL0-5]
ENST00000493037; ENSP00000420394; ENSG00000105784. [Q96NL0-4]
GeneIDi154661.
KEGGihsa:154661.
UCSCiuc003ujb.4. human. [Q96NL0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033596 mRNA. Translation: AAK52313.1.
AK055233 mRNA. Translation: BAB70882.1.
AK091536 mRNA. Translation: BAC03686.1.
AK294039 mRNA. Translation: BAG57391.1.
AC002457 Genomic DNA. No translation available.
AC003083 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24172.1.
CH471091 Genomic DNA. Translation: EAW76937.1.
BC022520 mRNA. Translation: AAH22520.1. Frameshift.
CCDSiCCDS47635.1. [Q96NL0-5]
CCDS47636.1. [Q96NL0-4]
CCDS5609.1. [Q96NL0-1]
RefSeqiNP_001127877.1. NM_001134405.1. [Q96NL0-5]
NP_001127878.1. NM_001134406.1. [Q96NL0-4]
NP_612147.1. NM_138290.2. [Q96NL0-1]
UniGeneiHs.411488.

3D structure databases

ProteinModelPortaliQ96NL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127550. 5 interactors.
IntActiQ96NL0. 4 interactors.
MINTiMINT-8247421.
STRINGi9606.ENSP00000337732.

PTM databases

iPTMnetiQ96NL0.
PhosphoSitePlusiQ96NL0.

Polymorphism and mutation databases

BioMutaiRUNDC3B.
DMDMi74732586.

Proteomic databases

MaxQBiQ96NL0.
PaxDbiQ96NL0.
PeptideAtlasiQ96NL0.
PRIDEiQ96NL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338056; ENSP00000337732; ENSG00000105784. [Q96NL0-1]
ENST00000394654; ENSP00000378149; ENSG00000105784. [Q96NL0-5]
ENST00000493037; ENSP00000420394; ENSG00000105784. [Q96NL0-4]
GeneIDi154661.
KEGGihsa:154661.
UCSCiuc003ujb.4. human. [Q96NL0-1]

Organism-specific databases

CTDi154661.
DisGeNETi154661.
GeneCardsiRUNDC3B.
HGNCiHGNC:30286. RUNDC3B.
HPAiHPA056968.
HPA057155.
neXtProtiNX_Q96NL0.
OpenTargetsiENSG00000105784.
PharmGKBiPA162402278.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4381. Eukaryota.
ENOG410XRAX. LUCA.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000143407.
HOVERGENiHBG052747.
InParanoidiQ96NL0.
OMAiTHLTNQW.
OrthoDBiEOG091G06Y5.
PhylomeDBiQ96NL0.
TreeFamiTF323904.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105784-MONOMER.

Miscellaneous databases

GenomeRNAii154661.
PROiQ96NL0.

Gene expression databases

BgeeiENSG00000105784.
CleanExiHS_RUNDC3B.
GenevisibleiQ96NL0. HS.

Family and domain databases

InterProiIPR004012. Run_dom.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
PROSITEiPS50826. RUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUN3B_HUMAN
AccessioniPrimary (citable) accession number: Q96NL0
Secondary accession number(s): B4DFD0
, E9PBR4, Q8IWW5, Q8NB55, Q8TBG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.