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Q96NK8

- NDF6_HUMAN

UniProt

Q96NK8 - NDF6_HUMAN

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Protein

Neurogenic differentiation factor 6

Gene

NEUROD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).By similarity

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. dentate gyrus development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 6
Short name:
NeuroD6
Alternative name(s):
Class A basic helix-loop-helix protein 2
Short name:
bHLHa2
Protein atonal homolog 2
Gene namesi
Name:NEUROD6
Synonyms:ATOH2, BHLHA2
ORF Names:My051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13804. NEUROD6.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Neurogenic differentiation factor 6PRO_0000127393Add
BLAST

Proteomic databases

PaxDbiQ96NK8.
PRIDEiQ96NK8.

PTM databases

PhosphoSiteiQ96NK8.

Expressioni

Gene expression databases

BgeeiQ96NK8.
CleanExiHS_NEUROD6.
GenevestigatoriQ96NK8.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Protein-protein interaction databases

BioGridi122021. 1 interaction.
STRINGi9606.ENSP00000297142.

Structurei

3D structure databases

ProteinModelPortaliQ96NK8.
SMRiQ96NK8. Positions 95-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 14653bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 867Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 6310Poly-Glu

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242996.
GeneTreeiENSGT00680000099860.
HOVERGENiHBG000250.
InParanoidiQ96NK8.
KOiK09080.
OMAiVERVKFR.
OrthoDBiEOG722J8S.
PhylomeDBiQ96NK8.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR
60 70 80 90 100
APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN
110 120 130 140 150
ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL
160 170 180 190 200
RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT
210 220 230 240 250
RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE
260 270 280 290 300
CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
310 320 330
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
Length:337
Mass (Da):38,705
Last modified:December 1, 2001 - v1
Checksum:i6B0F4127AC0F809E
GO

Sequence cautioni

The sequence AAG43167.1 differs from that shown. Reason: Frameshift at positions 300 and 307.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063609 mRNA. Translation: AAG43167.1. Frameshift.
AF248954 mRNA. Translation: AAO12759.1.
AK055238 mRNA. Translation: BAB70885.1.
AK289619 mRNA. Translation: BAF82308.1.
CH471073 Genomic DNA. Translation: EAW93979.1.
CCDSiCCDS5434.1.
RefSeqiNP_073565.2. NM_022728.3.
UniGeneiHs.45152.

Genome annotation databases

EnsembliENST00000297142; ENSP00000297142; ENSG00000164600.
GeneIDi63974.
KEGGihsa:63974.
UCSCiuc003tch.4. human.

Polymorphism databases

DMDMi20139067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063609 mRNA. Translation: AAG43167.1 . Frameshift.
AF248954 mRNA. Translation: AAO12759.1 .
AK055238 mRNA. Translation: BAB70885.1 .
AK289619 mRNA. Translation: BAF82308.1 .
CH471073 Genomic DNA. Translation: EAW93979.1 .
CCDSi CCDS5434.1.
RefSeqi NP_073565.2. NM_022728.3.
UniGenei Hs.45152.

3D structure databases

ProteinModelPortali Q96NK8.
SMRi Q96NK8. Positions 95-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122021. 1 interaction.
STRINGi 9606.ENSP00000297142.

PTM databases

PhosphoSitei Q96NK8.

Polymorphism databases

DMDMi 20139067.

Proteomic databases

PaxDbi Q96NK8.
PRIDEi Q96NK8.

Protocols and materials databases

DNASUi 63974.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297142 ; ENSP00000297142 ; ENSG00000164600 .
GeneIDi 63974.
KEGGi hsa:63974.
UCSCi uc003tch.4. human.

Organism-specific databases

CTDi 63974.
GeneCardsi GC07M031343.
HGNCi HGNC:13804. NEUROD6.
MIMi 611513. gene.
neXtProti NX_Q96NK8.
PharmGKBi PA31568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242996.
GeneTreei ENSGT00680000099860.
HOVERGENi HBG000250.
InParanoidi Q96NK8.
KOi K09080.
OMAi VERVKFR.
OrthoDBi EOG722J8S.
PhylomeDBi Q96NK8.
TreeFami TF315153.

Miscellaneous databases

ChiTaRSi NEUROD6. human.
GenomeRNAii 63974.
NextBioi 65770.
PROi Q96NK8.
SOURCEi Search...

Gene expression databases

Bgeei Q96NK8.
CleanExi HS_NEUROD6.
Genevestigatori Q96NK8.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view ]
PIRSFi PIRSF015618. bHLH_NeuroD. 1 hit.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, chromosome localization and features of a novel human gene, MATH2."
    Guo L., Jiang M., Ma Y., Cheng H., Ni X., Jin Y., Xie Y., Mao Y.-M.
    J. Genet. 81:13-17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNDF6_HUMAN
AccessioniPrimary (citable) accession number: Q96NK8
Secondary accession number(s): Q548T9, Q9H3H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3