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Protein

Neurogenic differentiation factor 6

Gene

NEUROD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 6
Short name:
NeuroD6
Alternative name(s):
Class A basic helix-loop-helix protein 2
Short name:
bHLHa2
Protein atonal homolog 2
Gene namesi
Name:NEUROD6
Synonyms:ATOH2, BHLHA2
ORF Names:My051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13804. NEUROD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31568.

Polymorphism and mutation databases

DMDMi20139067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Neurogenic differentiation factor 6PRO_0000127393Add
BLAST

Proteomic databases

PaxDbiQ96NK8.
PRIDEiQ96NK8.

PTM databases

PhosphoSiteiQ96NK8.

Expressioni

Gene expression databases

BgeeiQ96NK8.
CleanExiHS_NEUROD6.
ExpressionAtlasiQ96NK8. baseline and differential.
GenevisibleiQ96NK8. HS.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Protein-protein interaction databases

BioGridi122021. 1 interaction.
STRINGi9606.ENSP00000297142.

Structurei

3D structure databases

ProteinModelPortaliQ96NK8.
SMRiQ96NK8. Positions 95-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 14653bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 867Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 6310Poly-Glu

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242996.
GeneTreeiENSGT00680000099860.
HOVERGENiHBG000250.
InParanoidiQ96NK8.
KOiK09080.
OMAiVERVKFR.
OrthoDBiEOG722J8S.
PhylomeDBiQ96NK8.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR
60 70 80 90 100
APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN
110 120 130 140 150
ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL
160 170 180 190 200
RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT
210 220 230 240 250
RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE
260 270 280 290 300
CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
310 320 330
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
Length:337
Mass (Da):38,705
Last modified:December 1, 2001 - v1
Checksum:i6B0F4127AC0F809E
GO

Sequence cautioni

The sequence AAG43167.1 differs from that shown. Reason: Frameshift at positions 300 and 307. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063609 mRNA. Translation: AAG43167.1. Frameshift.
AF248954 mRNA. Translation: AAO12759.1.
AK055238 mRNA. Translation: BAB70885.1.
AK289619 mRNA. Translation: BAF82308.1.
CH471073 Genomic DNA. Translation: EAW93979.1.
CCDSiCCDS5434.1.
RefSeqiNP_073565.2. NM_022728.3.
UniGeneiHs.45152.

Genome annotation databases

EnsembliENST00000297142; ENSP00000297142; ENSG00000164600.
GeneIDi63974.
KEGGihsa:63974.
UCSCiuc003tch.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063609 mRNA. Translation: AAG43167.1. Frameshift.
AF248954 mRNA. Translation: AAO12759.1.
AK055238 mRNA. Translation: BAB70885.1.
AK289619 mRNA. Translation: BAF82308.1.
CH471073 Genomic DNA. Translation: EAW93979.1.
CCDSiCCDS5434.1.
RefSeqiNP_073565.2. NM_022728.3.
UniGeneiHs.45152.

3D structure databases

ProteinModelPortaliQ96NK8.
SMRiQ96NK8. Positions 95-151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122021. 1 interaction.
STRINGi9606.ENSP00000297142.

PTM databases

PhosphoSiteiQ96NK8.

Polymorphism and mutation databases

DMDMi20139067.

Proteomic databases

PaxDbiQ96NK8.
PRIDEiQ96NK8.

Protocols and materials databases

DNASUi63974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297142; ENSP00000297142; ENSG00000164600.
GeneIDi63974.
KEGGihsa:63974.
UCSCiuc003tch.4. human.

Organism-specific databases

CTDi63974.
GeneCardsiGC07M031343.
HGNCiHGNC:13804. NEUROD6.
MIMi611513. gene.
neXtProtiNX_Q96NK8.
PharmGKBiPA31568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG242996.
GeneTreeiENSGT00680000099860.
HOVERGENiHBG000250.
InParanoidiQ96NK8.
KOiK09080.
OMAiVERVKFR.
OrthoDBiEOG722J8S.
PhylomeDBiQ96NK8.
TreeFamiTF315153.

Miscellaneous databases

ChiTaRSiNEUROD6. human.
GenomeRNAii63974.
NextBioi65770.
PROiQ96NK8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NK8.
CleanExiHS_NEUROD6.
ExpressionAtlasiQ96NK8. baseline and differential.
GenevisibleiQ96NK8. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, chromosome localization and features of a novel human gene, MATH2."
    Guo L., Jiang M., Ma Y., Cheng H., Ni X., Jin Y., Xie Y., Mao Y.-M.
    J. Genet. 81:13-17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNDF6_HUMAN
AccessioniPrimary (citable) accession number: Q96NK8
Secondary accession number(s): Q548T9, Q9H3H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.