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Q96NK8

- NDF6_HUMAN

UniProt

Q96NK8 - NDF6_HUMAN

Protein

Neurogenic differentiation factor 6

Gene

NEUROD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. dentate gyrus development Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenic differentiation factor 6
    Short name:
    NeuroD6
    Alternative name(s):
    Class A basic helix-loop-helix protein 2
    Short name:
    bHLHa2
    Protein atonal homolog 2
    Gene namesi
    Name:NEUROD6
    Synonyms:ATOH2, BHLHA2
    ORF Names:My051
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13804. NEUROD6.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31568.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Neurogenic differentiation factor 6PRO_0000127393Add
    BLAST

    Proteomic databases

    PaxDbiQ96NK8.
    PRIDEiQ96NK8.

    PTM databases

    PhosphoSiteiQ96NK8.

    Expressioni

    Gene expression databases

    BgeeiQ96NK8.
    CleanExiHS_NEUROD6.
    GenevestigatoriQ96NK8.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.By similarity

    Protein-protein interaction databases

    BioGridi122021. 1 interaction.
    STRINGi9606.ENSP00000297142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NK8.
    SMRiQ96NK8. Positions 95-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 14653bHLHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi80 – 867Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 6310Poly-Glu

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242996.
    HOVERGENiHBG000250.
    InParanoidiQ96NK8.
    KOiK09080.
    OMAiVERVKFR.
    OrthoDBiEOG722J8S.
    PhylomeDBiQ96NK8.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96NK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR    50
    APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN 100
    ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL 150
    RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT 200
    RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE 250
    CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL 300
    GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN 337
    Length:337
    Mass (Da):38,705
    Last modified:December 1, 2001 - v1
    Checksum:i6B0F4127AC0F809E
    GO

    Sequence cautioni

    The sequence AAG43167.1 differs from that shown. Reason: Frameshift at positions 300 and 307.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063609 mRNA. Translation: AAG43167.1. Frameshift.
    AF248954 mRNA. Translation: AAO12759.1.
    AK055238 mRNA. Translation: BAB70885.1.
    AK289619 mRNA. Translation: BAF82308.1.
    CH471073 Genomic DNA. Translation: EAW93979.1.
    CCDSiCCDS5434.1.
    RefSeqiNP_073565.2. NM_022728.3.
    UniGeneiHs.45152.

    Genome annotation databases

    EnsembliENST00000297142; ENSP00000297142; ENSG00000164600.
    GeneIDi63974.
    KEGGihsa:63974.
    UCSCiuc003tch.4. human.

    Polymorphism databases

    DMDMi20139067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063609 mRNA. Translation: AAG43167.1 . Frameshift.
    AF248954 mRNA. Translation: AAO12759.1 .
    AK055238 mRNA. Translation: BAB70885.1 .
    AK289619 mRNA. Translation: BAF82308.1 .
    CH471073 Genomic DNA. Translation: EAW93979.1 .
    CCDSi CCDS5434.1.
    RefSeqi NP_073565.2. NM_022728.3.
    UniGenei Hs.45152.

    3D structure databases

    ProteinModelPortali Q96NK8.
    SMRi Q96NK8. Positions 95-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122021. 1 interaction.
    STRINGi 9606.ENSP00000297142.

    PTM databases

    PhosphoSitei Q96NK8.

    Polymorphism databases

    DMDMi 20139067.

    Proteomic databases

    PaxDbi Q96NK8.
    PRIDEi Q96NK8.

    Protocols and materials databases

    DNASUi 63974.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297142 ; ENSP00000297142 ; ENSG00000164600 .
    GeneIDi 63974.
    KEGGi hsa:63974.
    UCSCi uc003tch.4. human.

    Organism-specific databases

    CTDi 63974.
    GeneCardsi GC07M031343.
    HGNCi HGNC:13804. NEUROD6.
    MIMi 611513. gene.
    neXtProti NX_Q96NK8.
    PharmGKBi PA31568.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242996.
    HOVERGENi HBG000250.
    InParanoidi Q96NK8.
    KOi K09080.
    OMAi VERVKFR.
    OrthoDBi EOG722J8S.
    PhylomeDBi Q96NK8.
    TreeFami TF315153.

    Miscellaneous databases

    ChiTaRSi NEUROD6. human.
    GenomeRNAii 63974.
    NextBioi 65770.
    PROi Q96NK8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96NK8.
    CleanExi HS_NEUROD6.
    Genevestigatori Q96NK8.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosome localization and features of a novel human gene, MATH2."
      Guo L., Jiang M., Ma Y., Cheng H., Ni X., Jin Y., Xie Y., Mao Y.-M.
      J. Genet. 81:13-17(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala and Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNDF6_HUMAN
    AccessioniPrimary (citable) accession number: Q96NK8
    Secondary accession number(s): Q548T9, Q9H3H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3