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Q96NK8 (NDF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurogenic differentiation factor 6

Short name=NeuroD6
Alternative name(s):
Class A basic helix-loop-helix protein 2
Short name=bHLHa2
Protein atonal homolog 2
Gene names
Name:NEUROD6
Synonyms:ATOH2, BHLHA2
ORF Names:My051
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene By similarity.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence AAG43167.1 differs from that shown. Reason: Frameshift at positions 300 and 307.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Neurogenic differentiation factor 6
PRO_0000127393

Regions

Domain94 – 14653bHLH
Motif80 – 867Nuclear localization signal Potential
Compositional bias54 – 6310Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q96NK8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6B0F4127AC0F809E

FASTA33738,705
        10         20         30         40         50         60 
MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR APGEETEKEE 

        70         80         90        100        110        120 
EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV 

       130        140        150        160        170        180 
VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC 

       190        200        210        220        230        240 
LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY 

       250        260        270        280        290        300 
ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL 

       310        320        330 
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN 

« Hide

References

[1]"Cloning, chromosome localization and features of a novel human gene, MATH2."
Guo L., Jiang M., Ma Y., Cheng H., Ni X., Jin Y., Xie Y., Mao Y.-M.
J. Genet. 81:13-17(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala and Brain.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF063609 mRNA. Translation: AAG43167.1. Frameshift.
AF248954 mRNA. Translation: AAO12759.1.
AK055238 mRNA. Translation: BAB70885.1.
AK289619 mRNA. Translation: BAF82308.1.
CH471073 Genomic DNA. Translation: EAW93979.1.
CCDSCCDS5434.1.
RefSeqNP_073565.2. NM_022728.3.
UniGeneHs.45152.

3D structure databases

ProteinModelPortalQ96NK8.
SMRQ96NK8. Positions 95-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122021. 1 interaction.
STRING9606.ENSP00000297142.

PTM databases

PhosphoSiteQ96NK8.

Polymorphism databases

DMDM20139067.

Proteomic databases

PaxDbQ96NK8.
PRIDEQ96NK8.

Protocols and materials databases

DNASU63974.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297142; ENSP00000297142; ENSG00000164600.
GeneID63974.
KEGGhsa:63974.
UCSCuc003tch.4. human.

Organism-specific databases

CTD63974.
GeneCardsGC07M031343.
HGNCHGNC:13804. NEUROD6.
MIM611513. gene.
neXtProtNX_Q96NK8.
PharmGKBPA31568.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242996.
HOVERGENHBG000250.
InParanoidQ96NK8.
KOK09080.
OMAVERVKFR.
OrthoDBEOG722J8S.
PhylomeDBQ96NK8.
TreeFamTF315153.

Gene expression databases

BgeeQ96NK8.
CleanExHS_NEUROD6.
GenevestigatorQ96NK8.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEUROD6. human.
GenomeRNAi63974.
NextBio65770.
PROQ96NK8.
SOURCESearch...

Entry information

Entry nameNDF6_HUMAN
AccessionPrimary (citable) accession number: Q96NK8
Secondary accession number(s): Q548T9, Q9H3H6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM