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Protein

Zinc finger protein 3 homolog

Gene

ZFP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3 homolog
Short name:
Zfp-3
Alternative name(s):
Zinc finger protein 752
Gene namesi
Name:ZFP3
Synonyms:ZNF752
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180787.5.
HGNCiHGNC:12861. ZFP3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180787.
PharmGKBiPA37450.

Polymorphism and mutation databases

BioMutaiZFP3.
DMDMi74761006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337131 – 502Zinc finger protein 3 homologAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96NJ6.
MaxQBiQ96NJ6.
PaxDbiQ96NJ6.
PeptideAtlasiQ96NJ6.
PRIDEiQ96NJ6.

PTM databases

iPTMnetiQ96NJ6.
PhosphoSitePlusiQ96NJ6.

Expressioni

Gene expression databases

BgeeiENSG00000180787.
CleanExiHS_ZFP3.
GenevisibleiQ96NJ6. HS.

Organism-specific databases

HPAiHPA053085.
HPA057290.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC130P139944EBI-12302147,EBI-716093

Protein-protein interaction databases

IntActiQ96NJ6. 1 interactor.
STRINGi9606.ENSP00000320347.

Structurei

3D structure databases

ProteinModelPortaliQ96NJ6.
SMRiQ96NJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140817.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NJ6.
OMAiCARTFWD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96NJ6.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q96NJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTENKEVIP KEEISEESEP HGSLLEKFPK VVYQGHEFGA GCEEDMLEGH
60 70 80 90 100
SRESMEEVIE QMSPQERDFP SGLMIFKKSP SSEKDRENNE SERGCSPSPN
110 120 130 140 150
LVTHQGDTTE GVSAFATSGQ NFLEILESNK TQRSSVGEKP HTCKECGKAF
160 170 180 190 200
NQNSHLIQHM RVHSGEKPFE CKECGKTFGT NSSLRRHLRI HAGEKPFACN
210 220 230 240 250
ECGKAFIQSS HLIHHHRIHT GERPYKCEEC GKAFSQNSAL ILHQRIHTGE
260 270 280 290 300
KPYECNECGK TFRVSSQLIQ HQRIHTEERY HECNECGKAF KHSSGLIRHQ
310 320 330 340 350
KIHTGEKPYL CNECGKGFGQ SSELIRHQRI HTGDKPYECN ECGKTFGQNS
360 370 380 390 400
EIIRHIRIHT GEKPYVCKEC GKAFRGNSEL LRHERIHTGE KPYECFECGK
410 420 430 440 450
AFRRTSHLIV HQRIHTGEKP HQCNECARTF WDNSELLLHQ KIHIGEKPYE
460 470 480 490 500
CSECEKTFSQ HSQLIIHQRI HTGEKPYECQ ECQKTFSRSS HLLRHQSVHC

ME
Length:502
Mass (Da):57,662
Last modified:December 1, 2001 - v1
Checksum:iFFA5DF474A5059A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055288 mRNA. Translation: BAB70898.1.
CH471108 Genomic DNA. Translation: EAW90362.1.
BC142962 mRNA. Translation: AAI42963.1.
CCDSiCCDS11067.1.
RefSeqiNP_694563.1. NM_153018.2.
UniGeneiHs.48832.

Genome annotation databases

EnsembliENST00000318833; ENSP00000320347; ENSG00000180787.
GeneIDi124961.
KEGGihsa:124961.
UCSCiuc002gaq.4. human.

Similar proteinsi

Entry informationi

Entry nameiZFP3_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ6
Secondary accession number(s): A5PLL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families