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Protein

Zinc finger protein 3 homolog

Gene

ZFP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180787-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3 homolog
Short name:
Zfp-3
Alternative name(s):
Zinc finger protein 752
Gene namesi
Name:ZFP3
Synonyms:ZNF752
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12861. ZFP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180787.
PharmGKBiPA37450.

Polymorphism and mutation databases

BioMutaiZFP3.
DMDMi74761006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337131 – 502Zinc finger protein 3 homologAdd BLAST502

Proteomic databases

EPDiQ96NJ6.
MaxQBiQ96NJ6.
PaxDbiQ96NJ6.
PeptideAtlasiQ96NJ6.
PRIDEiQ96NJ6.

PTM databases

iPTMnetiQ96NJ6.
PhosphoSitePlusiQ96NJ6.

Expressioni

Gene expression databases

BgeeiENSG00000180787.
CleanExiHS_ZFP3.
GenevisibleiQ96NJ6. HS.

Organism-specific databases

HPAiHPA053085.

Interactioni

Protein-protein interaction databases

IntActiQ96NJ6. 1 interactor.
STRINGi9606.ENSP00000320347.

Structurei

3D structure databases

ProteinModelPortaliQ96NJ6.
SMRiQ96NJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NJ6.
OMAiTICFEAF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96NJ6.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTENKEVIP KEEISEESEP HGSLLEKFPK VVYQGHEFGA GCEEDMLEGH
60 70 80 90 100
SRESMEEVIE QMSPQERDFP SGLMIFKKSP SSEKDRENNE SERGCSPSPN
110 120 130 140 150
LVTHQGDTTE GVSAFATSGQ NFLEILESNK TQRSSVGEKP HTCKECGKAF
160 170 180 190 200
NQNSHLIQHM RVHSGEKPFE CKECGKTFGT NSSLRRHLRI HAGEKPFACN
210 220 230 240 250
ECGKAFIQSS HLIHHHRIHT GERPYKCEEC GKAFSQNSAL ILHQRIHTGE
260 270 280 290 300
KPYECNECGK TFRVSSQLIQ HQRIHTEERY HECNECGKAF KHSSGLIRHQ
310 320 330 340 350
KIHTGEKPYL CNECGKGFGQ SSELIRHQRI HTGDKPYECN ECGKTFGQNS
360 370 380 390 400
EIIRHIRIHT GEKPYVCKEC GKAFRGNSEL LRHERIHTGE KPYECFECGK
410 420 430 440 450
AFRRTSHLIV HQRIHTGEKP HQCNECARTF WDNSELLLHQ KIHIGEKPYE
460 470 480 490 500
CSECEKTFSQ HSQLIIHQRI HTGEKPYECQ ECQKTFSRSS HLLRHQSVHC

ME
Length:502
Mass (Da):57,662
Last modified:December 1, 2001 - v1
Checksum:iFFA5DF474A5059A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055288 mRNA. Translation: BAB70898.1.
CH471108 Genomic DNA. Translation: EAW90362.1.
BC142962 mRNA. Translation: AAI42963.1.
CCDSiCCDS11067.1.
RefSeqiNP_694563.1. NM_153018.2.
UniGeneiHs.48832.

Genome annotation databases

EnsembliENST00000318833; ENSP00000320347; ENSG00000180787.
GeneIDi124961.
KEGGihsa:124961.
UCSCiuc002gaq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055288 mRNA. Translation: BAB70898.1.
CH471108 Genomic DNA. Translation: EAW90362.1.
BC142962 mRNA. Translation: AAI42963.1.
CCDSiCCDS11067.1.
RefSeqiNP_694563.1. NM_153018.2.
UniGeneiHs.48832.

3D structure databases

ProteinModelPortaliQ96NJ6.
SMRiQ96NJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96NJ6. 1 interactor.
STRINGi9606.ENSP00000320347.

PTM databases

iPTMnetiQ96NJ6.
PhosphoSitePlusiQ96NJ6.

Polymorphism and mutation databases

BioMutaiZFP3.
DMDMi74761006.

Proteomic databases

EPDiQ96NJ6.
MaxQBiQ96NJ6.
PaxDbiQ96NJ6.
PeptideAtlasiQ96NJ6.
PRIDEiQ96NJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318833; ENSP00000320347; ENSG00000180787.
GeneIDi124961.
KEGGihsa:124961.
UCSCiuc002gaq.4. human.

Organism-specific databases

CTDi124961.
GeneCardsiZFP3.
HGNCiHGNC:12861. ZFP3.
HPAiHPA053085.
MIMi194480. gene.
neXtProtiNX_Q96NJ6.
OpenTargetsiENSG00000180787.
PharmGKBiPA37450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NJ6.
OMAiTICFEAF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96NJ6.
TreeFamiTF337005.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180787-MONOMER.

Miscellaneous databases

ChiTaRSiZFP3. human.
GenomeRNAii124961.
PROiQ96NJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180787.
CleanExiHS_ZFP3.
GenevisibleiQ96NJ6. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP3_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ6
Secondary accession number(s): A5PLL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.