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Q96NJ6

- ZFP3_HUMAN

UniProt

Q96NJ6 - ZFP3_HUMAN

Protein

Zinc finger protein 3 homolog

Gene

ZFP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 3 homolog
    Short name:
    Zfp-3
    Alternative name(s):
    Zinc finger protein 752
    Gene namesi
    Name:ZFP3
    Synonyms:ZNF752
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12861. ZFP3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37450.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Zinc finger protein 3 homologPRO_0000233713Add
    BLAST

    Proteomic databases

    MaxQBiQ96NJ6.
    PaxDbiQ96NJ6.
    PRIDEiQ96NJ6.

    PTM databases

    PhosphoSiteiQ96NJ6.

    Expressioni

    Gene expression databases

    BgeeiQ96NJ6.
    CleanExiHS_ZFP3.
    GenevestigatoriQ96NJ6.

    Organism-specific databases

    HPAiHPA053085.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NJ6.
    SMRiQ96NJ6. Positions 85-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96NJ6.
    OMAiLVTHQGD.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96NJ6.
    TreeFamiTF337005.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96NJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTENKEVIP KEEISEESEP HGSLLEKFPK VVYQGHEFGA GCEEDMLEGH    50
    SRESMEEVIE QMSPQERDFP SGLMIFKKSP SSEKDRENNE SERGCSPSPN 100
    LVTHQGDTTE GVSAFATSGQ NFLEILESNK TQRSSVGEKP HTCKECGKAF 150
    NQNSHLIQHM RVHSGEKPFE CKECGKTFGT NSSLRRHLRI HAGEKPFACN 200
    ECGKAFIQSS HLIHHHRIHT GERPYKCEEC GKAFSQNSAL ILHQRIHTGE 250
    KPYECNECGK TFRVSSQLIQ HQRIHTEERY HECNECGKAF KHSSGLIRHQ 300
    KIHTGEKPYL CNECGKGFGQ SSELIRHQRI HTGDKPYECN ECGKTFGQNS 350
    EIIRHIRIHT GEKPYVCKEC GKAFRGNSEL LRHERIHTGE KPYECFECGK 400
    AFRRTSHLIV HQRIHTGEKP HQCNECARTF WDNSELLLHQ KIHIGEKPYE 450
    CSECEKTFSQ HSQLIIHQRI HTGEKPYECQ ECQKTFSRSS HLLRHQSVHC 500
    ME 502
    Length:502
    Mass (Da):57,662
    Last modified:December 1, 2001 - v1
    Checksum:iFFA5DF474A5059A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055288 mRNA. Translation: BAB70898.1.
    CH471108 Genomic DNA. Translation: EAW90362.1.
    BC142962 mRNA. Translation: AAI42963.1.
    CCDSiCCDS11067.1.
    RefSeqiNP_694563.1. NM_153018.2.
    UniGeneiHs.48832.

    Genome annotation databases

    EnsembliENST00000318833; ENSP00000320347; ENSG00000180787.
    GeneIDi124961.
    KEGGihsa:124961.
    UCSCiuc002gaq.3. human.

    Polymorphism databases

    DMDMi74761006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055288 mRNA. Translation: BAB70898.1 .
    CH471108 Genomic DNA. Translation: EAW90362.1 .
    BC142962 mRNA. Translation: AAI42963.1 .
    CCDSi CCDS11067.1.
    RefSeqi NP_694563.1. NM_153018.2.
    UniGenei Hs.48832.

    3D structure databases

    ProteinModelPortali Q96NJ6.
    SMRi Q96NJ6. Positions 85-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320347.

    PTM databases

    PhosphoSitei Q96NJ6.

    Polymorphism databases

    DMDMi 74761006.

    Proteomic databases

    MaxQBi Q96NJ6.
    PaxDbi Q96NJ6.
    PRIDEi Q96NJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318833 ; ENSP00000320347 ; ENSG00000180787 .
    GeneIDi 124961.
    KEGGi hsa:124961.
    UCSCi uc002gaq.3. human.

    Organism-specific databases

    CTDi 124961.
    GeneCardsi GC17P004981.
    HGNCi HGNC:12861. ZFP3.
    HPAi HPA053085.
    MIMi 194480. gene.
    neXtProti NX_Q96NJ6.
    PharmGKBi PA37450.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96NJ6.
    OMAi LVTHQGD.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96NJ6.
    TreeFami TF337005.

    Miscellaneous databases

    ChiTaRSi ZFP3. human.
    GenomeRNAii 124961.
    NextBioi 81445.
    PROi Q96NJ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96NJ6.
    CleanExi HS_ZFP3.
    Genevestigatori Q96NJ6.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiZFP3_HUMAN
    AccessioniPrimary (citable) accession number: Q96NJ6
    Secondary accession number(s): A5PLL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3