Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96NJ6

- ZFP3_HUMAN

UniProt

Q96NJ6 - ZFP3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 3 homolog

Gene

ZFP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3 homolog
Short name:
Zfp-3
Alternative name(s):
Zinc finger protein 752
Gene namesi
Name:ZFP3
Synonyms:ZNF752
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12861. ZFP3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Zinc finger protein 3 homologPRO_0000233713Add
BLAST

Proteomic databases

MaxQBiQ96NJ6.
PaxDbiQ96NJ6.
PRIDEiQ96NJ6.

PTM databases

PhosphoSiteiQ96NJ6.

Expressioni

Gene expression databases

BgeeiQ96NJ6.
CleanExiHS_ZFP3.
GenevestigatoriQ96NJ6.

Organism-specific databases

HPAiHPA053085.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320347.

Structurei

3D structure databases

ProteinModelPortaliQ96NJ6.
SMRiQ96NJ6. Positions 114-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118961.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NJ6.
OMAiLVTHQGD.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96NJ6.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTENKEVIP KEEISEESEP HGSLLEKFPK VVYQGHEFGA GCEEDMLEGH
60 70 80 90 100
SRESMEEVIE QMSPQERDFP SGLMIFKKSP SSEKDRENNE SERGCSPSPN
110 120 130 140 150
LVTHQGDTTE GVSAFATSGQ NFLEILESNK TQRSSVGEKP HTCKECGKAF
160 170 180 190 200
NQNSHLIQHM RVHSGEKPFE CKECGKTFGT NSSLRRHLRI HAGEKPFACN
210 220 230 240 250
ECGKAFIQSS HLIHHHRIHT GERPYKCEEC GKAFSQNSAL ILHQRIHTGE
260 270 280 290 300
KPYECNECGK TFRVSSQLIQ HQRIHTEERY HECNECGKAF KHSSGLIRHQ
310 320 330 340 350
KIHTGEKPYL CNECGKGFGQ SSELIRHQRI HTGDKPYECN ECGKTFGQNS
360 370 380 390 400
EIIRHIRIHT GEKPYVCKEC GKAFRGNSEL LRHERIHTGE KPYECFECGK
410 420 430 440 450
AFRRTSHLIV HQRIHTGEKP HQCNECARTF WDNSELLLHQ KIHIGEKPYE
460 470 480 490 500
CSECEKTFSQ HSQLIIHQRI HTGEKPYECQ ECQKTFSRSS HLLRHQSVHC

ME
Length:502
Mass (Da):57,662
Last modified:December 1, 2001 - v1
Checksum:iFFA5DF474A5059A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055288 mRNA. Translation: BAB70898.1.
CH471108 Genomic DNA. Translation: EAW90362.1.
BC142962 mRNA. Translation: AAI42963.1.
CCDSiCCDS11067.1.
RefSeqiNP_694563.1. NM_153018.2.
UniGeneiHs.48832.

Genome annotation databases

EnsembliENST00000318833; ENSP00000320347; ENSG00000180787.
GeneIDi124961.
KEGGihsa:124961.
UCSCiuc002gaq.3. human.

Polymorphism databases

DMDMi74761006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055288 mRNA. Translation: BAB70898.1 .
CH471108 Genomic DNA. Translation: EAW90362.1 .
BC142962 mRNA. Translation: AAI42963.1 .
CCDSi CCDS11067.1.
RefSeqi NP_694563.1. NM_153018.2.
UniGenei Hs.48832.

3D structure databases

ProteinModelPortali Q96NJ6.
SMRi Q96NJ6. Positions 114-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000320347.

PTM databases

PhosphoSitei Q96NJ6.

Polymorphism databases

DMDMi 74761006.

Proteomic databases

MaxQBi Q96NJ6.
PaxDbi Q96NJ6.
PRIDEi Q96NJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318833 ; ENSP00000320347 ; ENSG00000180787 .
GeneIDi 124961.
KEGGi hsa:124961.
UCSCi uc002gaq.3. human.

Organism-specific databases

CTDi 124961.
GeneCardsi GC17P004981.
HGNCi HGNC:12861. ZFP3.
HPAi HPA053085.
MIMi 194480. gene.
neXtProti NX_Q96NJ6.
PharmGKBi PA37450.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118961.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96NJ6.
OMAi LVTHQGD.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q96NJ6.
TreeFami TF337005.

Miscellaneous databases

ChiTaRSi ZFP3. human.
GenomeRNAii 124961.
NextBioi 81445.
PROi Q96NJ6.
SOURCEi Search...

Gene expression databases

Bgeei Q96NJ6.
CleanExi HS_ZFP3.
Genevestigatori Q96NJ6.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZFP3_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ6
Secondary accession number(s): A5PLL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3