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Protein

Kelch-like protein 32

Gene

KLHL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 32
Alternative name(s):
BTB and kelch domain-containing protein 5
Gene namesi
Name:KLHL32
Synonyms:BKLHD5, KIAA1900
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21221. KLHL32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393552.

Polymorphism and mutation databases

BioMutaiKLHL32.
DMDMi116241269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Kelch-like protein 32PRO_0000119083Add
BLAST

Proteomic databases

PaxDbiQ96NJ5.
PeptideAtlasiQ96NJ5.
PRIDEiQ96NJ5.

PTM databases

iPTMnetiQ96NJ5.
PhosphoSiteiQ96NJ5.

Expressioni

Gene expression databases

BgeeiENSG00000186231.
CleanExiHS_KLHL32.
ExpressionAtlasiQ96NJ5. baseline and differential.
GenevisibleiQ96NJ5. HS.

Organism-specific databases

HPAiHPA039150.

Interactioni

Protein-protein interaction databases

BioGridi125354. 10 interactions.
IntActiQ96NJ5. 2 interactions.
STRINGi9606.ENSP00000358265.

Structurei

3D structure databases

ProteinModelPortaliQ96NJ5.
SMRiQ96NJ5. Positions 23-268, 286-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10968BTBPROSITE-ProRule annotationAdd
BLAST
Repeati290 – 34657Kelch 1Add
BLAST
Repeati347 – 39852Kelch 2Add
BLAST
Repeati399 – 44648Kelch 3Add
BLAST
Repeati447 – 49448Kelch 4Add
BLAST
Repeati496 – 54752Kelch 5Add
BLAST
Repeati549 – 59951Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG107125.
InParanoidiQ96NJ5.
KOiK10468.
OMAiRLMVYEP.
OrthoDBiEOG091G035Z.
PhylomeDBiQ96NJ5.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030570. KLHL32.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF65. PTHR24412:SF65. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE
60 70 80 90 100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA
110 120 130 140 150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL
160 170 180 190 200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT
210 220 230 240 250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL
260 270 280 290 300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
310 320 330 340 350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV
360 370 380 390 400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL
410 420 430 440 450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI
460 470 480 490 500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG
510 520 530 540 550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY
560 570 580 590 600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
610 620
YFTCPNLQTL QVPHHRIGTI
Length:620
Mass (Da):70,362
Last modified:October 17, 2006 - v2
Checksum:iAABDC5F667854931
GO
Isoform 2 (identifier: Q96NJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):66,562
Checksum:i6948DE1F0828FB14
GO
Isoform 3 (identifier: Q96NJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.
     105-137: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):62,953
Checksum:iABBF742A7ABFC9E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311P → S in BAB70899 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → C.
Corresponds to variant rs35143662 [ dbSNP | Ensembl ].
VAR_050053
Natural varianti129 – 1291N → S.
Corresponds to variant rs2294763 [ dbSNP | Ensembl ].
VAR_028279
Natural varianti146 – 1461D → G.
Corresponds to variant rs12662753 [ dbSNP | Ensembl ].
VAR_028280

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 10436Missing in isoform 2 and isoform 3. 1 PublicationVSP_054888Add
BLAST
Alternative sequencei105 – 13733Missing in isoform 3. 1 PublicationVSP_054889Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055292 mRNA. Translation: BAB70899.1.
AK295479 mRNA. Translation: BAH12082.1.
AK297240 mRNA. Translation: BAH12528.1.
AL033375, AL023656, AL356958 Genomic DNA. Translation: CAI19824.1.
AL023656, AL033375, AL356958 Genomic DNA. Translation: CAI20428.1.
AL356958, AL023656, AL033375 Genomic DNA. Translation: CAI21654.1.
CH471051 Genomic DNA. Translation: EAW48499.1.
CH471051 Genomic DNA. Translation: EAW48500.1.
AB067487 mRNA. Translation: BAB67793.1.
CCDSiCCDS5038.1. [Q96NJ5-1]
CCDS69154.1. [Q96NJ5-2]
CCDS69155.1. [Q96NJ5-3]
RefSeqiNP_001273179.1. NM_001286250.1. [Q96NJ5-2]
NP_001273180.1. NM_001286251.1. [Q96NJ5-3]
NP_001273183.1. NM_001286254.2.
NP_001310181.1. NM_001323252.1. [Q96NJ5-1]
NP_001310182.1. NM_001323253.1.
NP_001310183.1. NM_001323254.1.
NP_001310184.1. NM_001323255.1.
NP_001310185.1. NM_001323256.1.
NP_001310186.1. NM_001323257.1.
NP_001310188.1. NM_001323259.1.
NP_001310189.1. NM_001323260.1.
NP_001310190.1. NM_001323261.1.
NP_001310191.1. NM_001323262.1.
NP_001310192.1. NM_001323263.1.
NP_001310193.1. NM_001323264.1.
NP_443136.2. NM_052904.3. [Q96NJ5-1]
UniGeneiHs.45056.
Hs.742749.

Genome annotation databases

EnsembliENST00000369261; ENSP00000358265; ENSG00000186231. [Q96NJ5-1]
ENST00000536676; ENSP00000440382; ENSG00000186231. [Q96NJ5-2]
ENST00000539200; ENSP00000441527; ENSG00000186231. [Q96NJ5-3]
GeneIDi114792.
KEGGihsa:114792.
UCSCiuc010kcm.2. human. [Q96NJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055292 mRNA. Translation: BAB70899.1.
AK295479 mRNA. Translation: BAH12082.1.
AK297240 mRNA. Translation: BAH12528.1.
AL033375, AL023656, AL356958 Genomic DNA. Translation: CAI19824.1.
AL023656, AL033375, AL356958 Genomic DNA. Translation: CAI20428.1.
AL356958, AL023656, AL033375 Genomic DNA. Translation: CAI21654.1.
CH471051 Genomic DNA. Translation: EAW48499.1.
CH471051 Genomic DNA. Translation: EAW48500.1.
AB067487 mRNA. Translation: BAB67793.1.
CCDSiCCDS5038.1. [Q96NJ5-1]
CCDS69154.1. [Q96NJ5-2]
CCDS69155.1. [Q96NJ5-3]
RefSeqiNP_001273179.1. NM_001286250.1. [Q96NJ5-2]
NP_001273180.1. NM_001286251.1. [Q96NJ5-3]
NP_001273183.1. NM_001286254.2.
NP_001310181.1. NM_001323252.1. [Q96NJ5-1]
NP_001310182.1. NM_001323253.1.
NP_001310183.1. NM_001323254.1.
NP_001310184.1. NM_001323255.1.
NP_001310185.1. NM_001323256.1.
NP_001310186.1. NM_001323257.1.
NP_001310188.1. NM_001323259.1.
NP_001310189.1. NM_001323260.1.
NP_001310190.1. NM_001323261.1.
NP_001310191.1. NM_001323262.1.
NP_001310192.1. NM_001323263.1.
NP_001310193.1. NM_001323264.1.
NP_443136.2. NM_052904.3. [Q96NJ5-1]
UniGeneiHs.45056.
Hs.742749.

3D structure databases

ProteinModelPortaliQ96NJ5.
SMRiQ96NJ5. Positions 23-268, 286-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125354. 10 interactions.
IntActiQ96NJ5. 2 interactions.
STRINGi9606.ENSP00000358265.

PTM databases

iPTMnetiQ96NJ5.
PhosphoSiteiQ96NJ5.

Polymorphism and mutation databases

BioMutaiKLHL32.
DMDMi116241269.

Proteomic databases

PaxDbiQ96NJ5.
PeptideAtlasiQ96NJ5.
PRIDEiQ96NJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369261; ENSP00000358265; ENSG00000186231. [Q96NJ5-1]
ENST00000536676; ENSP00000440382; ENSG00000186231. [Q96NJ5-2]
ENST00000539200; ENSP00000441527; ENSG00000186231. [Q96NJ5-3]
GeneIDi114792.
KEGGihsa:114792.
UCSCiuc010kcm.2. human. [Q96NJ5-1]

Organism-specific databases

CTDi114792.
GeneCardsiKLHL32.
H-InvDBHIX0006082.
HGNCiHGNC:21221. KLHL32.
HPAiHPA039150.
neXtProtiNX_Q96NJ5.
PharmGKBiPA162393552.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG107125.
InParanoidiQ96NJ5.
KOiK10468.
OMAiRLMVYEP.
OrthoDBiEOG091G035Z.
PhylomeDBiQ96NJ5.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii114792.
PROiQ96NJ5.

Gene expression databases

BgeeiENSG00000186231.
CleanExiHS_KLHL32.
ExpressionAtlasiQ96NJ5. baseline and differential.
GenevisibleiQ96NJ5. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030570. KLHL32.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF65. PTHR24412:SF65. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH32_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ5
Secondary accession number(s): B7Z346
, B7Z4E2, E1P528, Q5THT0, Q96PY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.