UniProtKB - Q96NJ5 (KLH32_HUMAN)
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Protein
Kelch-like protein 32
Gene
KLHL32
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- fertilization Source: GO_Central
- male gonad development Source: GO_Central
- protein ubiquitination Source: GOC
- spermatid development Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Kelch-like protein 32Alternative name(s): BTB and kelch domain-containing protein 5 |
Gene namesi | Name:KLHL32 Synonyms:BKLHD5, KIAA1900 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186231.16. |
HGNCi | HGNC:21221. KLHL32. |
neXtProti | NX_Q96NJ5. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000186231. |
PharmGKBi | PA162393552. |
Polymorphism and mutation databases
BioMutai | KLHL32. |
DMDMi | 116241269. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119083 | 1 – 620 | Kelch-like protein 32Add BLAST | 620 |
Proteomic databases
MaxQBi | Q96NJ5. |
PaxDbi | Q96NJ5. |
PeptideAtlasi | Q96NJ5. |
PRIDEi | Q96NJ5. |
PTM databases
iPTMneti | Q96NJ5. |
PhosphoSitePlusi | Q96NJ5. |
Expressioni
Gene expression databases
Bgeei | ENSG00000186231. |
CleanExi | HS_KLHL32. |
ExpressionAtlasi | Q96NJ5. baseline and differential. |
Genevisiblei | Q96NJ5. HS. |
Organism-specific databases
HPAi | HPA039150. |
Interactioni
Protein-protein interaction databases
BioGridi | 125354. 10 interactors. |
IntActi | Q96NJ5. 2 interactors. |
STRINGi | 9606.ENSP00000358265. |
Structurei
3D structure databases
ProteinModelPortali | Q96NJ5. |
SMRi | Q96NJ5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 109 | BTBPROSITE-ProRule annotationAdd BLAST | 68 | |
Repeati | 290 – 346 | Kelch 1Add BLAST | 57 | |
Repeati | 347 – 398 | Kelch 2Add BLAST | 52 | |
Repeati | 399 – 446 | Kelch 3Add BLAST | 48 | |
Repeati | 447 – 494 | Kelch 4Add BLAST | 48 | |
Repeati | 496 – 547 | Kelch 5Add BLAST | 52 | |
Repeati | 549 – 599 | Kelch 6Add BLAST | 51 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG1072. Eukaryota. ENOG4110X8D. LUCA. |
GeneTreei | ENSGT00760000118825. |
HOGENOMi | HOG000231583. |
HOVERGENi | HBG107125. |
InParanoidi | Q96NJ5. |
KOi | K10468. |
OMAi | QIWQLAV. |
OrthoDBi | EOG091G035Z. |
PhylomeDBi | Q96NJ5. |
TreeFami | TF328485. |
Family and domain databases
Gene3Di | 2.120.10.80. 1 hit. |
InterProi | View protein in InterPro IPR011705. BACK. IPR017096. BTB-kelch_protein. IPR000210. BTB/POZ_dom. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. IPR030570. KLHL32. IPR011333. SKP1/BTB/POZ_sf. |
PANTHERi | PTHR24412:SF65. PTHR24412:SF65. 1 hit. |
Pfami | View protein in Pfam PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 3 hits. |
PIRSFi | PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit. |
SMARTi | View protein in SMART SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 5 hits. |
SUPFAMi | SSF117281. SSF117281. 1 hit. SSF54695. SSF54695. 1 hit. |
PROSITEi | View protein in PROSITE PS50097. BTB. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96NJ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE
60 70 80 90 100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA
110 120 130 140 150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL
160 170 180 190 200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT
210 220 230 240 250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL
260 270 280 290 300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
310 320 330 340 350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV
360 370 380 390 400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL
410 420 430 440 450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI
460 470 480 490 500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG
510 520 530 540 550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY
560 570 580 590 600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
610 620
YFTCPNLQTL QVPHHRIGTI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 331 | P → S in BAB70899 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050053 | 5 | R → C. Corresponds to variant dbSNP:rs35143662Ensembl. | 1 | |
Natural variantiVAR_028279 | 129 | N → S. Corresponds to variant dbSNP:rs2294763Ensembl. | 1 | |
Natural variantiVAR_028280 | 146 | D → G. Corresponds to variant dbSNP:rs12662753Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054888 | 69 – 104 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_054889 | 105 – 137 | Missing in isoform 3. 1 PublicationAdd BLAST | 33 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000369261; ENSP00000358265; ENSG00000186231. [Q96NJ5-1] ENST00000536676; ENSP00000440382; ENSG00000186231. [Q96NJ5-2] ENST00000539200; ENSP00000441527; ENSG00000186231. [Q96NJ5-3] |
GeneIDi | 114792. |
KEGGi | hsa:114792. |
UCSCi | uc010kcm.2. human. [Q96NJ5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | KLH32_HUMAN | |
Accessioni | Q96NJ5Primary (citable) accession number: Q96NJ5 Secondary accession number(s): B7Z346 Q96PY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 28, 2018 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |