Kelch-like protein 32

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• fertilization Source: GO_Central
• male gonad development Source: GO_Central
• protein ubiquitination Source: GOC
• spermatid development Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• Cul3-RING ubiquitin ligase complex Source: GO_Central
• cytoplasm Source: GO_Central

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE 
        60         70         80         90        100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA 
       110        120        130        140        150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL 
       160        170        180        190        200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT 
       210        220        230        240        250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL 
       260        270        280        290        300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE 
       310        320        330        340        350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV 
       360        370        380        390        400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL 
       410        420        430        440        450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI 
       460        470        480        490        500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG 
       510        520        530        540        550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY 
       560        570        580        590        600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP 
       610        620
YFTCPNLQTL QVPHHRIGTI                                  

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE 
        60         70         80         90        100
QKFHAHKAVL AACSDYFRIL LEPGVIQDVL AAGSHLQLLE LLNLCSHYLI 
       110        120        130        140        150
QELNSFNYLD LYRLADLFNL TLLEKAVIDF LVKHLSELLK SRPEEVLTLP 
       160        170        180        190        200
YCLLQEVLKS DRLTSLSEEQ IWQLAVRWLE HNCHYQYMDE LLQYIRFGLM 
       210        220        230        240        250
DVDTLHTVAL SHPLVQASET ATALVNEALE YHQSIYAQPV WQTRRTKPRF 
       260        270        280        290        300
QSDTLYIIGG KKREVCKVKE LRYFNPVDQE NALIAAIANW SELAPMPVGR 
       310        320        330        340        350
SHHCVAVMGD FLFVAGGEVE HASGRTCAVR TACRYDPRSN SWAEIAPMKN 
       360        370        380        390        400
CREHFVLGAM EEYLYAVGGR NELRQVLPTV ERYCPKKNKW TFVQSFDRSL 
       410        420        430        440        450
SCHAGYVADG LLWISGGVTN TAQYQNRLMV YEPNQNKWIS RSPMLQRRVY 
       460        470        480        490        500
HSMAAVQRKL YVLGGNDLDY NNDRILVRHI DSYNIDTDQW TRCNFNLLTG 
       510        520        530        540        550
QNESGVAVHN GRIYLVGGYS IWTNEPLACI QVLDVSREGK EEVFYGPTLP 
       560        570        580 
FASNGIAACF LPAPYFTCPN LQTLQVPHHR IGTI            

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE 
        60         70         80         90        100
QKFHAHKAVL AACSDYFREL NSFNYLDLYR LADLFNLTLL EKAVIDFLVK 
       110        120        130        140        150
HLSELLKSRP EEVLTLPYCL LQEVLKSDRL TSLSEEQIWQ LAVRWLEHNC 
       160        170        180        190        200
HYQYMDELLQ YIRFGLMDVD TLHTVALSHP LVQASETATA LVNEALEYHQ 
       210        220        230        240        250
SIYAQPVWQT RRTKPRFQSD TLYIIGGKKR EVCKVKELRY FNPVDQENAL 
       260        270        280        290        300
IAAIANWSEL APMPVGRSHH CVAVMGDFLF VAGGEVEHAS GRTCAVRTAC 
       310        320        330        340        350
RYDPRSNSWA EIAPMKNCRE HFVLGAMEEY LYAVGGRNEL RQVLPTVERY 
       360        370        380        390        400
CPKKNKWTFV QSFDRSLSCH AGYVADGLLW ISGGVTNTAQ YQNRLMVYEP 
       410        420        430        440        450
NQNKWISRSP MLQRRVYHSM AAVQRKLYVL GGNDLDYNND RILVRHIDSY 
       460        470        480        490        500
NIDTDQWTRC NFNLLTGQNE SGVAVHNGRI YLVGGYSIWT NEPLACIQVL 
       510        520        530        540        550
DVSREGKEEV FYGPTLPFAS NGIAACFLPA PYFTCPNLQT LQVPHHRIGT 

I                                             

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations