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Protein

Zinc finger protein 285

Gene

ZNF285

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 254C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32491-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 285
Alternative name(s):
Zinc finger protein 285A
Gene namesi
Name:ZNF285
Synonyms:ZNF285A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13079. ZNF285.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394833.

Polymorphism and mutation databases

BioMutaiZNF285.
DMDMi239938813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003781061 – 590Zinc finger protein 285Add BLAST590

Proteomic databases

EPDiQ96NJ3.
PaxDbiQ96NJ3.
PeptideAtlasiQ96NJ3.
PRIDEiQ96NJ3.

PTM databases

iPTMnetiQ96NJ3.
PhosphoSitePlusiQ96NJ3.

Expressioni

Gene expression databases

BgeeiENSG00000267508.
CleanExiHS_ZNF285A.
ExpressionAtlasiQ96NJ3. baseline and differential.
GenevisibleiQ96NJ3. HS.

Organism-specific databases

HPAiHPA046100.
HPA049212.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333595.

Structurei

3D structure databases

ProteinModelPortaliQ96NJ3.
SMRiQ96NJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 254C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG018163.
InParanoidiQ96NJ3.
KOiK09228.
PhylomeDBiQ96NJ3.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG
60 70 80 90 100
IKNNILNLQA KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP
110 120 130 140 150
HLEDVSLSEE WAGISLQISE NENYVVNAII KNQDITAWQS LTQVLTPESW
160 170 180 190 200
RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ HDDSLSWTSC DHHESQECKG
210 220 230 240 250
EDPGRHPNCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA FADDTDPHVH
260 270 280 290 300
HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
310 320 330 340 350
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG
360 370 380 390 400
KGFGFRSLLC IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY
410 420 430 440 450
KCSECGKCFS SSSVLQVHWR FHTGEKPYRC GECGKGFSQC THLHIHQRVH
460 470 480 490 500
TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG EKPYKCEVCG KCFSYSSYFH
510 520 530 540 550
LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTRERPY KCKACGKGFS
560 570 580 590
RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL
Length:590
Mass (Da):68,261
Last modified:June 16, 2009 - v2
Checksum:i0A3F51DEE2396462
GO
Isoform 2 (identifier: Q96NJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:435
Mass (Da):50,168
Checksum:iB7845B029FCE167C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057972208N → S.2 PublicationsCorresponds to variant rs2571089dbSNPEnsembl.1
Natural variantiVAR_057973536R → G.2 PublicationsCorresponds to variant rs12610859dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0375021 – 155Missing in isoform 2. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055309 mRNA. Translation: BAB70901.1.
AC138473 Genomic DNA. No translation available.
BC117300 mRNA. Translation: AAI17301.1.
BC117302 mRNA. Translation: AAI17303.1.
BC069384 mRNA. Translation: AAH69384.2.
BC074875 mRNA. Translation: AAH74875.2.
CCDSiCCDS12638.1. [Q96NJ3-1]
RefSeqiNP_001278417.1. NM_001291488.1.
NP_001278418.1. NM_001291489.1.
NP_001278419.1. NM_001291490.1.
NP_001278420.1. NM_001291491.1.
NP_689567.4. NM_152354.5.
UniGeneiHs.709428.

Genome annotation databases

EnsembliENST00000544719; ENSP00000439431; ENSG00000267508.
ENST00000614994; ENSP00000483662; ENSG00000267508.
GeneIDi26974.
KEGGihsa:26974.
UCSCiuc002ozd.5. human. [Q96NJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055309 mRNA. Translation: BAB70901.1.
AC138473 Genomic DNA. No translation available.
BC117300 mRNA. Translation: AAI17301.1.
BC117302 mRNA. Translation: AAI17303.1.
BC069384 mRNA. Translation: AAH69384.2.
BC074875 mRNA. Translation: AAH74875.2.
CCDSiCCDS12638.1. [Q96NJ3-1]
RefSeqiNP_001278417.1. NM_001291488.1.
NP_001278418.1. NM_001291489.1.
NP_001278419.1. NM_001291490.1.
NP_001278420.1. NM_001291491.1.
NP_689567.4. NM_152354.5.
UniGeneiHs.709428.

3D structure databases

ProteinModelPortaliQ96NJ3.
SMRiQ96NJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333595.

PTM databases

iPTMnetiQ96NJ3.
PhosphoSitePlusiQ96NJ3.

Polymorphism and mutation databases

BioMutaiZNF285.
DMDMi239938813.

Proteomic databases

EPDiQ96NJ3.
PaxDbiQ96NJ3.
PeptideAtlasiQ96NJ3.
PRIDEiQ96NJ3.

Protocols and materials databases

DNASUi26974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000544719; ENSP00000439431; ENSG00000267508.
ENST00000614994; ENSP00000483662; ENSG00000267508.
GeneIDi26974.
KEGGihsa:26974.
UCSCiuc002ozd.5. human. [Q96NJ3-1]

Organism-specific databases

CTDi26974.
GeneCardsiZNF285.
HGNCiHGNC:13079. ZNF285.
HPAiHPA046100.
HPA049212.
neXtProtiNX_Q96NJ3.
PharmGKBiPA165394833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG018163.
InParanoidiQ96NJ3.
KOiK09228.
PhylomeDBiQ96NJ3.
TreeFamiTF350845.

Enzyme and pathway databases

BioCyciZFISH:G66-32491-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii26974.
PROiQ96NJ3.

Gene expression databases

BgeeiENSG00000267508.
CleanExiHS_ZNF285A.
ExpressionAtlasiQ96NJ3. baseline and differential.
GenevisibleiQ96NJ3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN285_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ3
Secondary accession number(s): Q17RJ3, Q6B0A8, Q6ISR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.