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Protein

Zinc finger protein 570

Gene

ZNF570

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 570
Gene namesi
Name:ZNF570
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171827.10
HGNCiHGNC:26416 ZNF570
neXtProtiNX_Q96NI8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171827
PharmGKBiPA134943423

Polymorphism and mutation databases

BioMutaiZNF570
DMDMi74762681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476611 – 536Zinc finger protein 570Add BLAST536

Proteomic databases

PaxDbiQ96NI8
PeptideAtlasiQ96NI8
PRIDEiQ96NI8
ProteomicsDBi77518

PTM databases

iPTMnetiQ96NI8
PhosphoSitePlusiQ96NI8

Expressioni

Gene expression databases

BgeeiENSG00000171827
CleanExiHS_ZNF570
ExpressionAtlasiQ96NI8 baseline and differential
GenevisibleiQ96NI8 HS

Organism-specific databases

HPAiHPA028881

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331540

Structurei

3D structure databases

ProteinModelPortaliQ96NI8
SMRiQ96NI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96NI8
KOiK09228
PhylomeDBiQ96NI8
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGLLKAMY QELVTFRDVA VDFSQEEWDC LDSSQRHLYS NVMLENYRIL
60 70 80 90 100
VSLGLCFSKP SVILLLEQGK APWMVKRELT KGLCSGWEPI CETEELTPKQ
110 120 130 140 150
DFYEEHQSQK IIETLTSYNL EYSSLREEWK CEGYFERQPG NQKACFKEEI
160 170 180 190 200
ITHEEPLFDE REQEYKSWGS FHQNPLLCTQ KIIPKEEKVH KHDTQKRSFK
210 220 230 240 250
KNLMAIKPKS VCAEKKLLKC NDCEKVFSQS SSLTLHQRIH TGEKPYKCIE
260 270 280 290 300
CGKAFSQRSN LVQHQRIHTG EKPYECKECR KAFSQNAHLV QHLRVHTGEK
310 320 330 340 350
PYECKVCRKA FSQFAYLAQH QRVHTGEKPY ECIECGKAFS NRSSIAQHQR
360 370 380 390 400
VHTGEKPYEC NVCGKAFSLR AYLTVHQRIH TGERPYECKE CGKAFSQNSH
410 420 430 440 450
LAQHQRIHTG EKPYKCQECR KAFSQIAYLA QHQRVHTGEK PYECIECGKA
460 470 480 490 500
FSNDSSLTQH QRVHTGEKPY ECTVCGKAFS YCGSLAQHQR IHTGERPYEC
510 520 530
KECKKTFRQH AHLAHHQRIH IGESLSPPNP VNHQVL
Length:536
Mass (Da):62,330
Last modified:December 1, 2001 - v1
Checksum:iC3DD6CEE42C953EB
GO
Isoform 2 (identifier: Q96NI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,296
Checksum:i4D16AC2C6C59CF1D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559671 – 203Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055353 mRNA Translation: BAB70908.1
AK297561 mRNA Translation: BAG59953.1
AC008806 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56732.1
BC130425 mRNA Translation: AAI30426.1
BC130433 mRNA Translation: AAI30434.1
CCDSiCCDS12504.1 [Q96NI8-1]
RefSeqiNP_001308920.1, NM_001321991.1 [Q96NI8-1]
NP_001308921.1, NM_001321992.1
NP_001308922.1, NM_001321993.1 [Q96NI8-2]
NP_001308923.1, NM_001321994.1 [Q96NI8-2]
NP_653295.1, NM_144694.3 [Q96NI8-1]
XP_011524846.1, XM_011526544.2 [Q96NI8-1]
UniGeneiHs.126962
Hs.350875
Hs.714241

Genome annotation databases

EnsembliENST00000330173; ENSP00000331540; ENSG00000171827 [Q96NI8-1]
GeneIDi148268
KEGGihsa:148268
UCSCiuc002ogk.2 human [Q96NI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN570_HUMAN
AccessioniPrimary (citable) accession number: Q96NI8
Secondary accession number(s): A1L472, B4DMP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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