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Protein

Zinc finger protein 570

Gene

ZNF570

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 570
Gene namesi
Name:ZNF570
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26416. ZNF570.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943423.

Polymorphism and mutation databases

BioMutaiZNF570.
DMDMi74762681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Zinc finger protein 570PRO_0000047661Add
BLAST

Proteomic databases

PaxDbiQ96NI8.
PRIDEiQ96NI8.

PTM databases

iPTMnetiQ96NI8.
PhosphoSiteiQ96NI8.

Expressioni

Gene expression databases

BgeeiQ96NI8.
CleanExiHS_ZNF570.
ExpressionAtlasiQ96NI8. baseline and differential.
GenevisibleiQ96NI8. HS.

Organism-specific databases

HPAiHPA028881.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331540.

Structurei

3D structure databases

ProteinModelPortaliQ96NI8.
SMRiQ96NI8. Positions 14-54, 170-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NI8.
KOiK09228.
PhylomeDBiQ96NI8.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGLLKAMY QELVTFRDVA VDFSQEEWDC LDSSQRHLYS NVMLENYRIL
60 70 80 90 100
VSLGLCFSKP SVILLLEQGK APWMVKRELT KGLCSGWEPI CETEELTPKQ
110 120 130 140 150
DFYEEHQSQK IIETLTSYNL EYSSLREEWK CEGYFERQPG NQKACFKEEI
160 170 180 190 200
ITHEEPLFDE REQEYKSWGS FHQNPLLCTQ KIIPKEEKVH KHDTQKRSFK
210 220 230 240 250
KNLMAIKPKS VCAEKKLLKC NDCEKVFSQS SSLTLHQRIH TGEKPYKCIE
260 270 280 290 300
CGKAFSQRSN LVQHQRIHTG EKPYECKECR KAFSQNAHLV QHLRVHTGEK
310 320 330 340 350
PYECKVCRKA FSQFAYLAQH QRVHTGEKPY ECIECGKAFS NRSSIAQHQR
360 370 380 390 400
VHTGEKPYEC NVCGKAFSLR AYLTVHQRIH TGERPYECKE CGKAFSQNSH
410 420 430 440 450
LAQHQRIHTG EKPYKCQECR KAFSQIAYLA QHQRVHTGEK PYECIECGKA
460 470 480 490 500
FSNDSSLTQH QRVHTGEKPY ECTVCGKAFS YCGSLAQHQR IHTGERPYEC
510 520 530
KECKKTFRQH AHLAHHQRIH IGESLSPPNP VNHQVL
Length:536
Mass (Da):62,330
Last modified:December 1, 2001 - v1
Checksum:iC3DD6CEE42C953EB
GO
Isoform 2 (identifier: Q96NI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,296
Checksum:i4D16AC2C6C59CF1D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 203203Missing in isoform 2. 1 PublicationVSP_055967Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055353 mRNA. Translation: BAB70908.1.
AK297561 mRNA. Translation: BAG59953.1.
AC008806 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56732.1.
BC130425 mRNA. Translation: AAI30426.1.
BC130433 mRNA. Translation: AAI30434.1.
CCDSiCCDS12504.1. [Q96NI8-1]
RefSeqiNP_653295.1. NM_144694.3. [Q96NI8-1]
XP_011524843.1. XM_011526541.1. [Q96NI8-1]
XP_011524845.1. XM_011526543.1. [Q96NI8-1]
XP_011524846.1. XM_011526544.1. [Q96NI8-1]
UniGeneiHs.350875.

Genome annotation databases

EnsembliENST00000330173; ENSP00000331540; ENSG00000171827. [Q96NI8-1]
GeneIDi148268.
KEGGihsa:148268.
UCSCiuc002ogk.2. human. [Q96NI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055353 mRNA. Translation: BAB70908.1.
AK297561 mRNA. Translation: BAG59953.1.
AC008806 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56732.1.
BC130425 mRNA. Translation: AAI30426.1.
BC130433 mRNA. Translation: AAI30434.1.
CCDSiCCDS12504.1. [Q96NI8-1]
RefSeqiNP_653295.1. NM_144694.3. [Q96NI8-1]
XP_011524843.1. XM_011526541.1. [Q96NI8-1]
XP_011524845.1. XM_011526543.1. [Q96NI8-1]
XP_011524846.1. XM_011526544.1. [Q96NI8-1]
UniGeneiHs.350875.

3D structure databases

ProteinModelPortaliQ96NI8.
SMRiQ96NI8. Positions 14-54, 170-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331540.

PTM databases

iPTMnetiQ96NI8.
PhosphoSiteiQ96NI8.

Polymorphism and mutation databases

BioMutaiZNF570.
DMDMi74762681.

Proteomic databases

PaxDbiQ96NI8.
PRIDEiQ96NI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330173; ENSP00000331540; ENSG00000171827. [Q96NI8-1]
GeneIDi148268.
KEGGihsa:148268.
UCSCiuc002ogk.2. human. [Q96NI8-1]

Organism-specific databases

CTDi148268.
GeneCardsiZNF570.
HGNCiHGNC:26416. ZNF570.
HPAiHPA028881.
neXtProtiNX_Q96NI8.
PharmGKBiPA134943423.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NI8.
KOiK09228.
PhylomeDBiQ96NI8.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii148268.
PROiQ96NI8.

Gene expression databases

BgeeiQ96NI8.
CleanExiHS_ZNF570.
ExpressionAtlasiQ96NI8. baseline and differential.
GenevisibleiQ96NI8. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN570_HUMAN
AccessioniPrimary (citable) accession number: Q96NI8
Secondary accession number(s): A1L472, B4DMP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.