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Q96NI6 (LRFN5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Gene names
Name:LRFN5
Synonyms:C14orf146, SALM5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Promotes neurite outgrowth in hippocampal neurons. Ref.5 Ref.6

Subunit structure

Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LFRN4. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG1, DLG2, DLG3 and DLG4.

Subcellular location

Membrane By similarity; Single-pass type I membrane protein Potential.

Domain

Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins.

Sequence similarities

Belongs to the LRFN family.

Contains 1 fibronectin type-III domain.

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 7 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 719702Leucine-rich repeat and fibronectin type-III domain-containing protein 5
PRO_0000014845

Regions

Topological domain18 – 529512Extracellular Potential
Transmembrane530 – 55021Helical; Potential
Topological domain551 – 719169Cytoplasmic Potential
Domain18 – 5134LRRNT
Repeat52 – 7322LRR 1
Repeat76 – 9722LRR 2
Repeat100 – 12122LRR 3
Repeat124 – 14522LRR 4
Repeat148 – 16922LRR 5
Repeat172 – 19322LRR 6
Repeat196 – 21722LRR 7
Domain240 – 28647LRRCT
Domain287 – 37387Ig-like
Domain414 – 50390Fibronectin type-III

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential
Glycosylation3821N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation4521N-linked (GlcNAc...) Potential
Disulfide bond308 ↔ 357 By similarity

Experimental info

Sequence conflict5441F → L in BAG53340. Ref.1
Sequence conflict6791A → V in BAB70910. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96NI6 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: DD92951A9705FF4B

FASTA71979,445
        10         20         30         40         50         60 
MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID RRTVELRLAD 

        70         80         90        100        110        120 
NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN LRALHLNSNR LTKITNDMFS 

       130        140        150        160        170        180 
GLSNLHHLIL NNNQLTLISS TAFDDVFALE ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH 

       190        200        210        220        230        240 
NMIDNIPKGT FSHLHKMTRL DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN 

       250        260        270        280        290        300 
PLHCNCELLW LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE 

       310        320        330        340        350        360 
GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK DTGAFTCIAS 

       370        380        390        400        410        420 
NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS TKSGSNTSSS NGDTKLSQDK 

       430        440        450        460        470        480 
IVVAEATSST ALLKFNFQRN IPGIRMFQIQ YNGTYDDTLV YRMIPPTSKT FLVNNLAAGT 

       490        500        510        520        530        540 
MYDLCVLAIY DDGITSLTAT RVVGCIQFTT EQDYVRCHFM QSQFLGGTMI IIIGGIIVAS 

       550        560        570        580        590        600 
VLVFIIILMI RYKVCNNNGQ HKVTKVSNVY SQTNGAQIQG CSVTLPQSVS KQAVGHEENA 

       610        620        630        640        650        660 
QCCKATSDNV IQSSETCSSQ DSSTTTSALP PSWTSSTSVS QKQKRKTGTK PSTEPQNEAV 

       670        680        690        700        710 
TNVESQNTNR NNSTALQLAS RPPDSVTEGP TSKRAHIKPN ALLTNVDQIV QETQRLELI 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses."
Ko J., Kim S., Chung H.S., Kim K., Han K., Kim H., Jun H., Kaang B.-K., Kim E.
Neuron 50:233-245(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF INTERACTION WITH DLG1; DLG2; DLG3 AND DLG4.
[5]"The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes."
Seabold G.K., Wang P.Y., Chang K., Wang C.Y., Wang Y.X., Petralia R.S., Wenthold R.J.
J. Biol. Chem. 283:8395-8405(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH LRFN1; LRFN2; LRFN3; LRFN4 AND LRFN5.
[6]"Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth."
Wang P.Y., Seabold G.K., Wenthold R.J.
Mol. Cell. Neurosci. 39:83-94(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055365 mRNA. Translation: BAB70910.1.
AK096627 mRNA. Translation: BAG53340.1.
AL138498 Genomic DNA. No translation available.
BC043165 mRNA. Translation: AAH43165.1.
RefSeqNP_689660.2. NM_152447.3.
UniGeneHs.136893.

3D structure databases

ProteinModelPortalQ96NI6.
SMRQ96NI6. Positions 20-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298119.

PTM databases

PhosphoSiteQ96NI6.

Polymorphism databases

DMDM116242620.

Proteomic databases

PaxDbQ96NI6.
PRIDEQ96NI6.

Protocols and materials databases

DNASU145581.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298119; ENSP00000298119; ENSG00000165379.
GeneID145581.
KEGGhsa:145581.
UCSCuc001wvm.3. human.

Organism-specific databases

CTD145581.
GeneCardsGC14P042076.
HGNCHGNC:20360. LRFN5.
HPAHPA001177.
MIM612811. gene.
neXtProtNX_Q96NI6.
PharmGKBPA134888453.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG249839.
HOGENOMHOG000237343.
HOVERGENHBG052352.
InParanoidQ96NI6.
KOK16358.
OMATNVESQN.
OrthoDBEOG75B84P.
PhylomeDBQ96NI6.
TreeFamTF350185.

Gene expression databases

ArrayExpressQ96NI6.
BgeeQ96NI6.
CleanExHS_LRFN5.
GenevestigatorQ96NI6.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026879. Lrfn5.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
[Graphical view]
PANTHERPTHR24373:SF3. PTHR24373:SF3. 1 hit.
PfamPF07679. I-set. 1 hit.
PF13306. LRR_5. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi145581.
NextBio85141.
PROQ96NI6.
SOURCESearch...

Entry information

Entry nameLRFN5_HUMAN
AccessionPrimary (citable) accession number: Q96NI6
Secondary accession number(s): B3KU78, Q86XL2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM