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Protein

Leucine-rich repeat and fibronectin type-III domain-containing protein 5

Gene

LRFN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Promotes neurite outgrowth in hippocampal neurons.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Gene namesi
Name:LRFN5
Synonyms:C14orf146, SALM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165379.13
HGNCiHGNC:20360 LRFN5
MIMi612811 gene
neXtProtiNX_Q96NI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 529ExtracellularSequence analysisAdd BLAST512
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 719CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi145581
OpenTargetsiENSG00000165379
PharmGKBiPA134888453

Polymorphism and mutation databases

BioMutaiLRFN5
DMDMi116242620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001484518 – 719Leucine-rich repeat and fibronectin type-III domain-containing protein 5Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 357PROSITE-ProRule annotation
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96NI6
PeptideAtlasiQ96NI6
PRIDEiQ96NI6

PTM databases

iPTMnetiQ96NI6
PhosphoSitePlusiQ96NI6

Expressioni

Gene expression databases

BgeeiENSG00000165379
CleanExiHS_LRFN5
ExpressionAtlasiQ96NI6 baseline and differential
GenevisibleiQ96NI6 HS

Organism-specific databases

HPAiHPA001177

Interactioni

Subunit structurei

Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LFRN4. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG1, DLG2, DLG3 and DLG4.

Protein-protein interaction databases

STRINGi9606.ENSP00000298119

Structurei

Secondary structure

1719
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi32 – 36Combined sources5
Beta strandi54 – 57Combined sources4
Beta strandi79 – 81Combined sources3
Beta strandi103 – 105Combined sources3
Beta strandi116 – 119Combined sources4
Beta strandi127 – 129Combined sources3
Turni140 – 145Combined sources6
Beta strandi150 – 153Combined sources4
Helixi164 – 167Combined sources4
Beta strandi175 – 177Combined sources3
Turni188 – 193Combined sources6
Beta strandi199 – 201Combined sources3
Helixi214 – 218Combined sources5
Beta strandi224 – 227Combined sources4
Beta strandi234 – 236Combined sources3
Helixi246 – 248Combined sources3
Helixi249 – 253Combined sources5
Beta strandi262 – 266Combined sources5
Helixi267 – 269Combined sources3
Helixi274 – 276Combined sources3
Helixi279 – 281Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XNPX-ray3.73A/B18-374[»]
5XNQX-ray2.80A18-375[»]
ProteinModelPortaliQ96NI6
SMRiQ96NI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 51LRRNTAdd BLAST34
Repeati52 – 73LRR 1Add BLAST22
Repeati76 – 97LRR 2Add BLAST22
Repeati100 – 121LRR 3Add BLAST22
Repeati124 – 145LRR 4Add BLAST22
Repeati148 – 169LRR 5Add BLAST22
Repeati172 – 193LRR 6Add BLAST22
Repeati196 – 217LRR 7Add BLAST22
Domaini240 – 286LRRCTAdd BLAST47
Domaini287 – 373Ig-likeAdd BLAST87
Domaini414 – 503Fibronectin type-IIIAdd BLAST90

Domaini

Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins.

Sequence similaritiesi

Belongs to the LRFN family.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000237343
HOVERGENiHBG052352
InParanoidiQ96NI6
KOiK16358
OMAiTNVESQN
OrthoDBiEOG091G01R2
PhylomeDBiQ96NI6
TreeFamiTF350185

Family and domain databases

Gene3Di2.60.40.102 hits
3.80.10.102 hits
InterProiView protein in InterPro
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026879 Lrfn5
IPR026906 LRR_5
IPR032675 LRR_dom_sf
PANTHERiPTHR24373:SF3 PTHR24373:SF3, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13306 LRR_5, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96NI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID
60 70 80 90 100
RRTVELRLAD NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN
110 120 130 140 150
LRALHLNSNR LTKITNDMFS GLSNLHHLIL NNNQLTLISS TAFDDVFALE
160 170 180 190 200
ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH NMIDNIPKGT FSHLHKMTRL
210 220 230 240 250
DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN PLHCNCELLW
260 270 280 290 300
LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE
310 320 330 340 350
GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK
360 370 380 390 400
DTGAFTCIAS NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS
410 420 430 440 450
TKSGSNTSSS NGDTKLSQDK IVVAEATSST ALLKFNFQRN IPGIRMFQIQ
460 470 480 490 500
YNGTYDDTLV YRMIPPTSKT FLVNNLAAGT MYDLCVLAIY DDGITSLTAT
510 520 530 540 550
RVVGCIQFTT EQDYVRCHFM QSQFLGGTMI IIIGGIIVAS VLVFIIILMI
560 570 580 590 600
RYKVCNNNGQ HKVTKVSNVY SQTNGAQIQG CSVTLPQSVS KQAVGHEENA
610 620 630 640 650
QCCKATSDNV IQSSETCSSQ DSSTTTSALP PSWTSSTSVS QKQKRKTGTK
660 670 680 690 700
PSTEPQNEAV TNVESQNTNR NNSTALQLAS RPPDSVTEGP TSKRAHIKPN
710
ALLTNVDQIV QETQRLELI
Length:719
Mass (Da):79,445
Last modified:October 17, 2006 - v2
Checksum:iDD92951A9705FF4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti544F → L in BAG53340 (PubMed:14702039).Curated1
Sequence conflicti679A → V in BAB70910 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055365 mRNA Translation: BAB70910.1
AK096627 mRNA Translation: BAG53340.1
AL138498 Genomic DNA No translation available.
BC043165 mRNA Translation: AAH43165.1
CCDSiCCDS9678.1
RefSeqiNP_001333102.1, NM_001346173.1
NP_689660.2, NM_152447.4
XP_016876537.1, XM_017021048.1
UniGeneiHs.136893

Genome annotation databases

EnsembliENST00000298119; ENSP00000298119; ENSG00000165379
GeneIDi145581
KEGGihsa:145581
UCSCiuc001wvm.5 human

Similar proteinsi

Entry informationi

Entry nameiLRFN5_HUMAN
AccessioniPrimary (citable) accession number: Q96NI6
Secondary accession number(s): B3KU78, Q86XL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: April 25, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome