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Protein

Leucine-rich repeat and fibronectin type-III domain-containing protein 5

Gene

LRFN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Promotes neurite outgrowth in hippocampal neurons.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Gene namesi
Name:LRFN5
Synonyms:C14orf146, SALM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20360. LRFN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 529512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei530 – 55021HelicalSequence AnalysisAdd
BLAST
Topological domaini551 – 719169CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888453.

Polymorphism and mutation databases

BioMutaiLRFN5.
DMDMi116242620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 719702Leucine-rich repeat and fibronectin type-III domain-containing protein 5PRO_0000014845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 357PROSITE-ProRule annotation
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96NI6.
PRIDEiQ96NI6.

PTM databases

PhosphoSiteiQ96NI6.

Expressioni

Gene expression databases

BgeeiQ96NI6.
CleanExiHS_LRFN5.
ExpressionAtlasiQ96NI6. baseline and differential.
GenevestigatoriQ96NI6.

Organism-specific databases

HPAiHPA001177.

Interactioni

Subunit structurei

Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LFRN4. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG1, DLG2, DLG3 and DLG4.

Protein-protein interaction databases

STRINGi9606.ENSP00000298119.

Structurei

3D structure databases

ProteinModelPortaliQ96NI6.
SMRiQ96NI6. Positions 19-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5134LRRNTAdd
BLAST
Repeati52 – 7322LRR 1Add
BLAST
Repeati76 – 9722LRR 2Add
BLAST
Repeati100 – 12122LRR 3Add
BLAST
Repeati124 – 14522LRR 4Add
BLAST
Repeati148 – 16922LRR 5Add
BLAST
Repeati172 – 19322LRR 6Add
BLAST
Repeati196 – 21722LRR 7Add
BLAST
Domaini240 – 28647LRRCTAdd
BLAST
Domaini287 – 37387Ig-likeAdd
BLAST
Domaini414 – 50390Fibronectin type-IIIAdd
BLAST

Domaini

Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins.

Sequence similaritiesi

Belongs to the LRFN family.Curated
Contains 1 fibronectin type-III domain.Curated
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249839.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000237343.
HOVERGENiHBG052352.
InParanoidiQ96NI6.
KOiK16358.
OMAiTNVESQN.
OrthoDBiEOG75B84P.
PhylomeDBiQ96NI6.
TreeFamiTF350185.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026879. Lrfn5.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
[Graphical view]
PANTHERiPTHR24373:SF3. PTHR24373:SF3. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13306. LRR_5. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96NI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID
60 70 80 90 100
RRTVELRLAD NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN
110 120 130 140 150
LRALHLNSNR LTKITNDMFS GLSNLHHLIL NNNQLTLISS TAFDDVFALE
160 170 180 190 200
ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH NMIDNIPKGT FSHLHKMTRL
210 220 230 240 250
DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN PLHCNCELLW
260 270 280 290 300
LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE
310 320 330 340 350
GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK
360 370 380 390 400
DTGAFTCIAS NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS
410 420 430 440 450
TKSGSNTSSS NGDTKLSQDK IVVAEATSST ALLKFNFQRN IPGIRMFQIQ
460 470 480 490 500
YNGTYDDTLV YRMIPPTSKT FLVNNLAAGT MYDLCVLAIY DDGITSLTAT
510 520 530 540 550
RVVGCIQFTT EQDYVRCHFM QSQFLGGTMI IIIGGIIVAS VLVFIIILMI
560 570 580 590 600
RYKVCNNNGQ HKVTKVSNVY SQTNGAQIQG CSVTLPQSVS KQAVGHEENA
610 620 630 640 650
QCCKATSDNV IQSSETCSSQ DSSTTTSALP PSWTSSTSVS QKQKRKTGTK
660 670 680 690 700
PSTEPQNEAV TNVESQNTNR NNSTALQLAS RPPDSVTEGP TSKRAHIKPN
710
ALLTNVDQIV QETQRLELI
Length:719
Mass (Da):79,445
Last modified:October 17, 2006 - v2
Checksum:iDD92951A9705FF4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti544 – 5441F → L in BAG53340 (PubMed:14702039).Curated
Sequence conflicti679 – 6791A → V in BAB70910 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055365 mRNA. Translation: BAB70910.1.
AK096627 mRNA. Translation: BAG53340.1.
AL138498 Genomic DNA. No translation available.
BC043165 mRNA. Translation: AAH43165.1.
CCDSiCCDS9678.1.
RefSeqiNP_689660.2. NM_152447.3.
UniGeneiHs.136893.

Genome annotation databases

EnsembliENST00000298119; ENSP00000298119; ENSG00000165379.
GeneIDi145581.
KEGGihsa:145581.
UCSCiuc001wvm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055365 mRNA. Translation: BAB70910.1.
AK096627 mRNA. Translation: BAG53340.1.
AL138498 Genomic DNA. No translation available.
BC043165 mRNA. Translation: AAH43165.1.
CCDSiCCDS9678.1.
RefSeqiNP_689660.2. NM_152447.3.
UniGeneiHs.136893.

3D structure databases

ProteinModelPortaliQ96NI6.
SMRiQ96NI6. Positions 19-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298119.

PTM databases

PhosphoSiteiQ96NI6.

Polymorphism and mutation databases

BioMutaiLRFN5.
DMDMi116242620.

Proteomic databases

PaxDbiQ96NI6.
PRIDEiQ96NI6.

Protocols and materials databases

DNASUi145581.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298119; ENSP00000298119; ENSG00000165379.
GeneIDi145581.
KEGGihsa:145581.
UCSCiuc001wvm.3. human.

Organism-specific databases

CTDi145581.
GeneCardsiGC14P042076.
HGNCiHGNC:20360. LRFN5.
HPAiHPA001177.
MIMi612811. gene.
neXtProtiNX_Q96NI6.
PharmGKBiPA134888453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG249839.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000237343.
HOVERGENiHBG052352.
InParanoidiQ96NI6.
KOiK16358.
OMAiTNVESQN.
OrthoDBiEOG75B84P.
PhylomeDBiQ96NI6.
TreeFamiTF350185.

Miscellaneous databases

ChiTaRSiLRFN5. human.
GenomeRNAii145581.
NextBioi85141.
PROiQ96NI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NI6.
CleanExiHS_LRFN5.
ExpressionAtlasiQ96NI6. baseline and differential.
GenevestigatoriQ96NI6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026879. Lrfn5.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
[Graphical view]
PANTHERiPTHR24373:SF3. PTHR24373:SF3. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13306. LRR_5. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses."
    Ko J., Kim S., Chung H.S., Kim K., Han K., Kim H., Jun H., Kaang B.-K., Kim E.
    Neuron 50:233-245(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INTERACTION WITH DLG1; DLG2; DLG3 AND DLG4.
  5. "The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes."
    Seabold G.K., Wang P.Y., Chang K., Wang C.Y., Wang Y.X., Petralia R.S., Wenthold R.J.
    J. Biol. Chem. 283:8395-8405(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LRFN1; LRFN2; LRFN3; LRFN4 AND LRFN5.
  6. "Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth."
    Wang P.Y., Seabold G.K., Wenthold R.J.
    Mol. Cell. Neurosci. 39:83-94(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLRFN5_HUMAN
AccessioniPrimary (citable) accession number: Q96NI6
Secondary accession number(s): B3KU78, Q86XL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: May 27, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.