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Protein

Protein broad-minded

Gene

TBC1D32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein broad-minded
Alternative name(s):
TBC1 domain family member 32
Gene namesi
Name:TBC1D32
Synonyms:BROMI, C6orf170, C6orf171
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21485. TBC1D32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871908.

Polymorphism and mutation databases

BioMutaiTBC1D32.
DMDMi296439461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12571257Protein broad-mindedPRO_0000089557Add
BLAST

Proteomic databases

PaxDbiQ96NH3.
PRIDEiQ96NH3.

PTM databases

PhosphoSiteiQ96NH3.

Expressioni

Gene expression databases

BgeeiQ96NH3.
CleanExiHS_C6orf170.
ExpressionAtlasiQ96NH3. baseline and differential.
GenevisibleiQ96NH3. HS.

Organism-specific databases

HPAiHPA013413.

Interactioni

Subunit structurei

Interacts with CDK20, which promotes CDK20 stability and function.By similarity

Protein-protein interaction databases

BioGridi128710. 2 interactions.
IntActiQ96NH3. 1 interaction.
STRINGi9606.ENSP00000381270.

Structurei

3D structure databases

ProteinModelPortaliQ96NH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1119 – 1242124Rab-GAP TBCAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.Curated

Phylogenomic databases

eggNOGiNOG74284.
GeneTreeiENSGT00390000004463.
HOGENOMiHOG000111575.
HOVERGENiHBG087600.
InParanoidiQ96NH3.
OMAiKKWMHAY.
OrthoDBiEOG7H1JJR.
PhylomeDBiQ96NH3.
TreeFamiTF329092.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR005373. UPF0183.
[Graphical view]
PANTHERiPTHR13465. PTHR13465. 1 hit.
SUPFAMiSSF47923. SSF47923. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHFSSEDQA MLQAMLRRLF QSVKEKITGA PSLECAEEIL LHLEETDENF
60 70 80 90 100
HNYEFVKYLR QHIGNTLGSM IEEEMEKCTS DRNQGEECGY DTVVQQVTKR
110 120 130 140 150
TQESKEYKEM MHYLKNIMIA VVESMINKFE EDETRNQERQ KKIQKEKSHS
160 170 180 190 200
YRTDNCSDSD SSLNQSYKFC QGKLQLILDQ LDPGQPKEVR YEALQTLCSA
210 220 230 240 250
PPSDVLNCEN WTTLCEKLTV SLSDPDPVFS DRILKFCAQT FLLSPLHMTK
260 270 280 290 300
EIYTSLAKYL ESYFLSRENH IPTLSAGVDI TNPNMTRLLK KVRLLNEYQK
310 320 330 340 350
EAPSFWIRHP EKYMEEIVES TLSLLTVKHN QSHVVSQKIL DPIYFFALVD
360 370 380 390 400
TKAVWFKKWM HAHYSRTTVL RLLETKYKSL VTTAIQQCVQ YFEMCKTRKA
410 420 430 440 450
DETLGHSKHC RNKQKTFYYL GQELQYIYFI HSLCLLGRLL IYKQGRKLFP
460 470 480 490 500
IKLKNKKGLV SLIDLLVLFT QLIYYSPSCP KMTSAAHSEN YSPASMVTEV
510 520 530 540 550
LWILSDQKEC AVECLYNNIV IETLLQPIHN LMKGNEASPN CSETALIHIA
560 570 580 590 600
GILARIASVE EGLILLLYGA NMNSSEESPT GAHIIAQFSK KLLDEDISIF
610 620 630 640 650
SGSEMLPVVK GAFISVCRHI YSTCEGLQVL ITYNLHESIA KAWKKTSLLS
660 670 680 690 700
ERIPTPVEGS DSVSSVSQES QNIMAWEDNL LDDLLHFAAT PKGLLLLQRT
710 720 730 740 750
GAINECVTFI FNRYAKKLQV SRHKKFGYGV LVTRVASTAA GGIALKKSGF
760 770 780 790 800
INELITELWS NLEYGRDDVR VTHPRTTPVD PIDRSCQKSF LALVNLLSYP
810 820 830 840 850
AIYELVRNQD LPNKTEYSLR EVPTCVIDII DRLIILNSEA KIRSLFNYEQ
860 870 880 890 900
SHIFGLRDFI IDGLSVERNH VLVRINLVGG PLERILPPRL LEKSDNPYPW
910 920 930 940 950
PMFSSYPLPN CYLSDITRNA GIKQDNDLDK LLLCLKISDK QTEWIENCQR
960 970 980 990 1000
QFCKMMKAKP DIISGEALIE LLEKFVLHLT ESPSECYFPS VEYTATDANV
1010 1020 1030 1040 1050
KNESLSSVQQ LGIKMTVRYG KFLSLLKDGA ENDLTWVLKH CERFLKQQQT
1060 1070 1080 1090 1100
SIKSSLLCLQ GNYAGHDWFV SSLFMIMLGD KEKTFQFLHQ FSRLLTSAFL
1110 1120 1130 1140 1150
WLPRLHISSY LPNDTVESGI HPVYFCSTHY IEMLLKAELP LVFSAFHMSG
1160 1170 1180 1190 1200
FAPSQICLQW ITQCFWNYLD WIEICHYIAT CVFLGPDYQV YICIAVFKHL
1210 1220 1230 1240 1250
QQDILQHTQT QDLQVFLKEE ALHGFRVSDY FEYMEILEQN YRTVLLRDMR

NIRLQST
Note: No experimental confirmation available.
Length:1,257
Mass (Da):144,756
Last modified:May 18, 2010 - v4
Checksum:i3370457AB4238DC0
GO
Isoform 2 (identifier: Q96NH3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: R → RLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHR

Note: No experimental confirmation available.
Show »
Length:1,298
Mass (Da):149,428
Checksum:i5C26F7B38708E92C
GO
Isoform 3 (identifier: Q96NH3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-108: EYK → ELP
     109-1257: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:108
Mass (Da):12,529
Checksum:i36820D1BD1936EB6
GO

Sequence cautioni

The sequence BAB70925.1 differs from that shown. Reason: Frameshift at position 717. Curated
The sequence BAC03694.1 differs from that shown.Aberrant splicing.Curated
The sequence BAC03694.1 differs from that shown. Reason: Frameshift at position 143. Curated
The sequence BAC86152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18591.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAI16051.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20000.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM16339.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM17813.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM28224.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti554 – 5541A → V in BAC86152 (PubMed:14702039).Curated
Sequence conflicti906 – 9061Y → H in BAC03694 (PubMed:14702039).Curated
Sequence conflicti1210 – 12101T → A in BAC86152 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821R → Q.1 Publication
Corresponds to variant rs7767455 [ dbSNP | Ensembl ].
VAR_046958
Natural varianti280 – 2801I → V.
Corresponds to variant rs9490157 [ dbSNP | Ensembl ].
VAR_046959
Natural varianti375 – 3751T → K.1 Publication
Corresponds to variant rs9387944 [ dbSNP | Ensembl ].
VAR_046960
Natural varianti599 – 5991I → V.
Corresponds to variant rs7745023 [ dbSNP | Ensembl ].
VAR_046961

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1083EYK → ELP in isoform 3. 1 PublicationVSP_035579
Alternative sequencei109 – 12571149Missing in isoform 3. 1 PublicationVSP_035580Add
BLAST
Alternative sequencei857 – 8571R → RLLSVICCDLDTLLLLEAQY QVSEMLLNAQEENILEISES HR in isoform 2. 1 PublicationVSP_014546

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055461 mRNA. Translation: BAB70925.1. Frameshift.
AK091554 mRNA. Translation: BAC03694.1. Sequence problems.
AK125385 mRNA. Translation: BAC86152.1. Different initiation.
AK131446 mRNA. Translation: BAD18591.1. Sequence problems.
AL365508
, AL035593, AL589910, AL590225 Genomic DNA. Translation: CAI13226.2.
AL590225
, AL035593, AL365508, AL589910 Genomic DNA. Translation: CAI13628.2.
AL589910
, AL035593, AL139098, AL365508, AL590225 Genomic DNA. Translation: CAI16051.2. Sequence problems.
AL139098
, AL035593, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAI20000.2. Sequence problems.
AL035593
, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAI20139.2.
AL365508
, AL035593, AL139098, AL589910, AL590225 Genomic DNA. Translation: CAM16339.1. Sequence problems.
AL590225
, AL035593, AL139098, AL365508, AL589910 Genomic DNA. Translation: CAM17813.1. Sequence problems.
AL589910
, AL035593, AL365508, AL590225 Genomic DNA. Translation: CAM22453.1.
AL035593
, AL139098, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAM28224.1. Sequence problems.
CCDSiCCDS43501.1. [Q96NH3-1]
RefSeqiNP_689943.4. NM_152730.5. [Q96NH3-1]
XP_005266918.1. XM_005266861.2. [Q96NH3-4]
UniGeneiHs.121396.

Genome annotation databases

EnsembliENST00000275159; ENSP00000275159; ENSG00000146350. [Q96NH3-4]
ENST00000398212; ENSP00000381270; ENSG00000146350.
ENST00000464622; ENSP00000428839; ENSG00000146350. [Q96NH3-5]
GeneIDi221322.
KEGGihsa:221322.
UCSCiuc003pyo.1. human. [Q96NH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055461 mRNA. Translation: BAB70925.1. Frameshift.
AK091554 mRNA. Translation: BAC03694.1. Sequence problems.
AK125385 mRNA. Translation: BAC86152.1. Different initiation.
AK131446 mRNA. Translation: BAD18591.1. Sequence problems.
AL365508
, AL035593, AL589910, AL590225 Genomic DNA. Translation: CAI13226.2.
AL590225
, AL035593, AL365508, AL589910 Genomic DNA. Translation: CAI13628.2.
AL589910
, AL035593, AL139098, AL365508, AL590225 Genomic DNA. Translation: CAI16051.2. Sequence problems.
AL139098
, AL035593, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAI20000.2. Sequence problems.
AL035593
, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAI20139.2.
AL365508
, AL035593, AL139098, AL589910, AL590225 Genomic DNA. Translation: CAM16339.1. Sequence problems.
AL590225
, AL035593, AL139098, AL365508, AL589910 Genomic DNA. Translation: CAM17813.1. Sequence problems.
AL589910
, AL035593, AL365508, AL590225 Genomic DNA. Translation: CAM22453.1.
AL035593
, AL139098, AL365508, AL589910, AL590225 Genomic DNA. Translation: CAM28224.1. Sequence problems.
CCDSiCCDS43501.1. [Q96NH3-1]
RefSeqiNP_689943.4. NM_152730.5. [Q96NH3-1]
XP_005266918.1. XM_005266861.2. [Q96NH3-4]
UniGeneiHs.121396.

3D structure databases

ProteinModelPortaliQ96NH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128710. 2 interactions.
IntActiQ96NH3. 1 interaction.
STRINGi9606.ENSP00000381270.

PTM databases

PhosphoSiteiQ96NH3.

Polymorphism and mutation databases

BioMutaiTBC1D32.
DMDMi296439461.

Proteomic databases

PaxDbiQ96NH3.
PRIDEiQ96NH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275159; ENSP00000275159; ENSG00000146350. [Q96NH3-4]
ENST00000398212; ENSP00000381270; ENSG00000146350.
ENST00000464622; ENSP00000428839; ENSG00000146350. [Q96NH3-5]
GeneIDi221322.
KEGGihsa:221322.
UCSCiuc003pyo.1. human. [Q96NH3-1]

Organism-specific databases

CTDi221322.
GeneCardsiGC06M121401.
HGNCiHGNC:21485. TBC1D32.
HPAiHPA013413.
MIMi615867. gene.
neXtProtiNX_Q96NH3.
PharmGKBiPA134871908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74284.
GeneTreeiENSGT00390000004463.
HOGENOMiHOG000111575.
HOVERGENiHBG087600.
InParanoidiQ96NH3.
OMAiKKWMHAY.
OrthoDBiEOG7H1JJR.
PhylomeDBiQ96NH3.
TreeFamiTF329092.

Miscellaneous databases

ChiTaRSiTBC1D32. human.
GenomeRNAii221322.
NextBioi91289.
PROiQ96NH3.
SOURCEiSearch...

Gene expression databases

BgeeiQ96NH3.
CleanExiHS_C6orf170.
ExpressionAtlasiQ96NH3. baseline and differential.
GenevisibleiQ96NH3. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR005373. UPF0183.
[Graphical view]
PANTHERiPTHR13465. PTHR13465. 1 hit.
SUPFAMiSSF47923. SSF47923. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 408-1257 (ISOFORM 2), VARIANTS GLN-82 AND LYS-375.
    Tissue: Brain and Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBROMI_HUMAN
AccessioniPrimary (citable) accession number: Q96NH3
Secondary accession number(s): Q5SZD6
, Q5SZM6, Q6ZMY4, Q6ZUR7, Q8NB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.