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Protein

Zinc finger protein 582

Gene

ZNF582

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 582
Gene namesi
Name:ZNF582
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26421. ZNF582.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989661.

Polymorphism and mutation databases

BioMutaiZNF582.
DMDMi74732564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Zinc finger protein 582PRO_0000234591Add
BLAST

Proteomic databases

PaxDbiQ96NG8.
PeptideAtlasiQ96NG8.
PRIDEiQ96NG8.

PTM databases

iPTMnetiQ96NG8.
PhosphoSiteiQ96NG8.

Expressioni

Gene expression databases

BgeeiENSG00000018869.
CleanExiHS_ZNF582.
ExpressionAtlasiQ96NG8. baseline and differential.
GenevisibleiQ96NG8. HS.

Organism-specific databases

HPAiHPA028858.

Interactioni

Protein-protein interaction databases

BioGridi127104. 1 interaction.
STRINGi9606.ENSP00000301310.

Structurei

3D structure databases

ProteinModelPortaliQ96NG8.
SMRiQ96NG8. Positions 169-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NG8.
KOiK09228.
OMAiTFYQKIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96NG8.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96NG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGSELFRD VAIVFSQEEW QWLAPAQRDL YRDVMLETYS NLVSLGLAVS
60 70 80 90 100
KPDVISFLEQ GKEPWMVERV VSGGLCPVLE SRYDTKELFP KQHVYEVESP
110 120 130 140 150
QWEIMESLTS YGLECSSFQD DWECRNQFDR QQGNPDRHFH QMIIRHEEMP
160 170 180 190 200
TFDQHASLTF YQKIHTREKP FGYNKCRKDF WQKELLINHQ GIYTNEKPYK
210 220 230 240 250
CKECGKAFKY GSRLIQHENI HSGKKPYECK ECGKAFNSGS NFIQHQRVHT
260 270 280 290 300
GEKPYECKDC EKAFSRSSQL IEHQRTHTGE KPYQCKECGK AFNRISHLKV
310 320 330 340 350
HYRIHTGEKP YACKECGKTF SHRSQLIQHQ TVHTGRKLYE CKECGKAFNQ
360 370 380 390 400
GSTLIRHQRI HTGEKPYECK VCGKAFRVSS QLKQHQRIHT GEKPYQCKVC
410 420 430 440 450
GRAFKRVSHL TVHYRIHTGE KPYECKECGK AFSHCSQLIH HQVIHTEKKP
460 470 480 490 500
YEYKECEKTL SHDSTTVQPQ RMHNRETHVN IINVEKPSIS SYPLLIIREF
510
MLASNHMNGS NGESPLA
Length:517
Mass (Da):60,498
Last modified:December 1, 2001 - v1
Checksum:iFEE3AE28C6F8B53A
GO

Sequence cautioni

The sequence AAH11796 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAG61111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAH14399 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW72447 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861K → R in BAH14399 (PubMed:14702039).Curated
Sequence conflicti365 – 3651K → R in BAH14399 (PubMed:14702039).Curated
Sequence conflicti411 – 4111T → A in BAH14399 (PubMed:14702039).Curated
Sequence conflicti426 – 4261K → G in BAH14399 (PubMed:14702039).Curated
Sequence conflicti475 – 4751R → G in BAH14399 (PubMed:14702039).Curated
Sequence conflicti487 – 4871P → A in BAH14399 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651W → G Found in a patient with mild intellectual disability and eye movement disorder; unknown pathological significance. 1 Publication
Corresponds to variant rs369155373 [ dbSNP | Ensembl ].
VAR_070557
Natural varianti69 – 691R → T.
Corresponds to variant rs11883260 [ dbSNP | Ensembl ].
VAR_033578
Natural varianti345 – 3451G → E Found in a patient with mild intellectual disability and eye movement disorder; unknown pathological significance. 1 Publication
Corresponds to variant rs149022328 [ dbSNP | Ensembl ].
VAR_070558

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055489 mRNA. Translation: BAB70931.1.
AK299036 mRNA. Translation: BAG61111.1. Different initiation.
AK316028 mRNA. Translation: BAH14399.1. Different initiation.
CH471135 Genomic DNA. Translation: EAW72447.1. Sequence problems.
BC011796 mRNA. Translation: AAH11796.1. Sequence problems.
BC101008 mRNA. Translation: AAI01009.1.
BC101009 mRNA. Translation: AAI01010.1.
BC101010 mRNA. Translation: AAI01011.1.
BC101011 mRNA. Translation: AAI01012.1.
CCDSiCCDS33121.1.
RefSeqiNP_001307300.1. NM_001320371.1.
NP_653291.1. NM_144690.2.
UniGeneiHs.244391.
Hs.655905.

Genome annotation databases

EnsembliENST00000301310; ENSP00000301310; ENSG00000018869.
ENST00000586929; ENSP00000465619; ENSG00000018869.
ENST00000619584; ENSP00000483414; ENSG00000018869.
GeneIDi147948.
KEGGihsa:147948.
UCSCiuc002qmz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055489 mRNA. Translation: BAB70931.1.
AK299036 mRNA. Translation: BAG61111.1. Different initiation.
AK316028 mRNA. Translation: BAH14399.1. Different initiation.
CH471135 Genomic DNA. Translation: EAW72447.1. Sequence problems.
BC011796 mRNA. Translation: AAH11796.1. Sequence problems.
BC101008 mRNA. Translation: AAI01009.1.
BC101009 mRNA. Translation: AAI01010.1.
BC101010 mRNA. Translation: AAI01011.1.
BC101011 mRNA. Translation: AAI01012.1.
CCDSiCCDS33121.1.
RefSeqiNP_001307300.1. NM_001320371.1.
NP_653291.1. NM_144690.2.
UniGeneiHs.244391.
Hs.655905.

3D structure databases

ProteinModelPortaliQ96NG8.
SMRiQ96NG8. Positions 169-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127104. 1 interaction.
STRINGi9606.ENSP00000301310.

PTM databases

iPTMnetiQ96NG8.
PhosphoSiteiQ96NG8.

Polymorphism and mutation databases

BioMutaiZNF582.
DMDMi74732564.

Proteomic databases

PaxDbiQ96NG8.
PeptideAtlasiQ96NG8.
PRIDEiQ96NG8.

Protocols and materials databases

DNASUi147948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301310; ENSP00000301310; ENSG00000018869.
ENST00000586929; ENSP00000465619; ENSG00000018869.
ENST00000619584; ENSP00000483414; ENSG00000018869.
GeneIDi147948.
KEGGihsa:147948.
UCSCiuc002qmz.1. human.

Organism-specific databases

CTDi147948.
GeneCardsiZNF582.
HGNCiHGNC:26421. ZNF582.
HPAiHPA028858.
MIMi615600. gene.
neXtProtiNX_Q96NG8.
PharmGKBiPA134989661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NG8.
KOiK09228.
OMAiTFYQKIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96NG8.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii147948.
PROiQ96NG8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000018869.
CleanExiHS_ZNF582.
ExpressionAtlasiQ96NG8. baseline and differential.
GenevisibleiQ96NG8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN582_HUMAN
AccessioniPrimary (citable) accession number: Q96NG8
Secondary accession number(s): B4DQZ9, B7Z9R3, Q6PJT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.