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Protein

Zinc finger protein 558

Gene

ZNF558

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri180 – 20223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 558
Gene namesi
Name:ZNF558
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26422. ZNF558.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899314.

Polymorphism and mutation databases

BioMutaiZNF558.
DMDMi68566225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger protein 558PRO_0000047648Add
BLAST

Proteomic databases

EPDiQ96NG5.
PaxDbiQ96NG5.
PeptideAtlasiQ96NG5.
PRIDEiQ96NG5.
TopDownProteomicsiQ96NG5-1. [Q96NG5-1]

PTM databases

iPTMnetiQ96NG5.
PhosphoSiteiQ96NG5.

Expressioni

Gene expression databases

BgeeiQ96NG5.
CleanExiHS_ZNF558.
GenevisibleiQ96NG5. HS.

Organism-specific databases

HPAiHPA003151.

Interactioni

Protein-protein interaction databases

BioGridi127124. 9 interactions.
IntActiQ96NG5. 1 interaction.
STRINGi9606.ENSP00000301475.

Structurei

3D structure databases

ProteinModelPortaliQ96NG5.
SMRiQ96NG5. Positions 43-83, 143-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 11472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri180 – 20223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NG5.
KOiK09228.
OMAiKRIHNRW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96NG5.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVILPSTA APSSLFPASQ QKGHTQGGEL VNELLTSWLR GLVTFEDVAV
60 70 80 90 100
EFTQEEWALL DPAQRTLYRD VMLENCRNLA SLGCRVNKPS LISQLEQDKK
110 120 130 140 150
VVTEERGILP STCPDLETLL KAKWLTPKKN VFRKEQSKGV KTERSHRGVK
160 170 180 190 200
LNECNQCFKV FSTKSNLTQH KRIHTGEKPY DCSQCGKSFS SRSYLTIHKR
210 220 230 240 250
IHNGEKPYEC NHCGKAFSDP SSLRLHLRIH TGEKPYECNQ CFHVFRTSCN
260 270 280 290 300
LKSHKRIHTG ENHHECNQCG KAFSTRSSLT GHNSIHTGEK PYECHDCGKT
310 320 330 340 350
FRKSSYLTQH VRTHTGEKPY ECNECGKSFS SSFSLTVHKR IHTGEKPYEC
360 370 380 390 400
SDCGKAFNNL SAVKKHLRTH TGEKPYECNH CGKSFTSNSY LSVHKRIHNR

WI
Length:402
Mass (Da):45,755
Last modified:December 1, 2001 - v1
Checksum:iBB77228C89FBDD61
GO
Isoform 2 (identifier: Q96NG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):37,971
Checksum:i3BE50C78C82A97E5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7171Missing in isoform 2. 1 PublicationVSP_055963Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055494 mRNA. Translation: BAB70934.1.
AK291265 mRNA. Translation: BAF83954.1.
AK301664 mRNA. Translation: BAH13534.1.
AC008734 Genomic DNA. No translation available.
AC012616 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW83994.1.
BC064356 mRNA. Translation: AAH64356.1.
CCDSiCCDS12208.1. [Q96NG5-1]
RefSeqiNP_001291279.1. NM_001304350.1. [Q96NG5-2]
NP_653294.1. NM_144693.2. [Q96NG5-1]
XP_011526005.1. XM_011527703.1. [Q96NG5-2]
XP_011526006.1. XM_011527704.1. [Q96NG5-2]
UniGeneiHs.349444.
Hs.659797.

Genome annotation databases

EnsembliENST00000301475; ENSP00000301475; ENSG00000167785. [Q96NG5-1]
ENST00000601372; ENSP00000471277; ENSG00000167785. [Q96NG5-1]
GeneIDi148156.
KEGGihsa:148156.
UCSCiuc002mkn.1. human. [Q96NG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055494 mRNA. Translation: BAB70934.1.
AK291265 mRNA. Translation: BAF83954.1.
AK301664 mRNA. Translation: BAH13534.1.
AC008734 Genomic DNA. No translation available.
AC012616 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW83994.1.
BC064356 mRNA. Translation: AAH64356.1.
CCDSiCCDS12208.1. [Q96NG5-1]
RefSeqiNP_001291279.1. NM_001304350.1. [Q96NG5-2]
NP_653294.1. NM_144693.2. [Q96NG5-1]
XP_011526005.1. XM_011527703.1. [Q96NG5-2]
XP_011526006.1. XM_011527704.1. [Q96NG5-2]
UniGeneiHs.349444.
Hs.659797.

3D structure databases

ProteinModelPortaliQ96NG5.
SMRiQ96NG5. Positions 43-83, 143-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127124. 9 interactions.
IntActiQ96NG5. 1 interaction.
STRINGi9606.ENSP00000301475.

PTM databases

iPTMnetiQ96NG5.
PhosphoSiteiQ96NG5.

Polymorphism and mutation databases

BioMutaiZNF558.
DMDMi68566225.

Proteomic databases

EPDiQ96NG5.
PaxDbiQ96NG5.
PeptideAtlasiQ96NG5.
PRIDEiQ96NG5.
TopDownProteomicsiQ96NG5-1. [Q96NG5-1]

Protocols and materials databases

DNASUi148156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301475; ENSP00000301475; ENSG00000167785. [Q96NG5-1]
ENST00000601372; ENSP00000471277; ENSG00000167785. [Q96NG5-1]
GeneIDi148156.
KEGGihsa:148156.
UCSCiuc002mkn.1. human. [Q96NG5-1]

Organism-specific databases

CTDi148156.
GeneCardsiZNF558.
HGNCiHGNC:26422. ZNF558.
HPAiHPA003151.
neXtProtiNX_Q96NG5.
PharmGKBiPA134899314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96NG5.
KOiK09228.
OMAiKRIHNRW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96NG5.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii148156.
PROiQ96NG5.

Gene expression databases

BgeeiQ96NG5.
CleanExiHS_ZNF558.
GenevisibleiQ96NG5. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Esophagus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.

Entry informationi

Entry nameiZN558_HUMAN
AccessioniPrimary (citable) accession number: Q96NG5
Secondary accession number(s): A8K5F0, B7Z798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.