Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96NE9 (FRMD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FERM domain-containing protein 6
Alternative name(s):
Willin
Gene names
Name:FRMD6
Synonyms:C14orf31
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Can colocalize with actin. Ref.7

Sequence similarities

Contains 1 FERM domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96NE9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96NE9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.
Isoform 3 (identifier: Q96NE9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-358: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622FERM domain-containing protein 6
PRO_0000219448

Regions

Domain16 – 328313FERM
Compositional bias130 – 1334Poly-Tyr
Compositional bias506 – 5127Poly-Ser

Amino acid modifications

Modified residue5221Phosphoserine By similarity
Modified residue5251Phosphoserine By similarity
Modified residue5441Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 358358Missing in isoform 3.
VSP_008022
Alternative sequence91 – 988Missing in isoform 2.
VSP_008023

Experimental info

Sequence conflict521K → E in CAI46062. Ref.3
Sequence conflict671H → Y in CAI46062. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8AE617F769B29CF6

FASTA62272,044
        10         20         30         40         50         60 
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS 

        70         80         90        100        110        120 
VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG 

       130        140        150        160        170        180 
RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE 

       190        200        210        220        230        240 
AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK 

       250        260        270        280        290        300 
REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL 

       310        320        330        340        350        360 
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD 

       370        380        390        400        410        420 
QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKPRDTGPED SYSSSAIHRK 

       430        440        450        460        470        480 
LKTCSSMTSH GSSHTSGVES GGKDRLEEDL QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC 

       490        500        510        520        530        540 
IYITEDMLMS RKLNGHSGLI VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR 

       550        560        570        580        590        600 
HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP 

       610        620 
VKRTSKYFSL DLTHDEVPEF VV 

« Hide

Isoform 2 [UniParc].

Checksum: 7B5165CC7F3BC191
Show »

FASTA61470,982
Isoform 3 [UniParc].

Checksum: 1232D8C9C9542AB2
Show »

FASTA26429,235

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hair follicle dermal papilla.
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal skin and Uterus.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain and Uterus.
[7]"A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'."
Gunn-Moore F.J., Welsh G.I., Herron L.R., Brannigan F., Venkateswarlu K., Gillespie S., Brandwein-Gensler M., Madan R., Tavare J.M., Brophy P.J., Prystowsky M.B., Guild S.
FEBS Lett. 579:5089-5094(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055545 mRNA. Translation: BAB70950.1.
BX161430 mRNA. Translation: CAD61902.1.
BX647863 mRNA. Translation: CAI46062.1.
AL079307 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65666.1.
CH471078 Genomic DNA. Translation: EAW65671.1.
BC020521 mRNA. Translation: AAH20521.1.
BC029870 mRNA. Translation: AAH29870.1.
RefSeqNP_001035946.1. NM_001042481.2.
NP_001253975.1. NM_001267046.1.
NP_001253976.1. NM_001267047.1.
NP_689543.1. NM_152330.3.
UniGeneHs.434914.

3D structure databases

ProteinModelPortalQ96NE9.
SMRQ96NE9. Positions 17-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125795. 7 interactions.
IntActQ96NE9. 9 interactions.
MINTMINT-1455573.
STRING9606.ENSP00000348550.

PTM databases

PhosphoSiteQ96NE9.

Polymorphism databases

DMDM34098678.

Proteomic databases

PaxDbQ96NE9.
PRIDEQ96NE9.

Protocols and materials databases

DNASU122786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344768; ENSP00000343899; ENSG00000139926. [Q96NE9-1]
ENST00000356218; ENSP00000348550; ENSG00000139926. [Q96NE9-2]
ENST00000395718; ENSP00000379068; ENSG00000139926. [Q96NE9-2]
ENST00000553556; ENSP00000452529; ENSG00000139926. [Q96NE9-3]
GeneID122786.
KEGGhsa:122786.
UCSCuc001wzb.4. human. [Q96NE9-2]
uc001wzd.3. human. [Q96NE9-1]
uc001wzg.3. human. [Q96NE9-3]

Organism-specific databases

CTD122786.
GeneCardsGC14P051955.
H-InvDBHIX0011651.
HIX0023243.
HGNCHGNC:19839. FRMD6.
HPAHPA001297.
MIM614555. gene.
neXtProtNX_Q96NE9.
PharmGKBPA134913028.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272751.
HOGENOMHOG000294082.
HOVERGENHBG081539.
InParanoidQ96NE9.
KOK16822.
OMACLAQQCV.
OrthoDBEOG7PGDQ8.
PhylomeDBQ96NE9.
TreeFamTF319780.

Gene expression databases

ArrayExpressQ96NE9.
BgeeQ96NE9.
CleanExHS_FRMD6.
GenevestigatorQ96NE9.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
[Graphical view]
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTSM00295. B41. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
PROSITEPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFRMD6.
GenomeRNAi122786.
NextBio81001.
PROQ96NE9.
SOURCESearch...

Entry information

Entry nameFRMD6_HUMAN
AccessionPrimary (citable) accession number: Q96NE9
Secondary accession number(s): D3DSB9 expand/collapse secondary AC list , Q5HYF2, Q8N2X1, Q8WUH7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM