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Q96NE9

- FRMD6_HUMAN

UniProt

Q96NE9 - FRMD6_HUMAN

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Protein

FERM domain-containing protein 6

Gene
FRMD6, C14orf31
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. apical constriction Source: Ensembl
  2. cellular protein localization Source: Ensembl
  3. regulation of actin filament-based process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 6
Alternative name(s):
Willin
Gene namesi
Name:FRMD6
Synonyms:C14orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19839. FRMD6.

Subcellular locationi

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Note: Can colocalize with actin.1 Publication

GO - Cellular componenti

  1. apical junction complex Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. cytoskeleton Source: InterPro
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622FERM domain-containing protein 6PRO_0000219448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei522 – 5221Phosphoserine By similarity
Modified residuei525 – 5251Phosphoserine By similarity
Modified residuei544 – 5441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96NE9.
PaxDbiQ96NE9.
PRIDEiQ96NE9.

PTM databases

PhosphoSiteiQ96NE9.

Expressioni

Gene expression databases

ArrayExpressiQ96NE9.
BgeeiQ96NE9.
CleanExiHS_FRMD6.
GenevestigatoriQ96NE9.

Organism-specific databases

HPAiHPA001297.

Interactioni

Protein-protein interaction databases

BioGridi125795. 7 interactions.
IntActiQ96NE9. 9 interactions.
MINTiMINT-1455573.
STRINGi9606.ENSP00000348550.

Structurei

3D structure databases

ProteinModelPortaliQ96NE9.
SMRiQ96NE9. Positions 45-325.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 328313FERMAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1334Poly-Tyr
Compositional biasi506 – 5127Poly-Ser

Sequence similaritiesi

Contains 1 FERM domain.

Phylogenomic databases

eggNOGiNOG272751.
HOGENOMiHOG000294082.
HOVERGENiHBG081539.
InParanoidiQ96NE9.
KOiK16822.
OMAiCLAQQCV.
OrthoDBiEOG7PGDQ8.
PhylomeDBiQ96NE9.
TreeFamiTF319780.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96NE9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR    50
LKDCHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI 100
DQFGPPMIIH FRVQYYVENG RLISDRAARY YYYWHLRKQV LHSQCVLREE 150
AYFLLAAFAL QADLGNFKRN KHYGKYFEPE AYFPSWVVSK RGKDYILKHI 200
PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK REIEASLTLG 250
LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL 300
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY 350
ISDNLDLDMD QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD 400
TKPRDTGPED SYSSSAIHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDL 450
QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC IYITEDMLMS RKLNGHSGLI 500
VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL 550
YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP 600
VKRTSKYFSL DLTHDEVPEF VV 622

Note: No experimental confirmation available.

Length:622
Mass (Da):72,044
Last modified:December 1, 2001 - v1
Checksum:i8AE617F769B29CF6
GO
Isoform 2 (identifier: Q96NE9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.

Show »
Length:614
Mass (Da):70,982
Checksum:i7B5165CC7F3BC191
GO
Isoform 3 (identifier: Q96NE9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-358: Missing.

Note: No experimental confirmation available.

Show »
Length:264
Mass (Da):29,235
Checksum:i1232D8C9C9542AB2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 358358Missing in isoform 3. VSP_008022Add
BLAST
Alternative sequencei91 – 988Missing in isoform 2. VSP_008023

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521K → E in CAI46062. 1 Publication
Sequence conflicti67 – 671H → Y in CAI46062. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055545 mRNA. Translation: BAB70950.1.
BX161430 mRNA. Translation: CAD61902.1.
BX647863 mRNA. Translation: CAI46062.1.
AL079307 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65666.1.
CH471078 Genomic DNA. Translation: EAW65671.1.
BC020521 mRNA. Translation: AAH20521.1.
BC029870 mRNA. Translation: AAH29870.1.
CCDSiCCDS58318.1. [Q96NE9-1]
CCDS58319.1. [Q96NE9-3]
CCDS9704.1. [Q96NE9-2]
RefSeqiNP_001035946.1. NM_001042481.2. [Q96NE9-2]
NP_001253975.1. NM_001267046.1. [Q96NE9-1]
NP_001253976.1. NM_001267047.1. [Q96NE9-3]
NP_689543.1. NM_152330.3. [Q96NE9-2]
XP_006720092.1. XM_006720029.1. [Q96NE9-1]
XP_006720093.1. XM_006720030.1. [Q96NE9-2]
UniGeneiHs.434914.

Genome annotation databases

EnsembliENST00000344768; ENSP00000343899; ENSG00000139926. [Q96NE9-1]
ENST00000356218; ENSP00000348550; ENSG00000139926. [Q96NE9-2]
ENST00000395718; ENSP00000379068; ENSG00000139926. [Q96NE9-2]
ENST00000553556; ENSP00000452529; ENSG00000139926. [Q96NE9-3]
GeneIDi122786.
KEGGihsa:122786.
UCSCiuc001wzb.4. human. [Q96NE9-2]
uc001wzd.3. human. [Q96NE9-1]
uc001wzg.3. human. [Q96NE9-3]

Polymorphism databases

DMDMi34098678.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055545 mRNA. Translation: BAB70950.1 .
BX161430 mRNA. Translation: CAD61902.1 .
BX647863 mRNA. Translation: CAI46062.1 .
AL079307 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65666.1 .
CH471078 Genomic DNA. Translation: EAW65671.1 .
BC020521 mRNA. Translation: AAH20521.1 .
BC029870 mRNA. Translation: AAH29870.1 .
CCDSi CCDS58318.1. [Q96NE9-1 ]
CCDS58319.1. [Q96NE9-3 ]
CCDS9704.1. [Q96NE9-2 ]
RefSeqi NP_001035946.1. NM_001042481.2. [Q96NE9-2 ]
NP_001253975.1. NM_001267046.1. [Q96NE9-1 ]
NP_001253976.1. NM_001267047.1. [Q96NE9-3 ]
NP_689543.1. NM_152330.3. [Q96NE9-2 ]
XP_006720092.1. XM_006720029.1. [Q96NE9-1 ]
XP_006720093.1. XM_006720030.1. [Q96NE9-2 ]
UniGenei Hs.434914.

3D structure databases

ProteinModelPortali Q96NE9.
SMRi Q96NE9. Positions 45-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125795. 7 interactions.
IntActi Q96NE9. 9 interactions.
MINTi MINT-1455573.
STRINGi 9606.ENSP00000348550.

PTM databases

PhosphoSitei Q96NE9.

Polymorphism databases

DMDMi 34098678.

Proteomic databases

MaxQBi Q96NE9.
PaxDbi Q96NE9.
PRIDEi Q96NE9.

Protocols and materials databases

DNASUi 122786.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344768 ; ENSP00000343899 ; ENSG00000139926 . [Q96NE9-1 ]
ENST00000356218 ; ENSP00000348550 ; ENSG00000139926 . [Q96NE9-2 ]
ENST00000395718 ; ENSP00000379068 ; ENSG00000139926 . [Q96NE9-2 ]
ENST00000553556 ; ENSP00000452529 ; ENSG00000139926 . [Q96NE9-3 ]
GeneIDi 122786.
KEGGi hsa:122786.
UCSCi uc001wzb.4. human. [Q96NE9-2 ]
uc001wzd.3. human. [Q96NE9-1 ]
uc001wzg.3. human. [Q96NE9-3 ]

Organism-specific databases

CTDi 122786.
GeneCardsi GC14P051955.
H-InvDB HIX0011651.
HIX0023243.
HGNCi HGNC:19839. FRMD6.
HPAi HPA001297.
MIMi 614555. gene.
neXtProti NX_Q96NE9.
PharmGKBi PA134913028.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272751.
HOGENOMi HOG000294082.
HOVERGENi HBG081539.
InParanoidi Q96NE9.
KOi K16822.
OMAi CLAQQCV.
OrthoDBi EOG7PGDQ8.
PhylomeDBi Q96NE9.
TreeFami TF319780.

Miscellaneous databases

GeneWikii FRMD6.
GenomeRNAii 122786.
NextBioi 81001.
PROi Q96NE9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96NE9.
Bgeei Q96NE9.
CleanExi HS_FRMD6.
Genevestigatori Q96NE9.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view ]
SMARTi SM00295. B41. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50057. FERM_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hair follicle dermal papilla.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal skin and Uterus.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain and Uterus.
  7. Cited for: SUBCELLULAR LOCATION.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFRMD6_HUMAN
AccessioniPrimary (citable) accession number: Q96NE9
Secondary accession number(s): D3DSB9
, Q5HYF2, Q8N2X1, Q8WUH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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