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Protein

FERM domain-containing protein 6

Gene

FRMD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 6
Alternative name(s):
Willin
Gene namesi
Name:FRMD6
Synonyms:C14orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139926.15
HGNCiHGNC:19839 FRMD6
MIMi614555 gene
neXtProtiNX_Q96NE9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi122786
OpenTargetsiENSG00000139926
PharmGKBiPA134913028

Polymorphism and mutation databases

BioMutaiFRMD6
DMDMi34098678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194481 – 622FERM domain-containing protein 6Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei522PhosphoserineBy similarity1
Modified residuei523PhosphothreonineBy similarity1
Modified residuei525PhosphoserineBy similarity1
Modified residuei542PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96NE9
MaxQBiQ96NE9
PaxDbiQ96NE9
PeptideAtlasiQ96NE9
PRIDEiQ96NE9

PTM databases

iPTMnetiQ96NE9
PhosphoSitePlusiQ96NE9

Expressioni

Gene expression databases

BgeeiENSG00000139926
CleanExiHS_FRMD6
ExpressionAtlasiQ96NE9 baseline and differential
GenevisibleiQ96NE9 HS

Organism-specific databases

HPAiHPA001297

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125795, 29 interactors
IntActiQ96NE9, 23 interactors
MINTiQ96NE9
STRINGi9606.ENSP00000348550

Structurei

3D structure databases

ProteinModelPortaliQ96NE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 328FERMPROSITE-ProRule annotationAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 133Poly-Tyr4
Compositional biasi506 – 512Poly-Ser7

Phylogenomic databases

eggNOGiENOG410IUGZ Eukaryota
ENOG410Z6XT LUCA
GeneTreeiENSGT00900000141019
HOGENOMiHOG000294082
HOVERGENiHBG081539
InParanoidiQ96NE9
KOiK16822
OMAiAQQCVNI
OrthoDBiEOG091G0443
PhylomeDBiQ96NE9
TreeFamiTF319780

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR
60 70 80 90 100
LKDCHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI
110 120 130 140 150
DQFGPPMIIH FRVQYYVENG RLISDRAARY YYYWHLRKQV LHSQCVLREE
160 170 180 190 200
AYFLLAAFAL QADLGNFKRN KHYGKYFEPE AYFPSWVVSK RGKDYILKHI
210 220 230 240 250
PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK REIEASLTLG
260 270 280 290 300
LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
310 320 330 340 350
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY
360 370 380 390 400
ISDNLDLDMD QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD
410 420 430 440 450
TKPRDTGPED SYSSSAIHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDL
460 470 480 490 500
QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC IYITEDMLMS RKLNGHSGLI
510 520 530 540 550
VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL
560 570 580 590 600
YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP
610 620
VKRTSKYFSL DLTHDEVPEF VV
Note: No experimental confirmation available.
Length:622
Mass (Da):72,044
Last modified:December 1, 2001 - v1
Checksum:i8AE617F769B29CF6
GO
Isoform 2 (identifier: Q96NE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.

Show »
Length:614
Mass (Da):70,982
Checksum:i7B5165CC7F3BC191
GO
Isoform 3 (identifier: Q96NE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-358: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,235
Checksum:i1232D8C9C9542AB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52K → E in CAI46062 (PubMed:17974005).Curated1
Sequence conflicti67H → Y in CAI46062 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080221 – 358Missing in isoform 3. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_00802391 – 98Missing in isoform 2. 3 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055545 mRNA Translation: BAB70950.1
BX161430 mRNA Translation: CAD61902.1
BX647863 mRNA Translation: CAI46062.1
AL079307 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65666.1
CH471078 Genomic DNA Translation: EAW65671.1
BC020521 mRNA Translation: AAH20521.1
BC029870 mRNA Translation: AAH29870.1
CCDSiCCDS58318.1 [Q96NE9-1]
CCDS58319.1 [Q96NE9-3]
CCDS9704.1 [Q96NE9-2]
RefSeqiNP_001035946.1, NM_001042481.2 [Q96NE9-2]
NP_001253975.1, NM_001267046.1 [Q96NE9-1]
NP_001253976.1, NM_001267047.1 [Q96NE9-3]
NP_689543.1, NM_152330.3 [Q96NE9-2]
XP_006720092.1, XM_006720029.1 [Q96NE9-1]
XP_006720093.1, XM_006720030.1 [Q96NE9-2]
XP_011534725.1, XM_011536423.1 [Q96NE9-1]
XP_011534726.1, XM_011536424.1 [Q96NE9-1]
UniGeneiHs.434914

Genome annotation databases

EnsembliENST00000344768; ENSP00000343899; ENSG00000139926 [Q96NE9-1]
ENST00000356218; ENSP00000348550; ENSG00000139926 [Q96NE9-2]
ENST00000395718; ENSP00000379068; ENSG00000139926 [Q96NE9-2]
ENST00000553556; ENSP00000452529; ENSG00000139926 [Q96NE9-3]
GeneIDi122786
KEGGihsa:122786
UCSCiuc001wzb.5 human [Q96NE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFRMD6_HUMAN
AccessioniPrimary (citable) accession number: Q96NE9
Secondary accession number(s): D3DSB9
, Q5HYF2, Q8N2X1, Q8WUH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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