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Q96ND8

- ZN583_HUMAN

UniProt

Q96ND8 - ZN583_HUMAN

Protein

Zinc finger protein 583

Gene

ZNF583

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 583
    Alternative name(s):
    Zinc finger protein L3-5
    Gene namesi
    Name:ZNF583
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26427. ZNF583.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982111.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Zinc finger protein 583PRO_0000047674Add
    BLAST

    Proteomic databases

    PaxDbiQ96ND8.
    PRIDEiQ96ND8.

    PTM databases

    PhosphoSiteiQ96ND8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96ND8.
    BgeeiQ96ND8.
    CleanExiHS_ZNF583.
    GenevestigatoriQ96ND8.

    Organism-specific databases

    HPAiHPA023805.
    HPA023957.

    Interactioni

    Protein-protein interaction databases

    BioGridi127105. 1 interaction.
    STRINGi9606.ENSP00000291598.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96ND8.
    SMRiQ96ND8. Positions 6-46, 134-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96ND8.
    KOiK09228.
    OMAiHTMESFL.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96ND8.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96ND8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS    50
    KPDVISLLEQ GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK 100
    VVTVGARHLS YSLDYPSLRE DCQSEDWYKN QLGSQEVHLS QLIITHKEIL 150
    PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK EKAHKHEPQK KSYRKKSVEM 200
    KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY ACVECGKTFS 250
    QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE 300
    CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK 350
    PYVCNVCGKA FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR 400
    VHTGEKPYEC KVCRKAFSQI AYLDQHQRVH TGEKPYECIE CGKAFSNSSS 450
    LAQHQRSHTG EKPYMCKECR KTFSQNAGLA QHQRIHTGEK PYECNVCGKA 500
    FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER IHTMESFLTL 550
    SSPSPSTSNQ LPRPVGFIS 569
    Length:569
    Mass (Da):66,033
    Last modified:October 17, 2006 - v2
    Checksum:i6B0448281129F0E0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti351 – 3511P → R in AAB81088. 1 PublicationCurated
    Sequence conflicti556 – 5561S → P in BAB70964. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti324 – 3241F → I.
    Corresponds to variant rs12976917 [ dbSNP | Ensembl ].
    VAR_027978

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055592 mRNA. Translation: BAB70964.1.
    BC111772 mRNA. Translation: AAI11773.1.
    AF024698 mRNA. Translation: AAB81088.1.
    CCDSiCCDS12943.1.
    RefSeqiNP_001153332.1. NM_001159860.1.
    NP_001153333.1. NM_001159861.1.
    NP_689691.2. NM_152478.2.
    UniGeneiHs.146854.
    Hs.745489.

    Genome annotation databases

    EnsembliENST00000291598; ENSP00000291598; ENSG00000198440.
    ENST00000333201; ENSP00000388502; ENSG00000198440.
    GeneIDi147949.
    KEGGihsa:147949.
    UCSCiuc002qnc.2. human.

    Polymorphism databases

    DMDMi116242861.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055592 mRNA. Translation: BAB70964.1 .
    BC111772 mRNA. Translation: AAI11773.1 .
    AF024698 mRNA. Translation: AAB81088.1 .
    CCDSi CCDS12943.1.
    RefSeqi NP_001153332.1. NM_001159860.1.
    NP_001153333.1. NM_001159861.1.
    NP_689691.2. NM_152478.2.
    UniGenei Hs.146854.
    Hs.745489.

    3D structure databases

    ProteinModelPortali Q96ND8.
    SMRi Q96ND8. Positions 6-46, 134-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127105. 1 interaction.
    STRINGi 9606.ENSP00000291598.

    PTM databases

    PhosphoSitei Q96ND8.

    Polymorphism databases

    DMDMi 116242861.

    Proteomic databases

    PaxDbi Q96ND8.
    PRIDEi Q96ND8.

    Protocols and materials databases

    DNASUi 147949.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291598 ; ENSP00000291598 ; ENSG00000198440 .
    ENST00000333201 ; ENSP00000388502 ; ENSG00000198440 .
    GeneIDi 147949.
    KEGGi hsa:147949.
    UCSCi uc002qnc.2. human.

    Organism-specific databases

    CTDi 147949.
    GeneCardsi GC19P056953.
    HGNCi HGNC:26427. ZNF583.
    HPAi HPA023805.
    HPA023957.
    neXtProti NX_Q96ND8.
    PharmGKBi PA134982111.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96ND8.
    KOi K09228.
    OMAi HTMESFL.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96ND8.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 147949.
    NextBioi 85789.
    PROi Q96ND8.

    Gene expression databases

    ArrayExpressi Q96ND8.
    Bgeei Q96ND8.
    CleanExi HS_ZNF583.
    Genevestigatori Q96ND8.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Isolation and cloning of novel C2-H2 type zinc finger protein gene in human liver tissue."
      Wu G., Yu L., Sun X., Wu M., Fan Y., Jiang C., Zheng Q., Zhang Q., Zhao S.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 309-361.
      Tissue: Liver.

    Entry informationi

    Entry nameiZN583_HUMAN
    AccessioniPrimary (citable) accession number: Q96ND8
    Secondary accession number(s): O14850, Q2NKK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3