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Protein

Zinc finger protein 583

Gene

ZNF583

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 583
Alternative name(s):
Zinc finger protein L3-5
Gene namesi
Name:ZNF583
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26427. ZNF583.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982111.

Polymorphism and mutation databases

BioMutaiZNF583.
DMDMi116242861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Zinc finger protein 583PRO_0000047674Add
BLAST

Proteomic databases

PaxDbiQ96ND8.
PRIDEiQ96ND8.

PTM databases

PhosphoSiteiQ96ND8.

Expressioni

Gene expression databases

BgeeiQ96ND8.
CleanExiHS_ZNF583.
ExpressionAtlasiQ96ND8. baseline and differential.
GenevestigatoriQ96ND8.

Organism-specific databases

HPAiHPA023805.
HPA023957.

Interactioni

Protein-protein interaction databases

BioGridi127105. 1 interaction.
STRINGi9606.ENSP00000291598.

Structurei

3D structure databases

ProteinModelPortaliQ96ND8.
SMRiQ96ND8. Positions 6-46, 134-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 23423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121862.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96ND8.
KOiK09228.
OMAiHTMESFL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96ND8.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96ND8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS
60 70 80 90 100
KPDVISLLEQ GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK
110 120 130 140 150
VVTVGARHLS YSLDYPSLRE DCQSEDWYKN QLGSQEVHLS QLIITHKEIL
160 170 180 190 200
PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK EKAHKHEPQK KSYRKKSVEM
210 220 230 240 250
KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY ACVECGKTFS
260 270 280 290 300
QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE
310 320 330 340 350
CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK
360 370 380 390 400
PYVCNVCGKA FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR
410 420 430 440 450
VHTGEKPYEC KVCRKAFSQI AYLDQHQRVH TGEKPYECIE CGKAFSNSSS
460 470 480 490 500
LAQHQRSHTG EKPYMCKECR KTFSQNAGLA QHQRIHTGEK PYECNVCGKA
510 520 530 540 550
FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER IHTMESFLTL
560
SSPSPSTSNQ LPRPVGFIS
Length:569
Mass (Da):66,033
Last modified:October 17, 2006 - v2
Checksum:i6B0448281129F0E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti351 – 3511P → R in AAB81088 (Ref. 3) Curated
Sequence conflicti556 – 5561S → P in BAB70964 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241F → I.
Corresponds to variant rs12976917 [ dbSNP | Ensembl ].
VAR_027978

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055592 mRNA. Translation: BAB70964.1.
BC111772 mRNA. Translation: AAI11773.1.
AF024698 mRNA. Translation: AAB81088.1.
CCDSiCCDS12943.1.
RefSeqiNP_001153332.1. NM_001159860.1.
NP_001153333.1. NM_001159861.1.
NP_689691.2. NM_152478.2.
UniGeneiHs.146854.
Hs.745489.

Genome annotation databases

EnsembliENST00000291598; ENSP00000291598; ENSG00000198440.
ENST00000333201; ENSP00000388502; ENSG00000198440.
GeneIDi147949.
KEGGihsa:147949.
UCSCiuc002qnc.2. human.

Polymorphism and mutation databases

BioMutaiZNF583.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055592 mRNA. Translation: BAB70964.1.
BC111772 mRNA. Translation: AAI11773.1.
AF024698 mRNA. Translation: AAB81088.1.
CCDSiCCDS12943.1.
RefSeqiNP_001153332.1. NM_001159860.1.
NP_001153333.1. NM_001159861.1.
NP_689691.2. NM_152478.2.
UniGeneiHs.146854.
Hs.745489.

3D structure databases

ProteinModelPortaliQ96ND8.
SMRiQ96ND8. Positions 6-46, 134-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127105. 1 interaction.
STRINGi9606.ENSP00000291598.

PTM databases

PhosphoSiteiQ96ND8.

Polymorphism and mutation databases

BioMutaiZNF583.
DMDMi116242861.

Proteomic databases

PaxDbiQ96ND8.
PRIDEiQ96ND8.

Protocols and materials databases

DNASUi147949.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291598; ENSP00000291598; ENSG00000198440.
ENST00000333201; ENSP00000388502; ENSG00000198440.
GeneIDi147949.
KEGGihsa:147949.
UCSCiuc002qnc.2. human.

Organism-specific databases

CTDi147949.
GeneCardsiGC19P056962.
HGNCiHGNC:26427. ZNF583.
HPAiHPA023805.
HPA023957.
neXtProtiNX_Q96ND8.
PharmGKBiPA134982111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121862.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96ND8.
KOiK09228.
OMAiHTMESFL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96ND8.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii147949.
NextBioi85789.
PROiQ96ND8.

Gene expression databases

BgeeiQ96ND8.
CleanExiHS_ZNF583.
ExpressionAtlasiQ96ND8. baseline and differential.
GenevestigatoriQ96ND8.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Isolation and cloning of novel C2-H2 type zinc finger protein gene in human liver tissue."
    Wu G., Yu L., Sun X., Wu M., Fan Y., Jiang C., Zheng Q., Zhang Q., Zhao S.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 309-361.
    Tissue: Liver.

Entry informationi

Entry nameiZN583_HUMAN
AccessioniPrimary (citable) accession number: Q96ND8
Secondary accession number(s): O14850, Q2NKK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.