Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q96ND0 (CR019_HUMAN)

Last modified December 15, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Uncharacterized protein C18orf19
Gene names
Name: C18orf19
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 DUF1279 domain.

Hide | Top

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Transmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Uncharacterized protein C18orf19
PRO_0000274424

Regions

Transmembrane136 – 15621 Potential
Domain117 – 229113DUF1279
Coiled coil229 – 27143 Potential

Natural variations

Natural variant391Y → N: dbSNP rs35493157.
VAR_056844
Natural variant821R → H in a breast cancer sample; somatic mutation. Ref.2
VAR_035686
Natural variant1401V → E in a breast cancer sample; somatic mutation. Ref.2
VAR_035687
Natural variant1671E → K: dbSNP rs2847146.
VAR_060439

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q96ND0-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E3708A9C60EDA7E8

FASTA27230,805
        10         20         30         40         50         60 
MQWNVPRTVS RLARRTCLEP HNAGLFGHCQ NVKGPLLLYN AESKVVLVRG PQKQWLHLSA 

        70         80         90        100        110        120 
AQCVAKERRP LDAHPPQPGV LRHKQGKQHV SFRRVFSSSA TAQGTPEKKE EPDPLQDKSI 

       130        140        150        160        170        180 
SLYQRFKKTF RQYGKVLIPV HLITSGVWFG TFYYAALKGV NVVPFLELIG LPDSVVSILK 

       190        200        210        220        230        240 
NSQSGNALTA YALFKIATPA RYTVTLGGTS VTVKYLRSHG YMSTPPPVKE YLQDRMEETK 

       250        260        270 
ELITEKMEET KDRLTEKLQE TKEKVSFKKK VE

« Hide

Hide | Top

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-82 AND GLU-140.

Hide | Top

Cross-references

Sequence databases

AK055618 mRNA. Translation: BAB70973.1.
IPIIPI00290799.
UniGeneHs.13034

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ96ND0.

Genome annotation databases

EnsemblENST00000322247; ENSP00000323635; ENSG00000177150; Homo sapiens. [Genome view]
ENST00000402563; ENSP00000386115; ENSG00000177150; Homo sapiens. [Genome view]
ENST00000457610; ENSP00000412308; ENSG00000177150; Homo sapiens. [Genome view]
UCSCuc002ksj.2. human.

Organism-specific databases

GeneCardsGC18M013657.
HGNCHGNC:28346. C18orf19.
PharmGKBPA134993051.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG715931.
HOVERGENQ96ND0.
InParanoidQ96ND0.

Gene expression databases

ArrayExpressQ96ND0.
BgeeQ96ND0.
CleanExHS_C18orf19.
GenevestigatorQ96ND0.

Family and domain databases

InterProIPR009688. DUF1279.
[Graphical view]
PfamPF06916. DUF1279. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameCR019_HUMAN
AccessionPrimary (citable) accession number: Q96ND0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: December 15, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents