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Protein

Protein FAM210A

Gene

FAM210A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM210A
Gene namesi
Name:FAM210A
Synonyms:C18orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28346. FAM210A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993051.

Polymorphism and mutation databases

BioMutaiFAM210A.
DMDMi296434465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Protein FAM210APRO_0000274424Add
BLAST

Proteomic databases

EPDiQ96ND0.
MaxQBiQ96ND0.
PaxDbiQ96ND0.
PeptideAtlasiQ96ND0.
PRIDEiQ96ND0.
TopDownProteomicsiQ96ND0.

PTM databases

iPTMnetiQ96ND0.
PhosphoSiteiQ96ND0.

Expressioni

Gene expression databases

BgeeiQ96ND0.
CleanExiHS_C18orf19.
ExpressionAtlasiQ96ND0. baseline and differential.
GenevisibleiQ96ND0. HS.

Organism-specific databases

HPAiHPA014324.
HPA051564.

Interactioni

Subunit structurei

Interacts with ATAD3A.1 Publication

Protein-protein interaction databases

BioGridi125924. 6 interactions.
IntActiQ96ND0. 2 interactions.
STRINGi9606.ENSP00000323635.

Structurei

3D structure databases

ProteinModelPortaliQ96ND0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 229113DUF1279Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili229 – 27143Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM210 family.Curated
Contains 1 DUF1279 domain.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4082. Eukaryota.
ENOG4111GN5. LUCA.
GeneTreeiENSGT00530000063556.
HOGENOMiHOG000111948.
HOVERGENiHBG081335.
InParanoidiQ96ND0.
OMAiRLAHRTC.
OrthoDBiEOG7CRTR8.
PhylomeDBiQ96ND0.
TreeFamiTF313283.

Family and domain databases

InterProiIPR009688. DUF1279.
[Graphical view]
PfamiPF06916. DUF1279. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96ND0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWNVPRTVS RLARRTCLEP HNAGLFGHCQ NVKGPLLLYN AESKVVLVQG
60 70 80 90 100
PQKQWLHLSA AQCVAKERRP LDAHPPQPGV LRHKQGKQHV SFRRVFSSSA
110 120 130 140 150
TAQGTPEKKE EPDPLQDKSI SLYQRFKKTF RQYGKVLIPV HLITSGVWFG
160 170 180 190 200
TFYYAALKGV NVVPFLELIG LPDSVVSILK NSQSGNALTA YALFKIATPA
210 220 230 240 250
RYTVTLGGTS VTVKYLRSHG YMSTPPPVKE YLQDRMEETK ELITEKMEET
260 270
KDRLTEKLQE TKEKVSFKKK VE
Length:272
Mass (Da):30,777
Last modified:May 18, 2010 - v2
Checksum:i6053475E4CCF65C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491Q → R in BAB70973 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391Y → N.
Corresponds to variant rs35493157 [ dbSNP | Ensembl ].
VAR_056844
Natural varianti82 – 821R → H in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs116967198 [ dbSNP | Ensembl ].
VAR_035686
Natural varianti140 – 1401V → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_035687
Natural varianti167 – 1671E → K.
Corresponds to variant rs2847146 [ dbSNP | Ensembl ].
VAR_060439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055618 mRNA. Translation: BAB70973.1.
AP001010 Genomic DNA. No translation available.
AP001525 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01508.1.
CH471113 Genomic DNA. Translation: EAX01509.1.
CCDSiCCDS11866.1.
RefSeqiNP_001092271.1. NM_001098801.1.
NP_689565.2. NM_152352.3.
XP_006722361.1. XM_006722298.2.
UniGeneiHs.13034.

Genome annotation databases

EnsembliENST00000322247; ENSP00000323635; ENSG00000177150.
ENST00000402563; ENSP00000386115; ENSG00000177150.
GeneIDi125228.
KEGGihsa:125228.
UCSCiuc002ksj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055618 mRNA. Translation: BAB70973.1.
AP001010 Genomic DNA. No translation available.
AP001525 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01508.1.
CH471113 Genomic DNA. Translation: EAX01509.1.
CCDSiCCDS11866.1.
RefSeqiNP_001092271.1. NM_001098801.1.
NP_689565.2. NM_152352.3.
XP_006722361.1. XM_006722298.2.
UniGeneiHs.13034.

3D structure databases

ProteinModelPortaliQ96ND0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125924. 6 interactions.
IntActiQ96ND0. 2 interactions.
STRINGi9606.ENSP00000323635.

PTM databases

iPTMnetiQ96ND0.
PhosphoSiteiQ96ND0.

Polymorphism and mutation databases

BioMutaiFAM210A.
DMDMi296434465.

Proteomic databases

EPDiQ96ND0.
MaxQBiQ96ND0.
PaxDbiQ96ND0.
PeptideAtlasiQ96ND0.
PRIDEiQ96ND0.
TopDownProteomicsiQ96ND0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322247; ENSP00000323635; ENSG00000177150.
ENST00000402563; ENSP00000386115; ENSG00000177150.
GeneIDi125228.
KEGGihsa:125228.
UCSCiuc002ksj.5. human.

Organism-specific databases

CTDi125228.
GeneCardsiFAM210A.
H-InvDBHIX0021278.
HGNCiHGNC:28346. FAM210A.
HPAiHPA014324.
HPA051564.
neXtProtiNX_Q96ND0.
PharmGKBiPA134993051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4082. Eukaryota.
ENOG4111GN5. LUCA.
GeneTreeiENSGT00530000063556.
HOGENOMiHOG000111948.
HOVERGENiHBG081335.
InParanoidiQ96ND0.
OMAiRLAHRTC.
OrthoDBiEOG7CRTR8.
PhylomeDBiQ96ND0.
TreeFamiTF313283.

Miscellaneous databases

ChiTaRSiFAM210A. human.
GenomeRNAii125228.
PROiQ96ND0.

Gene expression databases

BgeeiQ96ND0.
CleanExiHS_C18orf19.
ExpressionAtlasiQ96ND0. baseline and differential.
GenevisibleiQ96ND0. HS.

Family and domain databases

InterProiIPR009688. DUF1279.
[Graphical view]
PfamiPF06916. DUF1279. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: INTERACTION WITH ATAD3A.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-82 AND GLU-140.

Entry informationi

Entry nameiF210A_HUMAN
AccessioniPrimary (citable) accession number: Q96ND0
Secondary accession number(s): D3DUJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.