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Protein

Zinc finger matrin-type protein 2

Gene

ZMAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 104Matrin-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146007-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 2
Gene namesi
Name:ZMAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26433. ZMAT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146007.
PharmGKBiPA134931664.

Polymorphism and mutation databases

BioMutaiZMAT2.
DMDMi52783532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000473272 – 199Zinc finger matrin-type protein 2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96NC0.
MaxQBiQ96NC0.
PaxDbiQ96NC0.
PeptideAtlasiQ96NC0.
PRIDEiQ96NC0.
TopDownProteomicsiQ96NC0.

PTM databases

iPTMnetiQ96NC0.
PhosphoSitePlusiQ96NC0.

Expressioni

Gene expression databases

BgeeiENSG00000146007.
CleanExiHS_ZMAT2.
ExpressionAtlasiQ96NC0. baseline and differential.
GenevisibleiQ96NC0. HS.

Organism-specific databases

HPAiHPA036518.
HPA058149.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AK8Q96MA63EBI-2682299,EBI-8466265
CCDC57Q2TAC23EBI-2682299,EBI-2808286
CEP76Q8TAP63EBI-2682299,EBI-742887
FSD2A1L4K13EBI-2682299,EBI-5661036
FXR2P511165EBI-2682299,EBI-740459
GOLGA2Q083793EBI-2682299,EBI-618309
HMBOX1Q6NT763EBI-2682299,EBI-2549423
HTTP428582EBI-2682299,EBI-466029
IKZF1Q134223EBI-2682299,EBI-745305
KRT40Q6A1623EBI-2682299,EBI-10171697
LZTS2Q9BRK43EBI-2682299,EBI-741037
MEOX2A4D1273EBI-2682299,EBI-10172134
MTUS2Q5JR593EBI-2682299,EBI-742948
PHC2Q8IXK03EBI-2682299,EBI-713786
SPAG5Q96R063EBI-2682299,EBI-413317
SPERTQ8NA613EBI-2682299,EBI-741724
SSX2IPQ9Y2D83EBI-2682299,EBI-2212028
TFIP11Q9UBB93EBI-2682299,EBI-1105213
TRAF2Q129335EBI-2682299,EBI-355744
TRIM36Q9NQ863EBI-2682299,EBI-2341518
TRIM37O949723EBI-2682299,EBI-741602
VPS52Q8N1B43EBI-2682299,EBI-2799833
ZBTB14O438293EBI-2682299,EBI-10176632
ZBTB8AQ96BR93EBI-2682299,EBI-742740

Protein-protein interaction databases

BioGridi127499. 40 interactors.
IntActiQ96NC0. 41 interactors.
MINTiMINT-3056426.
STRINGi9606.ENSP00000274712.

Structurei

3D structure databases

ProteinModelPortaliQ96NC0.
SMRiQ96NC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 matrin-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 104Matrin-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4727. Eukaryota.
ENOG4111GW4. LUCA.
GeneTreeiENSGT00390000010712.
HOGENOMiHOG000234390.
HOVERGENiHBG055346.
InParanoidiQ96NC0.
KOiK12848.
OMAiGYLDHIN.
OrthoDBiEOG091G0R04.
PhylomeDBiQ96NC0.
TreeFamiTF314475.

Family and domain databases

InterProiIPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96NC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSGTKNL DFRRKWDKDE YEKLAEKRLT EEREKKDGKP VQPVKRELLR
60 70 80 90 100
HRDYKVDLES KLGKTIVITK TTPQSEMGGY YCNVCDCVVK DSINFLDHIN
110 120 130 140 150
GKKHQRNLGM SMRVERSTLD QVKKRFEVNK KKMEEKQKDY DFEERMKELR
160 170 180 190
EEEEKAKAYK KEKQKEKKRR AEEDLTFEED DEMAAVMGFS GFGSTKKSY
Length:199
Mass (Da):23,612
Last modified:December 1, 2001 - v1
Checksum:iEF419358B7977E36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055683 mRNA. Translation: BAB70983.1.
BC056668 mRNA. Translation: AAH56668.1.
CCDSiCCDS4239.1.
RefSeqiNP_653324.1. NM_144723.2.
UniGeneiHs.350194.

Genome annotation databases

EnsembliENST00000274712; ENSP00000274712; ENSG00000146007.
GeneIDi153527.
KEGGihsa:153527.
UCSCiuc003lgy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055683 mRNA. Translation: BAB70983.1.
BC056668 mRNA. Translation: AAH56668.1.
CCDSiCCDS4239.1.
RefSeqiNP_653324.1. NM_144723.2.
UniGeneiHs.350194.

3D structure databases

ProteinModelPortaliQ96NC0.
SMRiQ96NC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127499. 40 interactors.
IntActiQ96NC0. 41 interactors.
MINTiMINT-3056426.
STRINGi9606.ENSP00000274712.

PTM databases

iPTMnetiQ96NC0.
PhosphoSitePlusiQ96NC0.

Polymorphism and mutation databases

BioMutaiZMAT2.
DMDMi52783532.

Proteomic databases

EPDiQ96NC0.
MaxQBiQ96NC0.
PaxDbiQ96NC0.
PeptideAtlasiQ96NC0.
PRIDEiQ96NC0.
TopDownProteomicsiQ96NC0.

Protocols and materials databases

DNASUi153527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274712; ENSP00000274712; ENSG00000146007.
GeneIDi153527.
KEGGihsa:153527.
UCSCiuc003lgy.2. human.

Organism-specific databases

CTDi153527.
GeneCardsiZMAT2.
HGNCiHGNC:26433. ZMAT2.
HPAiHPA036518.
HPA058149.
neXtProtiNX_Q96NC0.
OpenTargetsiENSG00000146007.
PharmGKBiPA134931664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4727. Eukaryota.
ENOG4111GW4. LUCA.
GeneTreeiENSGT00390000010712.
HOGENOMiHOG000234390.
HOVERGENiHBG055346.
InParanoidiQ96NC0.
KOiK12848.
OMAiGYLDHIN.
OrthoDBiEOG091G0R04.
PhylomeDBiQ96NC0.
TreeFamiTF314475.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146007-MONOMER.

Miscellaneous databases

ChiTaRSiZMAT2. human.
GenomeRNAii153527.
PROiQ96NC0.

Gene expression databases

BgeeiENSG00000146007.
CleanExiHS_ZMAT2.
ExpressionAtlasiQ96NC0. baseline and differential.
GenevisibleiQ96NC0. HS.

Family and domain databases

InterProiIPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZMAT2_HUMAN
AccessioniPrimary (citable) accession number: Q96NC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.