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Protein

Zinc finger protein 830

Gene

ZNF830

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 75C2H2-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 830Imported
Alternative name(s):
Coiled-coil domain-containing protein 16Curated
Gene namesi
Name:ZNF830Imported
Synonyms:CCDC16Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28291. ZNF830.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity
  • Nucleus speckle By similarity

  • Note: Excluded from nucleolus.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198783.
PharmGKBiPA162410767.

Polymorphism and mutation databases

BioMutaiZNF830.
DMDMi313104066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000761932 – 372Zinc finger protein 830Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96NB3.
MaxQBiQ96NB3.
PaxDbiQ96NB3.
PeptideAtlasiQ96NB3.
PRIDEiQ96NB3.

PTM databases

iPTMnetiQ96NB3.
PhosphoSitePlusiQ96NB3.

Expressioni

Gene expression databases

BgeeiENSG00000198783.
CleanExiHS_ZNF830.
ExpressionAtlasiQ96NB3. baseline and differential.
GenevisibleiQ96NB3. HS.

Organism-specific databases

HPAiHPA024754.
HPA027211.

Interactioni

Subunit structurei

Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124850. 23 interactors.
DIPiDIP-61544N.
IntActiQ96NB3. 14 interactors.
STRINGi9606.ENSP00000354518.

Structurei

3D structure databases

ProteinModelPortaliQ96NB3.
SMRiQ96NB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili312 – 349Sequence analysisAdd BLAST38

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 75C2H2-typeAdd BLAST23

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3032. Eukaryota.
ENOG4111GTR. LUCA.
GeneTreeiENSGT00390000012151.
HOGENOMiHOG000246999.
HOVERGENiHBG105347.
InParanoidiQ96NB3.
KOiK13104.
OMAiVLGKQHR.
OrthoDBiEOG091G0MBX.
PhylomeDBiQ96NB3.
TreeFamiTF315895.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Znf_U1.
SMARTiView protein in SMART
SM00451. ZnF_U1. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96NB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSASARTP AGKRVINQEE LRRLMKEKQR LSTSRKRIES PFAKYNRLGQ
60 70 80 90 100
LSCALCNTPV KSELLWQTHV LGKQHREKVA ELKGAKEASQ GSSASSAPHS
110 120 130 140 150
VKRKAPDADD QDVKRAKATL VPQVQPSTSA WTTNFDKIGK EFIRATPSKP
160 170 180 190 200
SGLSLLPDYE DEEEEEEEEE GDGERKRGDA SKPLSDAQGK EHSVSSSREV
210 220 230 240 250
TSSVLPNDFF STNPPKAPII PHSGSIEKAE IHEKVVERRE NTAEALPEGF
260 270 280 290 300
FDDPEVDARV RKVDAPKDQM DKEWDEFQKA MRQVNTISEA IVAEEDEEGR
310 320 330 340 350
LDRQIGEIDE QIECYRRVEK LRNRQDEIKN KLKEILTIKE LQKKEEENAD
360 370
SDDEGELQDL LSQDWRVKGA LL
Length:372
Mass (Da):41,999
Last modified:November 30, 2010 - v2
Checksum:iA06403B117672C8C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03094016I → V. Corresponds to variant dbSNP:rs8073825Ensembl.1
Natural variantiVAR_03094193S → P. Corresponds to variant dbSNP:rs8078059Ensembl.1
Natural variantiVAR_02405999H → QCombined sources2 PublicationsCorresponds to variant dbSNP:rs931196Ensembl.1
Natural variantiVAR_030942135F → L. Corresponds to variant dbSNP:rs8078217Ensembl.1
Natural variantiVAR_024060154S → T1 PublicationCorresponds to variant dbSNP:rs3744355Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055707 mRNA. Translation: BAB70992.1.
AC022903 Genomic DNA. No translation available.
BC002913 mRNA. Translation: AAH02913.2.
BC009044 mRNA. Translation: AAH09044.1.
BC011584 mRNA. Translation: AAH11584.2.
CCDSiCCDS32618.1.
RefSeqiNP_443089.3. NM_052857.3.
UniGeneiHs.413678.

Genome annotation databases

EnsembliENST00000361952; ENSP00000354518; ENSG00000198783.
GeneIDi91603.
KEGGihsa:91603.
UCSCiuc002hih.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055707 mRNA. Translation: BAB70992.1.
AC022903 Genomic DNA. No translation available.
BC002913 mRNA. Translation: AAH02913.2.
BC009044 mRNA. Translation: AAH09044.1.
BC011584 mRNA. Translation: AAH11584.2.
CCDSiCCDS32618.1.
RefSeqiNP_443089.3. NM_052857.3.
UniGeneiHs.413678.

3D structure databases

ProteinModelPortaliQ96NB3.
SMRiQ96NB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124850. 23 interactors.
DIPiDIP-61544N.
IntActiQ96NB3. 14 interactors.
STRINGi9606.ENSP00000354518.

PTM databases

iPTMnetiQ96NB3.
PhosphoSitePlusiQ96NB3.

Polymorphism and mutation databases

BioMutaiZNF830.
DMDMi313104066.

Proteomic databases

EPDiQ96NB3.
MaxQBiQ96NB3.
PaxDbiQ96NB3.
PeptideAtlasiQ96NB3.
PRIDEiQ96NB3.

Protocols and materials databases

DNASUi91603.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361952; ENSP00000354518; ENSG00000198783.
GeneIDi91603.
KEGGihsa:91603.
UCSCiuc002hih.5. human.

Organism-specific databases

CTDi91603.
GeneCardsiZNF830.
HGNCiHGNC:28291. ZNF830.
HPAiHPA024754.
HPA027211.
neXtProtiNX_Q96NB3.
OpenTargetsiENSG00000198783.
PharmGKBiPA162410767.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3032. Eukaryota.
ENOG4111GTR. LUCA.
GeneTreeiENSGT00390000012151.
HOGENOMiHOG000246999.
HOVERGENiHBG105347.
InParanoidiQ96NB3.
KOiK13104.
OMAiVLGKQHR.
OrthoDBiEOG091G0MBX.
PhylomeDBiQ96NB3.
TreeFamiTF315895.

Enzyme and pathway databases

ReactomeiR-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

GenomeRNAii91603.
PROiQ96NB3.

Gene expression databases

BgeeiENSG00000198783.
CleanExiHS_ZNF830.
ExpressionAtlasiQ96NB3. baseline and differential.
GenevisibleiQ96NB3. HS.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Znf_U1.
SMARTiView protein in SMART
SM00451. ZnF_U1. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZN830_HUMAN
AccessioniPrimary (citable) accession number: Q96NB3
Secondary accession number(s): Q96F60, Q96GZ5, Q9BU38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 30, 2010
Last modified: March 15, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.