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Q96NB2

- SFXN2_HUMAN

UniProt

Q96NB2 - SFXN2_HUMAN

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Protein

Sideroflexin-2

Gene

SFXN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-2
Gene namesi
Name:SFXN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16086. SFXN2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Sideroflexin-2PRO_0000177035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96NB2.
PaxDbiQ96NB2.
PRIDEiQ96NB2.

PTM databases

PhosphoSiteiQ96NB2.

Expressioni

Tissue specificityi

Widely expressed, highest levels in kidney, liver, and pancreas.1 Publication

Gene expression databases

BgeeiQ96NB2.
CleanExiHS_SFXN2.
ExpressionAtlasiQ96NB2. baseline and differential.
GenevestigatoriQ96NB2.

Organism-specific databases

HPAiHPA018150.
HPA026834.

Interactioni

Protein-protein interaction databases

BioGridi125630. 17 interactions.
IntActiQ96NB2. 1 interaction.
STRINGi9606.ENSP00000358909.

Structurei

3D structure databases

ProteinModelPortaliQ96NB2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei100 – 12223HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16423HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19219HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 25023HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283056.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ96NB2.
OMAiHNEIGHS.
OrthoDBiEOG70KGPJ.
PhylomeDBiQ96NB2.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96NB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV
60 70 80 90 100
EKSRMGVVPP GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM
110 120 130 140 150
IITGFMLQFY RTMPAVIFWQ WVNQSFNALV NYTNRNAASP TSVRQMALSY
160 170 180 190 200
FTATTTAVAT AVGMNMLTKK APPLVGRWVP FAAVAAANCV NIPMMRQQEL
210 220 230 240 250
IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM ILLPVIMERL
260 270 280 290 300
EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK
310 320
LQDTIKAKYG ELEPYVYFNK GL
Length:322
Mass (Da):36,232
Last modified:March 27, 2002 - v2
Checksum:i329D577B2583DF31
GO

Sequence cautioni

The sequence BAB70993.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 20460QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP(PubMed:14702039)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462052 mRNA. Translation: AAM09645.1.
CH471066 Genomic DNA. Translation: EAW49675.1.
CH471066 Genomic DNA. Translation: EAW49677.1.
BC022091 mRNA. Translation: AAH22091.1.
AK055711 mRNA. Translation: BAB70993.1. Different initiation.
CCDSiCCDS7539.1.
RefSeqiNP_849189.1. NM_178858.4.
UniGeneiHs.44070.

Genome annotation databases

EnsembliENST00000369893; ENSP00000358909; ENSG00000156398.
ENST00000459894; ENSP00000473325; ENSG00000156398.
GeneIDi118980.
KEGGihsa:118980.
UCSCiuc001kwb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462052 mRNA. Translation: AAM09645.1 .
CH471066 Genomic DNA. Translation: EAW49675.1 .
CH471066 Genomic DNA. Translation: EAW49677.1 .
BC022091 mRNA. Translation: AAH22091.1 .
AK055711 mRNA. Translation: BAB70993.1 . Different initiation.
CCDSi CCDS7539.1.
RefSeqi NP_849189.1. NM_178858.4.
UniGenei Hs.44070.

3D structure databases

ProteinModelPortali Q96NB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125630. 17 interactions.
IntActi Q96NB2. 1 interaction.
STRINGi 9606.ENSP00000358909.

PTM databases

PhosphoSitei Q96NB2.

Proteomic databases

MaxQBi Q96NB2.
PaxDbi Q96NB2.
PRIDEi Q96NB2.

Protocols and materials databases

DNASUi 118980.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369893 ; ENSP00000358909 ; ENSG00000156398 .
ENST00000459894 ; ENSP00000473325 ; ENSG00000156398 .
GeneIDi 118980.
KEGGi hsa:118980.
UCSCi uc001kwb.2. human.

Organism-specific databases

CTDi 118980.
GeneCardsi GC10P104464.
HGNCi HGNC:16086. SFXN2.
HPAi HPA018150.
HPA026834.
MIMi 615570. gene.
neXtProti NX_Q96NB2.
PharmGKBi PA38091.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283056.
GeneTreei ENSGT00390000002026.
HOGENOMi HOG000203440.
HOVERGENi HBG056083.
InParanoidi Q96NB2.
OMAi HNEIGHS.
OrthoDBi EOG70KGPJ.
PhylomeDBi Q96NB2.
TreeFami TF313205.

Miscellaneous databases

GenomeRNAii 118980.
NextBioi 80376.
PROi Q96NB2.
SOURCEi Search...

Gene expression databases

Bgeei Q96NB2.
CleanExi HS_SFXN2.
ExpressionAtlasi Q96NB2. baseline and differential.
Genevestigatori Q96NB2.

Family and domain databases

InterProi IPR004686. Mtc.
[Graphical view ]
PANTHERi PTHR11153. PTHR11153. 1 hit.
Pfami PF03820. Mtc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00798. mtc. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human putative anemia-related gene homologous to mouse sideroflexin."
    Ye X., Xu J., Cheng C., Yin G., Zeng L., Ji C., Gu S., Xie Y., Mao Y.
    Biochem. Genet. 41:119-125(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-204.
    Tissue: Neuroblastoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSFXN2_HUMAN
AccessioniPrimary (citable) accession number: Q96NB2
Secondary accession number(s): Q5JSM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3