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Protein

Sideroflexin-2

Gene

SFXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-2
Gene namesi
Name:SFXN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16086. SFXN2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei174 – 192HelicalSequence analysisAdd BLAST19
Transmembranei228 – 250HelicalSequence analysisAdd BLAST23
Transmembranei265 – 287HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi118980.
OpenTargetsiENSG00000156398.
PharmGKBiPA38091.

Polymorphism and mutation databases

BioMutaiSFXN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770351 – 322Sideroflexin-2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96NB2.
MaxQBiQ96NB2.
PaxDbiQ96NB2.
PeptideAtlasiQ96NB2.
PRIDEiQ96NB2.

PTM databases

iPTMnetiQ96NB2.
PhosphoSitePlusiQ96NB2.

Expressioni

Tissue specificityi

Widely expressed, highest levels in kidney, liver, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000156398.
CleanExiHS_SFXN2.
ExpressionAtlasiQ96NB2. baseline and differential.
GenevisibleiQ96NB2. HS.

Organism-specific databases

HPAiHPA018150.
HPA026834.

Interactioni

Protein-protein interaction databases

BioGridi125630. 16 interactors.
IntActiQ96NB2. 2 interactors.
STRINGi9606.ENSP00000358909.

Structurei

3D structure databases

ProteinModelPortaliQ96NB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ96NB2.
OMAiEQLHYAK.
OrthoDBiEOG091G0BOU.
PhylomeDBiQ96NB2.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96NB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV
60 70 80 90 100
EKSRMGVVPP GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM
110 120 130 140 150
IITGFMLQFY RTMPAVIFWQ WVNQSFNALV NYTNRNAASP TSVRQMALSY
160 170 180 190 200
FTATTTAVAT AVGMNMLTKK APPLVGRWVP FAAVAAANCV NIPMMRQQEL
210 220 230 240 250
IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM ILLPVIMERL
260 270 280 290 300
EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK
310 320
LQDTIKAKYG ELEPYVYFNK GL
Length:322
Mass (Da):36,232
Last modified:March 27, 2002 - v2
Checksum:i329D577B2583DF31
GO

Sequence cautioni

The sequence BAB70993 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 204QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP (PubMed:14702039).CuratedAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462052 mRNA. Translation: AAM09645.1.
CH471066 Genomic DNA. Translation: EAW49675.1.
CH471066 Genomic DNA. Translation: EAW49677.1.
BC022091 mRNA. Translation: AAH22091.1.
AK055711 mRNA. Translation: BAB70993.1. Different initiation.
CCDSiCCDS7539.1.
RefSeqiNP_849189.1. NM_178858.4.
XP_011537564.1. XM_011539262.2.
XP_016871152.1. XM_017015663.1.
UniGeneiHs.44070.

Genome annotation databases

EnsembliENST00000369893; ENSP00000358909; ENSG00000156398.
GeneIDi118980.
KEGGihsa:118980.
UCSCiuc001kwb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462052 mRNA. Translation: AAM09645.1.
CH471066 Genomic DNA. Translation: EAW49675.1.
CH471066 Genomic DNA. Translation: EAW49677.1.
BC022091 mRNA. Translation: AAH22091.1.
AK055711 mRNA. Translation: BAB70993.1. Different initiation.
CCDSiCCDS7539.1.
RefSeqiNP_849189.1. NM_178858.4.
XP_011537564.1. XM_011539262.2.
XP_016871152.1. XM_017015663.1.
UniGeneiHs.44070.

3D structure databases

ProteinModelPortaliQ96NB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125630. 16 interactors.
IntActiQ96NB2. 2 interactors.
STRINGi9606.ENSP00000358909.

PTM databases

iPTMnetiQ96NB2.
PhosphoSitePlusiQ96NB2.

Polymorphism and mutation databases

BioMutaiSFXN2.

Proteomic databases

EPDiQ96NB2.
MaxQBiQ96NB2.
PaxDbiQ96NB2.
PeptideAtlasiQ96NB2.
PRIDEiQ96NB2.

Protocols and materials databases

DNASUi118980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369893; ENSP00000358909; ENSG00000156398.
GeneIDi118980.
KEGGihsa:118980.
UCSCiuc001kwb.3. human.

Organism-specific databases

CTDi118980.
DisGeNETi118980.
GeneCardsiSFXN2.
HGNCiHGNC:16086. SFXN2.
HPAiHPA018150.
HPA026834.
MIMi615570. gene.
neXtProtiNX_Q96NB2.
OpenTargetsiENSG00000156398.
PharmGKBiPA38091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ96NB2.
OMAiEQLHYAK.
OrthoDBiEOG091G0BOU.
PhylomeDBiQ96NB2.
TreeFamiTF313205.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156398-MONOMER.

Miscellaneous databases

GenomeRNAii118980.
PROiQ96NB2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156398.
CleanExiHS_SFXN2.
ExpressionAtlasiQ96NB2. baseline and differential.
GenevisibleiQ96NB2. HS.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSFXN2_HUMAN
AccessioniPrimary (citable) accession number: Q96NB2
Secondary accession number(s): Q5JSM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.