Q96NB2 (SFXN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sideroflexin-2

Gene names

Name:

SFXN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential iron transporter.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the sideroflexin family.
Sequence caution	The sequence BAB70993.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	Iron
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: Compara
Molecular_function	cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Sideroflexin-2		PRO_0000177035
Regions
	Transmembrane	100 – 122	23	Helical; Potential
	Transmembrane	142 – 164	23	Helical; Potential
	Transmembrane	174 – 192	19	Helical; Potential
	Transmembrane	228 – 250	23	Helical; Potential
	Transmembrane	265 – 287	23	Helical; Potential
Experimental info
	Sequence conflict	145 – 204	60	QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96NB2 [UniParc]. Last modified March 27, 2002. Version 2. Checksum: 329D577B2583DF31	FASTA	322	36,232
	10 20 30 40 50 60 MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV EKSRMGVVPP 70 80 90 100 110 120 GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM IITGFMLQFY RTMPAVIFWQ 130 140 150 160 170 180 WVNQSFNALV NYTNRNAASP TSVRQMALSY FTATTTAVAT AVGMNMLTKK APPLVGRWVP 190 200 210 220 230 240 FAAVAAANCV NIPMMRQQEL IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM 250 260 270 280 290 300 ILLPVIMERL EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK 310 320 LQDTIKAKYG ELEPYVYFNK GL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-204. Tissue: Neuroblastoma.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC022091 mRNA. Translation: AAH22091.1. AK055711 mRNA. Translation: BAB70993.1. Different initiation.
IPI	IPI00043564.
RefSeq	NP_849189.1. NM_178858.4.
UniGene	Hs.44070.
3D structure databases
ProteinModelPortal	Q96NB2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358909.
PTM databases
PhosphoSite	Q96NB2.
Polymorphism databases
DMDM	20140143.
Proteomic databases
PaxDb	Q96NB2.
PRIDE	Q96NB2.
Protocols and materials databases
DNASU	118980.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369893; ENSP00000358909; ENSG00000156398.
GeneID	118980.
KEGG	hsa:118980.
UCSC	uc001kwb.2. human.
Organism-specific databases
CTD	118980.
GeneCards	GC10P104464.
HGNC	HGNC:16086. SFXN2.
HPA	HPA018150. HPA026834.
neXtProt	NX_Q96NB2.
PharmGKB	PA38091.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283056.
HOGENOM	HOG000203440.
HOVERGEN	HBG056083.
InParanoid	Q96NB2.
OMA	TIKAKYG.
OrthoDB	EOG44MXSN.
PhylomeDB	Q96NB2.
Gene expression databases
ArrayExpress	Q96NB2.
Bgee	Q96NB2.
CleanEx	HS_SFXN2.
Genevestigator	Q96NB2.
GermOnline	ENSG00000156398. Homo sapiens.
Family and domain databases
InterPro	IPR004686. Mtc. [Graphical view]
PANTHER	PTHR11153. PTHR11153. 1 hit.
Pfam	PF03820. Mtc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00798. mtc. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	118980.
NextBio	80376.

Entry information

Entry name

SFXN2_HUMAN

Accession

Primary (citable) accession number: Q96NB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.