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Q96NB2 (SFXN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sideroflexin-2
Gene names
Name:SFXN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential iron transporter.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Widely expressed, highest levels in kidney, liver, and pancreas. Ref.1

Sequence similarities

Belongs to the sideroflexin family.

Sequence caution

The sequence BAB70993.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Sideroflexin-2
PRO_0000177035

Regions

Transmembrane100 – 12223Helical; Potential
Transmembrane142 – 16423Helical; Potential
Transmembrane174 – 19219Helical; Potential
Transmembrane228 – 25023Helical; Potential
Transmembrane265 – 28723Helical; Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6

Experimental info

Sequence conflict145 – 20460QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q96NB2 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: 329D577B2583DF31

FASTA32236,232
        10         20         30         40         50         60 
MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV EKSRMGVVPP 

        70         80         90        100        110        120 
GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM IITGFMLQFY RTMPAVIFWQ 

       130        140        150        160        170        180 
WVNQSFNALV NYTNRNAASP TSVRQMALSY FTATTTAVAT AVGMNMLTKK APPLVGRWVP 

       190        200        210        220        230        240 
FAAVAAANCV NIPMMRQQEL IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM 

       250        260        270        280        290        300 
ILLPVIMERL EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK 

       310        320 
LQDTIKAKYG ELEPYVYFNK GL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel human putative anemia-related gene homologous to mouse sideroflexin."
Ye X., Xu J., Cheng C., Yin G., Zeng L., Ji C., Gu S., Xie Y., Mao Y.
Biochem. Genet. 41:119-125(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-204.
Tissue: Neuroblastoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF462052 mRNA. Translation: AAM09645.1.
CH471066 Genomic DNA. Translation: EAW49675.1.
CH471066 Genomic DNA. Translation: EAW49677.1.
BC022091 mRNA. Translation: AAH22091.1.
AK055711 mRNA. Translation: BAB70993.1. Different initiation.
CCDSCCDS7539.1.
RefSeqNP_849189.1. NM_178858.4.
UniGeneHs.44070.

3D structure databases

ProteinModelPortalQ96NB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125630. 13 interactions.
IntActQ96NB2. 1 interaction.
STRING9606.ENSP00000358909.

PTM databases

PhosphoSiteQ96NB2.

Proteomic databases

MaxQBQ96NB2.
PaxDbQ96NB2.
PRIDEQ96NB2.

Protocols and materials databases

DNASU118980.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369893; ENSP00000358909; ENSG00000156398.
ENST00000459894; ENSP00000473325; ENSG00000156398.
GeneID118980.
KEGGhsa:118980.
UCSCuc001kwb.2. human.

Organism-specific databases

CTD118980.
GeneCardsGC10P104464.
HGNCHGNC:16086. SFXN2.
HPAHPA018150.
HPA026834.
MIM615570. gene.
neXtProtNX_Q96NB2.
PharmGKBPA38091.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283056.
HOGENOMHOG000203440.
HOVERGENHBG056083.
InParanoidQ96NB2.
OMAHNEIGHS.
OrthoDBEOG70KGPJ.
PhylomeDBQ96NB2.
TreeFamTF313205.

Gene expression databases

ArrayExpressQ96NB2.
BgeeQ96NB2.
CleanExHS_SFXN2.
GenevestigatorQ96NB2.

Family and domain databases

InterProIPR004686. Mtc.
[Graphical view]
PANTHERPTHR11153. PTHR11153. 1 hit.
PfamPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00798. mtc. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi118980.
NextBio80376.
PROQ96NB2.
SOURCESearch...

Entry information

Entry nameSFXN2_HUMAN
AccessionPrimary (citable) accession number: Q96NB2
Secondary accession number(s): Q5JSM6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM