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Q96NB2

- SFXN2_HUMAN

UniProt

Q96NB2 - SFXN2_HUMAN

Protein

Sideroflexin-2

Gene

SFXN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Potential iron transporter.

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sideroflexin-2
    Gene namesi
    Name:SFXN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:16086. SFXN2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38091.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Sideroflexin-2PRO_0000177035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96NB2.
    PaxDbiQ96NB2.
    PRIDEiQ96NB2.

    PTM databases

    PhosphoSiteiQ96NB2.

    Expressioni

    Tissue specificityi

    Widely expressed, highest levels in kidney, liver, and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ96NB2.
    BgeeiQ96NB2.
    CleanExiHS_SFXN2.
    GenevestigatoriQ96NB2.

    Organism-specific databases

    HPAiHPA018150.
    HPA026834.

    Interactioni

    Protein-protein interaction databases

    BioGridi125630. 15 interactions.
    IntActiQ96NB2. 1 interaction.
    STRINGi9606.ENSP00000358909.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei100 – 12223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 25023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sideroflexin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283056.
    HOGENOMiHOG000203440.
    HOVERGENiHBG056083.
    InParanoidiQ96NB2.
    OMAiHNEIGHS.
    OrthoDBiEOG70KGPJ.
    PhylomeDBiQ96NB2.
    TreeFamiTF313205.

    Family and domain databases

    InterProiIPR004686. Mtc.
    [Graphical view]
    PANTHERiPTHR11153. PTHR11153. 1 hit.
    PfamiPF03820. Mtc. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00798. mtc. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96NB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV    50
    EKSRMGVVPP GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM 100
    IITGFMLQFY RTMPAVIFWQ WVNQSFNALV NYTNRNAASP TSVRQMALSY 150
    FTATTTAVAT AVGMNMLTKK APPLVGRWVP FAAVAAANCV NIPMMRQQEL 200
    IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM ILLPVIMERL 250
    EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK 300
    LQDTIKAKYG ELEPYVYFNK GL 322
    Length:322
    Mass (Da):36,232
    Last modified:March 27, 2002 - v2
    Checksum:i329D577B2583DF31
    GO

    Sequence cautioni

    The sequence BAB70993.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 20460QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP(PubMed:14702039)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462052 mRNA. Translation: AAM09645.1.
    CH471066 Genomic DNA. Translation: EAW49675.1.
    CH471066 Genomic DNA. Translation: EAW49677.1.
    BC022091 mRNA. Translation: AAH22091.1.
    AK055711 mRNA. Translation: BAB70993.1. Different initiation.
    CCDSiCCDS7539.1.
    RefSeqiNP_849189.1. NM_178858.4.
    UniGeneiHs.44070.

    Genome annotation databases

    EnsembliENST00000369893; ENSP00000358909; ENSG00000156398.
    ENST00000459894; ENSP00000473325; ENSG00000156398.
    GeneIDi118980.
    KEGGihsa:118980.
    UCSCiuc001kwb.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462052 mRNA. Translation: AAM09645.1 .
    CH471066 Genomic DNA. Translation: EAW49675.1 .
    CH471066 Genomic DNA. Translation: EAW49677.1 .
    BC022091 mRNA. Translation: AAH22091.1 .
    AK055711 mRNA. Translation: BAB70993.1 . Different initiation.
    CCDSi CCDS7539.1.
    RefSeqi NP_849189.1. NM_178858.4.
    UniGenei Hs.44070.

    3D structure databases

    ProteinModelPortali Q96NB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125630. 15 interactions.
    IntActi Q96NB2. 1 interaction.
    STRINGi 9606.ENSP00000358909.

    PTM databases

    PhosphoSitei Q96NB2.

    Proteomic databases

    MaxQBi Q96NB2.
    PaxDbi Q96NB2.
    PRIDEi Q96NB2.

    Protocols and materials databases

    DNASUi 118980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369893 ; ENSP00000358909 ; ENSG00000156398 .
    ENST00000459894 ; ENSP00000473325 ; ENSG00000156398 .
    GeneIDi 118980.
    KEGGi hsa:118980.
    UCSCi uc001kwb.2. human.

    Organism-specific databases

    CTDi 118980.
    GeneCardsi GC10P104464.
    HGNCi HGNC:16086. SFXN2.
    HPAi HPA018150.
    HPA026834.
    MIMi 615570. gene.
    neXtProti NX_Q96NB2.
    PharmGKBi PA38091.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283056.
    HOGENOMi HOG000203440.
    HOVERGENi HBG056083.
    InParanoidi Q96NB2.
    OMAi HNEIGHS.
    OrthoDBi EOG70KGPJ.
    PhylomeDBi Q96NB2.
    TreeFami TF313205.

    Miscellaneous databases

    GenomeRNAii 118980.
    NextBioi 80376.
    PROi Q96NB2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96NB2.
    Bgeei Q96NB2.
    CleanExi HS_SFXN2.
    Genevestigatori Q96NB2.

    Family and domain databases

    InterProi IPR004686. Mtc.
    [Graphical view ]
    PANTHERi PTHR11153. PTHR11153. 1 hit.
    Pfami PF03820. Mtc. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00798. mtc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel human putative anemia-related gene homologous to mouse sideroflexin."
      Ye X., Xu J., Cheng C., Yin G., Zeng L., Ji C., Gu S., Xie Y., Mao Y.
      Biochem. Genet. 41:119-125(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-204.
      Tissue: Neuroblastoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSFXN2_HUMAN
    AccessioniPrimary (citable) accession number: Q96NB2
    Secondary accession number(s): Q5JSM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3