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Q96NB1

- FOPNL_HUMAN

UniProt

Q96NB1 - FOPNL_HUMAN

Protein

LisH domain-containing protein FOPNL

Gene

FOPNL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of cilia.1 Publication

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. microtubule anchoring Source: InterPro

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LisH domain-containing protein FOPNL
    Alternative name(s):
    FGFR1OP N-terminal-like protein
    FOP-related protein of 20 kDa
    Gene namesi
    Name:FOPNL
    Synonyms:C16orf63, FOR20, PHSECRG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26435. FOPNL.

    Subcellular locationi

    Cell projectioncilium By similarity. Cytoplasmcytoskeletoncilium basal body By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmic granule 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite 1 Publication

    GO - Cellular componenti

    1. centriolar satellite Source: UniProtKB
    2. centrosome Source: UniProtKB
    3. ciliary basal body Source: UniProtKB
    4. motile cilium Source: UniProtKB
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 491E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-76. 1 Publication
    Mutagenesisi76 – 761E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-49. 1 Publication

    Organism-specific databases

    PharmGKBiPA143485399.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174LisH domain-containing protein FOPNLPRO_0000264465Add
    BLAST

    Proteomic databases

    MaxQBiQ96NB1.
    PaxDbiQ96NB1.
    PRIDEiQ96NB1.

    PTM databases

    PhosphoSiteiQ96NB1.

    Expressioni

    Tissue specificityi

    Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ96NB1.
    BgeeiQ96NB1.
    CleanExiHS_C16orf63.
    GenevestigatoriQ96NB1.

    Organism-specific databases

    HPAiHPA040599.

    Interactioni

    Subunit structurei

    Homooligomer; probably required for localization to centrosomes.

    Protein-protein interaction databases

    BioGridi125836. 3 interactions.
    IntActiQ96NB1. 2 interactions.
    STRINGi9606.ENSP00000255759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96NB1.
    SMRiQ96NB1. Positions 46-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 8133LisHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 104104Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellitesAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FGFR1OP family.Curated
    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41150.
    HOVERGENiHBG081316.
    InParanoidiQ96NB1.
    KOiK16535.
    OrthoDBiEOG7R2BMN.
    PhylomeDBiQ96NB1.
    TreeFamiTF328861.

    Family and domain databases

    InterProiIPR018993. FOP_dimerisation-dom_N.
    IPR006594. LisH_dimerisation.
    [Graphical view]
    PfamiPF09398. FOP_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96NB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVAELKAV LKDTLEKKGV LGHLKARIRA EVFNALDDDR EPRPSLSHEN    50
    LLINELIREY LEFNKYKYTA SVLIAESGQP VVPLDRQFLI HELNAFEESK 100
    DNTIPLLYGI LAHFLRGTKD GIQNAFLKGP SLQPSDPSLG RQPSRRKPMD 150
    DHLRKEEQKS TNIEDLHVSQ AVNR 174
    Length:174
    Mass (Da):19,778
    Last modified:December 1, 2001 - v1
    Checksum:i2362137C1024038F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY507846 mRNA. Translation: AAR98812.1.
    AK055715 mRNA. Translation: BAB70994.1.
    AC130651 Genomic DNA. No translation available.
    BC022321 mRNA. Translation: AAH22321.1.
    CCDSiCCDS10567.1.
    RefSeqiNP_653201.1. NM_144600.2.
    UniGeneiHs.514179.

    Genome annotation databases

    EnsembliENST00000255759; ENSP00000255759; ENSG00000133393.
    GeneIDi123811.
    KEGGihsa:123811.
    UCSCiuc002dec.1. human.

    Polymorphism databases

    DMDMi74732531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY507846 mRNA. Translation: AAR98812.1 .
    AK055715 mRNA. Translation: BAB70994.1 .
    AC130651 Genomic DNA. No translation available.
    BC022321 mRNA. Translation: AAH22321.1 .
    CCDSi CCDS10567.1.
    RefSeqi NP_653201.1. NM_144600.2.
    UniGenei Hs.514179.

    3D structure databases

    ProteinModelPortali Q96NB1.
    SMRi Q96NB1. Positions 46-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125836. 3 interactions.
    IntActi Q96NB1. 2 interactions.
    STRINGi 9606.ENSP00000255759.

    PTM databases

    PhosphoSitei Q96NB1.

    Polymorphism databases

    DMDMi 74732531.

    Proteomic databases

    MaxQBi Q96NB1.
    PaxDbi Q96NB1.
    PRIDEi Q96NB1.

    Protocols and materials databases

    DNASUi 123811.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255759 ; ENSP00000255759 ; ENSG00000133393 .
    GeneIDi 123811.
    KEGGi hsa:123811.
    UCSCi uc002dec.1. human.

    Organism-specific databases

    CTDi 123811.
    GeneCardsi GC16M015959.
    HGNCi HGNC:26435. FOPNL.
    HPAi HPA040599.
    neXtProti NX_Q96NB1.
    PharmGKBi PA143485399.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41150.
    HOVERGENi HBG081316.
    InParanoidi Q96NB1.
    KOi K16535.
    OrthoDBi EOG7R2BMN.
    PhylomeDBi Q96NB1.
    TreeFami TF328861.

    Miscellaneous databases

    ChiTaRSi FOPNL. human.
    GenomeRNAii 123811.
    NextBioi 81161.
    PROi Q96NB1.

    Gene expression databases

    ArrayExpressi Q96NB1.
    Bgeei Q96NB1.
    CleanExi HS_C16orf63.
    Genevestigatori Q96NB1.

    Family and domain databases

    InterProi IPR018993. FOP_dimerisation-dom_N.
    IPR006594. LisH_dimerisation.
    [Graphical view ]
    Pfami PF09398. FOP_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning and functional analysis of PHSECRG2 gene."
      Du J., Nie Z., Lin G., Lu G.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein."
      Sedjai F., Acquaviva C., Chevrier V., Chauvin J.P., Coppin E., Aouane A., Coulier F., Tolun A., Pierres M., Birnbaum D., Rosnet O.
      J. Cell Sci. 123:2391-2401(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLU-49 AND GLU-76, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFOPNL_HUMAN
    AccessioniPrimary (citable) accession number: Q96NB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3