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Protein

LisH domain-containing protein FOPNL

Gene

FOPNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of cilia.1 Publication

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • microtubule anchoring Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain-containing protein FOPNL
Alternative name(s):
FGFR1OP N-terminal-like protein
FOP-related protein of 20 kDa
Gene namesi
Name:FOPNL
Synonyms:C16orf63, FOR20, PHSECRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26435. FOPNL.

Subcellular locationi

GO - Cellular componenti

  • centriolar satellite Source: UniProtKB
  • centrosome Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • motile cilium Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-76. 1 Publication
Mutagenesisi76 – 761E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-49. 1 Publication

Organism-specific databases

PharmGKBiPA143485399.

Polymorphism and mutation databases

BioMutaiFOPNL.
DMDMi74732531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174LisH domain-containing protein FOPNLPRO_0000264465Add
BLAST

Proteomic databases

MaxQBiQ96NB1.
PaxDbiQ96NB1.
PRIDEiQ96NB1.

PTM databases

PhosphoSiteiQ96NB1.

Expressioni

Tissue specificityi

Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.1 Publication

Gene expression databases

BgeeiQ96NB1.
CleanExiHS_C16orf63.
ExpressionAtlasiQ96NB1. baseline and differential.
GenevisibleiQ96NB1. HS.

Organism-specific databases

HPAiHPA040599.

Interactioni

Subunit structurei

Homooligomer; probably required for localization to centrosomes.

Protein-protein interaction databases

BioGridi125836. 1 interaction.
IntActiQ96NB1. 2 interactions.
STRINGi9606.ENSP00000255759.

Structurei

3D structure databases

ProteinModelPortaliQ96NB1.
SMRiQ96NB1. Positions 46-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 8133LisHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellitesAdd
BLAST

Sequence similaritiesi

Belongs to the FGFR1OP family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41150.
GeneTreeiENSGT00390000007773.
HOGENOMiHOG000260089.
HOVERGENiHBG081316.
InParanoidiQ96NB1.
KOiK16535.
OMAiQPSGRKQ.
OrthoDBiEOG7R2BMN.
PhylomeDBiQ96NB1.
TreeFamiTF328861.

Family and domain databases

InterProiIPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH.
[Graphical view]
PfamiPF09398. FOP_dimer. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVAELKAV LKDTLEKKGV LGHLKARIRA EVFNALDDDR EPRPSLSHEN
60 70 80 90 100
LLINELIREY LEFNKYKYTA SVLIAESGQP VVPLDRQFLI HELNAFEESK
110 120 130 140 150
DNTIPLLYGI LAHFLRGTKD GIQNAFLKGP SLQPSDPSLG RQPSRRKPMD
160 170
DHLRKEEQKS TNIEDLHVSQ AVNR
Length:174
Mass (Da):19,778
Last modified:December 1, 2001 - v1
Checksum:i2362137C1024038F
GO
Isoform 2 (identifier: Q96NB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-149: Missing.

Note: No experimental confirmation available.
Show »
Length:100
Mass (Da):11,527
Checksum:iFE5EDA9FFBFC04E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 14974Missing in isoform 2. 1 PublicationVSP_056998Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507846 mRNA. Translation: AAR98812.1.
AK055715 mRNA. Translation: BAB70994.1.
AK056798 mRNA. Translation: BAG51811.1.
AC130651 Genomic DNA. No translation available.
BC022321 mRNA. Translation: AAH22321.1.
CCDSiCCDS10567.1. [Q96NB1-1]
CCDS76830.1. [Q96NB1-2]
RefSeqiNP_001291426.1. NM_001304497.1. [Q96NB1-2]
NP_653201.1. NM_144600.3. [Q96NB1-1]
UniGeneiHs.514179.

Genome annotation databases

EnsembliENST00000255759; ENSP00000255759; ENSG00000133393.
ENST00000573968; ENSP00000460312; ENSG00000133393. [Q96NB1-2]
ENST00000622266; ENSP00000481290; ENSG00000276914.
GeneIDi123811.
KEGGihsa:123811.
UCSCiuc002dec.1. human. [Q96NB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507846 mRNA. Translation: AAR98812.1.
AK055715 mRNA. Translation: BAB70994.1.
AK056798 mRNA. Translation: BAG51811.1.
AC130651 Genomic DNA. No translation available.
BC022321 mRNA. Translation: AAH22321.1.
CCDSiCCDS10567.1. [Q96NB1-1]
CCDS76830.1. [Q96NB1-2]
RefSeqiNP_001291426.1. NM_001304497.1. [Q96NB1-2]
NP_653201.1. NM_144600.3. [Q96NB1-1]
UniGeneiHs.514179.

3D structure databases

ProteinModelPortaliQ96NB1.
SMRiQ96NB1. Positions 46-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125836. 1 interaction.
IntActiQ96NB1. 2 interactions.
STRINGi9606.ENSP00000255759.

PTM databases

PhosphoSiteiQ96NB1.

Polymorphism and mutation databases

BioMutaiFOPNL.
DMDMi74732531.

Proteomic databases

MaxQBiQ96NB1.
PaxDbiQ96NB1.
PRIDEiQ96NB1.

Protocols and materials databases

DNASUi123811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255759; ENSP00000255759; ENSG00000133393.
ENST00000573968; ENSP00000460312; ENSG00000133393. [Q96NB1-2]
ENST00000622266; ENSP00000481290; ENSG00000276914.
GeneIDi123811.
KEGGihsa:123811.
UCSCiuc002dec.1. human. [Q96NB1-1]

Organism-specific databases

CTDi123811.
GeneCardsiGC16M015959.
HGNCiHGNC:26435. FOPNL.
HPAiHPA040599.
neXtProtiNX_Q96NB1.
PharmGKBiPA143485399.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41150.
GeneTreeiENSGT00390000007773.
HOGENOMiHOG000260089.
HOVERGENiHBG081316.
InParanoidiQ96NB1.
KOiK16535.
OMAiQPSGRKQ.
OrthoDBiEOG7R2BMN.
PhylomeDBiQ96NB1.
TreeFamiTF328861.

Miscellaneous databases

ChiTaRSiFOPNL. human.
GenomeRNAii123811.
NextBioi35469260.
PROiQ96NB1.

Gene expression databases

BgeeiQ96NB1.
CleanExiHS_C16orf63.
ExpressionAtlasiQ96NB1. baseline and differential.
GenevisibleiQ96NB1. HS.

Family and domain databases

InterProiIPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH.
[Graphical view]
PfamiPF09398. FOP_dimer. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning and functional analysis of PHSECRG2 gene."
    Du J., Nie Z., Lin G., Lu G.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. "Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein."
    Sedjai F., Acquaviva C., Chevrier V., Chauvin J.P., Coppin E., Aouane A., Coulier F., Tolun A., Pierres M., Birnbaum D., Rosnet O.
    J. Cell Sci. 123:2391-2401(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLU-49 AND GLU-76, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOPNL_HUMAN
AccessioniPrimary (citable) accession number: Q96NB1
Secondary accession number(s): B3KPU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.