Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96NB1 (FOPNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LisH domain-containing protein FOPNL
Alternative name(s):
FGFR1OP N-terminal-like protein
FOP-related protein of 20 kDa
Gene names
Name:FOPNL
Synonyms:C16orf63, FOR20, PHSECRG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biogenesis of cilia. Ref.5

Subunit structure

Homooligomer; probably required for localization to centrosomes. Ref.5

Subcellular location

Cell projectioncilium By similarity. Cytoplasmcytoskeletoncilium basal body By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmic granule. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite Ref.5.

Tissue specificity

Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine. Ref.5

Sequence similarities

Belongs to the FGFR1OP family.

Contains 1 LisH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174LisH domain-containing protein FOPNL
PRO_0000264465

Regions

Domain49 – 8133LisH
Region1 – 104104Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites

Experimental info

Mutagenesis491E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-76. Ref.5
Mutagenesis761E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-49. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q96NB1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 2362137C1024038F

FASTA17419,778
        10         20         30         40         50         60 
MATVAELKAV LKDTLEKKGV LGHLKARIRA EVFNALDDDR EPRPSLSHEN LLINELIREY 

        70         80         90        100        110        120 
LEFNKYKYTA SVLIAESGQP VVPLDRQFLI HELNAFEESK DNTIPLLYGI LAHFLRGTKD 

       130        140        150        160        170 
GIQNAFLKGP SLQPSDPSLG RQPSRRKPMD DHLRKEEQKS TNIEDLHVSQ AVNR 

« Hide

References

« Hide 'large scale' references
[1]"The cloning and functional analysis of PHSECRG2 gene."
Du J., Nie Z., Lin G., Lu G.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein."
Sedjai F., Acquaviva C., Chevrier V., Chauvin J.P., Coppin E., Aouane A., Coulier F., Tolun A., Pierres M., Birnbaum D., Rosnet O.
J. Cell Sci. 123:2391-2401(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLU-49 AND GLU-76, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY507846 mRNA. Translation: AAR98812.1.
AK055715 mRNA. Translation: BAB70994.1.
AC130651 Genomic DNA. No translation available.
BC022321 mRNA. Translation: AAH22321.1.
CCDSCCDS10567.1.
RefSeqNP_653201.1. NM_144600.2.
UniGeneHs.514179.

3D structure databases

ProteinModelPortalQ96NB1.
SMRQ96NB1. Positions 46-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125836. 3 interactions.
IntActQ96NB1. 2 interactions.
STRING9606.ENSP00000255759.

PTM databases

PhosphoSiteQ96NB1.

Polymorphism databases

DMDM74732531.

Proteomic databases

MaxQBQ96NB1.
PaxDbQ96NB1.
PRIDEQ96NB1.

Protocols and materials databases

DNASU123811.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255759; ENSP00000255759; ENSG00000133393.
GeneID123811.
KEGGhsa:123811.
UCSCuc002dec.1. human.

Organism-specific databases

CTD123811.
GeneCardsGC16M015959.
HGNCHGNC:26435. FOPNL.
HPAHPA040599.
neXtProtNX_Q96NB1.
PharmGKBPA143485399.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41150.
HOVERGENHBG081316.
InParanoidQ96NB1.
KOK16535.
OrthoDBEOG7R2BMN.
PhylomeDBQ96NB1.
TreeFamTF328861.

Gene expression databases

ArrayExpressQ96NB1.
BgeeQ96NB1.
CleanExHS_C16orf63.
GenevestigatorQ96NB1.

Family and domain databases

InterProIPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH_dimerisation.
[Graphical view]
PfamPF09398. FOP_dimer. 1 hit.
[Graphical view]
SMARTSM00667. LisH. 1 hit.
[Graphical view]
PROSITEPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOPNL. human.
GenomeRNAi123811.
NextBio81161.
PROQ96NB1.

Entry information

Entry nameFOPNL_HUMAN
AccessionPrimary (citable) accession number: Q96NB1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM