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Protein

LisH domain-containing protein FOPNL

Gene

FOPNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitement of PLK1 to centrosomes and S phase progression (PubMed:24018379).2 Publications

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • microtubule anchoring Source: InterPro

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain-containing protein FOPNL
Alternative name(s):
FGFR1OP N-terminal-like protein
FOP-related protein of 20 kDa
Gene namesi
Name:FOPNL
Synonyms:C16orf63, FOR20, PHSECRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000133393.12.
HGNCiHGNC:26435. FOPNL.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-76. 1 Publication1
Mutagenesisi49E → A: Strongly decreased interaction with KIAA0753; when associated with A-76. 1 Publication1
Mutagenesisi53I → Q: Loss of interaction with KIAA0753; when associated with A-76. 1 Publication1
Mutagenesisi76E → A: Loss of homooligomerization and loss of localization to centrosomes and pericentriolar satellites; when associated with A-49. 1 Publication1
Mutagenesisi76E → A: Strongly decreased interaction with KIAA0753; when associated with A-49. Loss of interaction with KIAA0753; when associated with Q-53. 1 Publication1
Mutagenesisi106L → R: No effect on interaction with KIAA0753. 1 Publication1

Organism-specific databases

DisGeNETi123811.
OpenTargetsiENSG00000133393.
PharmGKBiPA143485399.

Polymorphism and mutation databases

BioMutaiFOPNL.
DMDMi74732531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644651 – 174LisH domain-containing protein FOPNLAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96NB1.
MaxQBiQ96NB1.
PaxDbiQ96NB1.
PeptideAtlasiQ96NB1.
PRIDEiQ96NB1.

PTM databases

iPTMnetiQ96NB1.
PhosphoSitePlusiQ96NB1.

Expressioni

Tissue specificityi

Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.1 Publication

Gene expression databases

BgeeiENSG00000133393.
CleanExiHS_C16orf63.
ExpressionAtlasiQ96NB1. baseline and differential.
GenevisibleiQ96NB1. HS.

Organism-specific databases

HPAiHPA040599.

Interactioni

Subunit structurei

Homooligomer; probably required for localization to centrosomes (PubMed:20551181). Forms a complex with KIAA0753/OFIP and OFD1; within this complex may stabilize the interaction between OFD1 and KIAA0753/OFIP (PubMed:26643951). Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP (PubMed:26643951). Interacts with PLK1 in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes (PubMed:24018379).3 Publications

Protein-protein interaction databases

BioGridi125836. 32 interactors.
CORUMiQ96NB1.
IntActiQ96NB1. 29 interactors.
STRINGi9606.ENSP00000255759.

Structurei

3D structure databases

ProteinModelPortaliQ96NB1.
SMRiQ96NB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 81LisHPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellitesAdd BLAST104

Sequence similaritiesi

Belongs to the FGFR1OP family.Curated

Phylogenomic databases

eggNOGiENOG410IXQF. Eukaryota.
ENOG4111YXQ. LUCA.
GeneTreeiENSGT00390000007773.
HOGENOMiHOG000260089.
HOVERGENiHBG081316.
InParanoidiQ96NB1.
KOiK16535.
OrthoDBiEOG091G0V88.
PhylomeDBiQ96NB1.
TreeFamiTF328861.

Family and domain databases

InterProiView protein in InterPro
IPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH.
PfamiView protein in Pfam
PF09398. FOP_dimer. 1 hit.
SMARTiView protein in SMART
SM00667. LisH. 1 hit.
PROSITEiView protein in PROSITE
PS50896. LISH. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVAELKAV LKDTLEKKGV LGHLKARIRA EVFNALDDDR EPRPSLSHEN
60 70 80 90 100
LLINELIREY LEFNKYKYTA SVLIAESGQP VVPLDRQFLI HELNAFEESK
110 120 130 140 150
DNTIPLLYGI LAHFLRGTKD GIQNAFLKGP SLQPSDPSLG RQPSRRKPMD
160 170
DHLRKEEQKS TNIEDLHVSQ AVNR
Length:174
Mass (Da):19,778
Last modified:December 1, 2001 - v1
Checksum:i2362137C1024038F
GO
Isoform 2 (identifier: Q96NB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-149: Missing.

Note: No experimental confirmation available.
Show »
Length:100
Mass (Da):11,527
Checksum:iFE5EDA9FFBFC04E8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05699876 – 149Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507846 mRNA. Translation: AAR98812.1.
AK055715 mRNA. Translation: BAB70994.1.
AK056798 mRNA. Translation: BAG51811.1.
AC130651 Genomic DNA. No translation available.
BC022321 mRNA. Translation: AAH22321.1.
CCDSiCCDS10567.1. [Q96NB1-1]
CCDS76830.1. [Q96NB1-2]
RefSeqiNP_001291426.1. NM_001304497.1. [Q96NB1-2]
NP_653201.1. NM_144600.3. [Q96NB1-1]
UniGeneiHs.514179.

Genome annotation databases

EnsembliENST00000255759; ENSP00000255759; ENSG00000133393. [Q96NB1-1]
ENST00000573968; ENSP00000460312; ENSG00000133393. [Q96NB1-2]
ENST00000622266; ENSP00000481290; ENSG00000276914. [Q96NB1-1]
ENST00000631974; ENSP00000488488; ENSG00000276914. [Q96NB1-2]
GeneIDi123811.
KEGGihsa:123811.
UCSCiuc002dec.2. human. [Q96NB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOPNL_HUMAN
AccessioniPrimary (citable) accession number: Q96NB1
Secondary accession number(s): B3KPU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families