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Protein

t-SNARE domain-containing protein 1

Gene

TSNARE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
t-SNARE domain-containing protein 1
Gene namesi
Name:TSNARE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000171045.14
HGNCiHGNC:26437 TSNARE1
neXtProtiNX_Q96NA8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi203062
OpenTargetsiENSG00000171045
PharmGKBiPA142670693

Polymorphism and mutation databases

BioMutaiTSNARE1
DMDMi229462801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656681 – 513t-SNARE domain-containing protein 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei378PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96NA8
PeptideAtlasiQ96NA8
PRIDEiQ96NA8

PTM databases

iPTMnetiQ96NA8
PhosphoSitePlusiQ96NA8

Expressioni

Gene expression databases

BgeeiENSG00000171045
CleanExiHS_TSNARE1
ExpressionAtlasiQ96NA8 baseline and differential
GenevisibleiQ96NA8 HS

Organism-specific databases

HPAiHPA015890

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1284435 interactors.
IntActiQ96NA8 1 interactor.
STRINGi9606.ENSP00000303437

Structurei

3D structure databases

ProteinModelPortaliQ96NA8
SMRiQ96NA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini416 – 478t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi503 – 507Poly-Ile5

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00450000040239
HOGENOMiHOG000092756
HOVERGENiHBG079420
InParanoidiQ96NA8
KOiK13814
PhylomeDBiQ96NA8
TreeFamiTF335542

Family and domain databases

InterProiView protein in InterPro
IPR028002 Myb_DNA-bind_5
IPR010989 SNARE
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGSIARGG GLGSRGPFGG PSRQGCQPLE CARCWTEYGI RHFPCPSPES
60 70 80 90 100
KLQNRCVGKD GEGDLGPAGT PIVPRARKRG PGVAPEGSRM PEPTSSPTIG
110 120 130 140 150
PRKDSAAGPH GRMAGPSTTR AKKRKPNFCP QETEVLVSKV SKHHQLLFGT
160 170 180 190 200
GLLKAEPTRR YRVWSRILQA VNALGYCRRD VVDLKHKWRD LRAVVRRKLG
210 220 230 240 250
DLRKAAHGPS PGSGKPQALA LTPVEQVVAK TFSCQALPSE GFSLEPPRAT
260 270 280 290 300
QVDPCNLQEL FQEMSANVFR INSSVTSLER SLQSLGTPSD TQELRDSLHT
310 320 330 340 350
AQQETNKTIA ASASSVKQMA ELLRSSCPQE RLQQERPQLD RLKTQLSDAI
360 370 380 390 400
QCYGVVQKKI AEKSRALLPM AQRGSKQSPQ APFAELADDE KVFNGSDNMW
410 420 430 440 450
QGQEQALLPD ITEEDLEAIR LREEAILQME SNLLDVNQII KDLASMVSEQ
460 470 480 490 500
GEAVDSIEAS LEAASSHAEA ARQLLAGASR HQLQRHKIKC CFLSAGVTAL
510
LVIIIIIATS VRK
Length:513
Mass (Da):55,949
Last modified:May 5, 2009 - v2
Checksum:i415F67290CF97DA8
GO
Isoform 2 (identifier: Q96NA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: Missing.

Note: No experimental confirmation available.
Show »
Length:512
Mass (Da):55,821
Checksum:i00DD0255E1AB7031
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05514618F → L1 PublicationCorresponds to variant dbSNP:rs7814359Ensembl.1
Natural variantiVAR_05146155R → P1 PublicationCorresponds to variant dbSNP:rs33970858Ensembl.1
Natural variantiVAR_051462118T → A1 PublicationCorresponds to variant dbSNP:rs10100935Ensembl.1
Natural variantiVAR_051463268V → I. Corresponds to variant dbSNP:rs10435683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056304329Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055726 mRNA Translation: BAB70997.1
AC103758 Genomic DNA No translation available.
AC129918 Genomic DNA No translation available.
AC134682 Genomic DNA No translation available.
BC113556 mRNA Translation: AAI13557.1
BC143684 mRNA Translation: AAI43685.1
CCDSiCCDS6384.1 [Q96NA8-1]
RefSeqiNP_659440.2, NM_145003.4 [Q96NA8-1]
XP_016868667.1, XM_017013178.1 [Q96NA8-2]
UniGeneiHs.370931

Genome annotation databases

EnsembliENST00000524325; ENSP00000428763; ENSG00000171045 [Q96NA8-1]
GeneIDi203062
KEGGihsa:203062
UCSCiuc003ywk.4 human [Q96NA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSNA1_HUMAN
AccessioniPrimary (citable) accession number: Q96NA8
Secondary accession number(s): B7ZLB0, Q14D03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 5, 2009
Last modified: April 25, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome