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Protein

t-SNARE domain-containing protein 1

Gene

TSNARE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
t-SNARE domain-containing protein 1
Gene namesi
Name:TSNARE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26437. TSNARE1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670693.

Polymorphism and mutation databases

BioMutaiTSNARE1.
DMDMi229462801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513t-SNARE domain-containing protein 1PRO_0000065668Add
BLAST

Proteomic databases

PaxDbiQ96NA8.
PRIDEiQ96NA8.

PTM databases

iPTMnetiQ96NA8.
PhosphoSiteiQ96NA8.

Expressioni

Gene expression databases

BgeeiQ96NA8.
CleanExiHS_TSNARE1.
ExpressionAtlasiQ96NA8. baseline and differential.
GenevisibleiQ96NA8. HS.

Organism-specific databases

HPAiHPA015890.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128443. 4 interactions.
IntActiQ96NA8. 1 interaction.
MINTiMINT-6768620.
STRINGi9606.ENSP00000303437.

Structurei

3D structure databases

ProteinModelPortaliQ96NA8.
SMRiQ96NA8. Positions 421-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini416 – 47863t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi503 – 5075Poly-Ile

Sequence similaritiesi

Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000092756.
HOVERGENiHBG079420.
InParanoidiQ96NA8.
KOiK13814.
OrthoDBiEOG7N63MG.
PhylomeDBiQ96NA8.
TreeFamiTF335542.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGSIARGG GLGSRGPFGG PSRQGCQPLE CARCWTEYGI RHFPCPSPES
60 70 80 90 100
KLQNRCVGKD GEGDLGPAGT PIVPRARKRG PGVAPEGSRM PEPTSSPTIG
110 120 130 140 150
PRKDSAAGPH GRMAGPSTTR AKKRKPNFCP QETEVLVSKV SKHHQLLFGT
160 170 180 190 200
GLLKAEPTRR YRVWSRILQA VNALGYCRRD VVDLKHKWRD LRAVVRRKLG
210 220 230 240 250
DLRKAAHGPS PGSGKPQALA LTPVEQVVAK TFSCQALPSE GFSLEPPRAT
260 270 280 290 300
QVDPCNLQEL FQEMSANVFR INSSVTSLER SLQSLGTPSD TQELRDSLHT
310 320 330 340 350
AQQETNKTIA ASASSVKQMA ELLRSSCPQE RLQQERPQLD RLKTQLSDAI
360 370 380 390 400
QCYGVVQKKI AEKSRALLPM AQRGSKQSPQ APFAELADDE KVFNGSDNMW
410 420 430 440 450
QGQEQALLPD ITEEDLEAIR LREEAILQME SNLLDVNQII KDLASMVSEQ
460 470 480 490 500
GEAVDSIEAS LEAASSHAEA ARQLLAGASR HQLQRHKIKC CFLSAGVTAL
510
LVIIIIIATS VRK
Length:513
Mass (Da):55,949
Last modified:May 5, 2009 - v2
Checksum:i415F67290CF97DA8
GO
Isoform 2 (identifier: Q96NA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: Missing.

Note: No experimental confirmation available.
Show »
Length:512
Mass (Da):55,821
Checksum:i00DD0255E1AB7031
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181F → L.1 Publication
Corresponds to variant rs7814359 [ dbSNP | Ensembl ].
VAR_055146
Natural varianti55 – 551R → P.1 Publication
Corresponds to variant rs33970858 [ dbSNP | Ensembl ].
VAR_051461
Natural varianti118 – 1181T → A.1 Publication
Corresponds to variant rs10100935 [ dbSNP | Ensembl ].
VAR_051462
Natural varianti268 – 2681V → I.
Corresponds to variant rs10435683 [ dbSNP | Ensembl ].
VAR_051463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 3291Missing in isoform 2. 1 PublicationVSP_056304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055726 mRNA. Translation: BAB70997.1.
AC103758 Genomic DNA. No translation available.
AC129918 Genomic DNA. No translation available.
AC134682 Genomic DNA. No translation available.
BC113556 mRNA. Translation: AAI13557.1.
BC143684 mRNA. Translation: AAI43685.1.
CCDSiCCDS6384.1. [Q96NA8-1]
RefSeqiNP_659440.2. NM_145003.4. [Q96NA8-1]
UniGeneiHs.370931.

Genome annotation databases

EnsembliENST00000524325; ENSP00000428763; ENSG00000171045. [Q96NA8-1]
GeneIDi203062.
KEGGihsa:203062.
UCSCiuc003ywk.4. human. [Q96NA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055726 mRNA. Translation: BAB70997.1.
AC103758 Genomic DNA. No translation available.
AC129918 Genomic DNA. No translation available.
AC134682 Genomic DNA. No translation available.
BC113556 mRNA. Translation: AAI13557.1.
BC143684 mRNA. Translation: AAI43685.1.
CCDSiCCDS6384.1. [Q96NA8-1]
RefSeqiNP_659440.2. NM_145003.4. [Q96NA8-1]
UniGeneiHs.370931.

3D structure databases

ProteinModelPortaliQ96NA8.
SMRiQ96NA8. Positions 421-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128443. 4 interactions.
IntActiQ96NA8. 1 interaction.
MINTiMINT-6768620.
STRINGi9606.ENSP00000303437.

PTM databases

iPTMnetiQ96NA8.
PhosphoSiteiQ96NA8.

Polymorphism and mutation databases

BioMutaiTSNARE1.
DMDMi229462801.

Proteomic databases

PaxDbiQ96NA8.
PRIDEiQ96NA8.

Protocols and materials databases

DNASUi203062.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524325; ENSP00000428763; ENSG00000171045. [Q96NA8-1]
GeneIDi203062.
KEGGihsa:203062.
UCSCiuc003ywk.4. human. [Q96NA8-1]

Organism-specific databases

CTDi203062.
GeneCardsiTSNARE1.
HGNCiHGNC:26437. TSNARE1.
HPAiHPA015890.
neXtProtiNX_Q96NA8.
PharmGKBiPA142670693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000092756.
HOVERGENiHBG079420.
InParanoidiQ96NA8.
KOiK13814.
OrthoDBiEOG7N63MG.
PhylomeDBiQ96NA8.
TreeFamiTF335542.

Miscellaneous databases

ChiTaRSiTSNARE1. human.
GenomeRNAii203062.
PROiQ96NA8.

Gene expression databases

BgeeiQ96NA8.
CleanExiHS_TSNARE1.
ExpressionAtlasiQ96NA8. baseline and differential.
GenevisibleiQ96NA8. HS.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-18; PRO-55 AND ALA-118.
    Tissue: Kidney.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiTSNA1_HUMAN
AccessioniPrimary (citable) accession number: Q96NA8
Secondary accession number(s): B7ZLB0, Q14D03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.