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UniProtKB - Q96N95 (ZN396_HUMAN)

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Protein

Zinc finger protein 396

Gene

ZNF396

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 396
Alternative name(s):
Zinc finger and SCAN domain-containing protein 14
Gene namesi
Name:ZNF396
Synonyms:ZSCAN14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:18824. ZNF396.

Subcellular locationi

Isoform 1 :
Isoform 2 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186496.
PharmGKBiPA38697.

Polymorphism and mutation databases

BioMutaiZNF396.
DMDMi38258950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475631 – 335Zinc finger protein 396Add BLAST335

Proteomic databases

MaxQBiQ96N95.
PaxDbiQ96N95.
PeptideAtlasiQ96N95.
PRIDEiQ96N95.
TopDownProteomicsiQ96N95-3. [Q96N95-3]

PTM databases

iPTMnetiQ96N95.
PhosphoSitePlusiQ96N95.

Expressioni

Tissue specificityi

Expressed strongly in liver, moderately in skeletal muscle and weakly in kidney, pancreas, spleen and prostate.1 Publication

Gene expression databases

BgeeiENSG00000186496.
CleanExiHS_ZNF396.
ExpressionAtlasiQ96N95. baseline and differential.
GenevisibleiQ96N95. HS.

Organism-specific databases

HPAiHPA006686.

Interactioni

Subunit structurei

Isoforms 1 and 2 can both homo- and hetero-associate.1 Publication

Protein-protein interaction databases

BioGridi128934. 14 interactors.
IntActiQ96N95. 4 interactors.
STRINGi9606.ENSP00000302310.

Structurei

3D structure databases

ProteinModelPortaliQ96N95.
SMRiQ96N95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ96N95.
KOiK09230.
OMAiYACDECA.
OrthoDBiEOG091G09O3.
PhylomeDBiQ96N95.
TreeFamiTF338304.

Family and domain databases

InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N95-1) [UniParc]FASTAAdd to basket
Also known as: ZNF396-fu

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAKLGKSSS LLTQTSEECN GILTEKMEEE EQTCDPDSSL HWSSSYSPET 
        60         70         80         90        100
FRQQFRQFGY QDSPGPHEAL SRLWELCHLW LRPEVHTKEQ ILELLVLEQF 
       110        120        130        140        150
LAILPKELQA WVQKHHPENG EETVTMLEDV ERELDGPKQI FFGRRKDMIA 
       160        170        180        190        200
EKLAPSEITE ELPSSQLMPV KKQLQGASWE LQSLRPHDED IKTTNVKSAS 
       210        220        230        240        250
RQKTSLGIEL HCNVSNILHM NGSQSSTYRG TYEQDGRFEK RQGNPSWKKQ 
       260        270        280        290        300
QKCDECGKIF SQSSALILHQ RIHSGKKPYA CDECAKAFSR SAILIQHRRT 
       310        320        330 
HTGEKPYKCH DCGKAFSQSS NLFRHRKRHI RKKVP
Length:335
Mass (Da):38,612
Last modified:October 31, 2003 - v2
Checksum:i2EC72390016E3E4F
GO
Isoform 2 (identifier: Q96N95-2) [UniParc]FASTAAdd to basket
Also known as: Truncated, ZNF396-nf

The sequence of this isoform differs from the canonical sequence as follows:
     188-210: DEDIKTTNVKSASRQKTSLGIEL → GEGAGFSSCWKVWGPSAHHTHLS
     211-335: Missing.

Show »
Length:210
Mass (Da):24,061
Checksum:i59B01660963377C1
GO
Isoform 3 (identifier: Q96N95-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-335: GEKPYKCHDCGKAFSQSSNLFRHRKRHIRKKVP → DSKYEHAIAEAQKNMYFKTRLKCPRSLSGGR

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,258
Checksum:i138811B6D0533261
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125T → A in AAM09559 (PubMed:12801647).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057418211H → L. Corresponds to variant dbSNP:rs9963473Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008768188 – 210DEDIK…LGIEL → GEGAGFSSCWKVWGPSAHHT HLS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_006923211 – 335Missing in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_020993303 – 335GEKPY…RKKVP → DSKYEHAIAEAQKNMYFKTR LKCPRSLSGGR in isoform 3. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492004 mRNA. Translation: AAM09559.3.
AF533251 mRNA. Translation: AAM95992.1.
AK055775 mRNA. Translation: BAB71010.1.
CH471088 Genomic DNA. Translation: EAX01352.1.
BC130288 mRNA. Translation: AAI30289.1.
BC136314 mRNA. Translation: AAI36315.1.
CCDSiCCDS11913.1. [Q96N95-3]
CCDS82246.1. [Q96N95-2]
CCDS82247.1. [Q96N95-1]
RefSeqiNP_001309215.1. NM_001322286.1. [Q96N95-1]
NP_001309219.1. NM_001322290.1. [Q96N95-1]
NP_001309220.1. NM_001322291.1. [Q96N95-2]
NP_665699.1. NM_145756.2. [Q96N95-3]
XP_006722495.1. XM_006722432.3. [Q96N95-1]
XP_016881176.1. XM_017025687.1. [Q96N95-1]
XP_016881177.1. XM_017025688.1. [Q96N95-1]
UniGeneiHs.351005.

Genome annotation databases

EnsembliENST00000306346; ENSP00000302310; ENSG00000186496. [Q96N95-3]
ENST00000586687; ENSP00000467275; ENSG00000186496. [Q96N95-2]
ENST00000589332; ENSP00000466500; ENSG00000186496. [Q96N95-1]
GeneIDi252884.
KEGGihsa:252884.
UCSCiuc010xcf.1. human. [Q96N95-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN396_HUMAN
AccessioniPrimary (citable) accession number: Q96N95
Secondary accession number(s): A1L3V0, Q8NF98, Q8TD80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 31, 2003
Last modified: May 10, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families