UniProtKB - Q96N95 (ZN396_HUMAN)
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Protein
Zinc finger protein 396
Gene
ZNF396
Organism
Homo sapiens (Human)
Status
Functioni
Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.1 Publication
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 273 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 396Alternative name(s): Zinc finger and SCAN domain-containing protein 14 |
Gene namesi | Name:ZNF396 Synonyms:ZSCAN14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186496.10 |
HGNCi | HGNC:18824 ZNF396 |
MIMi | 609600 gene |
neXtProti | NX_Q96N95 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000186496 |
PharmGKBi | PA38697 |
Polymorphism and mutation databases
BioMutai | ZNF396 |
DMDMi | 38258950 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047563 | 1 – 335 | Zinc finger protein 396Add BLAST | 335 |
Proteomic databases
MaxQBi | Q96N95 |
PaxDbi | Q96N95 |
PeptideAtlasi | Q96N95 |
PRIDEi | Q96N95 |
TopDownProteomicsi | Q96N95-3 [Q96N95-3] |
PTM databases
iPTMneti | Q96N95 |
PhosphoSitePlusi | Q96N95 |
Expressioni
Tissue specificityi
Expressed strongly in liver, moderately in skeletal muscle and weakly in kidney, pancreas, spleen and prostate.1 Publication
Gene expression databases
Bgeei | ENSG00000186496 |
CleanExi | HS_ZNF396 |
ExpressionAtlasi | Q96N95 baseline and differential |
Genevisiblei | Q96N95 HS |
Organism-specific databases
HPAi | HPA006686 |
Interactioni
Subunit structurei
Isoforms 1 and 2 can both homo- and hetero-associate.1 Publication
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 12893414 interactors. |
IntActi | Q96N95 4 interactors. |
STRINGi | 9606.ENSP00000302310 |
Structurei
3D structure databases
ProteinModelPortali | Q96N95 |
SMRi | Q96N95 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 134 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 273 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00760000118881 |
HOGENOMi | HOG000234619 |
HOVERGENi | HBG018163 |
InParanoidi | Q96N95 |
KOi | K09230 |
OMAi | YACDECA |
OrthoDBi | EOG091G09O3 |
PhylomeDBi | Q96N95 |
TreeFami | TF338304 |
Family and domain databases
CDDi | cd07936 SCAN, 1 hit |
Gene3Di | 1.10.4020.101 hit |
InterProi | View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF02023 SCAN, 1 hit |
SMARTi | View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667 SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96N95-1) [UniParc]FASTAAdd to basket
Also known as: ZNF396-fu
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSAKLGKSSS LLTQTSEECN GILTEKMEEE EQTCDPDSSL HWSSSYSPET
60 70 80 90 100
FRQQFRQFGY QDSPGPHEAL SRLWELCHLW LRPEVHTKEQ ILELLVLEQF
110 120 130 140 150
LAILPKELQA WVQKHHPENG EETVTMLEDV ERELDGPKQI FFGRRKDMIA
160 170 180 190 200
EKLAPSEITE ELPSSQLMPV KKQLQGASWE LQSLRPHDED IKTTNVKSAS
210 220 230 240 250
RQKTSLGIEL HCNVSNILHM NGSQSSTYRG TYEQDGRFEK RQGNPSWKKQ
260 270 280 290 300
QKCDECGKIF SQSSALILHQ RIHSGKKPYA CDECAKAFSR SAILIQHRRT
310 320 330
HTGEKPYKCH DCGKAFSQSS NLFRHRKRHI RKKVP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 125 | T → A in AAM09559 (PubMed:12801647).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057418 | 211 | H → L. Corresponds to variant dbSNP:rs9963473Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008768 | 188 – 210 | DEDIK…LGIEL → GEGAGFSSCWKVWGPSAHHT HLS in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_006923 | 211 – 335 | Missing in isoform 2. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_020993 | 303 – 335 | GEKPY…RKKVP → DSKYEHAIAEAQKNMYFKTR LKCPRSLSGGR in isoform 3. 2 PublicationsAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF492004 mRNA Translation: AAM09559.3 AF533251 mRNA Translation: AAM95992.1 AK055775 mRNA Translation: BAB71010.1 CH471088 Genomic DNA Translation: EAX01352.1 BC130288 mRNA Translation: AAI30289.1 BC136314 mRNA Translation: AAI36315.1 |
CCDSi | CCDS11913.1 [Q96N95-3] CCDS82246.1 [Q96N95-2] CCDS82247.1 [Q96N95-1] |
RefSeqi | NP_001309215.1, NM_001322286.1 [Q96N95-1] NP_001309219.1, NM_001322290.1 [Q96N95-1] NP_001309220.1, NM_001322291.1 [Q96N95-2] NP_665699.1, NM_145756.2 [Q96N95-3] XP_006722495.1, XM_006722432.3 [Q96N95-1] XP_016881176.1, XM_017025687.1 [Q96N95-1] XP_016881177.1, XM_017025688.1 [Q96N95-1] |
UniGenei | Hs.351005 |
Genome annotation databases
Ensembli | ENST00000306346; ENSP00000302310; ENSG00000186496 [Q96N95-3] ENST00000586687; ENSP00000467275; ENSG00000186496 [Q96N95-2] ENST00000589332; ENSP00000466500; ENSG00000186496 [Q96N95-1] |
GeneIDi | 252884 |
KEGGi | hsa:252884 |
UCSCi | uc010xcf.1 human [Q96N95-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZN396_HUMAN | |
Accessioni | Q96N95Primary (citable) accession number: Q96N95 Secondary accession number(s): A1L3V0, Q8NF98, Q8TD80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | October 31, 2003 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |