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Protein

V-type proton ATPase subunit a

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei238 – 262HelicalUniRule annotationAdd BLAST25
Transmembranei274 – 295HelicalUniRule annotationAdd BLAST22
Transmembranei315 – 334HelicalUniRule annotationAdd BLAST20
Transmembranei444 – 469HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ96N91.
PaxDbiQ96N91.
PeptideAtlasiQ96N91.
PRIDEiQ96N91.

Structurei

3D structure databases

ProteinModelPortaliQ96N91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.

Family and domain databases

InterProiView protein in InterPro
IPR002490. V-ATPase_116kDa_su.
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiView protein in Pfam
PF01496. V_ATPase_I. 2 hits.

Sequencei

Sequence statusi: Complete.

Q96N91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKLGFIAG VINRERMASF ERLLWRICRG NVYLKFSEMD APLEDPVTKE
60 70 80 90 100
EIQKNIFIIF YQGEQLRQKI KKICDGFRAT VYPCPEPAVE RREMLESVNV
110 120 130 140 150
RLEDLITVIT QTESHRQRLL QEAAANWHSW LIKVQKMKAV YHILNMCNID
160 170 180 190 200
VTQQCVIAEI WFPVADATRI KRALEQGMEL SGSSMAPIMT TVQSKTAPPT
210 220 230 240 250
FNRTNKFTAG FQNIVDAYGV GSYREINPAP YTIITFPFLF AVMFGDCGHG
260 270 280 290 300
TVMLLAALWM ILNERRLLSQ KTDNEIWNTF FHGRYLIHFI NMFLFNYSDS
310 320 330 340 350
SNAPLYKHQQ EVQSFFVVMA LISVPWMLLI KPFILRASHR KSQLQASRIQ
360 370 380 390 400
EDATENIEGD SSSPSSRSGQ RTSADTHGAL DDHGEEFNFG DVFVHQAIHT
410 420 430 440 450
IEYCLGCISN TASYLRLWAL SLAHAQLSEV LWTMVMNSGL QTRGWGGIVG
460 470 480 490 500
VFIIFAVFAV LTVAILLIME GLSAFLHALR LHWVEFQNKF YVGDGYKFSP
510
FSFKHILDGT AEE
Length:513
Mass (Da):58,476
Last modified:December 1, 2001 - v1
Checksum:i1CABB7682F5E4A89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055789 mRNA. Translation: BAB71014.1.
UniGeneiHs.98967.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ96N91_HUMAN
AccessioniPrimary (citable) accession number: Q96N91
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.