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Protein

Podocalyxin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PodocalyxinUniRule annotation
Alternative name(s):
Podocalyxin-like protein 1UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Apical cell membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei418 – 441HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Cell projectionUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500432253624 – 518PodocalyxinSequence analysisAdd BLAST495

Proteomic databases

PeptideAtlasiQ96N83.
PRIDEiQ96N83.

Expressioni

Gene expression databases

GenevisibleiQ96N83. HS.

Structurei

3D structure databases

ProteinModelPortaliQ96N83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the podocalyxin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000115601.
HOVERGENiHBG053629.
KOiK06817.

Family and domain databases

InterProiIPR013836. CD34/Podocalyxin.
IPR017403. PODXL.
[Graphical view]
PANTHERiPTHR12067. PTHR12067. 1 hit.
PfamiPF06365. CD34_antigen. 1 hit.
[Graphical view]
PIRSFiPIRSF038143. Podocalyxin-like_p1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96N83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCALALSAL LLLLSTPPSP SPSQNATQTT TDSSNKTAPT PASSVTIMAT
60 70 80 90 100
DTAQQSTVPT SKANEILASV KATTLGVSSD SPGTTTLAQQ VSGPVNTTVA
110 120 130 140 150
RGGGSGNPTT TIESPKSTKS ADTTTVATST ATAKPNTTSS QNGAEDTTNS
160 170 180 190 200
GGKSSHSVTT DLTSTKAEHL TTPHPTSPLS PRQPTSTHPV ATPTSSGHDH
210 220 230 240 250
LMKISSSSST VAIPGYTFAS PGMTTTLPSS VISQRTQQTS SQMPASSTAP
260 270 280 290 300
SSQETVQPTS PATALRTPTL PETMSSSPTA ASTTHRYPKT PSPTVAHESN
310 320 330 340 350
WAKCEDLETQ TQSEKQLVLN LTGNTLCAGG ASDEKLISLI CRAVKATFNP
360 370 380 390 400
AQDKCGIRLA SVPGSQTVVV KEITIHTKLP AKDVYERLKD KWDELKEAGV
410 420 430 440 450
SDMKLGDQGP PEEAEDRFSM PLIITIVCMA SFLLLVAALY GCCHQRLSQR
460 470 480 490 500
KDQQRLTEEL QTVENGYHDN PTLEVMETSS EMQEKKVVSL NGELGDSWIV
510
PLDNLTKDDL DEEEDTHL
Length:518
Mass (Da):54,577
Last modified:December 1, 2001 - v1
Checksum:i174F0028CA7A3F01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055816 mRNA. Translation: BAB71022.1.
RefSeqiNP_001018121.1. NM_001018111.2.
NP_005388.2. NM_005397.3.
UniGeneiHs.744213.

Genome annotation databases

GeneIDi5420.
KEGGihsa:5420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055816 mRNA. Translation: BAB71022.1.
RefSeqiNP_001018121.1. NM_001018111.2.
NP_005388.2. NM_005397.3.
UniGeneiHs.744213.

3D structure databases

ProteinModelPortaliQ96N83.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ96N83.
PRIDEiQ96N83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5420.
KEGGihsa:5420.

Organism-specific databases

CTDi5420.
PharmGKBiPA33493.

Phylogenomic databases

HOGENOMiHOG000115601.
HOVERGENiHBG053629.
KOiK06817.

Miscellaneous databases

GenomeRNAii5420.

Gene expression databases

GenevisibleiQ96N83. HS.

Family and domain databases

InterProiIPR013836. CD34/Podocalyxin.
IPR017403. PODXL.
[Graphical view]
PANTHERiPTHR12067. PTHR12067. 1 hit.
PfamiPF06365. CD34_antigen. 1 hit.
[Graphical view]
PIRSFiPIRSF038143. Podocalyxin-like_p1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ96N83_HUMAN
AccessioniPrimary (citable) accession number: Q96N83
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.