Q96N67 (DOCK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dedicator of cytokinesis protein 7

Gene names

Name:	DOCK7
Synonyms:	KIAA1771

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. Ref.1
Subunit structure	Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3. Ref.1 Ref.8
Subcellular location	Cell projection › axon. Note: Enriched in the developing axons of hippocampal neurons. Ref.1
Tissue specificity	Widely expressed. Ref.5
Domain	The DHR-2 domain mediates GEF activity.
Sequence similarities	Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain.
Sequence caution	The sequence AAH16392.2 differs from that shown. Reason: Frameshift at position 1337. The sequence ABC33725.1 differs from that shown. Reason: Frameshift at position 911. The sequence BAB70933.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB71042.1 differs from that shown. Reason: Frameshift at position 1792. The sequence BAC86032.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell projection
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Developmental protein Guanine-nucleotide releasing factor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of Rac GTPase activity Inferred from direct assay Ref.1. Source: BHF-UCL axonogenesis Inferred from mutant phenotype Ref.1. Source: BHF-UCL establishment of neuroblast polarity Inferred from mutant phenotype Ref.1. Source: BHF-UCL microtubule cytoskeleton organization Inferred from mutant phenotype Ref.1. Source: BHF-UCL pigmentation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from mutant phenotype Ref.1. Source: BHF-UCL small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	axon Traceable author statement Ref.1. Source: BHF-UCL basal part of cell Traceable author statement Ref.1. Source: BHF-UCL growth cone Traceable author statement Ref.1. Source: BHF-UCL
Molecular_function	Rac GTPase binding Inferred from direct assay Ref.1. Source: BHF-UCL guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96N67-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96N67-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1419-1427: Missing.
     1832-1836: STGWE → DGK

Note: Contains a phosphoserine at position 1429. Contains a phosphoserine at position 1421. Contains a phosphoserine at position 1425.

Isoform 3 (identifier: Q96N67-3)

The sequence of this isoform differs from the canonical sequence as follows:
     923-953: Missing.
     1419-1427: Missing.

Note: Contains a phosphoserine at position 1398. Contains a phosphoserine at position 1390. Contains a phosphoserine at position 1394.

Isoform 4 (identifier: Q96N67-4)

The sequence of this isoform differs from the canonical sequence as follows:
     923-953: Missing.
     1419-1427: Missing.
     1832-1836: STGWE → DGK

Note: Contains a phosphoserine at position 1398. Contains a phosphoserine at position 1390. Contains a phosphoserine at position 1394.

Isoform 5 (identifier: Q96N67-5)

The sequence of this isoform differs from the canonical sequence as follows:
     923-953: Missing.

Isoform 6 (identifier: Q96N67-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1419-1427: Missing.

Note: Contains a phosphoserine at position 1429. Contains a phosphoserine at position 1421. Contains a phosphoserine at position 1425.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2140	2140	Dedicator of cytokinesis protein 7		PRO_0000189995
Regions
	Domain	561 – 727	167	DHR-1
	Domain	1678 – 2114	437	DHR-2
	Coiled coil	365 – 395	31	Potential
	Coiled coil	2086 – 2112	27	Potential
Amino acid modifications
	Modified residue	28	1	Phosphoserine Ref.14
	Modified residue	30	1	Phosphoserine Ref.10 Ref.14
	Modified residue	180	1	Phosphoserine Ref.10 Ref.12 Ref.14
	Modified residue	182	1	Phosphoserine Ref.10 Ref.14
	Modified residue	439	1	Phosphoserine By similarity
	Modified residue	440	1	Phosphoserine By similarity
	Modified residue	882	1	Phosphoserine Ref.10
	Modified residue	888	1	Phosphoserine Ref.10
	Modified residue	896	1	Phosphoserine Ref.12
	Modified residue	900	1	Phosphoserine Ref.10 Ref.12
	Modified residue	905	1	Phosphoserine Ref.12
	Modified residue	907	1	Phosphothreonine Ref.10 Ref.12
	Modified residue	909	1	Phosphothreonine Ref.12
	Modified residue	910	1	Phosphoserine Ref.10 Ref.12
	Modified residue	964	1	Phosphoserine By similarity
	Modified residue	966	1	Phosphothreonine By similarity
	Modified residue	1383	1	Phosphoserine Ref.10 Ref.16
	Modified residue	1430	1	Phosphoserine Ref.14
	Modified residue	1432	1	Phosphoserine Ref.10
	Modified residue	1438	1	Phosphoserine Ref.12
	Modified residue	1962	1	N6-acetyllysine Ref.13
Natural variations
	Alternative sequence	923 – 953	31	Missing in isoform 3, isoform 4 and isoform 5.		VSP_012440
	Alternative sequence	1419 – 1427	9	Missing in isoform 2, isoform 3, isoform 4 and isoform 6.		VSP_022240
	Alternative sequence	1832 – 1836	5	STGWE → DGK in isoform 2 and isoform 4.		VSP_007707
	Natural variant	824	1	I → T. Corresponds to variant rs35400360 [ dbSNP | Ensembl ].		VAR_057524
Experimental info
	Sequence conflict	750	1	H → R in BAC86032. Ref.4
	Sequence conflict	1440	1	E → G in BAC86032. Ref.4
	Sequence conflict	1520	1	S → N in BAB70933. Ref.4
	Sequence conflict	1521	1	A → V in BAC86032. Ref.4
	Sequence conflict	1639	1	P → L in BAC86032. Ref.4
	Sequence conflict	1859	1	E → K in BAB70933. Ref.4
	Sequence conflict	1908	1	K → T in BAB71042. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 4. Checksum: A14857DCB9C3AE6E	FASTA	2,140	242,561
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGGPKAAP WGSNPSPSAE STQAMDRSCN 970 980 990 1000 1010 1020 RMSSHTETSS FLQTLTGRLP TKKLFHEELA LQWVVCSGSV RESALQQAWF FFELMVKSMV 1030 1040 1050 1060 1070 1080 HHLYFNDKLE APRKSRFPER FMDDIAALVS TIASDIVSRF QKDTEMVERL NTSLAFFLND 1090 1100 1110 1120 1130 1140 LLSVMDRGFV FSLIKSCYKQ VSSKLYSLPN PSVLVSLRLD FLRIICSHEH YVTLNLPCSL 1150 1160 1170 1180 1190 1200 LTPPASPSPS VSSATSQSSG FSTNVQDQKI ANMFELSVPF RQQHYLAGLV LTELAVILDP 1210 1220 1230 1240 1250 1260 DAEGLFGLHK KVINMVHNLL SSHDSDPRYS DPQIKARVAM LYLPLIGIIM ETVPQLYDFT 1270 1280 1290 1300 1310 1320 ETHNQRGRPI CIATDDYESE SGSMISQTVA MAIAGTSVPQ LTRPGSFLLT STSGRQHTTF 1330 1340 1350 1360 1370 1380 SAESSRSLLI CLLWVLKNAD ETVLQKWFTD LSVLQLNRLL DLLYLCVSCF EYKGKKVFER 1390 1400 1410 1420 1430 1440 MNSLTFKKSK DMRAKLEEAI LGSIGARQEM VRRSRGQLGT YTIASPPERS PSGSAFGSQE 1450 1460 1470 1480 1490 1500 NLRWRKDMTH WRQNTEKLDK SRAEIEHEAL IDGNLATEAN LIILDTLEIV VQTVSVTESK 1510 1520 1530 1540 1550 1560 ESILGGVLKV LLHSMACNQS AVYLQHCFAT QRALVSKFPE LLFEEETEQC ADLCLRLLRH 1570 1580 1590 1600 1610 1620 CSSSIGTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS LSSLVGTSQN FNEEFLRRSL 1630 1640 1650 1660 1670 1680 KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK EHQEDPEMLI DLMYRIAKGY 1690 1700 1710 1720 1730 1740 QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC LVHSAALVAE YLSMLEDRKY LPVGCVTFQN 1750 1760 1770 1780 1790 1800 ISSNVLEESA VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ AAASFSMAGM YEAVNEVYKV 1810 1820 1830 1840 1850 1860 LIPIHEANRD AKKLSTIHGK LQEAFSKIVH QSTGWERMFG TYFRVGFYGT KFGDLDEQEF 1870 1880 1890 1900 1910 1920 VYKEPAITKL AEISHRLEGF YGERFGEDVV EVIKDSNPVD KCKLDPNKAY IQITYVEPYF 1930 1940 1950 1960 1970 1980 DTYEMKDRIT YFDKNYNLRR FMYCTPFTLD GRAHGELHEQ FKRKTILTTS HAFPYIKTRV 1990 2000 2010 2020 2030 2040 NVTHKEEIIL TPIEVAIEDM QKKTQELAFA THQDPADPKM LQMVLQGSVG TTVNQGPLEV 2050 2060 2070 2080 2090 2100 AQVFLSEIPS DPKLFRHHNK LRLCFKDFTK RCEDALRKNK SLIGPDQKEY QRELERNYHR 2110 2120 2130 2140 LKEALQPLIN RKIPQLYKAV LPVTCHRDSF SRMSLRKMDL
	Isoform 2 [UniParc]. Checksum: 56C741287C8296C4	FASTA	2,129	241,412
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGGPKAAP WGSNPSPSAE STQAMDRSCN 970 980 990 1000 1010 1020 RMSSHTETSS FLQTLTGRLP TKKLFHEELA LQWVVCSGSV RESALQQAWF FFELMVKSMV 1030 1040 1050 1060 1070 1080 HHLYFNDKLE APRKSRFPER FMDDIAALVS TIASDIVSRF QKDTEMVERL NTSLAFFLND 1090 1100 1110 1120 1130 1140 LLSVMDRGFV FSLIKSCYKQ VSSKLYSLPN PSVLVSLRLD FLRIICSHEH YVTLNLPCSL 1150 1160 1170 1180 1190 1200 LTPPASPSPS VSSATSQSSG FSTNVQDQKI ANMFELSVPF RQQHYLAGLV LTELAVILDP 1210 1220 1230 1240 1250 1260 DAEGLFGLHK KVINMVHNLL SSHDSDPRYS DPQIKARVAM LYLPLIGIIM ETVPQLYDFT 1270 1280 1290 1300 1310 1320 ETHNQRGRPI CIATDDYESE SGSMISQTVA MAIAGTSVPQ LTRPGSFLLT STSGRQHTTF 1330 1340 1350 1360 1370 1380 SAESSRSLLI CLLWVLKNAD ETVLQKWFTD LSVLQLNRLL DLLYLCVSCF EYKGKKVFER 1390 1400 1410 1420 1430 1440 MNSLTFKKSK DMRAKLEEAI LGSIGARQEM VRRSRGQLER SPSGSAFGSQ ENLRWRKDMT 1450 1460 1470 1480 1490 1500 HWRQNTEKLD KSRAEIEHEA LIDGNLATEA NLIILDTLEI VVQTVSVTES KESILGGVLK 1510 1520 1530 1540 1550 1560 VLLHSMACNQ SAVYLQHCFA TQRALVSKFP ELLFEEETEQ CADLCLRLLR HCSSSIGTIR 1570 1580 1590 1600 1610 1620 SHASASLYLL MRQNFEIGNN FARVKMQVTM SLSSLVGTSQ NFNEEFLRRS LKTILTYAEE 1630 1640 1650 1660 1670 1680 DLELRETTFP DQVQDLVFNL HMILSDTVKM KEHQEDPEML IDLMYRIAKG YQTSPDLRLT 1690 1700 1710 1720 1730 1740 WLQNMAGKHS ERSNHAEAAQ CLVHSAALVA EYLSMLEDRK YLPVGCVTFQ NISSNVLEES 1750 1760 1770 1780 1790 1800 AVSDDVVSPD EEGICSGKYF TESGLVGLLE QAAASFSMAG MYEAVNEVYK VLIPIHEANR 1810 1820 1830 1840 1850 1860 DAKKLSTIHG KLQEAFSKIV HQDGKRMFGT YFRVGFYGTK FGDLDEQEFV YKEPAITKLA 1870 1880 1890 1900 1910 1920 EISHRLEGFY GERFGEDVVE VIKDSNPVDK CKLDPNKAYI QITYVEPYFD TYEMKDRITY 1930 1940 1950 1960 1970 1980 FDKNYNLRRF MYCTPFTLDG RAHGELHEQF KRKTILTTSH AFPYIKTRVN VTHKEEIILT 1990 2000 2010 2020 2030 2040 PIEVAIEDMQ KKTQELAFAT HQDPADPKML QMVLQGSVGT TVNQGPLEVA QVFLSEIPSD 2050 2060 2070 2080 2090 2100 PKLFRHHNKL RLCFKDFTKR CEDALRKNKS LIGPDQKEYQ RELERNYHRL KEALQPLINR 2110 2120 KIPQLYKAVL PVTCHRDSFS RMSLRKMDL
	Isoform 3 [UniParc]. Checksum: 4A44093C2074BD4B	FASTA	2,100	238,534
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL 970 980 990 1000 1010 1020 QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLEA PRKSRFPERF MDDIAALVST 1030 1040 1050 1060 1070 1080 IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP 1090 1100 1110 1120 1130 1140 SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA 1150 1160 1170 1180 1190 1200 NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD 1210 1220 1230 1240 1250 1260 PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM 1270 1280 1290 1300 1310 1320 AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL 1330 1340 1350 1360 1370 1380 SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV 1390 1400 1410 1420 1430 1440 RRSRGQLERS PSGSAFGSQE NLRWRKDMTH WRQNTEKLDK SRAEIEHEAL IDGNLATEAN 1450 1460 1470 1480 1490 1500 LIILDTLEIV VQTVSVTESK ESILGGVLKV LLHSMACNQS AVYLQHCFAT QRALVSKFPE 1510 1520 1530 1540 1550 1560 LLFEEETEQC ADLCLRLLRH CSSSIGTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS 1570 1580 1590 1600 1610 1620 LSSLVGTSQN FNEEFLRRSL KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK 1630 1640 1650 1660 1670 1680 EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC LVHSAALVAE 1690 1700 1710 1720 1730 1740 YLSMLEDRKY LPVGCVTFQN ISSNVLEESA VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ 1750 1760 1770 1780 1790 1800 AAASFSMAGM YEAVNEVYKV LIPIHEANRD AKKLSTIHGK LQEAFSKIVH QSTGWERMFG 1810 1820 1830 1840 1850 1860 TYFRVGFYGT KFGDLDEQEF VYKEPAITKL AEISHRLEGF YGERFGEDVV EVIKDSNPVD 1870 1880 1890 1900 1910 1920 KCKLDPNKAY IQITYVEPYF DTYEMKDRIT YFDKNYNLRR FMYCTPFTLD GRAHGELHEQ 1930 1940 1950 1960 1970 1980 FKRKTILTTS HAFPYIKTRV NVTHKEEIIL TPIEVAIEDM QKKTQELAFA THQDPADPKM 1990 2000 2010 2020 2030 2040 LQMVLQGSVG TTVNQGPLEV AQVFLSEIPS DPKLFRHHNK LRLCFKDFTK RCEDALRKNK 2050 2060 2070 2080 2090 2100 SLIGPDQKEY QRELERNYHR LKEALQPLIN RKIPQLYKAV LPVTCHRDSF SRMSLRKMDL
	Isoform 4 [UniParc]. Checksum: A768EB92CB1CDB3D	FASTA	2,098	238,274
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL 970 980 990 1000 1010 1020 QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLEA PRKSRFPERF MDDIAALVST 1030 1040 1050 1060 1070 1080 IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP 1090 1100 1110 1120 1130 1140 SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA 1150 1160 1170 1180 1190 1200 NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD 1210 1220 1230 1240 1250 1260 PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM 1270 1280 1290 1300 1310 1320 AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL 1330 1340 1350 1360 1370 1380 SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV 1390 1400 1410 1420 1430 1440 RRSRGQLERS PSGSAFGSQE NLRWRKDMTH WRQNTEKLDK SRAEIEHEAL IDGNLATEAN 1450 1460 1470 1480 1490 1500 LIILDTLEIV VQTVSVTESK ESILGGVLKV LLHSMACNQS AVYLQHCFAT QRALVSKFPE 1510 1520 1530 1540 1550 1560 LLFEEETEQC ADLCLRLLRH CSSSIGTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS 1570 1580 1590 1600 1610 1620 LSSLVGTSQN FNEEFLRRSL KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK 1630 1640 1650 1660 1670 1680 EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC LVHSAALVAE 1690 1700 1710 1720 1730 1740 YLSMLEDRKY LPVGCVTFQN ISSNVLEESA VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ 1750 1760 1770 1780 1790 1800 AAASFSMAGM YEAVNEVYKV LIPIHEANRD AKKLSTIHGK LQEAFSKIVH QDGKRMFGTY 1810 1820 1830 1840 1850 1860 FRVGFYGTKF GDLDEQEFVY KEPAITKLAE ISHRLEGFYG ERFGEDVVEV IKDSNPVDKC 1870 1880 1890 1900 1910 1920 KLDPNKAYIQ ITYVEPYFDT YEMKDRITYF DKNYNLRRFM YCTPFTLDGR AHGELHEQFK 1930 1940 1950 1960 1970 1980 RKTILTTSHA FPYIKTRVNV THKEEIILTP IEVAIEDMQK KTQELAFATH QDPADPKMLQ 1990 2000 2010 2020 2030 2040 MVLQGSVGTT VNQGPLEVAQ VFLSEIPSDP KLFRHHNKLR LCFKDFTKRC EDALRKNKSL 2050 2060 2070 2080 2090 IGPDQKEYQR ELERNYHRLK EALQPLINRK IPQLYKAVLP VTCHRDSFSR MSLRKMDL
	Isoform 5 [UniParc]. Checksum: 0171AA19EEB3B57F	FASTA	2,109	239,422
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL 970 980 990 1000 1010 1020 QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLEA PRKSRFPERF MDDIAALVST 1030 1040 1050 1060 1070 1080 IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP 1090 1100 1110 1120 1130 1140 SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA 1150 1160 1170 1180 1190 1200 NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD 1210 1220 1230 1240 1250 1260 PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM 1270 1280 1290 1300 1310 1320 AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL 1330 1340 1350 1360 1370 1380 SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV 1390 1400 1410 1420 1430 1440 RRSRGQLGTY TIASPPERSP SGSAFGSQEN LRWRKDMTHW RQNTEKLDKS RAEIEHEALI 1450 1460 1470 1480 1490 1500 DGNLATEANL IILDTLEIVV QTVSVTESKE SILGGVLKVL LHSMACNQSA VYLQHCFATQ 1510 1520 1530 1540 1550 1560 RALVSKFPEL LFEEETEQCA DLCLRLLRHC SSSIGTIRSH ASASLYLLMR QNFEIGNNFA 1570 1580 1590 1600 1610 1620 RVKMQVTMSL SSLVGTSQNF NEEFLRRSLK TILTYAEEDL ELRETTFPDQ VQDLVFNLHM 1630 1640 1650 1660 1670 1680 ILSDTVKMKE HQEDPEMLID LMYRIAKGYQ TSPDLRLTWL QNMAGKHSER SNHAEAAQCL 1690 1700 1710 1720 1730 1740 VHSAALVAEY LSMLEDRKYL PVGCVTFQNI SSNVLEESAV SDDVVSPDEE GICSGKYFTE 1750 1760 1770 1780 1790 1800 SGLVGLLEQA AASFSMAGMY EAVNEVYKVL IPIHEANRDA KKLSTIHGKL QEAFSKIVHQ 1810 1820 1830 1840 1850 1860 STGWERMFGT YFRVGFYGTK FGDLDEQEFV YKEPAITKLA EISHRLEGFY GERFGEDVVE 1870 1880 1890 1900 1910 1920 VIKDSNPVDK CKLDPNKAYI QITYVEPYFD TYEMKDRITY FDKNYNLRRF MYCTPFTLDG 1930 1940 1950 1960 1970 1980 RAHGELHEQF KRKTILTTSH AFPYIKTRVN VTHKEEIILT PIEVAIEDMQ KKTQELAFAT 1990 2000 2010 2020 2030 2040 HQDPADPKML QMVLQGSVGT TVNQGPLEVA QVFLSEIPSD PKLFRHHNKL RLCFKDFTKR 2050 2060 2070 2080 2090 2100 CEDALRKNKS LIGPDQKEYQ RELERNYHRL KEALQPLINR KIPQLYKAVL PVTCHRDSFS RMSLRKMDL
	Isoform 6 [UniParc]. Checksum: 2C21C8938ACE0AD5	FASTA	2,131	241,673
	10 20 30 40 50 60 MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 70 80 90 100 110 120 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 130 140 150 160 170 180 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 190 200 210 220 230 240 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 250 260 270 280 290 300 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 310 320 330 340 350 360 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 370 380 390 400 410 420 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 430 440 450 460 470 480 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 490 500 510 520 530 540 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 550 560 570 580 590 600 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 610 620 630 640 650 660 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 670 680 690 700 710 720 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 730 740 750 760 770 780 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 790 800 810 820 830 840 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 850 860 870 880 890 900 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 910 920 930 940 950 960 NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGGPKAAP WGSNPSPSAE STQAMDRSCN 970 980 990 1000 1010 1020 RMSSHTETSS FLQTLTGRLP TKKLFHEELA LQWVVCSGSV RESALQQAWF FFELMVKSMV 1030 1040 1050 1060 1070 1080 HHLYFNDKLE APRKSRFPER FMDDIAALVS TIASDIVSRF QKDTEMVERL NTSLAFFLND 1090 1100 1110 1120 1130 1140 LLSVMDRGFV FSLIKSCYKQ VSSKLYSLPN PSVLVSLRLD FLRIICSHEH YVTLNLPCSL 1150 1160 1170 1180 1190 1200 LTPPASPSPS VSSATSQSSG FSTNVQDQKI ANMFELSVPF RQQHYLAGLV LTELAVILDP 1210 1220 1230 1240 1250 1260 DAEGLFGLHK KVINMVHNLL SSHDSDPRYS DPQIKARVAM LYLPLIGIIM ETVPQLYDFT 1270 1280 1290 1300 1310 1320 ETHNQRGRPI CIATDDYESE SGSMISQTVA MAIAGTSVPQ LTRPGSFLLT STSGRQHTTF 1330 1340 1350 1360 1370 1380 SAESSRSLLI CLLWVLKNAD ETVLQKWFTD LSVLQLNRLL DLLYLCVSCF EYKGKKVFER 1390 1400 1410 1420 1430 1440 MNSLTFKKSK DMRAKLEEAI LGSIGARQEM VRRSRGQLER SPSGSAFGSQ ENLRWRKDMT 1450 1460 1470 1480 1490 1500 HWRQNTEKLD KSRAEIEHEA LIDGNLATEA NLIILDTLEI VVQTVSVTES KESILGGVLK 1510 1520 1530 1540 1550 1560 VLLHSMACNQ SAVYLQHCFA TQRALVSKFP ELLFEEETEQ CADLCLRLLR HCSSSIGTIR 1570 1580 1590 1600 1610 1620 SHASASLYLL MRQNFEIGNN FARVKMQVTM SLSSLVGTSQ NFNEEFLRRS LKTILTYAEE 1630 1640 1650 1660 1670 1680 DLELRETTFP DQVQDLVFNL HMILSDTVKM KEHQEDPEML IDLMYRIAKG YQTSPDLRLT 1690 1700 1710 1720 1730 1740 WLQNMAGKHS ERSNHAEAAQ CLVHSAALVA EYLSMLEDRK YLPVGCVTFQ NISSNVLEES 1750 1760 1770 1780 1790 1800 AVSDDVVSPD EEGICSGKYF TESGLVGLLE QAAASFSMAG MYEAVNEVYK VLIPIHEANR 1810 1820 1830 1840 1850 1860 DAKKLSTIHG KLQEAFSKIV HQSTGWERMF GTYFRVGFYG TKFGDLDEQE FVYKEPAITK 1870 1880 1890 1900 1910 1920 LAEISHRLEG FYGERFGEDV VEVIKDSNPV DKCKLDPNKA YIQITYVEPY FDTYEMKDRI 1930 1940 1950 1960 1970 1980 TYFDKNYNLR RFMYCTPFTL DGRAHGELHE QFKRKTILTT SHAFPYIKTR VNVTHKEEII 1990 2000 2010 2020 2030 2040 LTPIEVAIED MQKKTQELAF ATHQDPADPK MLQMVLQGSV GTTVNQGPLE VAQVFLSEIP 2050 2060 2070 2080 2090 2100 SDPKLFRHHN KLRLCFKDFT KRCEDALRKN KSLIGPDQKE YQRELERNYH RLKEALQPLI 2110 2120 2130 NRKIPQLYKA VLPVTCHRDS FSRMSLRKMD L

References

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[1]	"The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18." Watabe-Uchida M., John K.A., Janas J.A., Newey S.E., Van Aelst L. Neuron 51:727-739(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RAC1 AND RAC3, FUNCTION, SUBCELLULAR LOCATION. Tissue: Fetal brain.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Molecular characterization of human Dock7." Yamauchi J., Miyamoto Y., Takashima S., Tanoue A. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-2140 (ISOFORMS 3 AND 4). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 830-2140 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1156-2140 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 585-2140 (ISOFORM 3). Tissue: Brain, Mesangial cell and Thalamus.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 830-2140 (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1332-2140 (ISOFORM 2). Tissue: Ovary.
[7]	"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity." Cote J.-F., Vuori K. J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[8]	"Phosphorylation and binding partner analysis of the TSC1-TSC2 complex." Nellist M., Burgers P.C., van den Ouweland A.M.W., Halley D.J.J., Luider T.M. Biochem. Biophys. Res. Commun. 333:818-826(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TSC1, IDENTIFICATION BY MASS SPECTROMETRY.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1429 (ISOFORMS 2 AND 6), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1398 (ISOFORMS 3 AND 4), MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-180; SER-182; SER-882; SER-888; SER-900; THR-907; SER-910; SER-1383 AND SER-1432, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1421; SER-1425 AND SER-1429 (ISOFORMS 2 AND 6), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1390; SER-1394 AND SER-1398 (ISOFORMS 3 AND 4), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-896; SER-900; SER-905; THR-907; THR-909; SER-910 AND SER-1438, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1962, MASS SPECTROMETRY.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-30; SER-180; SER-182 AND SER-1430, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1383, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ341187 mRNA. Translation: ABC68221.1. AL451044 , AC096946, AC103923, AL138847 Genomic DNA. Translation: CAI13104.1. AL451044, AC096946 Genomic DNA. Translation: CAI13105.1. AL138847 , AC096946, AC103923, AL451044 Genomic DNA. Translation: CAI22995.1. DQ309763 mRNA. Translation: ABC33725.1. Frameshift. DQ118679 mRNA. Translation: AAZ38451.1. DQ118680 mRNA. Translation: AAZ38452.1. AK055493 mRNA. Translation: BAB70933.1. Different initiation. AK055905 mRNA. Translation: BAB71042.1. Frameshift. AK125049 mRNA. Translation: BAC86032.1. Different initiation. AB051558 mRNA. Translation: BAB21862.1. BC016392 mRNA. Translation: AAH16392.2. Frameshift.
IPI	IPI00183572. IPI00513791. IPI00807434. IPI00815633. IPI00815886. IPI00816106.
RefSeq	NP_001258928.1. NM_001271999.1. NP_001258929.1. NM_001272000.1. NP_001258930.1. NM_001272001.1. NP_212132.2. NM_033407.3.
UniGene	Hs.406156.
3D structure databases
ProteinModelPortal	Q96N67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96N67. 9 interactions.
PTM databases
PhosphoSite	Q96N67.
Polymorphism databases
DMDM	122065170.
Proteomic databases
PaxDb	Q96N67.
PRIDE	Q96N67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251157; ENSP00000251157; ENSG00000116641. ENST00000340370; ENSP00000340742; ENSG00000116641.
GeneID	85440.
KEGG	hsa:85440.
UCSC	uc001dam.3. human. uc001dan.3. human. uc001dao.3. human. uc001dap.3. human. uc001daq.3. human.
Organism-specific databases
CTD	85440.
GeneCards	GC01M062920.
HGNC	HGNC:19190. DOCK7.
HPA	HPA008607.
neXtProt	NX_Q96N67.
PharmGKB	PA134872825.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242127.
HOVERGEN	HBG051390.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q96N67.
Bgee	Q96N67.
CleanEx	HS_DOCK7.
Genevestigator	Q96N67.
GermOnline	ENSG00000116641. Homo sapiens.
Family and domain databases
InterPro	IPR027007. DHR-1_domain. IPR027357. DHR-2. IPR026791. DOCK. IPR010703. DOCK_C. IPR021816. DOCK_C/D_N. IPR026798. DOCK_C_fam. [Graphical view]
PANTHER	PTHR23317. PTHR23317. 1 hit. PTHR23317:SF27. PTHR23317:SF27. 1 hit.
Pfam	PF06920. Ded_cyto. 1 hit. PF14429. DOCK-C2. 1 hit. PF11878. DUF3398. 1 hit. [Graphical view]
PROSITE	PS51650. DHR_1. 1 hit. PS51651. DHR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DOCK7. human.
GenomeRNAi	85440.
NextBio	76016.

Entry information

Entry name

DOCK7_HUMAN

Accession

Primary (citable) accession number: Q96N67
Secondary accession number(s): Q00M63 , Q2PPY7, Q45RE8, Q45RE9, Q5T1B9, Q5T1C0, Q6ZV32, Q8TB82, Q96NG6, Q9C092

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	January 9, 2007
Last modified:	May 29, 2013
This is version 99 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.