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Protein

PWWP domain-containing protein 2A

Gene

PWWP2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 2A
Gene namesi
Name:PWWP2A
Synonyms:KIAA1935, MST101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29406. PWWP2A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400500.

Polymorphism and mutation databases

BioMutaiPWWP2A.
DMDMi160419226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755PWWP domain-containing protein 2APRO_0000311363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineCombined sources
Modified residuei102 – 1021PhosphoserineCombined sources
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei119 – 1191PhosphoserineCombined sources
Cross-linki208 – 208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96N64.
MaxQBiQ96N64.
PaxDbiQ96N64.
PeptideAtlasiQ96N64.
PRIDEiQ96N64.

PTM databases

iPTMnetiQ96N64.
PhosphoSiteiQ96N64.

Expressioni

Gene expression databases

BgeeiENSG00000170234.
CleanExiHS_PWWP2A.
ExpressionAtlasiQ96N64. baseline and differential.
GenevisibleiQ96N64. HS.

Organism-specific databases

HPAiHPA046733.
HPA058233.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC1Q135475EBI-6597774,EBI-301834

Protein-protein interaction databases

BioGridi125375. 7 interactions.
IntActiQ96N64. 5 interactions.
STRINGi9606.ENSP00000305151.

Structurei

3D structure databases

ProteinModelPortaliQ96N64.
SMRiQ96N64. Positions 640-755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini655 – 71561PWWPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 14686Pro-richAdd
BLAST
Compositional biasi240 – 29152Pro-richAdd
BLAST
Compositional biasi575 – 63258Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXQI. Eukaryota.
ENOG4111IWH. LUCA.
GeneTreeiENSGT00530000063940.
HOGENOMiHOG000060329.
HOVERGENiHBG108311.
InParanoidiQ96N64.
OMAiSEVQDTN.
OrthoDBiEOG091G08LI.
PhylomeDBiQ96N64.
TreeFamiTF331271.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP
60 70 80 90 100
DGETDGQQSA PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA
110 120 130 140 150
ESAAAAPQGG PELPPSPASP PEQPPAPEER EEPPLPQPVA PALVPPAGGD
160 170 180 190 200
STVSQLIPGS EVRVTLDHII EDALVVSFRF GEKLFSGVLM DLSKRFGPHG
210 220 230 240 250
IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP DDPSPVPHPE
260 270 280 290 300
LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK
310 320 330 340 350
MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED
360 370 380 390 400
KKRRNESVTT VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK
410 420 430 440 450
VSAQANTSKA QLSTKKVLQS KNMDHAKARE VLKIAKEKAQ KKQNETSTSK
460 470 480 490 500
NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR YRNEENDSSL KTGLEKMRSG
510 520 530 540 550
KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT NEVHVPGDQD
560 570 580 590 600
EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS
610 620 630 640 650
SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG
660 670 680 690 700
RTICVGDIVW AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT
710 720 730 740 750
TSFLALSQLS PFLENFQSRF NKKRKGLYRK AITEAAKAAK QLTPEVRALL

TQFET
Length:755
Mass (Da):81,960
Last modified:November 13, 2007 - v2
Checksum:i6BF89E9C8D68EAA0
GO
Isoform 2 (identifier: Q96N64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-560: EAPSENQSPS...EPQTLGKKGS → LNKWQLLHQT...LTVKRAAQRH
     561-755: Missing.

Show »
Length:560
Mass (Da):60,684
Checksum:iAA8EE2743C67AB3A
GO
Isoform 3 (identifier: Q96N64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-520: GEAP → AQRH
     521-755: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:520
Mass (Da):56,315
Checksum:i951B12404F03C440
GO

Sequence cautioni

The sequence AAH35076 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB67828 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71045 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541S → L in AAH35076 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei517 – 5204GEAP → AQRH in isoform 3. CuratedVSP_054064
Alternative sequencei518 – 56043EAPSE…GKKGS → LNKWQLLHQTVTSPAAPLQC LTDHCGFRLGALKLTVKRAA QRH in isoform 2. 1 PublicationVSP_029547Add
BLAST
Alternative sequencei521 – 755235Missing in isoform 3. CuratedVSP_054065Add
BLAST
Alternative sequencei561 – 755195Missing in isoform 2. 1 PublicationVSP_029548Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067522 mRNA. Translation: BAB67828.1. Different initiation.
AK055921 mRNA. Translation: BAB71045.1. Different initiation.
AC008706 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61567.1.
CH471062 Genomic DNA. Translation: EAW61568.1.
BC035076 mRNA. Translation: AAH35076.2. Different initiation.
BC105110 mRNA. Translation: AAI05111.1.
CCDSiCCDS47331.1. [Q96N64-2]
CCDS47332.1. [Q96N64-1]
CCDS58990.1. [Q96N64-3]
RefSeqiNP_001124336.1. NM_001130864.1. [Q96N64-1]
NP_001253964.1. NM_001267035.1. [Q96N64-3]
NP_443159.1. NM_052927.2. [Q96N64-2]
UniGeneiHs.744960.

Genome annotation databases

EnsembliENST00000307063; ENSP00000305151; ENSG00000170234. [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234. [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234. [Q96N64-3]
GeneIDi114825.
KEGGihsa:114825.
UCSCiuc003lxv.5. human. [Q96N64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067522 mRNA. Translation: BAB67828.1. Different initiation.
AK055921 mRNA. Translation: BAB71045.1. Different initiation.
AC008706 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61567.1.
CH471062 Genomic DNA. Translation: EAW61568.1.
BC035076 mRNA. Translation: AAH35076.2. Different initiation.
BC105110 mRNA. Translation: AAI05111.1.
CCDSiCCDS47331.1. [Q96N64-2]
CCDS47332.1. [Q96N64-1]
CCDS58990.1. [Q96N64-3]
RefSeqiNP_001124336.1. NM_001130864.1. [Q96N64-1]
NP_001253964.1. NM_001267035.1. [Q96N64-3]
NP_443159.1. NM_052927.2. [Q96N64-2]
UniGeneiHs.744960.

3D structure databases

ProteinModelPortaliQ96N64.
SMRiQ96N64. Positions 640-755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125375. 7 interactions.
IntActiQ96N64. 5 interactions.
STRINGi9606.ENSP00000305151.

PTM databases

iPTMnetiQ96N64.
PhosphoSiteiQ96N64.

Polymorphism and mutation databases

BioMutaiPWWP2A.
DMDMi160419226.

Proteomic databases

EPDiQ96N64.
MaxQBiQ96N64.
PaxDbiQ96N64.
PeptideAtlasiQ96N64.
PRIDEiQ96N64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307063; ENSP00000305151; ENSG00000170234. [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234. [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234. [Q96N64-3]
GeneIDi114825.
KEGGihsa:114825.
UCSCiuc003lxv.5. human. [Q96N64-1]

Organism-specific databases

CTDi114825.
GeneCardsiPWWP2A.
H-InvDBHIX0005372.
HGNCiHGNC:29406. PWWP2A.
HPAiHPA046733.
HPA058233.
neXtProtiNX_Q96N64.
PharmGKBiPA162400500.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQI. Eukaryota.
ENOG4111IWH. LUCA.
GeneTreeiENSGT00530000063940.
HOGENOMiHOG000060329.
HOVERGENiHBG108311.
InParanoidiQ96N64.
OMAiSEVQDTN.
OrthoDBiEOG091G08LI.
PhylomeDBiQ96N64.
TreeFamiTF331271.

Miscellaneous databases

ChiTaRSiPWWP2A. human.
GenomeRNAii114825.
PROiQ96N64.

Gene expression databases

BgeeiENSG00000170234.
CleanExiHS_PWWP2A.
ExpressionAtlasiQ96N64. baseline and differential.
GenevisibleiQ96N64. HS.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPWP2A_HUMAN
AccessioniPrimary (citable) accession number: Q96N64
Secondary accession number(s): G5EA07
, Q2HJJ2, Q8IYR3, Q96PV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.