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Protein

Zinc finger protein 578

Gene

ZNF578

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 578
Gene namesi
Name:ZNF578
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26449. ZNF578.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000258405.
PharmGKBiPA134936072.

Polymorphism and mutation databases

BioMutaiZNF578.
DMDMi476007824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476681 – 590Zinc finger protein 578Add BLAST590

Proteomic databases

MaxQBiQ96N58.
PaxDbiQ96N58.
PeptideAtlasiQ96N58.
PRIDEiQ96N58.

PTM databases

iPTMnetiQ96N58.
PhosphoSitePlusiQ96N58.

Expressioni

Gene expression databases

BgeeiENSG00000258405.
CleanExiHS_ZNF578.
ExpressionAtlasiQ96N58. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi127070. 6 interactors.
IntActiQ96N58. 9 interactors.
STRINGi9606.ENSP00000459216.

Structurei

3D structure databases

ProteinModelPortaliQ96N58.
SMRiQ96N58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 98KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiQ96N58.
OMAiCHKIYSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96N58.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96N58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHEEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKRM MKEVLSTGQG NTEVIHTGML QRHESYHTGD
110 120 130 140 150
FCFQEIEKDI HDFEFQSQKD ERNGHEASMP KIKELMGSTD RHDQRHAGNK
160 170 180 190 200
PIKDQLGLSF HLHLPELHIF QPEEKIANQV EKSVNDASSI STSQRISCRP
210 220 230 240 250
ETHTPNNYGN NFFHSSLLTQ KQEVHMREKS FQCNETGEAF NCSSFVRKHQ
260 270 280 290 300
IIHLGEKQYK FDICGKVFNE KRYLARHRRC HTSEKPYKCN ECGKSFSYKS
310 320 330 340 350
SLTCHRRCHT GEKPYKCNEC GKSFSYKSSL TCHHRCHTGE KPYKCNECGK
360 370 380 390 400
SFSYKSSLRC HRRLHTGIKP YKCNECGKMF GQNSTLVIHK AIHTGEKPYK
410 420 430 440 450
CNECGKAFNQ QSHLSRHHRL HTGEKPYKCN DCGKAFIHQS SLARHHRLHT
460 470 480 490 500
GEKSYKCEEC DRVFSQKSNL ERHKIIHTGE KPYKCNECHK TFSHRSSLPC
510 520 530 540 550
HRRLHSGEKP YKCNECGKTF NVQSHLSRHH RLHTGEKPYK CKVCDKAFMC
560 570 580 590
HSYLANHTRI HSGEKPYKCN ECGKAHNHLI DSSIKPCMSS
Length:590
Mass (Da):68,531
Last modified:April 3, 2013 - v2
Checksum:iB2A987979C0574A9
GO

Sequence cautioni

The sequence BAB71051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069167238E → K.1 PublicationCorresponds to variant rs161931dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055946 mRNA. Translation: BAB71051.1. Different initiation.
AK299106 mRNA. Translation: BAG61163.1.
AC010332 Genomic DNA. No translation available.
AC010506 Genomic DNA. No translation available.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72083.1.
CCDSiCCDS54310.1.
RefSeqiNP_001093164.1. NM_001099694.1.
XP_016881791.1. XM_017026302.1.
UniGeneiHs.157287.

Genome annotation databases

EnsembliENST00000421239; ENSP00000459216; ENSG00000258405.
GeneIDi147660.
KEGGihsa:147660.
UCSCiuc002pzp.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055946 mRNA. Translation: BAB71051.1. Different initiation.
AK299106 mRNA. Translation: BAG61163.1.
AC010332 Genomic DNA. No translation available.
AC010506 Genomic DNA. No translation available.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72083.1.
CCDSiCCDS54310.1.
RefSeqiNP_001093164.1. NM_001099694.1.
XP_016881791.1. XM_017026302.1.
UniGeneiHs.157287.

3D structure databases

ProteinModelPortaliQ96N58.
SMRiQ96N58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127070. 6 interactors.
IntActiQ96N58. 9 interactors.
STRINGi9606.ENSP00000459216.

PTM databases

iPTMnetiQ96N58.
PhosphoSitePlusiQ96N58.

Polymorphism and mutation databases

BioMutaiZNF578.
DMDMi476007824.

Proteomic databases

MaxQBiQ96N58.
PaxDbiQ96N58.
PeptideAtlasiQ96N58.
PRIDEiQ96N58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421239; ENSP00000459216; ENSG00000258405.
GeneIDi147660.
KEGGihsa:147660.
UCSCiuc002pzp.5. human.

Organism-specific databases

CTDi147660.
GeneCardsiZNF578.
HGNCiHGNC:26449. ZNF578.
neXtProtiNX_Q96N58.
OpenTargetsiENSG00000258405.
PharmGKBiPA134936072.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiQ96N58.
OMAiCHKIYSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96N58.
TreeFamiTF341892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167556-MONOMER.

Miscellaneous databases

ChiTaRSiZNF578. human.
GenomeRNAii147660.
PROiQ96N58.

Gene expression databases

BgeeiENSG00000258405.
CleanExiHS_ZNF578.
ExpressionAtlasiQ96N58. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN578_HUMAN
AccessioniPrimary (citable) accession number: Q96N58
Secondary accession number(s): B4DR51, I3L1Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.