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Protein

Tetratricopeptide repeat protein 14

Gene

TTC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 14
Short name:
TPR repeat protein 14
Gene namesi
Name:TTC14
Synonyms:KIAA1980
ORF Names:UNQ5813/PRO19630
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24697. TTC14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937037.

Polymorphism and mutation databases

BioMutaiTTC14.
DMDMi42559864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Tetratricopeptide repeat protein 14PRO_0000106399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei671 – 6711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96N46.
MaxQBiQ96N46.
PaxDbiQ96N46.
PRIDEiQ96N46.

PTM databases

iPTMnetiQ96N46.
PhosphoSiteiQ96N46.

Expressioni

Gene expression databases

BgeeiQ96N46.
CleanExiHS_TTC14.
ExpressionAtlasiQ96N46. baseline and differential.
GenevisibleiQ96N46. HS.

Organism-specific databases

HPAiHPA009295.

Interactioni

Protein-protein interaction databases

BioGridi127391. 12 interactions.
IntActiQ96N46. 13 interactions.
MINTiMINT-4138751.
STRINGi9606.ENSP00000296015.

Structurei

3D structure databases

ProteinModelPortaliQ96N46.
SMRiQ96N46. Positions 313-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 20883S1 motifPROSITE-ProRule annotationAdd
BLAST
Repeati210 – 24334TPR 1Add
BLAST
Repeati307 – 34034TPR 2Add
BLAST
Repeati342 – 37433TPR 3Add
BLAST
Repeati382 – 41534TPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi393 – 3964Poly-Glu
Compositional biasi475 – 52551Ser-richAdd
BLAST
Compositional biasi475 – 4839Poly-Ser
Compositional biasi487 – 49711Poly-SerAdd
BLAST
Compositional biasi580 – 5834Poly-Ser

Sequence similaritiesi

Belongs to the TTC14 family.Curated
Contains 1 S1 motif domain.PROSITE-ProRule annotation
Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IGWP. Eukaryota.
ENOG410XQJ7. LUCA.
GeneTreeiENSGT00390000013701.
HOGENOMiHOG000154702.
HOVERGENiHBG059741.
InParanoidiQ96N46.
OMAiEQFMEIP.
OrthoDBiEOG7DNNV3.
PhylomeDBiQ96N46.
TreeFamiTF325777.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR003029. S1_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRDLLRQSL NCHGSSLLSL LRSEQQDNPH FRSLLGSAAE PARGPPPQHP
60 70 80 90 100
LQGRKEKRVD NIEIQKFISK KADLLFALSW KSDAPATSEI NEDSEDHYAI
110 120 130 140 150
MPPLEQFMEI PSMDRRELFF RDIERGDIVI GRISSIREFG FFMVLICLGS
160 170 180 190 200
GIMRDIAHLE ITALCPLRDV PSHSNHGDPL SYYQTGDIIR AGIKDIDRYH
210 220 230 240 250
EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYRRSVELN SNSLESYENV
260 270 280 290 300
MQSSLGFVNP GVVEFLLEKL GIDESNPPSL MRGLQSKNFS EDDFASALRK
310 320 330 340 350
KQSASWALKC VKIGVDYFKV GRHVDAMNEY NKALEIDKQN VEALVARGAL
360 370 380 390 400
YATKGSLNKA IEDFELALEN CPTHRNARKY LCQTLVERGG QLEEEEKFLN
410 420 430 440 450
AESYYKKALA LDETFKDAED ALQKLHKYMQ KSLELREKQA EKEEKQKTKK
460 470 480 490 500
IETSAEKLRK LLKEEKRLKK KRRKSTSSSS VSSADESVSS SSSSSSSGHK
510 520 530 540 550
RHKKHKRNRS ESSRSSRRHS SRASSNQIDQ NRKDECYPVP ANTSASFLNH
560 570 580 590 600
KQEVEKLLGK QDRLQYEKTQ IKEKDRCPLS SSSLEIPDDF GGRSEDPRDF
610 620 630 640 650
YNSYKTQAGS SKTEKPYKSE RHFSSRRNSS DSFCRNSEDK IYGYRRFEKD
660 670 680 690 700
IEGRKEHYRR WEPGSVRHST SPASSEYSWK SVEKYKKYAH SGSRDFSRHE
710 720 730 740 750
QRYRLNTNQG EYEREDNYGE DIKTEVPEED ALSSKEHSES SVKKNLPQNL
760 770
LNIFNQIAEF EKEKGNKSKN
Length:770
Mass (Da):88,319
Last modified:December 1, 2001 - v1
Checksum:i7ACF31418242A6B7
GO
Isoform 2 (identifier: Q96N46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-653: GRSEDPRDFY...YRRFEKDIEG → VYSYLFKKLT...DSGIDDPDHG
     654-770: Missing.

Note: May be due to a competing donor splice site.
Show »
Length:653
Mass (Da):73,826
Checksum:i430508F4CB64C1CD
GO
Isoform 3 (identifier: Q96N46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-770: KSLELREKQA...EKEKGNKSKN → VIPYFLLEI

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):49,735
Checksum:i658C57EFC5BD7995
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei431 – 770340KSLEL…NKSKN → VIPYFLLEI in isoform 3. CuratedVSP_047107Add
BLAST
Alternative sequencei592 – 65362GRSED…KDIEG → VYSYLFKKLTIKQPQAGPSG DIPEEGIVIIDDSSIHVTDP EDLQVGQDMEVEDSGIDDPD HG in isoform 2. 1 PublicationVSP_013480Add
BLAST
Alternative sequencei654 – 770117Missing in isoform 2. 1 PublicationVSP_013481Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055984 mRNA. Translation: BAB71064.1.
AY358762 mRNA. Translation: AAQ89122.1.
AC068298 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78377.1.
BC027990 mRNA. Translation: AAH27990.1.
AB075860 mRNA. Translation: BAB85566.2.
CCDSiCCDS3237.1. [Q96N46-1]
CCDS46963.1. [Q96N46-3]
CCDS75055.1. [Q96N46-2]
RefSeqiNP_001036066.1. NM_001042601.2. [Q96N46-3]
NP_001275511.1. NM_001288582.1. [Q96N46-2]
NP_597719.1. NM_133462.3. [Q96N46-1]
UniGeneiHs.43213.

Genome annotation databases

EnsembliENST00000296015; ENSP00000296015; ENSG00000163728. [Q96N46-1]
ENST00000382584; ENSP00000372027; ENSG00000163728. [Q96N46-2]
ENST00000412756; ENSP00000413743; ENSG00000163728. [Q96N46-3]
ENST00000470669; ENSP00000419562; ENSG00000163728. [Q96N46-3]
GeneIDi151613.
KEGGihsa:151613.
UCSCiuc003fkk.4. human. [Q96N46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055984 mRNA. Translation: BAB71064.1.
AY358762 mRNA. Translation: AAQ89122.1.
AC068298 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78377.1.
BC027990 mRNA. Translation: AAH27990.1.
AB075860 mRNA. Translation: BAB85566.2.
CCDSiCCDS3237.1. [Q96N46-1]
CCDS46963.1. [Q96N46-3]
CCDS75055.1. [Q96N46-2]
RefSeqiNP_001036066.1. NM_001042601.2. [Q96N46-3]
NP_001275511.1. NM_001288582.1. [Q96N46-2]
NP_597719.1. NM_133462.3. [Q96N46-1]
UniGeneiHs.43213.

3D structure databases

ProteinModelPortaliQ96N46.
SMRiQ96N46. Positions 313-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127391. 12 interactions.
IntActiQ96N46. 13 interactions.
MINTiMINT-4138751.
STRINGi9606.ENSP00000296015.

PTM databases

iPTMnetiQ96N46.
PhosphoSiteiQ96N46.

Polymorphism and mutation databases

BioMutaiTTC14.
DMDMi42559864.

Proteomic databases

EPDiQ96N46.
MaxQBiQ96N46.
PaxDbiQ96N46.
PRIDEiQ96N46.

Protocols and materials databases

DNASUi151613.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296015; ENSP00000296015; ENSG00000163728. [Q96N46-1]
ENST00000382584; ENSP00000372027; ENSG00000163728. [Q96N46-2]
ENST00000412756; ENSP00000413743; ENSG00000163728. [Q96N46-3]
ENST00000470669; ENSP00000419562; ENSG00000163728. [Q96N46-3]
GeneIDi151613.
KEGGihsa:151613.
UCSCiuc003fkk.4. human. [Q96N46-1]

Organism-specific databases

CTDi151613.
GeneCardsiTTC14.
H-InvDBHIX0003886.
HGNCiHGNC:24697. TTC14.
HPAiHPA009295.
neXtProtiNX_Q96N46.
PharmGKBiPA134937037.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWP. Eukaryota.
ENOG410XQJ7. LUCA.
GeneTreeiENSGT00390000013701.
HOGENOMiHOG000154702.
HOVERGENiHBG059741.
InParanoidiQ96N46.
OMAiEQFMEIP.
OrthoDBiEOG7DNNV3.
PhylomeDBiQ96N46.
TreeFamiTF325777.

Miscellaneous databases

ChiTaRSiTTC14. human.
GenomeRNAii151613.
NextBioi86737.
PROiQ96N46.

Gene expression databases

BgeeiQ96N46.
CleanExiHS_TTC14.
ExpressionAtlasiQ96N46. baseline and differential.
GenevisibleiQ96N46. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR003029. S1_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-770 (ISOFORM 1).
    Tissue: Brain.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTC14_HUMAN
AccessioniPrimary (citable) accession number: Q96N46
Secondary accession number(s): G5E9X0, Q6UWJ7, Q8TF22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.