ID   ZN714_HUMAN             Reviewed;         554 AA.
AC   Q96N38; Q49AI1; Q86W65; Q8ND40;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 3.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Zinc finger protein 714;
GN   Name=ZNF714;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-331.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-331.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP   ARG-331.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q96N38-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96N38-2; Sequence=VSP_033320, VSP_033321;
CC       Name=3;
CC         IsoId=Q96N38-3; Sequence=VSP_033319;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH50468.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAD39077.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK056006; BAB71072.1; -; mRNA.
DR   EMBL; AL834415; CAD39077.1; ALT_INIT; mRNA.
DR   EMBL; AC010620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC037782; AAH37782.1; -; mRNA.
DR   EMBL; BC050468; AAH50468.2; ALT_INIT; mRNA.
DR   RefSeq; NP_872321.2; NM_182515.3.
DR   AlphaFoldDB; Q96N38; -.
DR   SMR; Q96N38; -.
DR   BioGRID; 127129; 16.
DR   IntAct; Q96N38; 4.
DR   STRING; 9606.ENSP00000478345; -.
DR   iPTMnet; Q96N38; -.
DR   PhosphoSitePlus; Q96N38; -.
DR   BioMuta; ZNF714; -.
DR   DMDM; 527504073; -.
DR   jPOST; Q96N38; -.
DR   MassIVE; Q96N38; -.
DR   PaxDb; 9606-ENSP00000478345; -.
DR   PeptideAtlas; Q96N38; -.
DR   ProteomicsDB; 77461; -. [Q96N38-1]
DR   ProteomicsDB; 77462; -. [Q96N38-2]
DR   ProteomicsDB; 77463; -. [Q96N38-3]
DR   Pumba; Q96N38; -.
DR   DNASU; 148206; -.
DR   GeneID; 148206; -.
DR   KEGG; hsa:148206; -.
DR   AGR; HGNC:27124; -.
DR   CTD; 148206; -.
DR   GeneCards; ZNF714; -.
DR   HGNC; HGNC:27124; ZNF714.
DR   neXtProt; NX_Q96N38; -.
DR   PharmGKB; PA143485680; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q96N38; -.
DR   OrthoDB; 3120079at2759; -.
DR   PhylomeDB; Q96N38; -.
DR   TreeFam; TF342117; -.
DR   PathwayCommons; Q96N38; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q96N38; -.
DR   BioGRID-ORCS; 148206; 19 hits in 1079 CRISPR screens.
DR   ChiTaRS; ZNF714; human.
DR   GenomeRNAi; 148206; -.
DR   Pharos; Q96N38; Tdark.
DR   PRO; PR:Q96N38; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q96N38; Protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24404:SF41; ZINC FINGER PROTEIN 835; 1.
DR   Pfam; PF00096; zf-C2H2; 12.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..554
FT                   /note="Zinc finger protein 714"
FT                   /id="PRO_0000331749"
FT   DOMAIN          1..47
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         116..138
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         144..166
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         172..194
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         200..222
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         256..278
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         284..306
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         424..446
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..474
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         480..502
FT                   /note="C2H2-type 14; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         1..154
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033319"
FT   VAR_SEQ         516..523
FT                   /note="RGLGEQIA -> GGQGRWIT (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_033320"
FT   VAR_SEQ         524..554
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_033321"
FT   VARIANT         331
FT                   /note="K -> R (in dbSNP:rs2884554)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT                   /id="VAR_042936"
FT   VARIANT         472
FT                   /note="I -> V (in dbSNP:rs10427116)"
FT                   /id="VAR_057448"
FT   VARIANT         473
FT                   /note="I -> V (in dbSNP:rs10427116)"
FT                   /id="VAR_042937"
FT   CONFLICT        102
FT                   /note="Y -> YN (in Ref. 1; BAB71072, 2; CAD39077 and 4;
FT                   AAH50468)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        513
FT                   /note="N -> S (in Ref. 2; CAD39077)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   554 AA;  63883 MW;  09150D7B5CF383C4 CRC64;
     MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC SSFTRDLWPE
     QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK GYELNQCLTT TQSKIFPCDK
     YIKVFHKIFN SNRHKTRHTG EKPFKCKKCD ESFCMLLHLH QHKRIHIREN SYQCEECDKV
     FKRFSTLTRH KRVHTGEKPF KCEECGKAFK HSSTLTTHKM IHTGEKPYRC EECGKAFYHS
     SHLTTHKVIH TGEKPFKCEE CGKAFNHPSA LTTHKFIHVK EKPYKCEECD KAFNRFSYLT
     KHKIIHSGEK SYKCEQCGKG FNWSSTLTKH KRIHTGEKPY KCEECGKAFN VSSHLTTHKM
     IHTGEKPYKC EECGKAFNHS SKLTIHKIIH TGEKPYKCEE CGKAFNQSSN LTKHKIIHTG
     EKLYKCEECG KAFNRSSNLT THKRIHTGEK PYKCEECGKA FNRSSNLTKH NIIHTGEKSY
     KCEECGKAFN QSSTLTKHRK IQQGMVAHAC NPNTLRGLGE QIARSGVQDQ PGQHGKTPSL
     LKIQKFAGCG GRRL
//